在研项目：

国自然面上项目     外泌体miR-21介导上皮-中性粒细胞cross-talk在牙周感染影响气道炎症的作用机制研究      

重要学术论文：

1.    Yang Y, Guo J, Zhou X, Liu Z, Wang C,Wang K, Zhang J, Wang Z. A novel cold atmospheric pressure air plasma jet forperi-implantitis treatment: An in vitro study. Dental Materials Journal. 2018, 37(1):157-166.(IF：1.073)

2.     ZhangZ, Zhao D, Lin M, Zhang D, Bai R, Fan J, Wang Z. Application of health quotientto enhance chronic periodontitis treatments. Patient Preference and Adherence.2018;12:359-362.(IF：1.798)        

3.      Zhao Q, Hu Y, Deng S, Yu P, Chen B, WangZ, Han X. Cytidine-phosphate-guanosine oligodeoxynucleotides in combinationwith CD40 ligand decrease periodontal inflammation and alveolar bone loss in aTLR9-independent manner. Journal of Applied Oral Science. 2018;26:e20170451. (IF：1.342)

4.     Zhao W, Ma X, Liu L, Chen Q, Liu Z, ZhangZ, Ma S, Wang Z, Li H*, Wang Z*, WuJ*. SNHG20: A vital lncRNA in multiple human cancers. J Cell Physiol. 2019;234(9): 14519-14525. (IF:3.923)

5.    Han J, Cheng C, Zhu Z, Lin M, Zhang DX, Wang ZM, Wang SL*. Vitamin D alleviates serum inflammatory cytokinesin rat models with periodontitis and chronic obstructive pulmonary disease. JOral Sci. 2019;61(1):53-60. (IF:0.853)

6.    ZhaoQ, Wang SB, Xu G, Song Y, Han X, Liu Z, Zhou X, Zhang T, Huang K, Yang T, LinY, Wu S, Wang Z, Wang C. Periodontalhealth: a national cross-sectional study of knowledge, attitudes and practicesfor the public oral health strategy in China. J Clin Periodontol. 2019;46(4):406-419.(IF:7.478)

7.    Zhou X*, Lin M, Zhang D, Song Y, Wang Z. Efficacy of Er:YAG laser on periodontitis as an adjunctivenon-surgical treatment: a split-mouth randomized controlled study. Journal ofClinical Periodon6(5):539-547. (IF:7.478)

8.    WuJ, Qi X, Liu L, Hu X, Liu J, Yang J, Yang J, Lu L, Zhang Z, Ma S, Li H, Yun X,Sun T, Wang Y, Wang Z*, Liu Z*, ZhaoW*. Emerging Epigenetic Regulation of Circular RNAs in Human Cancer. Mol TherNucleic Acids. 2019 Jun 7; 16: 589–596. (IF:5.660)

9.    WangH, Li W, Zhang D, Li W, Wang Z.Adjunctive photodynamic therapy improves the outcomes of peri-implantitis: arandomized controlled trial. Aust Dent J. 2019 Sep;64(3):256-262. (IF:1.494)

10.  Zhang Z, Li X, Zhao J, Jia W, Wang Z.Effect of autogenous growth factors released from platelet concentrates on theosteogenic differentiation of periodontal ligament fibroblasts: a comparative study.PeerJ. 2019 Oct 31;7:e7984. doi: 10.7717/peerj.7984. eCollection 2019. (IF: 2.353)

11.  Zhang Z, Yuan W, Deng J, Wang D, Zhang T, PengL, Tian H, Wang Z*, Ma J*. Granulocyte colony stimulating factor (G-CSF)regulates neutrophils infiltration and periodontal tissue destruction in anexperimental periodontitis. Molecular Immunology. 2020;117:110-121 (IF: 3.064)

12.  Zhao W, Cui Y, Liu L, Qi X, Liu J, Ma S,Hu X, Zhang Z, Wang Y, Li H, Wang Z*, Liu Z*, Wu J*. Splicing factorderived circular RNA circUHRF1 accelerates oralsquamous cell carcinomatumorigenesis via feedback loop. Cell Death Differ. 2020 Mar;27(3):919-933. (IF:8.086)doi: 10.1038/s41418-019-0423-5

13.  Lin M, Li X, Wang J, Cheng C, Zhang T, HanX, Song Y, Wang Z*, Wang S*. Saliva Microbiome Changes in Patients withPeriodontitis with and without Chronic Obstructive Pulmonary Disease. FrontCell Infect Microbiol. 2020 Apr 15;10:124. doi: 10.3389/fcimb.2020.00124. (IF:3.518)

14.  Gao W, Tang H, Wang D, Zhou X, Song Y, WangZ*. Effect of short-term vitamin D supplementation after nonsurgicalperiodontal treatment: A randomized, double-masked, placebo-controlled clinicaltrial. J Periodont Res. 2020; 55(3):354-362. doi: 10.1111/jre.12719. (IF:2.613) 

15. Zhou X*, Wang J, Liu W, Huang X, Song Y, Wang Z, Jia X.Periodontal Status and Microbiologic Pathogens in Patients with ChronicObstructive Pulmonary Disease and Periodontitis: A Case-Control Study. Int JChron Obstruct Pulmon Dis. 2020;15:2071-2079. doi: 10.2147/COPD.S266612.(IF: 2.772)

16.  LiW, Zhang Z, Wang ZM*. Differential immune cell infiltrations between healthyperiodontal and chronic periodontitis tissues. BMC Oral Health. 2020 Oct27;20(1):293. doi: 10.1186/s12903-020-01287-0. (IF:1.911)

17.  Wu P#, Hu L#, Li H,Feng L, Liu Y, Zhang S, Li XC, Zhang ML, Yang SY, Lu RJ. Clinical applicationand accuracy analysis of 3D printing guide plate based on polylactic acid inmandible reconstruction with fibula flap. Ann Transl Med. 2021 Mar;9(6):460.doi: 10.21037/atm-20-6781. (IF： 3.932)

18.  Yu H, Zhang T, Lu H, Ma Q,Zhao D, Sun J*, Wang Z*. Granulocyte colony-stimulating factor (G-CSF)mediates bone resorption in periodontitis. BMC Oral Health. 2021 Jun 12;21(1):299.doi: 10.1186/s12903-021-01658-1.(IF：2.757)

19. Zhang D, Liu W, Miao R, Wang L, Zhou X, Wang H, Li Y, Wang Z*.Chronic Periodontitis is a Risk Factor of Renal Dysfunction in Patients withType 2 Diabetes. Exp Clin Endocrinol Diabetes. 2021 Jun;129(6):407-412. doi: 10.1055/a-0895-5275. (IF:2.949)

20.  Wang P, Wang B, Zhang Z, WangZ*. Identification of inflammation-related DNA methylation biomarkers inperiodontitis patients based on weighted co-expression analysis. Aging (AlbanyNY). 2021 Aug 4;13(15):19678-19695. doi: 10.18632/aging.203378. (IF:5.682)

21.  Wang L#, Zhang T#, Zhang Z,Wang Z, Zhou YJ*, Wang Z*. B cell activating factor regulatesperiodontitis development by suppressing inflammatory responses in macrophages.BMC Oral Health. 2021 Sep 4;21(1):426. doi: 10.1186/s12903-021-01788-6. (IF：2.757)

22.  Wang P, Tian H, Zhang Z*, Wang Z*.EZH2 Regulates Lipopolysaccharide-Induced Periodontal Ligament Stem CellProliferation and Osteogenesis through TLR4/MyD88/NF-κB Pathway. Stem CellsInt. 2021 Dec 1;2021:7625134. doi: 10.1155/2021/7625134. (IF:5.443)

23.  Wang H, Liu Y, Li W, Li W, Xu H, Niu G*, WangZ*. Microbiota in Gingival Crevicular Fluid Before and After MechanicalDebridement With Antimicrobial Photodynamic Therapy in Peri-Implantitis. FrontCell Infect Microbiol. 2022 Jan 7;11:777627. doi: 10.3389/fcimb.2021.777627. (IF:6.073)

24.  Zhang D, Liu W, Peng L, Wang H, Lin M, LiY*, Wang Z*. Difference in oral microbial composition between chronicperiodontitis patients with and without diabetic nephropathy. BMC Oral Health.2022 Jan 16;22(1):12. doi: 10.1186/s12903-021-01985-3. (IF: 3.918)

25.  Li W, Zhang Z, Li Y, Wang Z*.Abnormal hsa_circ_0003948 expression affects chronic periodontitis developmentby regulating miR-144-3p/NR2F2/PTEN signaling. J Periodontal Res. 2022Apr;57(2):316-323. doi: 10.1111/jre.12961. (IF: 3.946)

26.  Gao X#, Zhao D#, HanJ, Zhang Z*, Wang Z*. Identification of microRNA-mRNA-TF regulatory networks inperiodontitis by bioinformatics analysis. BMC Oral Health. 2022 Apr9;22(1):118. doi: 10.1186/s12903-022-02150-0.  (IF: 3.918)

27.  Qiao D#, LiY#, Pan J*,Zhang J*, Tian Y, Wang K. Effect of Plasma Activated Water in CariesPrevention: The Caries Related Biofilm Inhibition Effects and Mechanisms.Plasma Chem Plasma Process 2022 ;42: 801–814. (IF：3.337)

28.  Zhang Z, Zheng Y, Bian X, Wang M, Chou J,Liu H*, Wang Z*. Identification of Key Genes and Pathways Associatedwith Oxidative Stress in Periodontitis. Oxid Med Cell Longev. 2022 Sep13;2022:9728172. doi: 10.1155/2022/9728172. (IF:7.31)

29.  Tian H, Zhang Z, Wang X, Liu W, Wang Z*.Role of experimental periodontitis in inducing pulmonary inflammation in mice.Oral Dis. 2022 Nov;28(8):2294-2303. (IF：4.068)

30.  Zhang D, Zhao C, Liu Z, Ding Y, Li W, YangH, Wang Z*, Li Y*. Relationship between periodontal status and dyslipidemia inpatients with type 2 diabetic nephropathy and chronic periodontitis: Across-sectional study. J Periodontal Res. 2022 Oct;57(5):969-976. doi:10.1111/jre.13033. (IF: 3.946)

31.  Sheng C#, Guo X#, Wan Z, Bai X, Liu H,Zhang X, Zhang P, Liu Y, Li W*, Zhou Y*, Lv L*. Exosomes derived fromhuman adipose-derived stem cells ameliorate osteoporosis throughmiR-335-3p/Aplnr axis. Nano Research. 2022;15(10) :9135-9148.doi.org/10.1007/s12274-022-4554-5. (IF：10.269)

32.  Wang K, Zhang Z, Wang Z. Assessment of theassociation between periodontal disease and total cancer incidence andmortality: a meta-analysis. PeerJ. 2022 Nov 7;10:e14320. doi:10.7717/peerj.14320. (IF:3.061)

33.  Yang X, Sun K, Zhu W, Li Y*, Pan J*.Time-dependent efficacy and safety of tooth bleaching with cold plasma andH2O2 gel. BMC Oral Health. 2022 Nov 24;22(1):535. doi:10.1186/s12903-022-02601-8.  (IF: 3.918)

34. Liu Z, Gao X, Liang L, Zhou X, HanX, Yang T, Huang K, Lin Y, Deng S, Wang Z*, Wang C*. Prevalence, General andPeriodontal Risk Factors of Gastroesophageal Reflux Disease in China. J InflammRes. 2023 Jan 17;16:235-244. doi: 10.2147/JIR.S395777. (IF:4.631)

35. Gao X, Guo Z, Wang P, Liu Z* andWang Z*. Transcriptomic analysis reveals the potential crosstalk genes andimmune relationship between IgA nephropathy and periodontitis. Front. Immunol.2023;14:1062590. doi: 10.3389/fimmu.2023.1062590  (IF:8.786)

著作：

《口腔激光治疗临床应用指南》  主译   河南科学技术出版社   202102

《口腔内科学》 主编   科学出版社   202212

医疗卫生蓝皮书《中国口腔健康发展报告（2022）老年人口腔健康状况》  202302

《口腔激光疗法》 副主编  人民卫生出版社   201609

重要奖项：

牙周炎与慢性阻塞性肺疾病相关关系的临床与基础研究    中华口腔医学会科技奖    三等奖   201609

本科课程《口腔科学B》    首都医科大学“课程思政”示范课     202212

团体标准：《Nd:YAG激光口腔临床应用规范》、《无光纤Er：YAG激光口腔临床应用规范》

专家共识：《慢性气道疾病患者口腔健康管理及诊疗风险防范专家共识（2022版）》

获批及申请6项国家专利，其中1项《一种预成牙冠及其制备工艺》专利成功转化