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主任医师，教授，博士生导师。首都医科大学宣武医院神经内科神经肌肉病组主任。 擅长各种神经肌肉病的诊断和治疗。国际首次报道新型遗传性包涵体肌病家系和周期性麻痹新的治疗方法；报道首个中国人ALS8家系和全球第三个肢带型肌营养不良D3型家系；首次发现并报道环境因素与重症肌无力全身型转化相关。
2007-2009年曾先后在德国乌尔姆大学和美国罗切斯特大学神经肌病中心作高级访问学者。现任中华医学会神经病学分会神经肌病学组委员，国家周围神经病规范诊治培训中心委员及分中心主任，肌萎缩侧索硬化协作组委员；中国神经科学学会神经免疫学分会委员；中国罕见病联盟神经系统罕见病专业委员会委员；中国医疗保健国际交流促进会神经病学分会委员；北京神经内科学会神经肌肉与遗传专业副主任委员。
主要从事神经肌肉病的临床病理研究和重症肌无力的临床与基础研究。承担科技部十三五“精准医学”重点研发专项1项，建立起我国首个多中心重症肌无力队列；承担和参与国家自然科学基金等各级课题10 余项。近5年在国际知名杂志Neurology等发表SCI论文30余篇，参编高等医科学校教材2部。
宣武医院神经内科是中华医学会神经病学分会神经肌肉病组成员单位，具备独立的周围神经肌肉病理实验室，目前能够开展肌肉病理常规组化染色和免疫组织化学染色，神经活检的石蜡和半薄染色、皮肤组织病理常规化染色和免疫组织化学染色等。年神经肌肉活检的总例数200余例，在全国处于领先水平。目前团队共有固定成员12人，其中医生9人，技术员2人，科研助理1人；在读学生团队8人，其中博士5人，硕士3人。
2017.7-2021.12国家重点研发计划项目“神经系统疾病专病队列研究”子课题“重症肌无力临床队列研究”建立了全国多中心的重症肌无力临床患者专病数据库、样本库及随访体系；2022.01-2025.12国自然面上项目“知识图谱驱动的重症肌无力患者个体化治疗方案推荐的方法研究”，构建重症肌无力知识图谱，进而借助结构化的专病数据库和专病知识图谱辅助数据处理，完成OCT训练MG个性化用药决策树模型；最终实现MG患者的个性化用药推荐。
在研项目：国自然面上项目-知识图谱驱动的重症肌无力患者个体化治疗方案推荐的方法研究
在神经肌肉病领域做了较多的探索，并建立起我国首个多中心前瞻性MG队列，已收集2300余例患者。
代表性论文：
1. Qi Wen, Wenjia Zhu, XinmeiWen, Shu Zhang, Yanan Sun , Yun Li, Jingsi Wang, Yaye Wang, Jianying Duo , YueHuang, Yan Lu, Li Di, Min Xu , Min Wang, Hai Chen , Yuwei Da, A synonymouscodon variant altering splicing of RBCK1 expands the phenotype and genotypespectra of polyglucosan body myopathy 1, Clin Genet,2023 Sep;104(3):387-389.
2. Zhirong Fan , Lin Lei , Shengyao Su , Shu Zhang , Nairong Xie , Ling Li, Yan Lu , Li Di , Min Wang , Min Xu , Xin-Ming Shen , Yuwei Da ,Comparisonbetween mono-tacrolimus and mono-glucocorticoid in the treatment of myastheniagravis，AnnClin Transl Neurol 2023 Apr;10(4):589-598.
3. 3. Li Di, Faxiu Shen, Xinmei Wen, Yan Lu, WenjiaZhu, MinWang and Yuwei Da*, A RandomizedOpen-Labeled Trial ofMethotrexate as a Steroid-Sparing Agent for Patients With GeneralizedMyasthenia Gravis, FrontImmunol, published: 18 March 2022,doi: 10.3389/fimmu.2022.839075.
4. 4. Shengyao Su, LinLei,Zhirong Fan, Shu Zhang, Qi Wen, Jingsi Wang, Yan Lu, Li Di, Min Wang, HaiChenand Yuwei Da*，Clinical Predictorsof Relapse in a Cohort of Steroid-TreatedPatients With Well-ControlledMyasthenia Gravis，Front Neurol, doi:10.3389/fneur.2022.816243.
5. 5. Shu Zhang,LinLei, Zhirong Fan, Shengyao Su, JianyingDuo, QinrongLuan, Yan Lu, LiDi, Min Wang and Yuwei Da* . DelayedRespiratory Insufficiencyand Extramuscular Abnormalities in SelenoproteinN-Related Myopathies，Front Neurol, 2021Nov19;12:766942.doi: 10.3389/fneur.2021.766942. eCollection 2021.
6. 4.Xinmei Wen, Wenjia Zhu,NanL. Xia, Qianwen Li , Li Di, Shu Zhang, Hai Chen,Yan Lu, Min Wang, MinXu,Suobin Wang, Xin-Ming Shen, Jie Lu* and Yuwei Da*.MissenseMutations of Codon 116 in theSOD1 Gene Cause Rapid Progressive Familial ALS andPredict Short Viability WithPMA Phenotype, frontiers in genetics, 12 November2021,doi:10.3389/fgene.2021.776831.
7. 5. LinLei, Zhirong Fan,Shengyao Su, Min Xu, Hai Chen, Wenjia Zhu, Qinrong Luan,Yuwei Da, Involvementof Ocular Musclers in Patients With Myasthenia GravisWith Nonocular Onset, JNeuroophthalmol2021;doi:10.1097/WNO.0000000000001325.online ahead of print.
8. 6. ZhirongFan, DeqiangZheng, Xinmei Wen, Faxiu Shen, Lin Lei, Shengyao Su, Shu Zhang,Qing Liu,Xueping Zhang, Yan Lu, Li Di, Xin-Ming Shen, Yuwei Da,* CYP3A5*3polymorphismand age affect tacrolimus blood trough concentration in myastheniagravispatients, JNeuroimmunol,2021,15;355:577571.doi:10.1016/j.jneuroim.2021.577571. Epub2021 Apr 9.
9. 7. Shengyao Su, Qing Liu, Xueping Zhang, Xinmei Wen, Lin Lei, Faxiu Shen, Zhirong Fan, Jianying Duo, Yan Lu, Li Di, Min Wang, Hai Chen, Wenjia Zhu, Min Xu, Suobin Wang, Yuwei Da*,VNTR2/VNTR3 genotype in the FCGRT gene isassociated with reduced effectivenessof intravenous imunoglobulin in patientswith myasthenia gravis,Ther Adv NeurolDisord, 2021,13:1-11.
10. 8.Lin Lei, Hai Chen, Yan Lu, Wenjia Zhu, Yasheng Ouyang, Jianying Duo, Zhiguo Chen, Yuwei Da#. Unusualelectrophysiological findings in a Chinese ALS 4 family withSETX-L389Smutation: a three-year follow-up, J Neurol. 2021,268(3):1050-1058.
11. 9. DiL, Chen H, Lu Y, Selcen D, Engel AG, Da Y#, Shen XM. Determinantsof the repetitive-CMAP occurrence and therapyefficacy in slow-channel myasthenia. Neurology. 2020,95(20):e2781- e2793.
12. 10. ZhirongFan, Zunbo Li, Faxiu Shen, Xueping Zhang, Lin Lei,Shengyao Su, Yan Lu, Li Di,Min Wang, Min Xu, Yuwei Da*. Favorable effects oftacrolimus monotherapy on myastheniagravis patients. Frontiers inneurology2020;11:594152.
13. 11. Sun Y,Chen H,Lu Y,Duo J,Lei L,OuYang Y,Hao Y,Da Y*,Shen XM.Limbgirdle muscular dystrophy D3 HNRNPDL related in a Chinese family withdistalmuscle weakness caused by a mutation in the prion-like domain, J Neurol. 2019,266(2):498-506.
14. 12. Lu Y, Da YW*, ZhangYB, Li XG, Wang M, Di L, Pang M, Lei L. Identification of the CFTR c.1666A>G Mutation inHereditary InclusionBody Myopathy Using Next-Generation Sequencing Analysis. FrontNeurosci. 2018 ,12: 329.
15. 13.Min Xu,David L HBennett,Luis Antonio Querol,Long-Jun Wu,Sarosh R Irani,James C Watson,Sean JPittock,Christopher J Klein，Pain and the immune system:emerging concepts of IgG-mediated autoimmunepain and immunotherapies，J Neurol NeurosurgPsychiatry ，2018-Sep-17 ，2018,0，1-12.
16. 14.Min Xu, Marcus Pinto,Chenjing Sun, Janean K Engelstad, PJames Dyck, Peter J Dyck, Christopher JKlein ，Expandedteased nerve fibre pathologicalconditions in disease association.，J Neurol Neurosurg Psychiatry，2018，0,1-3.
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