所带领的团队为北京市唯一1家产前超声筛查考核培训基地，首批北京市超声远程会诊中心、北京市产前超声诊断会诊中心、妇产科超声国际合作基地。培养硕、博士研究生50余名，发表文章约200篇。通过采用“请进来”“走出去”的方式，培养团队成员短期和中长期到美国、英国等培训几十人次，拓宽视野。年轻医生获得北京市科技新星、青苗人才、国家自然科学基金、北京市自然科学基金项目、发明专利等。团队成绩在全国妇产科超声及胎儿出生缺陷研究位居前列。培养的博士生已经有3名成为了硕士生导师。

       建立胎儿出生缺陷数据库，创建胎儿出生缺陷超声产前诊断远程会诊平台，深入开展胎儿结构畸形及先心病遗传学研究，开展国际合作与交流项目，培养多名学科骨干人员，建立高层次产前超声诊断梯队。培养临床科研能力及创新能力强的学术人才。大力开展科技创新项目，将胎儿医学影像与医工交叉人工智能结合开展科研及创新项目研究，开发孕早期超声筛查胎儿染色体异常综合征的风险计算器及专利产品。主办国内国际学术会议，加强与国际专家交流和合作。建立出生缺陷人口队列-先天性心脏病围孕期危险因素研究，在出生缺陷防控研究方面在本领域达到国内一流水平。

1.国家重点研发计划生育健康及妇女儿童健康保障专项，2022YFC2703300，“常见早孕期超声异常的临床队列建设、染色体及单基因变异诊断新技术和临床干预研究” 2022/12-2025/11,1690.5万元，在研，主持

2.国家自然科学基金委员会，面上项目，81971619，基于超声影像组学技术的孕早期胎儿神经系统畸形预测模型研究，2020/01-2023/12，55万元，在研，主持 

一、重要论文（近5年）

[1] Sun L, Guo C, Yao L, Zhang T, Wang J, Wang L, Liu Y, Wang K, Wang L, Wu Q#. Quantitative diagnostic advantages of three-dimensional ultrasound volume imaging for fetal posterior fossa anomalies: Preliminary establishment of a prediction model. Prenat Diagn. 2019;39(12):1086-1095.

[2] Li Z, Li C, Liang Y, Wang K, Zhang W, Chen R, Wu Q#, Zhang X#. Altered Functional Connectivity and Brain Network Property in Pregnant Women With Cleft Fetuses. Front Psychol. 2019;10:2235.

[3] Ma Y, Pei Y, Yin C, Jiang Y, Wang J, Li X, Li L, Kagan KO, Wu Q#. Subchromosomal anomalies in small for gestational-age fetuses and newborns. Arch Gynecol Obstet. 2019;300(3):633-639.

[4] Liu D, Gu X, Liu F, Shi F, Yang M, Wu Q#. Application of contrast-enhanced ultrasound for scar pregnancy cases misdiagnosed as other diseases. Clin Chim Acta. 2019;496:134-139.

[5] Hao Y, Li SJ, Zheng P, Wu X, Sheng J, Yuan DL, Zhou Q, Wei W, Duan AH, Wu QQ#, Lu D#. Intraoperative ultrasound-assisted enucleation of residual fibroids following laparoscopic myomectomy. Clin Chim Acta. 2019;495:652-655.

[6] Liu Y, Wang L, Yang YK, Liang Y, Zhang TJ, Liang N, Yang LM, Li SJ, Shan D, Wu QQ#. Prenatal diagnosis of fetal skeletal dysplasia using targeted next-generation sequencing: an analysis of 30 cases. Diagn Pathol. 2019;14(1):76.

[7] Zhang L, Han J, Zhang N, Li Z, Wang J, Xuan Y, Kagan KO, Wu Q#, Sun L#. Assessment of fetal modified myocardial performance index in early-onset and late-onset fetal growth restriction. Echocardiography. 2019;36(6):1159-1164.

[8] Liu Y, Wang L, Xu B, Yang Y, Shan D, Wu Q#. X-linked dominant chondrodysplasia punctata with severe phenotype in a female fetus: A case report. Medicine (Baltimore). 2019;98(1):e13850.

[9] Yue S, Xuan Y, Wang J, Yang L, An Y, Wu Q#. Study on the Effects of Potential Affecting Factors on the Midurethral Volume by High-Frequency 3-Dimensional Transvaginal Ultrasound. J Ultrasound Med. 2020;39(8):1633-1638.

[10] Sun L, Zhang L, Zhang N, Han J, Li Z, Zhang T, Yao L, Ma Y, Wang L, Liu Y, Guo C, Wu Q#. Evaluation of Hemodynamic Changes in Fetuses With Isolated Mild-to-Moderate Ventriculomegaly by Transabdominal Ultrasound. J Ultrasound Med. 2020;39(3):453-461.

[11] He P, Wang JJ, Duan W, Song C, Yang Y, Wu QQ#. Estimating the risk of malignancy of adnexal masses: validation of the ADNEX model in the hands of nonexpert ultrasonographers in a gynaecological oncology centre in China. J Ovarian Res. 2021;14(1):169.

[12] Xia TH*, Tan M*, Li JH, Wang JJ, Wu QQ#, Kong DX#. Establish a normal fetal lung gestational age grading model and explore the potential value of deep learning algorithms in fetal lung maturity evaluation. Chin Med J (Engl). 2021;134(15):1828-1837.

[13] Sun Y*, Zhang L*, Dong D*, Li X, Wang J, Yin C#, Poon LC#, Tian J#, Wu Q#. Application of an individualized nomogram in first-trimester screening for trisomy 21. Ultrasound Obstet Gynecol. 2021;58(1):56-66.

[14] Meng X, Han J, Wang L, Wu Q#. Aortic dissection during pregnancy and postpartum. J Card Surg. 2021;36(7):2510-2517.

[15] Kang L, Wu QQ#, Sun LJ, Gao FY, Wang JJ. Predicting fetal weight by three-dimensional limb volume ultrasound (AVol/TVol) and abdominal circumference. Chin Med J (Engl). 2021;134(9):1070-1078.

[16] Wang W*, Zhang M*, Gong L, Wu Q#. Necrotizing funisitis and calcification of umbilical vein: case report and review. BMC Pregnancy Childbirth. 2021;21(1):296.

[17] Sun L, Wang J, Su X, Chen X, Zhou Y, Zhang X, Lu H, Niu J, Yu L, Sun C, Zhang W, Han J, Zhang L, Wang Z, Chen P, Chen T, Hong H, Zhou L, Ye B, Guo W, Zhao W, Zhang N, Li Z, Zhao S, Wu Q#, Tian J#, Jiang Y#. Reference ranges of fetal heart function using a Modified Myocardial Performance Index: a prospective multicentre, cross-sectional study. BMJ Open. 2021;11(7):e049640.

[18] Su F, Zhang X, Han J, Wang J, Li L, Kong D, Wu Q#. Application of computer-aided diagnosis of congenital heart disease in four-chamber view of fetal heart basic screening. Chin Med J (Engl). 2022;135(24):3010-3012.

[19] Feng L, Sun L, Wang J, Sun C, Lu L, Zhang Z, Hu Y, Wu Q#. Qualitative and quantitative study of fetal posterior fossa during the first trimester in a Chinese population. BMC Pregnancy Childbirth. 2022;22(1):760.

[20] Yang K, Liu Y, Wu J, Zhang J, Hu HY, Yan YS, Chen WQ, Yang SF, Sun LJ, Sun YQ, Wu QQ#, Yin CH#. Prenatal Cases Reflect the Complexity of the COL1A1/2 Associated Osteogenesis Imperfecta. Genes (Basel). 2022;13(9):1578.

[21] Li Z, Li C, Liang Y, Wang K, Wang L, Zhang X#, Wu Q#. Anomalous cerebral morphology of pregnant women with cleft fetuses. Front Hum Neurosci. 2022;16:959710.

[22] Zhang L#, Dong D#, Sun Y#, Hu C, Sun C#,Sun C, Wu Q#, Tian J#. Development and Validation of a Deep Learning Model to Screen for Trisomy 21 During the First Trimester From Nuchal Ultrasonographic Images. JAMA Netw Open. 2022;5(6):e2217854.

[23] Song S, Wang J, Wang L, Wu Q#. Visualisation of the fetal uvula on three-dimensional ultrasonography. Aust N Z J Obstet Gynaecol. 2022;62(3):E6-E8.

[24] Li X, Xuan Y, Wang J, Wang L, Papageorghiou AT, Wu Q#. Crown-Rump Length Discordance, Increased Nuchal Translucency, and Detection of Fetal Structural Anomalies in Twin Pregnancies in the First Trimester: 5 Years of Experience in a Tertiary Hospital in China. J Ultrasound Med. 2022;41(4):971-982.

[25] Song S, Wang J, Han J, Xuan Y, Zhi W, Wu Q#. A case report of serpentine-like syndrome and review of literature. BMC Pregnancy Childbirth. 2022;22(1):181.

[26] Sun Y*, Zhang M*, Liu R, Wang J, Yang K, Wu Q#, Yue W#, Yin C#. Protective Effect of Maternal First-Trimester Low Body Mass Index Against Macrosomia: A 10-Year Cross-Sectional Study. Front Endocrinol (Lausanne). 2022;13:805636.

[27] Wang J, Han J, Li L, Wang L, Wu Q#. Retrospective analysis of 2054 cases from 24 hospitals underwent ultrasonic consultation in a tertiary prenatal diagnosis center in Beijing, China. J Clin Ultrasound. 2023;51(1):66-71.

[28] Zhang S, Wang J, Han J, Wang L, Wang L, Xiong X, Wu Q#. Prenatal ultrasound findings, genetic testing, and literature review of Isolated left subclavian artery. Echocardiography. 2023;40(7):732-738.

[29] Gao X*, Sun Y*, Wang J, Wu Q#. Predicting the risk of Turner syndrome based on ultrasonographic markers in the first trimester of pregnancy. Chin Med J (Engl). 2023;136(15):1879-1881.

[30] Song S, Wang J, Wang L, Hou C, Wu Q#. The upper airway parameters: the potential diagnostic clues for congenital intrathoracic lesions. BMC Pregnancy Childbirth. 2023;23(1):373.

[31] Zhang S, Wang J, Pei Y, Han J, Xiong X, Yan Y, Zhang J, Liu Y, Su F, Xu J, Wu Q#. Diagnostic Value of Chromosomal Microarray Analysis for Fetal Congenital Heart Defects with Different Cardiac Phenotypes and Extracardiac Abnormalities. Diagnostics (Basel). 2023;13(8):1493.

[32] Sun Y*, Zhang M*, Chen S*, Zhang W*, Zhang Y, Su S, Zhang E, Sun L, Yang K, Wang J, Yue W#, Wu Q#, Liu R#, Yin C#. Potential impact of ambient temperature on maternal blood pressure and hypertensive disorders of pregnancy: A nationwide multicenter study based on the China birth cohort. Environ Res. 2023;227:115733.

[33] Hu Y*, Sun L*, Feng L, Wang J, Zhu Y, Wu Q#. The role of routine first-trimester ultrasound screening for central nervous system abnormalities: a longitudinal single-center study using an unselected cohort with 3-year experience. BMC Pregnancy Childbirth. 2023;23(1):312.

[34] Sun Y*, Zhang M*, Wu W*, Liu R*, Zhang Y, Su S, Zhang E, Sun L, Yue W, Wu Q#, Chen G#, Zhang W#, Yin C#. Ambient cold exposure amplifies the effect of ambient PM1 on blood pressure and hypertensive disorders of pregnancy among Chinese pregnant women: A nationwide cohort study [published online ahead of print, 2023 Jul 1]. Sci Total Environ. 2023;897:165234.

[35] Hou C, Wang J, Song S, Wu Q#. The grading of stomach position for postnatal outcomes in isolated left-sided congenital diaphragmatic hernia: A systematic review and meta-analysis. Prenat Diagn. 2023;43(8):1008-1017.

二、主编主译的著作/译著

1. 《实用产前超声诊断学》 主编 人民卫生出版社 202301

2. 《胎儿颅脑超声》 主译 人民卫生出版社 201804

3. 《超声医学专科能力建设专用初级教材——妇产和计划生育分册》 主编 人民卫生出版社 201604

三、重要奖项

1. 胎儿结构出生缺陷与染色体结构异常的系列研究 第十二届宋庆龄儿科医学奖 2022

2. 胎儿畸形产前超声早、中、晚序贯化筛查技术方案研究、模型构建及推广应用 全国妇幼健康科学技术奖 二等奖 201909

3. 适合中国国情的标准化产前超声筛查与诊断体系的建立和推广应用 科学技术进步奖 二等奖 201901

4. 北京市出生缺陷二级预防体系的建立和实践研究 全国妇幼健康科学技术奖 一等奖 201511

5. 新生儿先天性膈疝诊疗创新技术的建立及推广应用 中国出生缺陷干预救助基金会科技成果奖 三等奖 202106

6. 先天性膈疝等重症高危儿多学科联合诊疗创新体系的建立应用 医院科技创新奖 三等奖 202109