段美丽教授所在的首都医科大学附属北京友谊医院重症医学科自 2004 年成立以来，已发展成为行业内的重要标杆。作为国家卫健委临床重点专科、北京市临床重点专科，同时也是北京市重症医学质量控制与改进中心主任单位，在区域重症医疗质量提升中发挥着关键引领作用。此外，这里还是首都医科大学危重症医学系研究生培养点，为重症医学领域输送高层次专业人才；全国名老中医药专家张淑文教授传承工作室挂靠于此，推动中西医结合在重症医学中的应用与发展。同时，科室作为首批国家重症医学专科医师、住院医师规范化培训基地，积累了丰富的教学与培训经验。

一、临床团队

        重症医学科设有三区八部，共34名医师，其中主任医师6名，副主任医师7名。凭借强大的医疗实力，每年收治重症患者约 3000 人次。科室病种覆盖全面，涵盖内外妇儿各专业的危重患者，如重症感染、脓毒症、严重创伤、各种休克、ARDS、急性重症胰腺炎、各外科围手术期危重患者、病理产科、内分泌急症、重症疟疾等热带疾病、自生免疫性疾病等导致的各种危重症，开展体外膜肺氧合（ECMO）、SWAN - GANZ 导管、PICCO血流动力学监测、有创 / 无创机械通气及呼吸力学监测、电阻抗断层成像（EIT）技术、床旁血液净化、重症超声、颅内压及腹内压监测、双频指数脑电监测（BIS）、俯卧位通气、床旁空肠管置入、重症支气管镜、气管镜引导经皮扩张气管切开术等监测治疗技术，全方位保障重症患者的救治质量。

二、科研教学团队

        科室的科研团队自2006年组建以来，始终以临床需求为导向，以提升危重症救治水平为目标，深耕重症医学领域科学研究。经过十余年的创新积累，团队已发展成为科研基础坚实、学科特色鲜明、创新能力突出的专业团队，在课题攻关、学术成果、人才培养及技术转化等方面取得显著成效。团队累计主持国家级、省部级及院级科研课题47项，牵头开展学科建设项目4项，获科研经费资助总额达1757.85万元（人民币），核心研究方向涵盖器官功能支持、脓毒症机制、中西医结合、人工智能辅助诊疗等前沿领域，形成了多学科交叉融合的创新研究体系。团队成员在重症医学领域核心期刊发表论文207篇，体现扎实的临床研究能力；同时，发表SCI论文54篇，累计影响因子151.399分，团队坚持“引育结合”的人才战略，培养出北京市科技新星1人、北京市卫生系统高层次卫生技术人才1人，院级“种子计划”青年骨干2人，形成以学科领军人才为引领、中青年骨干为中坚的高水平科研队伍。团队同时注重临床需求与科研创新的无缝衔接，获批实用新型专利8项。

        科室的教学体系完善，配备模拟ECMO、心肺超声训练器、气管插管、支气管镜、深静脉穿刺、CPR 等先进模拟教学设备，为学生提供仿真的实践操作环境。教学培训课程丰富且实用，定期开展重症基础课程培训及文献解读或科研方法培训，帮助学生夯实理论基础、提升科研素养，课程涵盖理论及操作训练，内容紧贴临床实际，实用性极强。

主持科研项目：

1、国家级课题

国家自然科学基金——内皮细胞微粒介导钙粘蛋白解离促进脓毒症小鼠脑微循环血管通透性增加的体内外研究

国家中西医结合重大疑难疾病专项——多重耐药菌感染

2、省部级课题

首都卫生发展科研专项———重症患者连续性肾脏替代治疗质量管理体系的建立及评价

3、市局级课题

北京市自然科学基金——自噬介导血管钙粘蛋白解离对脓毒症大鼠肾脏微循环通透性的作用机制

北京市科委“首都临床特色应用研究”专项——急性肾损伤合并液体过负荷状态患者肾替代治疗启动时机的随机对照研究

获批人才学科建设项目：

1、北京市卫生系统高层次卫生技人才培养计划（215人才学科骨干）

2、北京市医管局重点学科项目

3、北京市临床重点专科卓越项目

4、北京市科技新星

主持科研项目：

1、国家级课题

国家自然科学基金——内皮细胞微粒介导钙粘蛋白解离促进脓毒症小鼠脑微循环血管通透性增加的体内外研究

国家中西医结合重大疑难疾病专项——多重耐药菌感染

2、省部级课题

首都卫生发展科研专项———重症患者连续性肾脏替代治疗质量管理体系的建立及评价

3、市局级课题

北京市自然科学基金——自噬介导血管钙粘蛋白解离对脓毒症大鼠肾脏微循环通透性的作用机制

北京市科委“首都临床特色应用研究”专项——急性肾损伤合并液体过负荷状态患者肾替代治疗启动时机的随机对照研究

获批人才学科建设项目：

1、北京市卫生系统高层次卫生技人才培养计划（215人才学科骨干）

2、北京市医管局重点学科项目

3、北京市临床重点专科卓越项目

4、北京市科技新星

获奖情况：

2021年获中华医学科技奖二等奖：重症急性胰腺炎的诊疗新技术建立和推广应用，排名第五。

2021年获北京医学科技一等奖：重症急性胰腺炎的诊疗新技术建立和推广应用，排名第五。

2024年北京市科学技术进步二等奖：基于重症医学质量控制的脓毒症救治关键技术体系的建立与应用

2020年获北京市抗击新冠肺炎疫情先进个人

出版专著、牵头或参与制定诊疗规范：

1. 中国医药科技出版社，《重症医学科诊疗常规》，主审，2019年

2. 中华医学电子音像出版社，中国医学发展系列研究报告《重症医学2024》，编委，2024年

3. 重症医学科新冠感染预防与控制工作共识，主编，2020年

4. 重症大数据应用中国专家共识，编委，2022年

代表性论著：

1. Zhao M, Guan Y, Lin J, Qiu Y, Zhao S, Duan M. Acute Kidney Injury in Critical Care: Complications of Hemophagocytic Lymphohistiocytosis, Frontiers in Immunology, 2024, 15(1396124),1-14

2. Zhao M, Liu J, Zhuang H, Qiu Y, He Z, Lin J, Duan M. Beta 2-microglobulin is an independent risk marker of acute kidney injury in adult patients with hemophagocytic lymphohistiocytosis, JOURNAL OF NEPHROLOGY, 2024, 1-9

3. Dong L, Liu P, Qi Z, Lin J, Duan M. Development and validation of a machine-learning model for predicting the risk of death in sepsis patients with acute kidney injury, Heliyon, 2024, 10(9),e29985-

4. Qi Z, Dong L, Lin J, Duan M. Development and validation a nomogram prediction model for early diagnosis of bloodstream infections in the intensive care unit, Frontiers in Cellular and Infection Microbiology,2024, 14(1348896), 1-12

5. Pang R, Dong L, Liu J, Ji X, Zhuang H, Duan M. The study on role of endothelial cell autophagy in rats with sepsis-induced acute kidney injury, Heliyon, 2023,9(3),1-9

6. Wang Y, Liu P, Duan M. Prevalence Risk Factors and Clinical Outcomes of Acute Kidney Injury after Paediatric Liver Transplantation, ARCHIVOS ESPANOLES DE UROLOGIA, 2023,76(7), 1-7

7. Bai J, Wen A, Li Z, Li X, Duan M. Population pharmacokinetics and dosing optimisation of imipenem in critically ill patients, European Journal of Hospital Pharmacy,2023,1-6

8. Qi Z, Lu J, Liu P, Li T, Li A, Duan M. Nomogram Prediction Model of Hypernatremia  on Mortality in Critically Ill Patients, Infection and Drug Resistance, 2023,6(16), 143-153

9. He J, Zhao S, Duan M. The Response of Macrophages in Sepsis Induced Acute Kidney Injury, Journal of Clinical Medicine,2023,12(3),1101-1101

10. Liu P, Zhi D, Wang Y, Lin J, Zhang M, Duan M. Effects of Albumin Supplements on In-Hospital Mortality in Patients with Sepsis or Septic Shock: A Systemic Review and Meta-Analysis, Evidence-based Complementary and Alternative Medicine, 2022, 2022(2384730), 1-9 (Restracted)

10. Guo DC, Zhuang HZ, Lin J, Zhi DY, Duan ML. Epidemiology of sepsis in Beijing from 2012 to 2018: analysis of hospital homepage databases derived from the Beijing Public Health System, BMC PUBLIC HEALTH, 2022,22(2237),1-9

11. Zhi D, Zhang M, Lin J, Liu P, Wang Y, Duan M. Role of HMGB1-PTEN Signaling in T Lymphocytes and Monocytes Upon Sepsis, Clinical Laboratory, 2022,68(5), 1072-1080

12. Zhang M, Zhi D, Lin J, Liu P, Wang Y, Duan M. miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute Kidney Injury through Downregulation of NEK7, Journal of Immunology Research, 2022,2022(1825490), 1-13

13. Zhou X, Yao J, Lin J, Liu J, Dong L, Duan M. Th17/Regulatory T-Cell Imbalance and Acute Kidney Injury in Patients with Sepsis, Journal of Clinical Medicine, 2022,11(4027),1-18

14. Zhou X, Bai G, Dong L, Zhuang H, Duan M. Successful Treatment of Severe Community-Acquired Pneumonia caused by Chlamydia Psittaci: a Case Report, Clinical Laboratory,2022,68(5),1093-1097

15. Liu J, Wang Z, Lin J, Li T, Guo X, Pang R, Dong L, Duan M. Xuebijing injection in septic rats mitigates kidney injury, reduces cortical microcirculatory disorders, and suppresses activation of local inflammation, JOURNAL OF ETHNOPHARMACOLOGY, 2021,276(114199),1-9

16. Establishment and validation of the predictive model for the in-hospital death in patients with sepsis, AMERICAN JOURNAL OF INFECTION CONTROL,2021, 49(12),1515-1521

17. He J, Lin J, Duan M. Application of Machine Learning to Predict Acute Kidney Disease in Patients with Sepsis Associated Acute Kidney Injury, Frontiers in Medicine,2021, 8(792974), 1-11

18. Wang H, Ji X, Wang AY, Wu PK, Liu Z, Dong L, Liu J, Duan M. Epidemiology of Sepsis-Associated Acute Kidney Injury in Beijing, China: A Descriptive Analysis, International Journal of General Medicine,2021,14(0),5631-5649

19. Zhou X, Duan ML. Malaria-associated secondary hemophagocytic lymphohistiocytosis: A case report, World Journal of Clinical Cases,2021,9(22),6403-6409

20. Zhou X, Zeng N, Liu P, Liu Z, Duan M. Sex Differences in In-hospital Mortality of Patients With Septic Shock:An Observational Study Based on Data Analysis From a Cover Sheet of Medical Records in Beijing, Frontiers in Medicine, 2021,8(377410),1-6

21. Lin J, Zhuang HZ, Zhi Y, Qi Z, Bai J, Dong L, Liu S, Duan M. The Impact of Cumulative Fluid Balance during Continuous Renal Replacement Therapy on Mortality in Patients with Septic Acute Kidney Injury: Retrospective Cohort Study, Frontiers in Medicine,2021,8(762112),1-12

22. Liu S, Zhao R, Yang R, Zhao H, Ji C, Duan M, Liu J. Are dexmedetomidine and olanzapine suitable to control delirium in critically ill elderly patients? A retrospective cohort study, BIOMEDICINE & PHARMACOTHERAPY, 2021, 139(111617),1-8

23. Wang Z, Liu J, Liu X, Guo X, Li T, Pang R, Duan M. Perfusion microvessel density in the cerebral cortex of septic rats is negatively correlated with endothelial microparticles in circulating plasma, METABOLIC BRAIN DISEASE, 2021,36(5),1029-1036

24. Lin J, Ji XJ, Wang AY, Liu JF, Liu P, Zhang M, Qi ZL, Guo DC, Bellomo R, Bagshaw SM, Wald R, Gallagher M, Duan ML. Timing of continuous renal replacement therapy in severe acute kidney injury patients with fluid overload: A retrospective cohort study, JOURNAL OF CRITICAL CARE,2021,64,226-236

25. Zhang M, Duan M, Zhi D, Lin J, Liu P, Wang Y. Risk factors for 28-day mortality in patients with sepsis-related myocardial injury in intensive care units, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2021,49(4),1-9

26. Zhi D, Zhang M, Lin J, Liu P, Wang Y, Duan M. Wedelolactone improves the renal injury induced by lipopolysaccharide in HK-2 cells by upregulation of protein tyrosine phosphatase non-receptor type 2, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2021,49(5),1-14

27. Zhi D, Lin J, Dong L, Ji X, Zhuang H, Liu Z, Liu J, Duan M. Risk predictive role of hypernatremia for occurrence of sepsis-induced acute kidney injury, Annals of Palliative Medicine,2021,10(4),4075-4715

28. Zhi D, Zhang M, Lin J, Liu P, Duan M. GPR120 Ameliorates Apoptosis and Inhibits the Production of Inflammatory Cytokines in Renal Tubular Epithelial Cells, INFLAMMATION,2021,44(2),493-505

29. Qi ZL, Sun LY, Bai J, Zhuang HZ, Duan ML. Japanese encephalitis following liver transplantation A rare case report, World Journal of Clinical Cases,2020,8(2),337-342

30. Yu YB, Zhuang HZ, Ji XJ, Dong L, Duan ML. Hydroxytyrosol suppresses LPS-induced intrahepatic inflammatory responses via inhibition of ERK signaling pathway activation in acute liver injury, European Review for Medical and Pharmacological Sciences,2020,24(11),6455-6462

31. Zhi DY, Lin J, Zhuang HZ, Dong L, Ji XJ, Guo DC, Yang XW, Liu S, Yue Z, Yu SJ, Duan ML. Acute Kidney Injury in Critically Ill Patients with Sepsis: Clinical Characteristics and Outcomes, Journal of investigative surgery,2019,32(8),689-696

32. Yang ZQ, Yang Z, Duan ML. Dietary approach to stop hypertension diet and risk of coronary artery disease: a meta-analysis of prospective cohort studies, INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2019,70(6),668-674

33. Li J, Tan H, Zhou X, Zhang C, Jin H, Tian Y, Zhao X, Li X, Sun X, Duan M, Zhang D. The Protection of Midazolam Against Immune Mediated Liver Injury Induced by Lipopolysaccharide and Galactosamine in Mice, Frontiers in Pharmacology, 2019,9,1-9

34. Jin Lin, Martin Gallagher, Rinaldo Bellomo, Meili Duan, Konlawi Trongtrakul, Amanda Ying Wang ; Renal Study Investigators and the Anzics Clincal Trials Group. SOFA coagulation score and changes in platelet counts in severe acute kidney injury: Analysis from the randomized evaluation of normal versus augmented level (RENAL) study. Nephrology (Carlton). 2019 May;24(5):518-525.

35. Jia'an Qin , Yuhe Yang , Chao Ai , Zhaoshuai Ji , Wei Chen , Yingchang Song , Jiayu Zeng , Meili Duan , Wenjie Qi , Shutian Zhang , Zhuoling An , Yang Lin , Sha Xu , Kejun Deng , Hao Lin , Dan Yan. Antibiotic combinations prediction based on machine learning to multicentre clinical data and drug interaction correlation. Int J Antimicrob Agents. 2024 May;63(5):107122.

36. Run Dong, Hongcheng Tian , Jianfang Zhou, Li Weng, Xiaoyun Hu, Jinmin Peng , Chunyao Wang , Wei Jiang , Xueping Du , Xiuming Xi , Youzhong An , Meili Duan , Bin Du ; China Critical Care Clinical Trials Group. External validity of Adult Sepsis Event's simplified eSOFA criteria: a retrospective analysis of patients with confirmed infection in China. Ann Intensive Care. 2020 Feb 4;10(1):14

37. Meiping Wang , Li Jiang , Bo Zhu , Wen Li , Bin Du , Yan Kang , Li Weng , Tiehe Qin , Xiaochun Ma , Duming Zhu , Yushan Wang , Qingyuan Zhan, Meili Duan , Wenxiong Li , Bing Sun , Xiangyuan Cao, Yuhang Ai , Tong Li , Xi Zhu , Jianguo Jia , Jianxin Zhou, Yan He, Xiuming Xi; China Critical Care Sepsis Trial (CCCST) workgroup. The Prevalence, Risk Factors, and Outcomes of Sepsis in Critically Ill Patients in China: A Multicenter Prospective Cohort Study. Front Med (Lausanne). 2020 Dec 17:7:593808

38. Long-Xiang Su, Sheng-Jun Liu, Xiang Zhou, Mei-Li Duan, Jian Liu , Bin Ouyang , Bing-Yu Qin , Hong-Liang Wang, Xue Wang, Lei Xu , Xiang-You Yu , Fei-Hu Zhou, Yun Long. Current status of China's critical care medicine big data platform and future prospects. Chin Med J (Engl). 2021 Jan 25;134(14):1684-1686

39. Jia-Bao Li , Miao-Rong Xie , Mei-Li Duan, Ya-Nan Yu , Chen-Chen Hang , Zi-Ren Tang , Chun-Sheng Li. Over-expression of programmed death-ligand 1 and programmed death-1 on antigen-presenting cells as a predictor of organ dysfunction and mortality during early sepsis: a prospective cohort study. World J Emerg Med. 2023;14(3):179-185

40. Tian Li , Jing Yuan Liu , Jing Feng Liu, Meili Duan , Ang Li. The Correlation Between the Types of Initial Bacterial Infection and Clinical Prognosis in Patients With Septic AKI. Front Med (Lausanne). 2022 Jan 27:8:800532

41. Tian Li , Xiaojun Ji , Jingfeng Liu , Xinjie Guo , Ran Pang , Haizhou Zhuang , Lei Dong , Meili Duan , Ang Li. Ulinastatin Improves Renal Microcirculation by Protecting Endothelial Cells and Inhibiting Autophagy in a Septic Rat Model. Kidney Blood Press Res. 2022;47(4):256-269.

42. Ying Xie, Jin Lin, Martin Gallagher , Rinaldo Bellomo , Xia Wang , Meg Jardine  Meili Duan , Amanda Wang ; Renal Study Investigators and the Anzics Clinical Trials Group. Prognostic Significance of Baseline Blood Glucose Levels and Glucose Variability in Severe Acute Kidney Injury: A Secondary Analysis from the RENAL Study. J Clin Med. 2022 Dec 20;12(1):15

43. Yuan Gao, Xin Liu , Yunyi Gao , Meili Duan , Bing Hou , Yu Chen. Pharmacological Interventions for Cirrhotic Ascites: From Challenges to Emerging Therapeutic Horizons. Gut Liver. 2024 Aug 29

44. Zhe Li , Jing Bai , Aiping Wen , Su Shen , Meili Duan , Xingang Li. Pharmacokinetic and Pharmacodynamic Analysis of Critically Ill Patients Undergoing Continuous Renal Replacement Therapy With Imipenem. Clin Ther. 2020 Aug;42(8):1564-1577

45. Jiaqi Lu, Zhili Qi , Jingyuan Liu, Pei Liu , Tian Li , Meili Duan , Ang Li. Nomogram Prediction Model of Serum Chloride and Sodium Ions on the Risk of Acute Kidney Injury in Critically Ill Patients. Infect Drug Resist. 2022 Aug 24:15:4785-4798

46. Hong-Cheng Tian, Jian-Fang Zhou, Li Weng, Xiao-Yun Hu, Jin-Min Peng, Chun-Yao Wang, Wei Jiang, Xue-Ping Du , Xiu-Ming Xi , You-Zhong An, Mei-Li Duan , Bin Du ; for China Critical Care Clinical Trials Group (CCCCTG). Epidemiology of Sepsis-3 in a sub-district of Beijing: secondary analysis of a population-based database. Chin Med J (Engl). 2019 Sep 5;132(17):2039-2045

47. Hongli Xiao, Hanyu Zhang , Guoxing Wang , Yan Wang , Zhimin Tan , Xuelian Sun , Jie Zhou , Meili Duan , Deyuan Zhi , Chenchen Hang , Guoqiang Zhang , Yan Li , Caijun Wu , Haiyan Zhang , Miaorong Xie , Chunsheng Li. COMPARISON AMONG PRESEPSIN, PROCALCITONIN, AND C-REACTIVE PROTEIN IN PREDICTING BLOOD CULTURE POSITIVITY AND PATHOGEN IN SEPSIS PATIENTS. Shock. 2024 Mar 1;61(3):387-394

48. Penglin Ma, Jingtao Liu , Feng Shen , Xuelian Liao , Ming Xiu , Heling Zhao , Mingyan Zhao , Jing Xie , Peng Wang , Man Huang , Tong Li , Meili Duan , Kejian Qian , Yue Peng , Feihu Zhou, Xin Xin , Xianyao Wan , ZongYu Wang , Shusheng Li , Jianwei Han, Zhenliang Li, Guolei Ding, Qun Deng , Jicheng Zhang , Yue Zhu , Wenjing Ma , Jingwen Wang , Yan Kang , Zhongheng Zhang. Individualized resuscitation strategy for septic shock formalized by finite mixture modeling and dynamic treatment regimen. Crit Care. 2021 Jul 12;25(1):243

49. Songqiao Liu , Chen Yao , Jianfeng Xie , Hong Liu , Hongliang Wang , Zhaofen Lin , Bingyu Qin , Difen Wang , Weihua Lu , Xiaochun Ma , Yan Liu , Ling Liu , Chi Zhang , Lei Xu , Ruiqiang Zheng , Feihu Zhou , Zhongmin Liu , Guoqiang Zhang , Lixin Zhou , Jian Liu , Aihua Fei , Guoxiu Zhang , Yimin Zhu , Kejian Qian , Ruilan Wang , Yafeng Liang , Meili Duan , Dawei Wu , Rongqing Sun , Ying Wang , Xijing Zhang , Quan Cao , Mingshi Yang , Minggen Jin , Yan Song , Ling Huang , Fachun Zhou , Dechang Chen , Qun Liang , Chuanyun Qian , Zhongzhi Tang , Zhong Zhang , Qiming Feng , Zhiyong Peng , Renhua Sun , Zhenju Song , Yunbo Sun , Yanfen Chai , Lihua Zhou , Chen Cheng , Li Li , Xiaoyan Yan , Junhua Zhang , Yingzi Huang , Fengmei Guo , Chuan Li , Yi Yang , Hongcai Shang , Haibo Qiu ; EXIT-SEP Investigator. Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis: The EXIT-SEP Randomized Clinical Trial. JAMA Intern Med. 2023 Jul 1;183(7):647-655

50. 白静，刘景峰，庄海舟，段美丽. 儿童活体肝移植术后感染临床特征分析. 医学研究杂志,2023;52(10):117-121

51. 齐志丽, 林瑾, 董磊, 刘景峰, 段美丽. 重症监护病房血流感染危险因素的Meta分析. 首都医科大学学报, 2021, 42 (6): 923-930.

52. 王海曼,张萌,段美丽. 巨噬细胞在脓毒症小鼠急性肾损伤发生中的可能作用机制. 临床和实验医学杂志,2023,22(15):1569-1573

53. 王海曼,国新杰,李甜,段美丽. 感染性休克患者NT-proBNP与液体复苏量的相关性研究. 中国分子心脏病学杂志,2023,23(3):5433-5440

54. 王亚军,林瑾,刘培,张萌,支德源,段美丽; 胆道闭锁患儿肝移植术后急性肾损伤危险因素分析. 国际外科学杂志,2023,50(4): 229-235

55. 周晓,郭东晨,林瑾,段美丽; 血清胆碱酯酶对脓毒症相关急性肾损伤患者的预测价值.中华重症医学电子杂志（网络版）,2022,8(2):133-139

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