团队成员：李丽英 教授，常娜 副教授，杨乐 副教授，杨琳 副主任技师。博士研究生：董成宾，侯雷，赵新浩，马悦涵，武志强；硕士研究生：纪晓方，祁长波，杨苑儒，周璇，张芝，薛仁敏，张凯，刘昱然；本科生：张航

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1.乌头酸脱羧酶1/衣康酸免疫代谢通路参与肝损伤/炎症/纤维化的分子机制研究，2022.1-2025.12，国家自然科学基金面上项目；

2.磷酸鞘胺醇诱导的M1型巨噬细胞逆转肝纤维化硬化的分子机制，2020.1-2023.12，国家自然科学基金面上项目；

3.大麻素受体介导中性粒细胞参与肝脏炎症及纤维化的机制，2017.1-2020.12，国家自然科学基金面上项目；

4.炎症在脂肪性肝病发生发展过程中的关键作用与分子机理，2015.1-2019.12，国家自然科学基金重点项目；

5.内源性大麻素系统介导骨髓细胞参与肝纤维化的作用机制，2012.1-2015.12，国家自然科学基金面上项目；

6.肝损伤过程中的细胞学机制研究，2011.1-2014.12，国家自然科学基金重点项目；

7.S1P介导骨髓间充质干细胞参与肝纤维化的机制研究，2010.1-2012.12，国家自然科学基金面上项目

8.S1P信号轴介导中性粒细胞参与非酒精性脂肪性肝炎的分子机理研究，2017.1-2019.12，北京市自然科学基金面上项目

代表性文章：

1.Lu Y, Chang N, Zhao X, Xue R, Liu J, Yang L and Li L. Activated Neutrophils Secrete Chitinase-Like 1 and Attenuate Liver Inflammation by Inhibiting Pro-Inflammatory Macrophage Responses. Front. Immunol. 2022;13:824385. 

2.Yang L, Yue W, Zhang H, Zhang Z, Xue R, Dong C, Liu F, Chang N, Yang L, Li L. Dual Targeting of Angipoietin-1 and von Willebrand Factor by microRNA-671-5p Attenuates Liver Angiogenesis and Fibrosis. Hepatol Commun. 2022 Jun;6(6):1425-1442.  

3.Yang J, He L, Gao M, Xiao F, Zhang F, Wang S, Shu Y, Ye X, Qu W, Li L*, Wei H*. Collagen β(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice. Metabolism. 2021 Jul;120:154777. 

4.Hou L, Zhang Z, Yang L, Chang N, Zhao X, Zhou X, Yang L, Li L. NLRP3 inflammasome priming and activation in cholestatic liver injury via the sphingosine 1-phosphate/S1P receptor 2/Ga(12/13)/MAPK signaling pathway. J Mol Med (Berl). 2021 Feb;99(2):273-288. 

5.Zhao X, Yang L, Chang N, Hou L, Zhou X, Dong C, Liu F, Yang L, Li L. Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury. Cell Immunol. 2021 Jan;359:104243.

6.Ji X, Yang L, Zhang Z, Zhang K, Chang N, Zhou X, Hou L, Yang L, Li L. Sphingosine 1-phosphate/microRNA-1249-5p/MCP-1 axis is involved in macrophage-associated inflammation in fatty liver injury in mice. Eur J Immunol. 2020 Nov;50(11):1746-1756. 

7.Hou L, Yang L, Chang N, Zhao X, Zhou X, Dong C, Liu F, Yang L, Li L. Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome. Front Immunol. 2020 Jun 26;11:1149. 

8.Zhao X, Yang L, Chang N, Hou L, Zhou X, Yang L, Li L. Neutrophils undergo switch of apoptosis to NETosis during murine fatty liver injury via S1P receptor 2 signaling. Cell Death Dis. 2020 May 18;11(5):379. 

9.Yang J, Chang N, Yang L, Ji X, Zhou X, Tian L, Ma Y, Yang Y, Liu Y, Yang L, Li L. Sphingosine 1-Phosphate Receptor Blockade Affects Pro-Inflammatory Bone Marrow-Derived Macrophages and Relieves Mouse Fatty Liver Injury. Int J Mol Sci. 2019 Sep 22;20(19):4695. 

10.Chang N, Tian L, Ji X, Zhou X, Hou L, Zhao X, Yang Y, Yang L, Li L. Single-Cell Transcriptomes Reveal Characteristic Features of Mouse Hepatocytes with Liver Cholestatic Injury. Cells. 2019 Sep 11;8(9):1069. 

11.Yang L, Dong C, Tian L, Ji X, Yang L, Li L. Gadolinium Chloride Restores the Function of the Gap Junctional Intercellular Communication between Hepatocytes in a Liver Injury. Int J Mol Sci. 2019 Jul 31;20(15):3748.

12.Yang L, Dong C, Yang J, Yang L, Chang N, Qi C, Li L. MicroRNA-26b-5p Inhibits Mouse Liver Fibrogenesis and Angiogenesis by Targeting PDGF Receptor-Beta. Mol Ther Nucleic Acids. 2019 Feb 26;16:206-217.

13. Yang L, Yang L, Dong C, Li L. The class D scavenger receptor CD68 contributes to mouse chronic liver injury. Immunol Res. 2018 Jun;66(3):414-424.

14. Tian L, Li W, Yang L, Chang N, Fang X, Ji X, Xie J, Yang L, Li L. Cannabinoid Receptor 1 Participatesin Liver Inflammation by Promoting M1 Macrophage Polarization via RhoA/NF-κB p65 and ERK1/2Pathways, Respectively, in Mouse Liver Fibrogenesis. Front Immunol. 2017 Sep 28;8:1214.

15. Li W, Chang N, Tian L, Yang J, Ji X, Xie J, Yang L, Li L. miR-27b-3p, miR-181a-1-3p, and miR-326-5p are involved in the inhibition of macrophage activation in chronic liver injury. J Mol Med (Berl). 2017;95:1091-105.

16. Chang N, Ge J, Xiu L, Zhao Z, Duan X, Tian L, Xie J, Yang L, Li L. HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. J Mol Med (Berl).  2017;95:69-82.

17. Wang L, Yang L, Tian L, Mai P, Jia S, Yang L, Li L. Cannabinoid Receptor 1 Mediates Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury. J Cell Physiol. 2017;232:110-21.

18. Liu X, Jia S, Li W, Yang L, Yang L, Wang L, Li L. 15-Deoxy-Δ(12,14)-Prostaglandin J2 Inhibits Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury via Redox Pathway. PPAR Res. 2015;2015:876160. 

19. Yang L, Han Z, Tian L, Mai P, Zhang Y, Wang L, Li L. Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice. Sci Rep. 2015 Sep 1;5:13423.

20. Mai P, Yang L, Tian L, Wang L, Jia S, Zhang Y, Liu X, Yang L, Li L. Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow-Derived Monocytes/Macrophages in a CB1-Dependent Manner. J Immunol. 2015;195(7):3390-401.

21. Mai P, Tian L, Yang L, Wang L, Yang L, Li L. Cannabinoid receptor 1 but not 2 mediates macrophage phagocytosis by G(α)i/o /RhoA/ROCK signaling pathway. J Cell Physiol. 2015;230:1640-50.

22. Xiu L, Chang N, Yang L, Liu X, Yang L, Ge J, Li L. Intracellular Sphingosine 1-Phosphate Contributes to Collagen Expression of Hepatic Myofibroblasts in Human Liver Fibrosis Independent of Its Receptors. Am J Pathol. 2015;185(2):387-398. 

23. Chang N, Xiu L, Li L. Sphingosine 1-Phosphate Receptors Negatively Regulate Collagen Type I/III Expression in Human Bone Marrow-derived Mesenchymal Stem Cell. J Cell Biochem. 2014;115:359-67.

24. Yang L, Yue S, Yang L, Liu X, Han Z, Zhang Y, Li L. Sphingosine Kinase/ Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis is Involved in Liver Fibrosis-Associated Angiogenesis. J Hepatol. 2013;59:114-23.

25. Han Z, Zhu T, Liu X, Li C, Yue S, Liu X, Yang L, Yang L, Li L.15-Deoxy-Δ12,14 -prostaglandin J(2) reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury in mice. Hepatology. 2012;56:350-60.

26. Yang L, Chang N, Liu X, Han Z, Zhu T, Li C, Yang L, Li L. Bone Marrow-Derived Mesenchymal Stem Cells Differentiate to Hepatic Myofibroblasts by Transforming Growth Factor-b1 via Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1PReceptors Axis. Am J Pathol.  2012;181:85-97.

27. Liu X, Yu H, Yang L, Li C, Li L. 15-Deoxy-D12,14-prostaglandin J2 attenuates the biological activities of monocyte/macrophage cell lines. Eur J Cell Biol. 2012;91:654-61. 

28. Li C, Zheng S, You H, Liu X, Lin M, Yang L, Li L. Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility (Erratum in: J Hepatol. 2012 Mar;56(3):749.). J Hepatol. 2011;54:1205-13.

29. Liu X, Yue S, Li C, Yang L, You H, Li L. Essential roles of sphingosine 1-phosphate receptor type 1 and 3 in human hepatic stellate cells motility and activation. J Cell Physiol. 2011;226:2370-7.

30. Li C, Kong Y, Wang H, Wang S, Yu H, Liu X, Yang L, Jiang X, Li L*, Li L*. Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. J Hepatol. 2009;50:1174-83. 

31. Li C, Jiang X, Yang L,Liu X, Yue S, Li L. Involvement of Sphingosine 1-Phosphate (S1P)/S1P3 Signaling in Cholestasis-Induced Liver Fibrosis. Am J Pathol.  2009;175:1464-72.

32. Wang H, Wang S, Hu J, Kong Y, Chen S, Li L*, Li L*. Oct4 is expressed in Nestin-positive cells as a marker for pancreatic endocrine progenitor. Histochem Cell Biol. 2009;131:553-63.