团队成员：李丽英 教授，常娜 副教授，杨乐 副教授，杨琳 副主任技师。博士研究生：董成宾，侯雷，赵新浩，马悦涵，武志强；硕士研究生：纪晓方，祁长波，杨苑儒，周璇，张芝，薛仁敏，张凯，刘昱然；本科生：张航

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1. 首都医学科学创新中心有组织科研专项重点项目，靶向胶原纤维交联逆转肝纤维化的基础临床转化研究（CX25YZ01），150万元, 2025.7-2028.6

2. 国家自然科学基金面上项目，吞噬受体MSR1介导单核细胞来源Kupffer细胞重塑其吞噬功能促进肝损伤修复的分子机理（82470645），49万元， 2025.1-2028.12，；

2. 国家自然科学基金面上项目，乌头酸脱羧酶1/衣康酸免疫代谢通路参与肝损伤/炎症/纤维化的分子机制研究（82170622），56万元， 2022.1-2025.12，；

3. 北京市自然科学基金面上项目，衣康酸通过烷基化 GSDMD 抑制中性粒细胞胞外诱捕网释放进而调节肝脏炎症的机制研究（7232004），20万元， 2023.1-2025.12。

重要学术论文：

1.Chang N#, Ma Y#, Liu J, Li W, Zhao J, Liu Y, Liu F, Dong C, Liu C, Qi C, Yang L, Li L*. IQGAP1 participates in bone marrow-derived macrophage recruitment and involves in liver inflammation/fibrosis. J Mol Med (Berl). 2025 Jul 19. doi: 10.1007/s00109-025-02573-6.

2.Yue W, Zhang H, Gao Y, Ding J, Xue R, Dong C, Liu F, Yang L, Yang L*, Li L*. Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis. Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167205. 

3.Chang N#, Liu Y#, Li W, Ma Y, Zhou X, Zhao X, Yang L, Li L*. Neutrophil-secreted S100A8/A9 participates in fatty liver injury and fibrosis by promoting myofibroblast migration. J Mol Med (Berl). 2024 Sep;102(9):1117-1133. 

4.Li W, Yang Y, Yang L, Chang N*, Li L*. Monocyte-derived Kupffer cells dominate in the Kupffer cell pool during liver injury. Cell Rep. 2023, 42(10): 113164.

5.Li W, Xie J, Yang L, Yang Y, Yang L, Li L*. 15-deoxy-Δ12,14-prostaglandin J2 relieved acute liver injury by inhibiting macrophage migration inhibitory factor expression via PPARγ in hepatocyte. Int Immunopharmacol. 2023 Jun 15;121:110491.

6.Yang Y#, Li W#, Liu C, Liu J, Yang L, Yue W, Yang L, Xue R, Zhang K, Zhang H, Chang N*, Li L*. Single-cell RNA seq identifies Plg-RKT-PLG as signals inducing phenotypic transformation of scar-associated macrophage in liver fibrosis. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166754.

7.Yang S#, Chang N#, Li W#, Yang T, Xue R, Liu J, Zhang L, Yao X, Chen Y, Wang H, Yang L, Huang J*, Li L*. Necroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p-MLKL axis. Cell Death Dis. 2023 Mar 1;14(3):175. 

8.Yang L#, Zhang H#, Dong C, Yue W, Xue R, Liu F, Yang L, Li L*. Neuron-Glial Antigen 2 Participates in Liver Fibrosis via Regulating the Differentiation of Bone Marrow Mesenchymal Stem Cell to Myofibroblast. Int J Mol Sci. 2023 Jan 7;24(2):1177.  

9.Lu Y, Chang N, Zhao X, Xue R, Liu J, Yang L, Li L*. Activated Neutrophils Secrete Chitinase-Like 1 and Attenuate Liver Inflammation by Inhibiting Pro-Inflammatory Macrophage Responses. Front. Immunol. 2022;13:824385. 

10.Yang L, Yue W, Zhang H, Zhang Z, Xue R, Dong C, Liu F, Chang N, Yang L, Li L*. Dual Targeting of Angipoietin-1 and von Willebrand Factor by microRNA-671-5p Attenuates Liver Angiogenesis and Fibrosis. Hepatol Commun. 2022 Jun;6(6):1425-1442.  

11.Yang J, He L, Gao M, Xiao F, Zhang F, Wang S, Shu Y, Ye X, Qu W, Li L*, Wei H*. Collagen β(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice. Metabolism. 2021 Jul;120:154777. 

12.Hou L, Zhang Z, Yang L, Chang N, Zhao X, Zhou X, Yang L, Li L*. NLRP3 inflammasome priming and activation in cholestatic liver injury via the sphingosine 1-phosphate/S1P receptor 2/Ga(12/13)/MAPK signaling pathway. J Mol Med (Berl). 2021 Feb;99(2):273-288. 

13.Zhao X, Yang L, Chang N, Hou L, Zhou X, Dong C, Liu F, Yang L, Li L*. Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury. Cell Immunol. 2021 Jan;359:104243.

14.Ji X, Yang L, Zhang Z, Zhang K, Chang N, Zhou X, Hou L, Yang L, Li L*. Sphingosine 1-phosphate/microRNA-1249-5p/MCP-1 axis is involved in macrophage-associated inflammation in fatty liver injury in mice. Eur J Immunol. 2020 Nov;50(11):1746-1756. 

15.Hou L, Yang L, Chang N, Zhao X, Zhou X, Dong C, Liu F, Yang L, Li L*. Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome. Front Immunol. 2020 Jun 26;11:1149. 

16.Zhao X, Yang L, Chang N, Hou L, Zhou X, Yang L, Li L*. Neutrophils undergo switch of apoptosis to NETosis during murine fatty liver injury via S1P receptor 2 signaling. Cell Death Dis. 2020 May 18;11(5):379.