培养硕士、博士研究生以及博士后二十余名，在研博士研究生3名，硕士研究生2名。

1.   国家自然科学基金面上项目，GBP5通过影响蛋白质乳酸化修饰调控巨噬细胞抗结核免疫应答的机制研究，55万，81871617，年限2022.01-2025.12，课题负责人申阿东。

2.   国家自然科学基金委员会与俄罗斯基础研究基金会合作研究项目，成人与儿童结核病发展的综合研究：细菌菌株和周围微生物组的影响，资助编号81961138012，100万元，2020.1.1-2022.12.31中方负责人：申阿东。

3.   国家自然科学基金面上项目，GBP5和IRF9相互作用介导结核感染后IFN-β抑制巨噬细胞炎症小体活化的机制研究，57万，81871617，年限2019.01-2022.12，课题负责人申阿东。

1.       Liao Q#, Zheng Y#, Wang Y#, Ye L#, Liu X#, Jiao W#, Liu Y, Zhu Y, Jia J, Sun L*, ShenA*, Wan C*. Effectiveness of Bacillus Calmette-Guérinvaccination against severe childhood tuberculosis in China: a case-based,multicenter retrospective study. Int J Infect Dis. 2022 Apr13:S1201-9712(22)00220-X. 

2.       JiangT#, Wang Y#, Jiao W, Song Y, Zhao Q, Wang T, Bi J*, ShenA*. Recombinase polymerase amplification combined with real-time fluorescentprobes for Mycoplasma pneumoniaedetection. J Clin Med. 2022, 11: 1780.

3.       PengX#, Liao Q#, Fang M#, Zhu Y, Shi Y, Quan S,Wang Y, Duan L, Shi X, Liu Y, Wang M, Wei Q, Zhou H, Wang Y, Wu X, Yao Y, SunL*, Shen A*, Wan C*. Detection of pulmonary tuberculosis in children using theXpert MTB/RIF Ultra assay on sputum: a multicenter study. Eur J Clin Microbiol. 2022,41(2): 235-243.

4.        Sun L#, Liu Y#,Fang M#, Chen Y#, Zhu Y, Xia C, Jia J, Quan S, Wang Y,Tian X, Shi Y, Duan L, Shi X, Liao Q, Wan C*, Shen A*. Use of Xpert MTB/RIFUltra assay on stool and gastric aspirate samples to diagnose pulmonarytuberculosis in children in a high-tuberculosis-burden but resource-limitedarea of China. Int J Infect Dis. 2022, 114: 236-243.

5.       QuanS, Jiang T, Jiao W, Zhu Y, Liao Q, Liu Y, Fang M, Shi Y, Duan L, Shi X, Wang Y,Tian X, Wang C*, Sun L*, Shen A*. A Novel Cross-Priming Amplification-BasedAssay for Tuberculosis Diagnosis in Children Using Gastric Aspirate. Front.Microbiol. 2022, 13: 819654.

6.       刘芳,焦伟伟, 申阿东.儿童结核病诊断与治疗面临的问题与思考. 中华实用儿科临床杂志, 2022, 37(7): 486-489.

7.       刘芳，饶小春，马渝燕，孟辰芳，潘跃娜，刘涵，申阿东*，焦安夏*. 252例儿童气管支气管结核分型探讨. 中华结核和呼吸杂志, 2022, 45(3) : 282-288.

8.       刘芳，饶小春，马渝燕，孟辰芳，潘跃娜，焦安夏*，申阿东*.经支气管镜介入治疗儿童淋巴结瘘型气管支气管结核有效性评价. 中国防痨杂志. 2021,43(8),826-831.

9.       刘芳，刘涵，饶小春，马渝燕，焦安夏*，申阿东*. 儿童原发性肺结核合并支气管结石1例病例报告. 中国循证儿科杂志. 2021,16(3),252-254.

10.     JiaoWW#, Wang GR#, Sun L, Xiao J, Li JQ,Wang YC, Quan ST, Huang HR*, Shen AD*. Multiple Cross DisplacementAmplification Combined With Real-Time Polymerase Chain Reaction Platform: ARapid, Sensitive Method to Detect Mycobacteriumtuberculosis. Front. Microbiol. 2021,12: 812690. doi: 10.3389/fmicb.2021.812690.

11.     Sun L#, Qi X#,Guo Y, Qi H, Li J, Wu X, Yin Q, Guo Y, Xu B, Wang Y, Jin Q, Gao L*, Shen A*.Tuberculosis infection screening in children with close contact: ahospital-based study. BMC Infect Dis. 2021, 21(1): 815.

12.     Li X#, Qi H#, JinF#, Yao BF, Wu YE, Qi YJ, Kou C, Wu XR, Luo XJ, Shen YH, Zheng X, Wang YH, XuF, Jiao WW, Li JQ, Xiao J,Dong YN, Du B, Shi HY, Xu BP, Shen AD*, Zhao W*. Populationpharmacokinetics-pharmacodynamics of ceftazidime in neonates and young infants:Dosing optimization for neonatal sepsis. Eur J Pharm Sci. 2021 May 2; 163:105868. 

13.      XWu, Y Wang, Q Yin, W Jiao, L Sun, H Qi, JLi, S Quan, B Xu, A Shen*. A diagnostic test that usesisothermal amplification and lateral flow detection sdaA can detecttuberculosis in 60 min. Journal of Applied Microbiology. 2021 Jun;130(6):2102-211

14.     Wang XY, Wang GR, Wang YC, QuanST, Qi H, Sun L, Shen C, Huang HR, Jiao WW*, Shen AD*. Developmentand preliminary application of multiplex loop-mediated isothermal amplificationcoupled with lateral flow biosensor for detection of Mycobacteriumtuberculosis complex. Front Cell Infect Microbiol. 2021, 11: 666492.

15.     ZhengHW#, He WC#, Jiao WW, Xia H, Sun L, Wang SF, Xiao J, OuXC, Zhao YL*, Shen AD*. Molecular characterization of multidrugresistanttuberculosis against levofloxacin, moxifloxacin, bedaquiline, linezolid,clofazimine, and delamanid in southwest of China. BMC Infect Dis. 2021, 21:330.

16.      Hui Qi,Yue-E Wu, Ya-Li Liu, Chen Kou, Ze-Ming Wang, Xiao-Xia Peng, Liang Chen, HongCui, Ya-Juan Wang, Li Jieqiong, Wei Zhao* and A-dong Shen*. Latamoxeffor neonates with early-onset neonatal sepsis: a study protocol for arandomized controlled trial. Frontiers in Pharmacology. published: 09 June2021. DOI: 10.3389/fphar.2021.635517.

17.      Wang Y,Xu B, Wu X, Yin Q, Wang Y, Li J, Jiao W, Quan S, Sun L, Wang Y, Shen A*.Increased Macrolide Resistance Rate of M3562 Mycoplasma pneumoniae CorrelatedWith Macrolide Usage and Genotype Shifting. Front Cell Infect Microbiol. 2021May 12; 11: 675466.

18.      祁雪,吴喜蓉,郭雅洁,王咏红,马琦,陈玉莹,孙琳#,申阿东#. 住院儿童结核分枝杆菌潜伏感染筛查情况分析.中国防痨杂志. 2021,43(7):653-658.

19.      Wang M, Liu F, Li Q, Yin Q, Shen A*.Quality assessment of guidelines forthe management of Mycobacterium tuberculosis infection in children.Int J Tuberc Lung Dis. 2020 Mar; 24(3): 287-294. doi: 10.5588/ijtld.19.0224

20.      Ze-Ming Wang, Xiao-Yu Chen, Jing Bi, Mei-Ying Wang,Bao-Ping Xu, Bo-Hao Tang, Cen Li, Wei Zhao, and A-Dong Shen*. Reappraisal of Optimal Dose of Meropenem inCritically Ill Infants and Children: A Developemental PharmaockienticPharmacodynamic Analysis. Antimicrobial Agents and Chemotherapy. 2020 Jul 22;64(8): e00760-20. doi: 10.1128/AAC.00760-20.

21.      Sun L#, Zhu Y#, Fang M#, Shi Y, Peng X, Liao Q, WangX, Quan S, Wang Y, Duan L, Shi X, Zhao Z, Chen L, Xu Y, Zhang T, Cui X, Wan C*,Shen A*. Evaluation of Xpert MTB/RIF Ultra assay for the diagnosis ofchildhood tuberculosis: a multicenter accuracy study. J Clin Microbiol. 2020Aug 24;58(9): e00702-20. doi: 10.1128/JCM.00702-20. 

22.      Fang Xu,Hui Qi, Jieqiong Li, Lin Sun, Juanjuan Gong, Yuanying Chen, Adong Shen*, Wei Li*. Mycobacterium tuberculosis infectionupregulates MFN2 expression to promote NLRP3 inflammasome formation. J BiolChem. 2020 Oct 16; 295(51): 17684-17697.

23.      Wang,Yi, Wei-wei Jiao, Yu Wang, Ya-cui Wang, Chen Shen, Hui Qi and A-Dong Shen *. Graphene oxide andself-avoiding molecular recognition systems-assisted recombinase polymeraseamplification coupled with lateral flow bioassay for nucleic aciddetection. Microchimica Acta 187.12(2020): 1-11.

24.     李洁琼, 申阿东*.结核病疫苗研发进展及挑战.中华实用儿科临床杂志. 2020, 35(10): 721-725.

25.     肖婧, 焦伟伟,申晨,申阿东*.卡介苗免疫预防研究新进展.中华实用儿科临床杂志. 2020, 35(10): 725-729.

26.     肖婧, 焦伟伟,申阿东*.新型生物标志物在儿童结核病诊断中的应用进展.中华实用儿科临床杂志. 2020, 35(10): 737-743.

27.     王泽明, 申阿东*.儿童结核性脑膜炎的诊断与治疗.中华实用儿科临床杂志. 2020, 35(10): 749-753.

28.     焦伟伟, 申阿东*.儿童结核病药物治疗现状及进展.中华实用儿科临床杂志. 2020, 35(10): 753-758.

29.     王泽明, 申阿东*.利奈唑胺治疗儿童耐多药结核病的应用进展.中华实用儿科临床杂志. 2020, 35(10): 758-761.

30.     綦辉, 申晨,李颖佳,申阿东*.异烟肼致肝损伤的宿主易感基因多态性研究进展.中华实用儿科临床杂志. 2020, 35(10): 762-766.

31.     孙琳, 徐保平,申阿东,申昆玲*.氟喹诺酮类药物在儿科呼吸系统感染性疾病中的应用.中华实用儿科临床杂志. 2020, 35(10): 766-769.

32.     徐放, 申阿东*.宏基因组测序在儿童呼吸感染性疾病研究中的应用.中华实用儿科临床杂志. 2020, 35(10): 783-786.

33.     孙琳,焦伟伟, 李亮*, 申阿东*. 儿童结核分枝杆菌潜伏感染筛查和预防性治疗专家共识. 中华结核和呼吸杂志. 2020，43（4）：345-349.

34.     王泽明，孙琳，申阿东*. 儿童结核感染临床实践指南的现状与思考. 中国防痨杂志，2020, 42(10): 1025-1028.

35.     孙琳，申阿东*.提高儿童结核病诊治的认识并加快规范化进程. 中国防痨杂志，2020, 42(10): 1017-1019.

36.     赵延如，李洁琼，刘芳，吴喜蓉，赵志鹏，尹青琴，王咏红，马琦，全舒婷，王亚翠，孙琳*，申阿东*.呼吸道病原体多重核酸检测方法在社区获得性肺炎患儿诊断中的应用. 标记免疫分析与临床. 2020,27（12）：2030-2034.

37.      Qi H#,Kou C#, Qi YJ#, Tang BH, Wu YE, Jin F, Luo XJ, Shen YH, Guo YJ, Qi X, Wang YC,Dong Q, Chen XK, Shi HY, Zheng Y, Zhao W*,Shen AD*.Population pharmacokinetics and dosing optimization oflatamoxef in neonates and young infants.Int J Antimicrob Agents. 2019 Mar;53(3): 347-351.(IF4.253)

38.      Wang Y,Sun L, Li JQ, Wang ZM, Jiao WW, Xiao J, Shen C, Xu F, Qi H, Wang YH, Guo YJ, Shen AD*.Detection of NucleicAcids and Prevention of Carryover Contamination Using Cross-PrimingAmplification Combined with Nanoparticles-Based Biosensor and Antarctic ThermalSensitive Uracil-DNA-Glycosylase. J Biomed Nanotechnol. 2019 May 1; 15(5):878-892.(IF 5.068)

39.      Wang Y,Lin S, Li J, Wang Z, JiaoW, Xiao J, Shen C, Xu F, Qi H,Wang Y, Guo Y and Shen A*. Label-FreeCross-Priming Amplification Coupled With Endonuclease Restriction andNanoparticles-Based Biosensor for Simultaneous Detection of Nucleic Acids andPrevention of Carryover Contamination. Front Chem. 2019; 7:322.(IF4.155)

40.      Sun L#,Zhang L#, Wang T, Jiao W, Li Q,Yin Q, Li J, Qi H, Xu F, Shen C, Xiao J, Liu S, Mokrousov I*, Huang H*, Shen A*. Mutations of Mycobacterium tuberculosis induced by anti-tuberculosistreatment result in metabolism changes and elevation of ethambutolresistance.Infect Genet Evol. 2019 Aug; 72: 151-158.(IF2.611)

41.      Yacui Wang, Yi Wang, shuting Quan, Jiao Weiwei,Jieqiong Li, Sun Lin, Yonghong Wang, xue Qi, xingyun Wang, A-Dong Shen*. Establishment and Application of a MultipleCross Displacement Amplification Coupled With Nanoparticle-Based Lateral FlowBiosensor Assay for Detection of Mycoplasma pneumoniae. Frontiers in Cellularand Infection Microbiology, 23 September 2019 | https://doi.org/10.3389/fcimb.2019.00325(IF3.518)

42.     Jiao WW, Wang Y, Wang GR, WangYC, Xiao J, Sun L, Li JQ, Wen SA, Zhang TT, Ma Q, Huang HR*, ShenAD*. Development and clinical validation of multiple cross displacementamplification combined with nanoparticles-based biosensor for detection ofMycobacterium tuberculosis: preliminary results. Front Microbiol. 2019 Sep 13;10: 2135. (IF 4.259)

43.      Li Jieqiong#,Sun Lin#, Wu Xirong, Guo Yan,Jiao Weiwei, Xiao Jing, Xu Baoping* and A-Dong Shen*. EarlyDiagnosis of Mycoplasmapneumoniae in Children:Simultaneous AmplificationandTesting (SAT) Is the Key. Frontiers in Pediatrics. Published: 25 October2019. http://doi: 10.3389/fped.2019.00441(IF2.349)

44.      Lin Sun, Xue Qi, Fang Liu, Xirong Wu, Qingqin Yin,Yan Guo, Baoping Xu, Anxia Jiao, Yajie Guo, Weiwei Jiao, Chen Shen, Jing Xiao, AdongShen*. A Test for more accurate diagnosis of pulmonary Tuberculosis.Pediatrics. 2019 Nov;144(5)：e20190262. (IF5.401)

45.     Wang Y, Jiao WW, Wang Y, Sun L,Li JQ, Wang ZM, Xiao J, Shen C, Xu F, Qi H, Wang YH, Guo YJ, ShenAD*. Simultaneous nucleic acids detection and elimination of carryovercontamination with nanoparticles-based biosensor- and antarctic thermalsensitive uracil-DNA-glycosylase-supplemented polymerase spiral reaction. FrontBioeng Biotechnol. 2019 Dec 13; 7: 401. (IF5.122)

46.      Wang Y, Wang Y, Jiao W, Li J, Quan S, Sun L, Wang Y,Qi X, Wang X, ShenA*.Development of loop-mediated isothermal amplification coupled with nanoparticle-basedlateral flow biosensor assay for Mycoplasma pneumoniae detection.AMBExpress. 2019 Dec 5;9(1):196. doi: 10.1186/s13568-019-0921-3.(IF2.226)