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安威教授率先在国内开展肝再生增强子(ALR,前称肝刺激因子HSS)保护肝细胞的研究工作。1993年留学归国引进到首都医科大学后,先后承担10项国家自然科学基金面上项目和“973”计划及“863”计划各1项,发表研究论文70多篇,包括Hepatology,Cell Death Differ, Am J Transplant,Stem Cells,Cell Res等高水平论文。
2.Weng J, Li W, Jia X, An W*.Alleviationof Ischemia-Reperfusion Injury in Liver Steatosis by Augmenter of LiverRegeneration Is Attributed to Antioxidation and Preservation of Mitochondria. Transplantation.2017 Oct;101(10):2340-2348.
3.Zhang C, Huang J, An W*. Hepaticstimulator substance resists hepatic ischemia/reperfusion injury by regulatingDrp1 translocation and activation. Hepatology. 2017Dec;66(6):1989-2001.
6.Ai WL, Dong LY, WangJ, Li ZW, Wang X, Gao J, Wu Y, An W*. Deficiencyin augmenter of liver regeneration accelerates liver fibrosis by promotingmigration of hepatic stellate cell. Biochim Biophys Acta Mol BasisDis. 2018 Nov;1864(11):3780-3791.
7. Liu LM, Xie P, Li W, Wu Y, An W*.Augmenter of liver regeneration protects against ethanol-induced acute liver injuryby promoting autophagy. Am J Pathol. 2019Mar;189(3):552-567.
8. Wang X# , Dong LY# , Gai QJ , Ai WL , Wu Y , Xiao WC , Zhang J , An W*. Lack of Augmenter of Liver RegenerationDisrupts Cholesterol Homeostasis of Liver in Mice by Inhibiting the AMPKPathway. Hepatol Commun. 2020 Jun 2;4(8):1149-1167.
9. Huang J#,Xie P#, Dong Y, An W*. Inhibition ofDrp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury. CellDeath Differ. 2021 Apr;28(4):1174-1192.
10. Zhang X, Zhan Y, Lin W, Zhao F, Guo C,Chen Y, Du M, Li D, Zhang L, An W*,Wang HR*, Xie P*. Smurf1 aggravates non-alcoholic fatty liver disease bystabilizing SREBP-1c in an E3 activity-independent manner. FASEB J. 2020Jun;34(6):7631-7643.
11. Kong WN#, LiW#, Bai C, Dong Y, Wu Y, An W*.Augmenter ofliver regeneration-mediated mitophagy protects against hepaticischemia/reperfusion injury. Am J Transplant. 2022 Jan;22(1):130-143.
12. Dong Y, Kong W, AnW*. Downregulationof augmenter of liver regeneration impairs the therapeutic efficacy of liverepithelial progenitor cells against acute liver injury by enhancingmitochondrial fission. Stem Cells. 2021 Nov;39(11):1546-1562.
13. ZhangJ, Chen SL, Li Y, Xiao WC *, An W.*Alleviationof CCCP-induced mitochondrial injury by augmenter of liver regeneration via thePINK1/Parkin pathway-dependent mitophagy. Exp Cell Res. 2021 Dec 1;409(1):112866.
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