1.基于流固耦合模拟和机器学习的角膜区域性生物力学模型构建与验证-国家自然科学基金（面上）（2022.01-2025.12）主持.在研

2.亮视嘉智能视力表仪的重复性和一致性分析-企业横向课题（2022.01-2024.12）主持.在研

3.0.05%环孢霉素滴眼液治疗干燥综合征相关干眼患者的疗效及对眼表和全身免疫调节的研究-企业横向课题（2021.01-2024.11）主持.在研

4.基于Scheimpflug高速摄像技术的在体角膜生物力学测量方法的建立与应用研究-国家自然科学基金（青年）（2017.01-2019.12）主持.已结题

5.基于高频超声印压技术的在体角膜生物力学测量方法的建立与应用研究-北京市自然科学基金（青年）（2017.01-2018.12）主持.已结题

6.在体角膜生物力学测量方法的建立-北京市科学技术委员会（2018.01-2020.12）主持.已结题

7.基于微力测量系统的眼睑压力与眼表微创伤疾病关系的研究-北京同仁医院（2018.01-2021.12）主持.已结题

8.基于Scheimpflug高速摄像技术的在体角膜生物力学测量方法的建立与应用研究-北航-首医大数据精准医疗高精尖创新中心（2020.01-2021.12）主持.已结题

9.微红牌雨生红球藻虾青素治疗干眼的单中心研究-企业横向课题（2020.04-2022.04）主持.已结题

10. 眼科显微手术机器人系统集成与临床试验研究-国家重点研发计划（2017.12-2020.11）参与.已结题

一、近五年以第一/通讯作者发表的重要科研论文：

1.Tian L, Cao K, Ma DL, Lu LX, Zhao SQ, Li A, Chen CX, Ma ZF, Jin ZB, Ma CR, Jie Y. Six-month repeated irradiation of 650 nm low-level red light reduces the risk of myopia in children: a randomized controlled trial. Int Ophthalmol. 2023 Oct;43(10):3549-3558. doi: 10.1007/s10792-023-02762-7.

2.Tian L, Gao Z, Zhu L, Shi X, Zhao S, Gu H, Xu G, Wang L, Dai H, Zhang H, Jin X, Ma K, Xu Y, Ma L, Pei C, Ke B, Krösser S, Zhang Y, Jie Y*. Perfluorohexyloctane Eye Drops for Dry Eye Disease Associated With Meibomian Gland Dysfunction in Chinese Patients: A Randomized Clinical Trial. JAMA Ophthalmol. 2023 Apr 1;141(4):385-392. doi:10.1001/jamaophthalmol.2023.0270.

3.Deng X, Tian L, Zhang Y, Li A, Cai S, Zhou Y, Jie Y. Is histogram manipulation always beneficial when trying to improve model performance across devices? Experiments using a Meibomian gland segmentation model. Front Cell Dev Biol. 2022 Dec 5;10:1067914. doi: 10.3389/fcell.2022.1067914.

4.Yan C, Li A, Hao Y, Zhang X, Guo Y, Gu Y, Wang Y, Wen Y, Tian L, Jie Y. The Relationship Between Circadian Typology and Dry Eye Symptoms in Chinese College Students. Nat Sci Sleep. 2022;14:1919-1925 doi：org/10.2147/NSS.S378612.

5.Tian L, Cao K, Ma DL, Zhao SQ, Lu LX, Li A, Chen CX, Ma CR, Ma ZF, Jie Y. Investigation of the Efficacy and Safety of 650 nm Low-Level Red Light for Myopia Control in Children: A Randomized Controlled Trial. Ophthalmol Ther. 2022 Oct 8. doi: 10.1007/s40123-022-00585-w.

6.Zhang D, Tian L, Zhang H,Zheng Y, Fu C, Zhai C, Jie Y and Li L. Differences of Corneal BiomechanicsAmong Thin Normal Cornea, Forme-Fruste Keratoconus, and Cornea After SMILE. Front.Bioeng. Biotechnol. 10:861924. doi: 10.3389/fbioe.2022.861924.

7.Qin X, Tian L, Zhang H,Zhang D, Jie Y, Zhang H-X and Li L.Determine Corneal Biomechanical Parametersby Finite Element Simulation and Parametric Analysis Based on ORA Measurements.Front. Bioeng. Biotechnol. 10:862947. doi: 10.3389/fbioe.2022.862947.

8.Zhang P, Tian L, Bao J, LiS, Li A, Wen Y, Wang J and Jie Y. Isotretinoin impairs the secretory functionof meibomian gland via the PPARγ signaling pathway. Invest Ophthalmol VisSci. 2022;63(3):29. https://doi.org/10.1167/iovs.63.3.29.

9.Bao J, Tian L, Meng Y, Wu B,Wang J, He J, Shao Q, Wang C, Jie Y and Zhang L. Total IgE in tears accuratelyreflects the severity and predicts the prognosis of seasonal allergicconjunctivitis. Clinical and Translational Allergy. 2022;e12139.doi.org/10.1002/clt2.12139.

10.Li Y, Tian L, Hao Y, GuoL-L and Jie Y. In Vivo Corneal Biomechanical Properties in a Selected ChinesePopulation, Measured Using the Corneal Visualization Scheimpflug Technology. Front.Bioeng. Biotechnol. 10:863240. doi: 10.3389/fbioe.2022.863240.

11.Hao Y, Zhang X, Bao J, Tian L and Jie Y. Demodex folliculorum Infestation in Meibomian Gland DysfunctionRelated Dry Eye Patients. Front. Med. 9:833778. doi:10.3389/fmed.2022.833778.

12.Wang J, Bao J, Song W, Li S, HaoY, Tian L and Jie Y. Assessment of Eyelid Pressure Using a NovelPressure Measurement Device in Patients With Moderate-to-Severe Dry EyeDisease. Front. Med. 9:833576. doi: 10.3389/fmed.2022.833576.

13.Li F, He J, Bai H, Huang Y, WangF, Tian L. An Arg124Cys mutation in transforming growth factor β‑inducedgene associated with lattice corneal dystrophy type I in a Chinese pedigree. IndianJ Ophthalmol, 2022;70(1):85-9. doi: 10.4103/ijo.IJO_33_21.

14.Li S, Yang K, Wang J, Li S, Zhu L,Feng J, Tian L, Jie Y. Effect of a Novel Thermostatic Device onMeibomian Gland Dysfunction: A Randomized Controlled Trial in Chinese Patients.Ophthalmol Ther. 2022 Feb;11(1):261-270. doi:10.1007/s40123-021-00431-5. PMID: 34822140.

15.Tian L, Wen Y, Li S, Zhang P, Wang Y, Wang J, Cao K, Du L, Wang N and Jie Y. Benefitsand Safety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease.Front. Nutr. 8:796951. doi: 10.3389/fnut.2021.796951.

16.Tian L, Zhang H, Guo L-L, Qin X, Zhang D, Li L, Wu Y, Jie Y, ZhangH. Distribution of Corneal Geometric Landmarks and Relationship Between TheirDistances and Biomechanical Parameters in the Development of Keratoconus. Front.Bioeng. Biotechnol. 2021 Dec 22;9:766163. doi: 10.3389/fbioe.2021.766163.PMID: 35004637.

17.Tian L, Qin X, Zhang H, Zhang D, Guo L-L, Zhang H-X, Wu Y, Jie Y, Li L. A PotentialScreening Index of Corneal Biomechanics in Healthy Subjects, Forme FrusteKeratoconus Patients and Clinical Keratoconus Patients. Front. Bioeng.Biotechnol. 2021 Dec 23;9:766605. doi: 10.3389/fbioe.2021.766605. PMID:35004638.

18.Tian L, Zhang D, Guo L, Qin X, Zhang H, Zhang H, Jie Y, Li L. Comparisons ofcorneal biomechanical and tomographic parameters among thin normal cornea,forme fruste keratoconus, and mild keratoconus. Eye and vision (London,England). 2021 Nov 16;8(1):44. doi: 10.1186/s40662-021-00266-y.

19.Hao Y, Tian L, Cao K, JieY. Repeatability and Reproducibility of SMTube Measurement in Dry Eye DiseasePatients. Journal of Ophthalmology, 2021 Oct 8;2021:1589378. doi:10.1155/2021/1589378.

20.Wu Y, Guo LL,Tian L, XuZQ, Li Q, Hu J, Huang YF, Wang LQ. Comparative analysis of themorphological and biomechanical properties of normal cornea and keratoconus atdifferent stages. Int Ophthalmol. 2021 Nov;41(11):3699-3711. doi:10.1007/s10792-021-01929-4. doi: 10.1007/s10792-021-01929-4.

21.Deng XY, Tian L, Liu ZY, Zhou YJ, Jie Y. A deep learning approach for thequantification of lower tear meniscus height, Biomedical Signal Processingand Control, 2021, doi.org/10.1016/j.bspc.2021.102655.

22.Wang YH, Hu XD, Yang K, Zhang Y, DengSJ, Wang ZQ, Li S, Tian L, Jie Y . Clinical Outcomes of Modified SimpleLimbal Epithelial Transplantation for Limbal Stem Cell Deficiency in ChinesePopulation: A Retrospective Case Series. Stem Cell Research & Therapy. 2021May 1;12(1):259. doi: 10.1186/s13287-021-02345-2.

23.Guo LL, Tian L, Cao Kai, LiYX, Jie Y. Comparison of the Morphological and Biomechanical Characteristics ofKeratoconus, Forme Fruste Keratoconus, and Normal Corneas, Seminars inOphthalmology, 2021, Nov17;36(8):671-678. DOI: 10.1080/08820538.2021.1896752.

24.Zhang H, Tian L, Guo LL,Qin X, Zhang D, Li L, Zhang HX, Jie Y. Comprehensive Evaluation of Corneas fromNormal, Forme Fruste Keratoconus, and Clinical Keratoconus Patients usingMorphological and Biomechanical Properties, International Ophthalmology,2021 Apr;41(4):1247-1259. DOI: 10.1007/s10792-020-01679-9.

25.Lin D, Tian L, Zhang S, Wang LK, Jie Y, Zhou YJ. Keratoconus Diagnosis:Validation of a Novel Parameter Set Derived from IOP-Matched Scenario, Journalof Ophthalmology, 2020; 2020:Article ID 6530279, 6 pages.

二、学术著作

1.《干眼病》主译 科学技术文献出版社2023

2.《同仁干眼实用诊疗》主编 人民卫生出版社 2023

3.《巩膜炎》副主译 科学技术文献出版社 2020

4.《眼健康大百科》副主编 科学技术文献出版社 2019

三、重要奖项

 眼表疾病中西医结合理论基础及创新诊疗策略研究 中国中西医结合学会科学技术奖 一等奖 202112