导师风采
赵蕾
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个人信息

Personal Information

  • 主任医师
  • 导师类别:硕士生导师
  • 性别: 女
  • 学历:硕士研究生
  • 学位:博士

联系方式

Contact Information

  • 所属院系:附属北京安贞医院
  • 所属专业: 放射影像学
  • 邮箱 : s2006430@126.com
  • 工作电话 : -

个人简介

Personal Profile

赵蕾,副教授,硕士研究生导师。主要从事心血管影像临床和研究工作,曾在美国Emory大学和奥地利Innsbruck Medical University医院访问学习。中华医学会心血管病分会影像学组委员;北京医学会放射学分会磁共振学组委员、青年学组委员;中国研究型医院学会心血管影像专委会委员;中国研究型医院学会心血管影像专委会儿科学组副组长;中国装备协会心胸组委员;中国微循环学会周围血管疾病专委会中青年委员;医促会心血管磁共振专委会委员。国内核心期刊发表文章五十多篇、国外SCI杂志发表论著40篇,是多个SCI期刊审稿人;参与6部心血管影像专业著作的编写工作;主持国家级及市级课题5项。


  • 研究方向Research Directions
心血管影像
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
项目情况

1、结合磁共振成像研究NLRP3炎症小体在心房颤动心肌纤维化中的作用及其机制,2022-1至2024-12,北京市自然科学基金,20万元

2、基于心脏磁共振细胞外容积成像研究Galectin-3在心房颤动诱导心肌间质纤维化中的作用及其机制,2018-1至2021-12,国家自然科学基金,60.5万元

3、ECV成像定量评估心房颤动患者左心室心肌纤维化,2016-1至2018-12,北京市委组织部项目,5万元

4、房颤患者心室纤维化的磁共振定量分析及其在消融术后评价中的应用,2016-1至2018-12,首都卫生发展科研专项,13万元


科研项目

1、结合磁共振成像研究NLRP3炎症小体在心房颤动心肌纤维化中的作用及其机制,2022-1至2024-12,北京市自然科学基金

2、基于心脏磁共振细胞外容积成像研究Galectin-3在心房颤动诱导心肌间质纤维化中的作用及其机制,2018-1至2021-12,国家自然科学基金

3、ECV成像定量评估心房颤动患者左心室心肌纤维化,2016-1至2018-12,北京市委组织部项目

4、房颤患者心室纤维化的磁共振定量分析及其在消融术后评价中的应用,2016-1至2018-12,首都卫生发展科研专项


研究成果

1. Wei X, Zhao L, Xie J, Liu Y, Du Z, Zhong X, Ye W, Wang Y, Chen Y, Lu M, Liu H. Cardiac Phenotype Characterization at MRI in Patients with Danon Disease: A Retrospective Multicenter Case Series. Radiology. 2021 May;299(2):303-310. doi: 10.1148/radiol.2021203996. Epub 2021 Mar 23. PMID: 33754825.

2. Li SN, Zhang JR, Zhou L, Xi H, Li CY, Zhao L. Sacubitril/Valsartan Decreases Atrial Fibrillation Susceptibility by Inhibiting Angiotensin II-Induced Atrial Fibrosis Through p-Smad2/3, p-JNK, and p-p38 Signaling Pathways. J Cardiovasc Transl Res. 2022 Feb;15(1):131-142. doi: 10.1007/s12265-021-10137-5. Epub 2021 Jun 1. PMID: 34075552.

3. Xie J, Liu Y, Wei X, Ye W, Ma Z, Lu G, Tan Z, Li T, Wang Y, Zhao L, Lu M, Li X, Chen Y, Liu H. Relationship Between Fragmented QRS Complex and Left Ventricular Fibrosis and Function in Patients With Danon Disease. Front Cardiovasc Med. 2022 Feb 21;9:790917. doi: 10.3389/fcvm.2022.790917. PMID: 35299984; PMCID: PMC8923125.

4. Zhang H, Zhao L, Zhang C, Tian J, Ding Y, Zhao X, Ma X. Quantification of Myocardial Deformation in Patients with Takayasu Arteritis by Cardiovascular Magnetic Resonance Feature Tracking Imaging. J Magn Reson Imaging. 2022 Jun;55(6):1828-1840. doi: 10.1002/jmri.27942. Epub 2021 Sep 28. PMID: 34582063.

5. Zhao L, Li S, Zhang C, Tian J, Lu A, Bai R, An J, Greiser A, Huang J, Ma X. Cardiovascular magnetic resonance-determined left ventricular myocardium impairment is associated with C-reactive protein and ST2 in patients with paroxysmal atrial fibrillation. J Cardiovasc Magn Reson. 2021 Mar 22;23(1):30. doi: 10.1186/s12968-021-00732-5. PMID: 33745456; PMCID: PMC7983280.

6. Zhao L, Zhang C, Tian J, Saiedi M, Ma C, Li N, Fang F, Ma X, Selvanayagam J. Quantification of myocardial deformation in patients with Fabry disease by cardiovascular magnetic resonance feature tracking imaging. Cardiovasc Diagn Ther. 2021 Feb;11(1):91-101. doi: 10.21037/cdt-20-897. PMID: 33708481; PMCID: PMC7944214.

7. Zhao L, Zhang C, Tian J, DeLano M, Ma X. Myocardial Deformation Assessed by MR Feature Tracking in Groups of Patients With Ischemic Heart Disease. J Magn Reson Imaging. 2021 Sep;54(3):808-815. doi: 10.1002/jmri.27588. Epub 2021 Mar 4. PMID: 33665932.

8. Zhang C, Zhao L, Zhu E, Schoenhagen P, Tian J, Lai YQ, Ma X. Predictors of moderate to severe ischemic mitral regurgitation after myocardial infarction: a cardiac magnetic resonance study. Eur Radiol. 2021 Aug;31(8):5650-5658. doi: 10.1007/s00330-020-07658-z. Epub 2021 Jan 15. PMID: 33449179.

9. Li CY, Zhang JR, Li XX, Zhao L, Xi H, Hu WN, Li SN. Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways. J Cardiovasc Transl Res. 2021 Aug;14(4):636-646. doi: 10.1007/s12265-020-10089-2. Epub 2021 Jan 6. PMID: 33409963.

10. Li S, Zhao L, Lu A, Tian J, Gong L, Ma X. Comparison of Left Ventricular Global Strain in Anterior and Non-anterior Wall Myocardial Infarction With CMR Tissue Tracking. Front Physiol. 2020 Dec 10;11:530108. doi: 10.3389/fphys.2020.530108. PMID: 33362570; PMCID: PMC7758347.

11. Zhao L, Lu A, Tian J, Huang J, Ma X. Effects of Different LVEF Assessed by Echocardiography and CMR on the Diagnosis and Therapeutic Decisions of Cardiovascular Diseases. Front Physiol. 2020 Jun 16;11:679. doi: 10.3389/fphys.2020.00679. PMID: 32612544; PMCID: PMC7308546.

12. Chen H, Xie RM, Zhao L, Zhang XY, Zhao YK, Wang Z, Xie GX, Ma XH. Evaluation of left ventricular strain in patients with arrhythmia based on the 3T MR temporal parallel acquisition technique. Sci Rep. 2020 Jun 9;10(1):9342. doi: 10.1038/s41598-020-66315-z. PMID: 32518330; PMCID: PMC7283215.

13. Song L, Ma X, Zhao X, Zhao L, DeLano M, Fan Y, Wu B, Lu A, Tian J, He L. Validation of black blood late gadolinium enhancement (LGE) for evaluation of myocardial infarction in patients with or without pathological Q-wave on electrocardiogram (ECG). Cardiovasc Diagn Ther. 2020 Apr;10(2):124-134. doi: 10.21037/cdt.2019.12.11. PMID: 32420092; PMCID: PMC7225441.

14. Schoenhagen P, Ma X, Zhao L. Management of type-A intramural hematoma: Does classification matter? Int J Cardiol. 2020 Aug 15;313:121-122. doi: 10.1016/j.ijcard.2020.04.034. Epub 2020 Apr 14. PMID: 32359861.

15. Li S, Zhao L, Ma X, Bai R, Tian J, Selvanayagam JB. Left ventricular fibrosis by extracellular volume fraction and the risk of atrial fibrillation recurrence after catheter ablation. Cardiovasc Diagn Ther. 2019 Dec;9(6):578-585. doi: 10.21037/cdt.2019.12.03. PMID: 32038947; PMCID: PMC6987514.

16. Zhao L, Li S, Ma X, Bai R, Liu N, Li N, Schoenhagen P, Ma C. Prognostic Significance of Left Ventricular Fibrosis Assessed by T1 Mapping in Patients with Atrial Fibrillation and Heart Failure. Sci Rep. 2019 Sep 16;9(1):13374. doi: 10.1038/s41598-019-49793-8. PMID: 31527757; PMCID: PMC6746785.

17. Chen R, Lu A, Wang J, Ma X, Zhao L, Wu W, Du Z, Fei H, Lin Q, Yu Z, Liu H. Using machine learning to predict one-year cardiovascular events in patients with severe dilated cardiomyopathy. Eur J Radiol. 2019 Aug;117:178-183. doi: 10.1016/j.ejrad.2019.06.004. Epub 2019 Jun 11. PMID: 31307645.

18. Zhao L, Wang Z, Lu A, Ma X. Discordant clinical presentation and pathophysiology: insights with cardiac magnetic resonance. Cardiovasc Diagn Ther. 2019 Apr;9(2):189-193. doi: 10.21037/cdt.2019.02.04. PMID: 31143641; PMCID: PMC6511683.

19. Wang Y, Hu YC, Zhou Y, Zhao L, Chen D, Li LL, Jiang L, Zhang ZC, Li SN, Wen SN, Ruan YF, Liu N, Qiao Y, Lv Q, Hu R, Du X, Liu XH, Ma CS, Dong JZ, Bai R. Relationship between coronary artery calcification and calcium deposition in the myocardium. J Int Med Res. 2019 Jul;47(7):2910-2920. doi: 10.1177/0300060519848587. Epub 2019 May 22. PMID: 31117861; PMCID: PMC6683874.

20. Liu W, Zheng J, Dong J, Bai R, Song D, Ma X, Zhao L, Yao Y, Zhang H, Liu T. Association of miR-197-5p, a Circulating Biomarker for Heart Failure, with Myocardial Fibrosis and Adverse Cardiovascular Events among Patients with Stage C or D Heart Failure. Cardiology. 2018;141(4):212-225. doi: 10.1159/000493419. Epub 2019 Mar 5. PMID: 30836355.

21. Zheng T, Ma X, Li S, Ueda T, Wang Z, Lu A, Zhou W, Zou H, Zhao L, Gong L. Value of Cardiac Magnetic Resonance Fractal Analysis Combined With Myocardial Strain in Discriminating Isolated Left Ventricular Noncompaction and Dilated Cardiomyopathy. J Magn Reson Imaging. 2019 Jul;50(1):153-163. doi: 10.1002/jmri.26616. Epub 2018 Dec 19. PMID: 30565346.

22. Leng S, Zhao X, Koh AS, Zhao L, Allen JC, Tan RS, Ma X, Zhong L. Age-related changes in four-dimensional CMR-derived atrioventricular junction velocities and displacements: Implications for the identification of altered annular dynamics for ventricular function assessment. Int J Cardiol Heart Vasc. 2018 Nov 16;22:6-12. doi: 10.1016/j.ijcha.2018.11.001. PMID: 30480084; PMCID: PMC6240643.

23. Peng J, Zhao X, Zhao L, Fan Z, Wang Z, Chen H, Leng S, Allen J, Tan RS, Koh AS, Ma X, Lou M, Zhong L. Normal Values of Myocardial Deformation Assessed by Cardiovascular Magnetic Resonance Feature Tracking in a Healthy Chinese Population: A Multicenter Study. Front Physiol. 2018 Sep 3;9:1181. doi: 10.3389/fphys.2018.01181. PMID: 30233388; PMCID: PMC6129778.

24. Liu T, Song D, Dong J, Zhu P, Liu J, Liu W, Ma X, Zhao L, Ling S. Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure. Front Physiol. 2017 Apr 24;8:238. doi: 10.3389/fphys.2017.00238. PMID: 28484397; PMCID: PMC5402617.

25. Liu D, Ma X, Liu J, Zhao L, Chen H, Xu L, Sun Z, Fan Z. Quantitative analysis of late gadolinium enhancement in hypertrophic cardiomyopathy: comparison of diagnostic performance in myocardial fibrosis between gadobutrol and gadopentetate dimeglumine. Int J Cardiovasc Imaging. 2017 Aug;33(8):1191-1200. doi: 10.1007/s10554-017-1101-7. Epub 2017 Mar 13. PMID: 28289991.

26. Liu T, Ma X, Liu W, Ling S, Zhao L, Xu L, Song D, Liu J, Sun Z, Fan Z, Luo T, Kang J, Liu X, Dong J. Late Gadolinium Enhancement Amount As an Independent Risk Factor for the Incidence of Adverse Cardiovascular Events in Patients with Stage C or D Heart Failure. Front Physiol. 2016 Oct 28;7:484. doi: 10.3389/fphys.2016.00484. PMID: 27840608; PMCID: PMC5083842.

27. Zhao L, Li S, Ma X, Greiser A, Zhang T, An J, Bai R, Dong J, Fan Z. Systolic MOLLI T1 mapping with heart-rate-dependent pulse sequence sampling scheme is feasible in patients with atrial fibrillation. J Cardiovasc Magn Reson. 2016 Mar 15;18:13. doi: 10.1186/s12968-016-0232-7. PMID: 26980571; PMCID: PMC4793619.


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