（1） 比较不同眼压设置的白内障手术治疗原发性闭角型青光眼（PACG）术后前房炎症反应的差异：一项前瞻性随机对照研究，范志刚，企业委托横向项目，2023.1-2024.1，40.767万

（2） 新型多通道房水引流术治疗中青年晚期原发性开角型青光眼的疗效及机制研究，范志刚，首都临床特色诊疗技术研究及转化应用，Z221100007422057, 2022.11-2025.12，35万

（3） MYRF基因突变在真性小眼球继发闭角型青光眼晶状体悬韧带病变中的作用和机制研究，范志刚，国家自然科学基金面上项目，82171050，2022.01-2025.12，54万，主持

（4） MYRF基因突变导致真性小眼球发病机制研究，范志刚，广东省自然科学基金，2020A1515010168，2019.4-2022.9，10万，主持

（5） 广州市民生科技攻关计划民生科技攻关专题，2019.04-2020.03，神经致盲性眼病早期诊疗关键技术研究，主持，100万，结题，主持

（6） 广州市健康医疗协同创新重大计划项目，201803040020，帕金森病早期综合诊断技术研究，2018.4.1-2021.3.31, 30万，结题，子项目负责人

（7） 国家自然科学基金重点项目，81630022，血管重建治疗视网膜变性疾病的作用及机制研究，2017.01-2021.12，277万元，结题，排名第二；

（8） 国家自然科学基金-广东省联合基金重点项目，U1601226，肠道微生物通过ILC3s介导免疫失衡在葡萄膜炎发生中的作用与机制，2017.01-2020.12，240万元，结题，排名第二；

（9） 中山大学重大项目培育和新兴交叉学科资助计划项目，患者自体诱导多潜能干细胞进行青光眼相关基因功能和体内移植研究，2017.01-2018.12, 20万元，结题，主持

（10） 中山大学百人引进计划启动基金，中心科研启动经费，2015.11-，200万元，主持

（11） 中山大学中山眼科中心国重PI研究基金，国重PI研究经费，2017.7-2020.12, 40万/年，主持

（12） 中山大学中山眼科中心资助项目，共同申报NSFC-广东省联合基金重点项目，2017.6.22-2022.6.21，48万，主持

（13） 国家重点实验室开放课题，原发性开角型青光眼（POAG）的药物基因组学研究，2016.4.4-2016-12-31，15万，主持

1. 张天睿,余晓伟,石砚,范志刚*.真性小眼球性葡萄膜渗漏综合征的病理生理学机制与治疗进展[J].微创医学,2023,18(02):137-142.

2. 孙珑彦,石砚,范志刚*.他氟前列素滴眼液治疗青光眼的应用研究进展[J].国际眼科纵览,2023,47(03):193-202.

3. Tang Yizhen#, Shi Yan, Zhigang Fan*. The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy. Front Endocrinol (Lausanne). 2023 Jan 23;14:1102361. doi: 10.3389/fendo.2023.1102361.

4. Zhang Dandan#, Sun Nannan#, Guo Congcong, Lee Junhui, Zhang Jiamin, Zhao Zhenni, Yu Xiaowei, Han Yin, Ge Jian*, Zhigang Fan*. Psychological stress induces moderate pathology in the ganglion cell layer in mice. Molecular Vision. 2022 Dec 21;28:451-459.

5. Xiaowei Yu#, Brad Kline, Ying Han, Yan Gao, Zhigang Fan*, Yan Shi*. Weill-Marchesani syndrome 4 caused by compound heterozygosity of a maternal submicroscopic deletion and a paternal nonsense variant in the ADAMTS17 gene: A case report[J]. American Journal of Ophthalmology Case Reports, 2022 Apr 14;26:101541.

6. 高妍,辛晨,石砚,余晓伟,范志刚*.改良式小梁切除联合深层巩膜切除术[J].眼科,2022,31(03):175-180.DOI:10.13281/j.cnki.issn.1004-4469.2022.03.003.

7. 余晓伟,石砚,高妍, 范志刚*. TMEM98 基因突变致真性小眼球1 家系[J]. 中华眼科杂志, 2022, 58(11): 932-935.

8. 葛坚, 石砚, 范志刚*. Ahmed青光眼引流阀植入术的应用及进展[J]. 中华眼科杂志, 2022, 58(1):8.

9. Xiaowei Yu#, Nannan Sun#, Congcong Guo, Zhenni Zhao, Meifang Ye, Jiamin Zhang, Jian Ge*, Zhigang Fan*, Evaluation of MYRF as a candidate gene for primary angle closure glaucoma. Molecular Vision, 2021, Dec 29;27:734-740.

10. Xue Yang, Xiaowei Yu, Zhenni Zhao, Yuqing He, Jiamin Zhang, Xiaoqian Su, Nannan Sun*, Zhigang Fan*, Endoplasmic reticulum stress is involved in retinal injury induced by repeated transient spikes of intraocular pressure, Journal of Zhejiang University Science, 2021, 22(9):746-756.

11. Xiaowei Yu#, Zhenni Zhao#, Dandan Zhang, Xue Yang, Nannan Sun, Yixiu Lin, Jiamin Zhang, Zhigang Fan*, Anterior vitrectomy, phacoemulsification cataract extraction and irido-zonulo-hyaloid-vitrectomy in protracted acute angle closure crisis, Int Ophthalmol, 2021 Sep;41(9):3087-3097.

12. Xiaowei Yu#, Nannan Sun#, Xue Yang#, Zhenni Zhao, Jiamin Zhang, Miao Zhang, Dandan Zhang, Jian Ge*, Zhigang Fan*, Myelin regulatory factor deficiency is associated with the retinal photoreceptor defects in mice, Vis Neurosci, 2021, 5(38):E005

13. Xiaowei Yu#, Nannan Sun#, Xue Yang, Zhenni Zhao, Xiaoqian Su, Jiamin Zhang, Yuqing He, Yixiu Lin, Jian Ge*, Zhigang Fan*, Nanophthalmos-Associated MYRF Gene Mutation Causes Ciliary Zonule Defects in Mice, Invest. Ophthalmol. Vis. Sci, 2021, Mar;62(3):1

14. Xue Yang, Nannan Sun, Zhenni Zhao, Shuxiang He , Miao Zhang, Dandan Zhang, Xiaowei Yu, Jiamin Zhang, Zhigang Fan*, Coinheritance of OLFM2 and SIX6 variants in a Chinese family with juvenile-onset primary open-angle glaucoma: A case report, World J Clin Cases, 2021, 9(3): 697-706

15. 杨雪#，余晓伟，范志刚*，原发性开角型青光眼的免疫机制，眼科，2021（1）：5-10

16. Zhenni Zhao#, Xiaowei Yu#, Xue Yang, Jiamin Zhang, Dandan Zhang, Nannan Sun*, Zhigang Fan*, Elevated intraocular pressure causes cellular and molecular retinal injuries, advocating a more moderate intraocular pressure setting during phacoemulsification surgery, International Ophthalmology, 2020 Dec;40(12):3323-3336.

17. Xue Yang#, Xiaowei Yu, Dandan Zhang, Zhigang Fan*, The blood-retinal barrier, as a converging pivot in understanding the initiation and propagation of retinal diseases: a literature review, Chinese Medical Journal ,2020, Nov 5;133(21):2586-2594.

18. 余晓伟#，杨雪，赵珍妮，范志刚*,原发性闭角型青光眼发病机制和致病基因探索到新思路，眼科，2020,29(04):246-254

19. 余晓伟#，赵珍妮，杨雪，范志刚*，青光眼发病机制：从临床复杂表型剖析到基本科学问题探索，眼科，2020,29(01):1-5.

20. Cheng Li#, Congcong Guo, Yangfan Yang, Minbin Yu, Jian Ge, Zhigang Fan*, Newly Onset Optic Disc Pit Maculopathy (ODP-M) in a Patient With Primary Angle-closure, Journal of Glaucoma, 2020;4(6)

21. Congcong Guo#, Zhenni Zhao#, Denghui Chen, Shuxiang He, Nannan Sun, Zhongwen Li, Jiafan Liu, Dandan Zhang, Jiamin Zhang, Jianlong Li, Miao Zhang, Jian Ge, Xing Liu, Xiaoling Zhang*, Zhigang Fan*, Detection of Clinically Relevant Genetic Variants in Chinese Patients With Nanophthalmos by Trio-Based Whole-Genome Sequencing Study, Invest. Ophthalmol. Vis. Sci, 2019;7:2904-2913

22. Congcong Guo#, Zhenni Zhao#, Dandan Zhang, Jiafan Liu, Jianlong Li, Jiamin Zhang, Nannan Sun, Denghui Chen, Miao Zhang, Zhigang Fan*, Anterior Segment Features in Nanophthalmos With Secondary Chronic Angle Closure Glaucoma: An Ultrasound Biomicroscopy Study, Invest. Ophthalmol. Vis. Sci, 2019; 5:2248-2256

23. Dandan Zhang#, Crystal Le#, Jiafan Liu, Congcong Guo, Jianlong Li, Jiamin Zhang, Zhongwen Li1, Zhenni Zhao, Denghui Chen, Miao Zhang, Nannan Sun, Ying Han, Chunmei Li1, Zhigang Fan*, Clinical characterization of refractory virus-related inflammation inside aqueous outflow pathways in Chinese immunocompetent patients, Chinese Medical Journal 2019;132(3)