2019年调入首都医科大学附属北京同仁医院，每年已经招收1名博士，1名统招硕士和1名5+3长学制硕士，目前是首医博士后导师、阶平班导师和留学生导师。每位在校博士至少已经发表SCI论文2篇（IF＞10分），每位硕士发表1篇SCI论文（IF＞2分）和1篇中华系列文章。

团队学术氛围浓厚，互相团结帮助，老师亲自指导课题研究与论文撰写修改。

Our team focuses on the basic and clinical research of bone and cartilage, especially on cartilage tissue engineering and the diagnosis and treatment of foot and ankle related diseases.

本团队研究方向包括软骨损伤与关节炎，足踝外科基础与临床，数字化骨科，干细胞成骨和软骨分化，骨代谢

· 主持国家自然科学基金3项，在研1项

· 省部级课题6项，包括北京市自然基金重点项目.北京市自然基金面上项目，北京市教委课题

· 入选省部级人才计划5项，包括北京市高层次人才建设项目培养计划, 北京市百千万人才工程，登峰人才计划，上海市优秀学术带头人计划，上海市医学人才杰青项目

1. 足踝矫形外科：并发症的处理，人民卫生出版社，主译

2. 足踝外科翻修手术：策略与技术，北京大学医学出版社，主译

3. 俞光荣 主编，跟骨骨折的基础与临床，参编

4. 赵定麟 主编，骨科手术学，参编

5. 王正义 主编，足踝外科学，参编

6. 王正义 主编，足踝外科手术学，参编

7. 唐康来主译，曼氏足踝外科学，担任主译助理

8.足踝外科精要，科学出版社，主译

团队研究网页地址，欢迎访问： https://www.researchgate.net/profile/Mingzhu-Zhang-6

1. Sun Y, Ding SL, Zhao X, Sun D, Yang Y, Chen M, Zhu C, Jiang B, Gu Q, Liu H, Zhang M. Self-reinforced MOF-based nanogel alleviates osteoarthritis by long-acting drug release.Advanced Materials. 2024 Apr 29:e2401094. doi: 10.1002/adma.202401094（IF 27.4）

2. Ding SL, Zhao XY, Xiong W, Ji L , Jia M, Liu Y, Guo  H, Qu F, Cui WG , Gu Q ,Zhang MZ*. Cartilage Lacuna-inspired Microcarriers Drive Hyaline Neocartilage Regeneration. Advanced Materials. 2023 Mar 6;e2212114, doi.org/10.1002/adma.202212114 （IF 27.4）

3. Han Z, Wang F, Xiong W, Meng C, Yao Y, Cui W, Zhang M. Precise Cell Type Electrical Stimulation Therapy Via Force-electric Hydrogel Microspheres for Cartilage Healing. Adv Mater. 2025 Feb;37(7):e2414555. doi: 10.1002/adma.202414555. (IF 27.4）

4.Shen J, Liu J, Liang F, Liu X, Zhang M. Prevalence of flatfoot and analysis of plantar pressure distribution in adolescents based on body mass index: a regional study. J Orthop Surg Res. 2024 Dec 23;19(1):864. doi: 10.1186/s13018-024-05365-9. (IF 2.8)

5.Qu F, Ji L, Sun C, Zhu M, Myerson MS, Li S, Zhang M. Arthroscopic Anterior Talofibular Ligament Repair Combined With All-Inside Suture Tape Augmentation for Treatment of Chronic Lateral Ankle Instability With Generalized Joint Laxity. Foot Ankle Int. 2024 Oct;45(10):1102-1110. doi: 10.1177/10711007241271247. (IF 2.4)

6. Cui Y , Shan Yizhu , Jiaxuan Li, Meng Kiao, Yuan Ki, Jianving Ji, Engui Wang, BaokumnZhang, Lingling Xu , Mingzhu Zhang*, Li Zhou  and Zhang Yingzi. Bifunctional Piezo-enhanced PLLAZA Coating Prevents Aseptic Loosening of Bone lmplants. Advanced Functional Materials, 2024, adfm.202403759 （IF 18.9）

7. Xiong W, Han Z, Ding SL, Wang H, Du Y, Cui W, Zhang MZ. In Situ Remodeling of Efferocytosis via Lesion-Localized Microspheres to Reverse Cartilage Senescence..Advanced Science. 2024 Mar 11(19):e2400345. doi: 10.1002/advs.202400345. （IF 14.3）

8. Yao Y, Cui X, Ding S, Wang K, Zhang M.Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives. Adv Sci (Weinh). 2025 Feb 14:e2411209. doi: 10.1002/advs.202411209. (IF 14.3)

9. Han Z, Wang K, Ding S, Zhang M.Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis. Bone Res. 2024 Dec 3;12(1):69. doi: 10.1038/s41413-024-00375-z. （IF 14.3）

10. Zhao ZY, Ruan H，Chen A, Xiong W, Zhang MZ, Cai M, Cui W. Genetic engineered ultrasound-triggered injectable hydrogels for promoting bone reconstruction.Research. 17 Aug 2023, doi.org/10.34133/research.0221 (IF 11.0)

11. Han ZY; Bai L, Zhou J, Qian YH ; Tang Y,Han Q, Zhang X, Zhang MZ*. Yang X, Cui WG ,Hao Y. Nanofat functionalized injectable super-lubricating microfluidic microspheres for treatment of osteoarthritis.Biomaterials. 2022, 285:121545.doi.org/10.1016/j.biomaterials.2022.121545.（IF15.304）

12. Ding SL,Liu X ,Zhao XY,Wang KT,Xiong Wei,Gao Zi-Li ,Sun Cheng-Yi ,Jia MX,Li C ,Gu Q ,Zhang MZ* . Microcarriers in application for cartilage tissue engineering: Recent progress and challenges.Bioactive Materials, 2022, 17（11）:81-108 （IF 18）

13. Wang K, Li Ji, Wang Y, Wang Y, Qin Y, Yang F,, Zhang MZ*, Zhu H *, Li Z* Orchestrated cellular, biochemical, and biomechanical optimizations endow platelet-rich plasma-based engineered cartilage with structural and biomechanical recovery. Bioactive Materials, 2021, 6(11): 3824-3838. （IF 18）

14. Zhao ZY ,Li R  Ruan H,Cai Z , Zhuang Y ,  Han Z , Zhang MZ* , Cui W , Cai M. Biological Signal Integrated Microfluidic Hydrogel Microspheres for Promoting Bone Regeneration. Chemical Engineering Journal,2022，436,135176,doi.org/10.1016/j.cej.2022.135176.（IF16.744）

15. Huang WH, Ding SL, Zhao XY, Li K, Guo HT, Zhang MZ, Gu Q. Collagen for neural tissue engineering: Materials, strategies, and challenges.Mater Today Bio. 2023 May 2;20:100639 (IF 8)

16. Zhou J, Li Q, Tian Z, Yao Q, Zhang M Recent advances in 3D bioprinted cartilage-mimicking constructs for applications in tissue engineering..Mater Today Bio. 2023 Nov 17;23:100870. doi: 10.1016/j.mtbio.2023.100870 (IF 8)

17.  Gao Z, Ding S, Fan T, Huang W, Zhao X, Liu X, Liu W, Zhang M, Gu Q.Protocol for embedded 3D printing of heart tissues using thiol-norbornene collagen.STAR Protoc. 2024 Apr 2;5(2):102994. doi: 10.1016/j.xpro.2024.102994 （IF 1.3）

18. Zhang MZ, Ferrigno O, Wang Z, Ohnishi M, Prunier C, Levy L, Razzaque M, Horne WC, Romero D, Tzivion G, Colland F, Baron R, Atfi A. TGIF Governs a Feed-Forward Network that Empowers Wnt Signaling to Drive Mammary Tumorigenesis, Cancer Cell，2015 Apr 13;27(4):547-560.（IF 48.8）

19. Song L, Li H, Liu Y, Zhang X, Wen Y, Zhang K, Zhang MZ*. Postnatal deletion of β-catenin in preosteoblasts regulates global energy metabolism through increasing bone resorption and adipose tissue fibrosis. Bone. 2022 Mar;156:116320. doi: 10.1016/j.bone.2021.116320(  IF 4.626)

20. Ding SL, Ji LF, Zhang MZ, Xiong W, Sun CY, Han ZY, Wang C.Safety and efficacy of intra-articular injection of platelet-rich plasma for the treatment of ankle osteoarthritis: a systematic review and meta-analysis.Int Orthop. 2023 Aug;47(8):1963-1974. doi: 10.1007/s00264-023-05773-2. （IF 2.0）

21. Ji L, Ding S, Zhang M, Colon Reyes K, Zhu M, Sun C.The Role of First Tarsometatarsal Joint Morphology and Instability in the Etiology of Hallux Valgus: A Case-Control Study.Foot Ankle Int. 2023 Aug;44(8):778-787. doi: 10.1177/10711007231175846. （IF 2.4）

22. Zhang S, Sun C, Zhang J, Wang Z, Zhao H, Zhang M. Changes in the subtalar joint alignment after supramalleolar osteotomy for varus ankle arthritis.Foot Ankle Surg. 2023 Aug;29(6):475-480. （IF 1.9）

23. Zhang S, Sun C, Zhang J, Wang Z, Li S, Zhang M.Subchondral bone cysts remodel after correction of varus deformity in ankle arthritis. Foot Ankle Surg. 2023 Jul;29(5):419-423.（IF 1.9）

24. Prunier C#, Zhang MZ#, Kumar S, Levy L, Ferrigno O, Tzivion G, Atfi A. Disruption of the PHRF1 Tumor Suppressor Network by PML-RARα Drives Acute Promyelocytic Leukemia Pathogenesis. Cell Reports, 2015 February 17,10( 6): 883–890 ( IF  9.993)

25. Zhang S, Aiyer A, Sun C, Wang Z, Lin D, Qu F, Wei F, Wang X, Zhang F, Li S, Chen Y, Zhang J, Lintz F, Zhang M*, Operative Treatment for Ganglion Cyst of Flexor Hallucis Longus Sheath. Foot Ankle International. 2020 Aug;41(8): 978-983. (  IF 3.569)

26. Yu Q, Li Z, Li J, Yu Q, Zhang L, Liu D, Zhang M*, Tang P.J.Calcaneal fracture maps and their determinants. Journal of Orthopaedic Surgery and Research. 2022 Jan 21;17(1):39. doi: 10.1186/s13018-022-02930-y  (  IF 2.677)

27. Ji L, Wang K, Ding S, Sun C, Sun S, Zhang M*. Minimally Invasive vs. Open Surgery for Hallux Valgus: A Meta-Analysis. Frontiers in Surgery.2022 March.volume 9,843410-843421. doi: 10.3389/fsurg.2022.843410  (  IF 2.568)

28. Sun C, Miao X, Zhang M*, Yang Y, Zhao H, Tang X, Yu G.Lisfranc injuries with dislocation the frst tarsometatarsal joint: primary arthrodesis or internal fxation (a randomized controlled trial).International Orthopaedics. 2022 Jun 20. doi: 10.1007/s00264-022-05478-y （IF 3.479）

29. Yu G, Zhang M*, Aiyer A,Tang X, Xie M, Zeng Li, Zhao Y, Zhou J, Li B,Yang Y Repair of the acute deltoid ligament complex rupture associated with ankle fractures: a multicenter clinical study. Journal of Foot and Ankle Surgery，2015，Mar-Apr;54(2):198-202.(  IF 1.286)

30. Ettahar A, Ferrigno O, Zhang MZ, Ohnishi M, Ferrand N, Prunier C, Levy L, Bourgeade MF, Bieche I, Romero DG, Colland F, Atfi A. Identification of PHRF1 as a Tumor Suppressor that Promotes the TGF-β Cytostatic Program through Selective Release of TGIF-Driven PML Inactivation. Cell Reports. 2013,4(3) 530-541（IF 9.99）

31. Yu GR, Zhang MZ, Yang YF, Corrective Osteotomies for Malunited Tongue-Type Calcaneal Fractures, Foot Ankle Clin. 2016 Mar;21(1):123-134.(IF 1.653)

32. Yu G, Zhao Y, Zhou J, Zhang M. Surgical fusion of talonavicular joint and naviculocuneiform joint for Müller-Weiss disease. Journal of Foot and Ankle Surgery, 2012,51(4) :415-419 (IF 1.286)

33. Zhang M, Zhao Q, Tang X, Yu G, Inhibitory effect of siRNAs on glial fibrillary acidic expression in astrocytes, Neural Regen Res,2008, 3(9): 950-953. (IF 6.058)

34.李鹏飞,王智,曲峰,等. 急性跟腱断裂愈合后腱体延长的评估及影响因素研究进展[J]. 中华创伤杂志,2023,39(10):940-946.

35. 王超，丁声龙，张明珠. 医源性内翻发病原因及治疗的研究进展. 中华解剖与临床杂志，2023，28(02):136-140. 

36. 曲峰，孙成宜，张明珠, 张琳, 王智, 孙超, 王显军, 张建中. 关节镜下改良Broström术联合腓骨肌腱清理治疗慢性踝关节外侧不稳伴腓骨肌腱炎. 中华创伤杂志，2023，39(08):680-687. 

37.李琪，张明珠. 抗衰老药物治疗骨关节炎的研究进展. 中华实验外科杂志，2023，40(07):1439-1445. 

38.王昊，曲峰，丁声龙, 孙颂民, 张明珠. 细胞移植技术治疗距骨骨软骨损伤的研究进展. 中华创伤杂志，2023，39(07):665-672. 

39,王超，王智，孙超, 张建中, 王显军, 丁声龙, 张明珠. 改良卡槽单钉Scarf截骨术与传统Scarf截骨术治疗足拇外翻畸形效果的比较. 中华解剖与临床杂志，2023，28(07):423-430. 

40.王智，孙成宜，张建中, 张明珠. 副舟骨植骨与髂骨植骨Cotton截骨术对儿童柔韧性平足症的疗效对比研究. 中华医学杂志，2023，103(37):2926-2932. 

41.张建中，曲峰，张明珠. 进行性塌陷足畸形专家共识解读. 中华医学杂志，2023，103(37):2907-2911.

42.纪霖锋，丁声龙，张明珠. 第一跖楔关节矢状不稳与拇外翻合并转移性跖骨痛的相关性. 中华医学杂志，2023，103(01):25-31. 

43.张树，张建中，王智，孙超，张明珠. 胫前肌腱外移联合踝上截骨治疗3b期内翻性踝关节炎的临床疗效. 中华医学杂志，2023，103(39):3136-3139. 

44.张明珠,杨云峰,苗旭东,徐海林,黄建华,张洪涛,张晖,王志坚,杨茂伟,栾波,阿发武,俞光荣.切开复位内固定与Ⅰ期融合治疗伴第一跖跗关节脱位Lisfranc损伤的疗效比较. 中华创伤杂志 2018,34:(7) 585-590

45.张明珠,和文宝,李润民,赵有光,李兵,于涛,杨云峰,尤春芳,姚英,俞光荣,踝关节骨折伴三角韧带完全断裂的手术治疗.中华解剖与临床杂志,2019,24:(2) 118-122

46.张明珠,王智,曲峰,魏芳远,张树, 孙超, 王显军, 张建中,俞光荣.闭合复位经皮内固定治疗低能量Lisfranc损伤的临床疗效,中华骨与关节外科杂志，2020，13:(9) 757-760

47.张明珠,王智,曲峰,魏芳远,张树, 孙超, 王显军, 张建中.女性拇外翻引起籽骨嵴磨损的影响因素分析，中华解剖与临床杂志，2020,25:(5) 478-483

48.张明珠,纪霖锋,张英琪.3D打印导板辅助微创复位内固定治疗Sanders Ⅱ型跟骨骨折的疗效分析,中华创伤骨科杂志,2022,24(04):310-315.

49.张明珠,纪霖锋.微创Chevron联合Akin截骨治疗足拇外翻的研究进展,中华解剖与临床杂志,2022,27(05):364-367.

1. American Society for Bone and Mineral Research (ASBMR，美国骨矿研究学会年会) 31st Annual Meeting September 11-15, 2009, Colorado Convention Center, Denver, Colorado, USA

2. 37th European Symposium on Calcified Tissues(ECTS，欧洲骨矿研究学会年会), 26-30 June 2010, Glasgow, Scotland, UK

3. TGIF Is Required for Canonical Wnt Signaling-induced Bone Formation. American Society for Bone and Mineral Research (ASBMR，美国骨矿研究学会年会)  Annual Meeting September 12-15,Houston, Taxas, USA，2014, September 12

4. Biomechanical Analysis of Calcaneocuboid Joint Pressure after Sequential Lengthening of the Lateral Column. The American Orthopaedic Foot & Ankle Society (AOFAS，美国足踝外科年会)，September 19-22,2014, Chicago, USA

5. TGIF promotes Wnt Signaling and Bone Formation.European Symposium on Calcified Tissues(ECTS，欧洲骨矿研究学会年会)和 International Bone and Mineral Society (IBMS，国际骨矿研究学会年会)联合会议，25 - 28 April 2015，Rotterdam, Netherlands

6. SICOT(国际骨科大会)，16-19 September,2015, Guangzhou, China

7. Repair of the deltoid ligament associated with ankle fractures. SICOT(国际骨科大会)，8-11 September, 2016, Rome, Italy

8. Primary arthrodesis vs ORIF for Lisfranc injuries with the first TMT dislocation. A multicenter study. IFFAS(国际足踝外科大会)，27-29 September，2017，Lisbon, Portugal.

9. Primary arthrodesis for Lisfranc injuries with the first TMT dislocation. A multicenter study. The American Orthopaedic Foot & Ankle Society (AOFAS，美国足踝外科年会)，July 11-14,2018, Boston, USA

10. Treatment of Lisfranc injuries. SICOT(国际骨科大会)，9-14 October,2018, Montreal, Canada

11. Primary arthrodesis compared with open reduction and internal fixation for Lisfranc injuries。美国足踝外科学会（AOFAS）年会 美国足踝外科学会（ AOFAS）2019-9 美国芝加哥

12. Minimally invasive treatment of calcaneal fractures via the sinus tarsi approach based on a 3D printing technique.亚洲足踝外科学 会（AFFAS）年会 亚洲足踝外科学会 （ AFFA S） 2019-10 泰国曼谷

13. Close reduction and percutaneous internal fixation for low energic Lisfranc injuries. SICOT(国际骨科大会)， 布达佩斯，网络会议 September,2021

14.The Role of First Tarsometatarsal Joint Morphology and Instability in the Etiology of Hallux Valgus: A Case-Control Study. 美国足踝外科学会（AOFAS）年会 美国足踝外科学会（ AOFAS） 2024-9 加拿大温哥华