1. 国家重点研发计划“常见多发病防治研究”重点专项，2022YFC2504100（2022YFC2504101），过敏性鼻炎关键诊疗技术和防控策略研究（中国大气花粉检测网络及过敏性鼻炎预警播报系统的建立），2022.11-2025.12，294万元，在研，主持。

2. 青年北京学者，2023.01-2027.12，400万元，在研，主持。

3. 国家自然科学基金重点项目，82230109，环境污染致认知功能损伤关键毒性组分联合暴露的肠-脑轴免疫调控机制研究，2023.01-2027.12，262万元，在研，主持。

4. 北京市卫生健康委员会，首都卫生发展科研专项重点攻关项目，首发2022-1G-4261，基于重大传染病疫情情景构建的首都公共卫生应急能力建设研究，2022.01-2023.12，90万元，在研，主持。

5. 国家自然科学基金杰出青年基金，82025031，卫生毒理学，2021.01-2025.12，400万元，在研，主持。

6. 浙江大学, 浙江大学新型冠状病毒肺炎（COVID-19）应急科研专项资金资助，无，新型冠状病毒及相近症候群病毒核酸的多重快速检测仪器与试剂的研发，2020.02-2020.06，50万元，结题，主持。

7. 国家自然科学基金重点项目，81730088，大气细颗粒物致气道重塑和肺气肿的非编码RNA相关分子标志筛选及早期预警体系研究，2018.01-2022.12，295万元，结题，主持。

8. 国家自然科学基金委员会与意大利外交与国际合作部合作研究项目，81861138017，肿瘤微环境调控乙酸代谢通路参与结直肠癌转移和预后的作用及其机制研究，2018.01-2020.12，200万元，结题，主持。

9. 国家重点研发计划“大气污染成因与控制技术研究”重点专项，2017YFC0211600（2017YFC0211603），大气污染对呼吸和心血管系统健康影响的早期识别技术，2017.07-2021.12，总经费2967万元，子课题三451万元，结题，子课题三负责人。

10. 国家自然科学基金重大研究计划（培育项目），91643109，长三角地区细颗粒物毒性组分致肺癌表遗传机制研究，2017.01-2019.12，75万元，结题，主持。

11. 江苏省“双创团队”，2017-2019，300万元，结题，参与（核心成员）。

12. 江苏省第十三批“六大人才高峰”高层次人才，细颗粒物的致癌效应，2016-2019，4万元，结题，主持。

13. 江苏省杰出青年基金，BK20150021, 乙酸代谢异常影响结直肠癌发生和转移的调控机制研究，2015.07-2018.06，100万元，结题，主持。

14. 江苏省“双创计划”个人，2015.06-2018.06，100万元，结题，主持。

15. 第十一批国家“青年千人计划”，2015.02-2018.02，200万元，结题，主持。

16. 国家自然科学基金面上项目，81472938，肿瘤微环境诱导乙酸代谢异常影响结肠癌发生和转移，2015.01-2018.12，75万元，结题，主持。

17. 江苏特聘教授，2014.11-2017.11，200万元，优先资助，结题，主持。

(1) Ren C, Yan R, Yuan Z, Yin L, Li H,Ding J, Wu T*, Chen R*. Maternal exposure to sunlight-irradiatedgraphene oxide induces neurodegeneration-like symptoms in zebrafish offspringthrough intergenerational translocation and genomic DNA methylationalterations. Environ Int, 2023 Sep;179:108188. doi: 10.1016/j.envint.2023.108188.

(2) Wang J, Shen S, Yan B, He Y, Zhang G,Shan C, Yang Q, Qin L, Duan Z, Jiang L, Wang X, Wei X, Wang C, Chen R*,Zhang L*. Individual exposure of ambient particulate matters andeosinophilic chronic rhinosinusitis with nasal Polyps: Dose-Response, mediationeffects and recurrence prediction. Environ Int, 2023 Jul;177:108031.doi: 10.1016/j.envint.2023.108031.

(3) Ren Q, Ma J, Li X, Meng Q, Wu S, XieY, Qi Y*, Liu S, Chen R*. Intestinal Toxicity of Metal Nanoparticles: Silver Nanoparticles Disorder theIntestinal Immune Microenvironment. ACS Appl Mater Interfaces. 2023 Jun14;15(23):27774-27788. doi: 10.1021/acsami.3c05692.

(4) Wu S, Yun J, Tang W, Familiari G,Relucenti M, Wu J, Li X, Chen H*, Chen R*, Therapeutic m6A Eraser ALKBH5mRNA-Loaded Exosome-Liposome Hybrid Nanoparticles Inhibit Progression ofColorectal Cancer in Preclinical Tumor Models, ACS Nano, 2023 Jun27;17(12):11838-11854.

(5) Shenshen Wu,Jiajia Wang Zan Fu, Giuseppe Familiari, Michela Relucenti, Michael Aschner,Xiaobo Li, Hanqing Chen*, Rui Chen*, Matairesinol NanoparticlesRestore Chemosensitivity and Suppress Colorectal Cancer Progression inPreclinical Models: Role of Lipid Metabolism Reprogramming, NanoLetters, 2023 Mar 8;23(5):1970-1980.

(6) Qingtao Meng, HaoSun, Shenshen Wu, Giuseppe Familiari, Michela Relucenti, Aschner, Xiaobo Li*, Rui Chen*, Epstein-Barr Virus-encodedMicroRNA-BART18-3p Promotes Colorectal Cancer Progression by Targeting de novoLipogenesis, Advanced Science, 2022, Oct 28;e2202116.

(7) Qingtao Meng,Jing Wang, Bo Jiang, Xinwei Zhang, Jie Xu, Yuanyuan Cao, Hongbao Yang, ShenshenWu, Na Gao, Yu Zhang, Jin Xu, Hanqing Chen*, Xiaobo Li*, Rui Chen*, SiRNA-based delivery nanoplatform attenuates the CRCprogression via HIF1α-AS2, Nano Today, 2022, 101667.

(8) Sun H, Meng Q,Shi C, Yang H, Li X, Wu S, Familiari G, Relucenti M, Aschner M, Wang X*, Chen R*. Hypoxia-inducible exosomesfacilitate liver-tropic pre-metastatic niche in colorectal cancer.Hepatology. 2021 Nov;74(5):2633-2651.

(9) Li X, Sun H, Li B, Zhang X, Cui J, YunJ, Yang Y, Zhang L, Meng Q, Wu S, Duan J, Yang H, Wu J, Sun Z, Zou Y, ChenR*. Probiotics Ameliorate Colon Epithelial Injury Induced by AmbientUltrafine Particles Exposure. Advanced Science, 2019 Jul22;6(18):1900972. DOI: 10.1002/advs.201900972IF: 17.521 Q1 B1.

(10) Yang H, Li X, Meng Q, Sun H, Wu S, HuW, Liu G, Li X, Yang Y*, Chen R*.CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastaticcolorectal cancer. Mol Cancer. 2020 Jan 23;19(1):13.

(11) Li X, Cui J, Yang H, Sun H, Lu R, Gao N, Meng Q,Wu S, Wu J, Aschner M, Chen R*. ColonicInjuries Induced by Inhalational Exposure to Particulate-Matter Air Pollution. AdvancedScience. 2019 Apr 9;6(11):1900180. doi: 10.1002/advs.201900180IF: 17.521 Q1 .

(12)Meng Q#, Wu S#, Wang Y, Sun H, Lu R, Gao N, Yang H, Li X, Achner M, Chen R*. MPO promoter polymorphismrs2333227 enhances malignant phenotypes of colorectal cancer by altering thebinding affinity of AP-2α. Cancer Res. 2018 May15;78(10):2760-2769. doi: 10.1158/0008-5472.CAN-17-2538IF: 13.312 Q1 B1.

(13) Li X,Yang H, Sun H, Lu R, Zhang C, Gao N, Meng Q, Wu S, Wang S, Achner M, Wu J, TangB, Gu A, Kay S*, Chen R*, Taurine AmelioratesParticulate Matter-induced Emphysema by Switching on Mitochondrial NADH DehydrogenaseGenes, Proceedings of the National Academy of Sciences. 2017 Nov 7;114(45): E9655-E9664. 

(14) Li X, Yang H, Wu S, Meng Q, Sun H, LuR, Cui J, Zheng Y, Chen W, Zhang R, Aschner M, Chen R*. Suppression of PTPN6 exacerbates aluminum oxidenanoparticle-induced COPD-like lesions in mice through activation of STATpathway. Particle and fibre toxicology. 2017 Dec 12;14(1):53. doi:10.1186. 

(15) Qingtao Meng#, JiajiaWang#, Jian Cui#, Bin Li, Shenshen Wu, Jun Yun, Michael Aschner, ChengshuoWang, Luo Zhang*, Xiaobo Li*, Rui Chen*,Prediction of COPD Acute Exacerbation in Response to Air Pollution usingExosomal circRNA Profile and Machine Learning, Environment International, 2022 Aug 20;168:107469. 

(16) Shenshen Wu, Lijia Yin, Ke Han, Bo Jiang, Qingtao Meng, MichaelAschner, Xiaobo Li, Rui Chen*, NAT10accelerates pulmonary fibrosis through N4-acetylated TGFB1-initiatedepithelial-to-mesenchymal transition upon ambient fine particulate matterexposure. Environmental Pollution. 2023 Apr 1;322:121149. 

(17) Qing Li, Xiaobo Li, Pengyou Zhou, Rui Chen***, Rui Xiao**, YuanfengPang*, Split aptamer regulated CRISPR/Cas12a biosensor for 17β-estradiol througha gap-enhanced Raman tags based lateral flow strategy. Biosensors and Bioelectronics.2022Nov 1;215:114548. 

(18) Shenshen Wu, Xi Yang, Weiyan Tang, Giuseppe Familiari, MichelaRelucenti, Michael Aschner, Xiaobo Li*, RuiChen*, Chemotherapeutic Risk lncRNA-PVT1 SNP Sensitizes MetastaticColorectal Cancer to FOLFOX Regimen. Frontiers in Oncology. 2022 Mar31;12:808889. 

(19) Yanran Huang#, Yuan Zhang#, Jiajia Wang, Xiaobo Li, ChengshuoWang, Rui Chen*, Luo Zhang*, Impactof Air Pollutants and Pollen on the Severity of Nonallergic Rhinitis: AData-Oriented Analysis. Journal of Asthma and Allergy, 2022Aug 6;15:1045-1054. 

(20) Wang J(#), Wu S(#), Cui J, Ding Z, Meng Q, Sun H, Li B, Teng J,Dong Y, Aschner M, Wu S, Li X, Chen R*,The influences of ambient fine particulate matter constituents on plasmahormones, circulating TMAO levels and blood pressure: A panel study in China. EnvironmentalPollution. 2022 Mar 1;296:118746. 

(21) Meng Q(#), Li B(#), Huang N, Wei S, Ren Q, Wu S, Li X*, ChenR*, Folic acid targets splenic extramedullary hemopoiesis to attenuatecarbon black-induced coagulation-thrombosis potential. Journal of Hazardous Materials.2022 Feb 15;424(Pt B):127354. 

(22) Guan R, Wang T, Dong X, Du K, Li J, Zhao F, Xu J, Li B, Zheng G,Shen X, Cao B, Wang J, Aschner M, Liu M, ChenR*. Effects of co-exposure to lead and manganese on learning and memory deficits.Journalof Environmental Sciences. 2021.doi:10.1016/j.jes.2021.09.012. 

(23) Xu J, Meng Q, Sun H,Zhang X, Yun J, Li B, Wu S, Li X, Yang H, Zhu H, Aschner M, Relucenti M,Familiari G, Chen R*,HER2-specific chimeric antigen receptor-T cells for targeted therapy ofmetastatic colorectal cancer. CellDeath & Disease. 2021Nov 27;12(12):1109.

(24) Fu Y, Li B, Yun J, Xu J, Meng Q, Li X*, Chen R*. lncRNA SOX2-OT ceRNA network enhances the malignancy oflong-term PM 2.5-exposed human bronchial epithelia. Ecotoxicology and EnvironmentalSafety. 2021 Jul 1; 217: 112242.

(25) Li B, Huang N, Wei S, Xu J, Meng Q, Aschner M, Li X*, Chen R*. lncRNA TUG1 as a ceRNApromotes PM exposure-induced airway hyper-reactivity. Journal of Hazardous Materials.2021 Aug: 15 (416).

(26) Zhang X, Zhang Y, MengQ, Sun H, Wu S, Xu J, Yun J, Yang Y, Li B, Zhu H, Xue L, Li X, Chen R*.MicroRNA-382-5p Is Involved in Pulmonary Inflammation Induced by FineParticulate Matter Exposure. Environ Pollut, 2020 Jul;262:114278.

(27) Li X, Zhang Y, Li B, Yang H, Cui J, Li X,Zhang X, Sun H, Meng Q, Wu S, Li S, Wang J, Aschner M, Chen R*.Activation of NLRP3 in Microglia Exacerbates Diesel Exhaust Particles-InducedImpairment in Learning and Memory in Mice. Environ Int,2020 Mar;136:105487.

(28) Yang X, Wu S, LiX, Yin Y, Chen R*. MAGI2-AS3 rs7783388 Polymorphism Contributes toColorectal Cancer Risk Through Altering the Binding Affinity of theTranscription Factor GR to the MAGI2-AS3 Promoter. J Clin Lab Anal.2020Jun 12; e23431.doi: 10.1002/jcla.23431.

(29) Kassim SA, AbbasM, Tang Wy, Wu Ss, Meng QT, Naee S, Li X, Chen R*. Retrospective studyon melanosis coli as risk factor of colorectal neoplasm: a 3-year colonoscopicfinding in Zhuhai Hospital, China. International Journal of Colorectal Disease. 2020Feb;35(2):213-222. 

(30) Li X(#),Zhang Y(#), Li B, Cui J, Gao N, Sun H, Meng Q, Wu S, Bo J, Yan L, Wu J, Chen R*. Prebiotic protects againstanatase titanium dioxide nanoparticles-induced microbiota-mediated colonicbarrier defects. NanoImpact. 2019 Feb: 14. 

(31)Li Y(#), Duan J(#), Chai X, Yang M, Wang J, Chen R*, Sun Z*. Microarray-assisted size-effect study of amorphous silica nanoparticles on human bronchialepithelial cells. Nanoscale. 2019 Dec 21;11(47):22907-22923. 

(32)Yun J, Yang H, Li X, Sun H, Meng Q, Wu S, Zhang X, Yang X, Li B, Chen R*.Up-regulation of miR-297 mediates aluminum oxide nanoparticle-induced lunginflammation through activation of Notch pathway. Environ Pollut.2019 Dec 23; 259:113839. 

(33) Kassim SA(#), Yang X(#), Abbas M, Wu S,Faran Ashraf Baig MM, Meng QT, Zhang C, Li X, Chen R*. Pri-miR-34b/crs4938723 Polymorphism is Associated with Decreased Risk and Better Prognosisfor Colorectal Cancer Patients. Arch Med Res. 2019Feb;50(2):55-62. 

(34)Wang Y, Wu S, Yang X, Li X, Chen R*. Associationbetween polymorphism in the promoter region of lncRNA GAS5 and the risk ofcolorectal cancer. Biosci Rep. 2019 Apr 16;39(4). 

(35)Abasse Kassim S, Tang W, Abbas M, Wu S, Meng Q, ZhangC, Li X, Chen R*. Clinicopathologic and epidemiological characteristicsof prognostic factors in post-surgical survival of colorectal cancer patientsin Jiangsu Province, China. Cancer Epidemiol. 2019 Jul16;62:101565. 

(36) Wu S, Sun H, Wang Y, Yang X, Meng Q,Yang H, Zhu H, Tang W, Li X, Aschner M, Chen R*. MALAT1 rs664589polymorphism inhibits binding to miR-194-5p contributing to colorectal cancerrisk, growth and metastasis. Cancer Res. 2019 Jul 16.

(37) Xu J#,Meng Q#, Li X, Yang H, Xu J, Gao N, Sun H, Wu S, Familiari G, Relucenti M, ZhuH, Wu J, Chen R*. Long non-coding RNA MIR17HG promotes colorectal cancerprogression via miR-17-5p. Cancer Res. 2019 Aug 13.

(38)Wu S, Meng Q, Zhang C, Sun H, Lu R, Gao N, Yang H, LiX, Achner M, Chen R*. DR4 mediatedprogression, invasion, metastasis and survival of colorectal cancer through theSP1/NF1 switch axis on genomic locus. Int J Cancer. 2018 Jul15;143(2):289-297. doi: 10.1002/ijc.31318IF: 7.316 Q1 B1.