首都医科大学附属北京中医医院刘春红教授研究团队主要致力于耳针与情感疾病的影像学研究，其研究方向属医学影像学，神经精神科学以及工科等学科交叉，团队的研究工作是利用精准、快速、高效的功能和结构磁共振成像方法研究抑郁症等情感类疾病的脑影像异常表征，基于多模态磁共振成像探索MDD发病机制以及中医耳针疗法对不同亚型MDD进行治疗的机制研究。经过多年研究，以多模态磁共振影像为基础，通过各种图像处理技方法发现MDD脑结构，脑活动，脑连接，脑网络等方面的异常改变，从而为基于影像特征实现MDD疾病检测及疗效预测奠定基础。本团队先后与新加坡国立大学、德国图宾根大学、美国耶鲁大学、纽约大学等国外知名研究机构开展广泛合作与交流。项目负责人刘春红主任医师、教授主持和参与科研项目共12项，其中近五年主持国家自然科学基金面上项目2项、北京市自然科学基金面上项目1项。本团队所取得的研究成果获得了国内外广泛认可，其中近十年，团队已发表高质量SCI论文 28 篇(近 5 年 18 篇)，主要发表在本领域的权威期刊，如Journal of Clinical Psychiatry，Journal of Affective Disorders，Progress in Neuro-Psychopharmacology & Biological Psychiatry，Neuroscience等。在Journal of Neuroinflammation撰写了题为“Role of inflammation in depression relapse（炎症在抑郁症复发中的作用）”和“Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression（经耳迷走神经刺激通过抗炎及调节脑神经网络来治疗抑郁症）”的综述，获得实用新型专利一项。

1. 主持北京市自然科学基金面上项目（grantno.7212200）：耳针对复发性抑郁症及其未患病同胞的脑机制研究，2021.01-2023.12

2. 主持国家自然科学基金面上项目（grantno. 81871507）：耳电针调节炎症参与的抑郁症奖赏环路的磁共振研究，2019.01-2022.12

3. 主持国家自然科学基金面上项目（grantno. 81471389）：双相I型情感障碍岛叶参与的情感认知环路的脑成像研究，2015.1-2018.12

4. 主持精神疾病诊断与治疗北京市重点实验室开放课题(grant no. 2021JSJB04)：睡眠剥夺后认知损害的影像表征与taVNS疗效预测研究

1. 主持北京市自然科学基金面上项目（grantno.7212200）：耳针对复发性抑郁症及其未患病同胞的脑机制研究，2021.01-2023.12

2. 主持国家自然科学基金面上项目（grantno. 81871507）：耳电针调节炎症参与的抑郁症奖赏环路的磁共振研究，2019.01-2022.12

3. 主持国家自然科学基金面上项目（grantno. 81471389）：双相I型情感障碍岛叶参与的情感认知环路的脑成像研究，2015.1-2018.12

4. 参与国家科技支撑计划重点项目（grantno. 2007BAI17B05）：抑郁症早期诊断方法和标准化综合治疗模式研究

5．参与北京市科委项目(grant no. D121100005012002)：抑郁症和双相障碍早期诊断技术研究

6. 主持首都医科大学临床-基础课题(grant no.14JL80)：双相障碍患者额叶-边缘神经环路与血清BDNF水平变化的相关性研究

7．主持首都医科大学基础-临床课题(grant no.12JL73)：基于脑网络计算的多模态磁共振成像在抑郁症及其同胞中的应用

8．主持首都医科大学基础-临床课题(grant no.10JL63)：子宫内膜癌的MRI、超声和病理对照研究

9.主持中华医学会精神病学分会青年基金二等资助：基于多模态磁共振评价五羟色胺转运体基因多态性对双相情感障碍相关脑区的影响

10. 主持神经再生修复北京市重点实验室开放课题(grant no. 2014SJZS02)：早发型抑郁症神经环路机制的脑影像研究

11．主持省部共建国家重点实验室培育基地脑重大疾病实验室开放课题：基于多模态磁共振评价五羟色胺转运体基因多态性对抑郁症及其一级亲属相关脑区的影响

12．主持精神疾病诊断与治疗北京市重点实验室开放课题(grant no. 2021JSJB04)：睡眠剥夺后认知损害的影像表征与taVNS疗效预测研究

1.      Zhang ZQ, Yang MH, Guo ZP,Liao D, Sörös P, Li M, Walter M, Wang L, Liu CH（刘春红）. Increased prefrontalcortex connectivity associated with depression vulnerability and relapse. JAffect Disord. 2022. 304: 133-141.

2.      Zhang ZQ, Guo ZP, Lv XY,Sörös P, Wang XX, Wang L, Liu CH（刘春红）. Effect and neural mechanisms of the transcutaneousvagus nerve stimulation for relapse prevention in patients with remitted majordepressive disorder: protocol for a longitudinal study. BMJ Open. 2022.12(2):e050446.

3.      Yang MH, Guo ZP, Lv XY,Zhang ZQ, Wang WD, Wang J, Hong L, Lin YN, Liu CH（刘春红）. BMRMI Reduces DepressiveRumination Possibly through Improving Abnormal FC of Dorsal ACC. NeuralPlasticity. 2022. 2022:8068988.

4.      Guo ZP, Sörös P, Zhang ZQ,Yang MH, Liao D, Liu CH（刘春红）. Use of Transcutaneous Auricular Vagus Nerve Stimulationas an Adjuvant Therapy for the Depressive Symptoms of COVID-19: A LiteratureReview. Front Psychiatry. 2021. 12:765106.

5.      Liu CH（刘春红）, Yang MH, Zhang GZ, Wang XX, Li B, LiM, Woelfer M, Walter M, Wang L.J Neural networks and the anti-inflammatory effect oftranscutaneous auricular vagus nerve stimulation in depression. JNeuroinflammation. 2020 Feb 12;17(1):54.

6.      Liu CH（刘春红）, Lv XY, Guo ZP, Zhang ZQ, Yang MH, Fang J, Wang W. Enhancedfunctional connectivity between insular subregions correlates with the efficacyof music and instruction-guided relaxation in depression. Neuroreport. 2020 Dec 9;31(17):1215-1224.

7.       Liu CH（刘春红）, Zhang GZ, Li B, Li M, Woelfer M,Walter M, Wang L. Role of inflammation in depression relapse.JNeuroinflammation. 2019 Apr 17;16(1):90.

8.       Liu CH（刘春红）, Tang LR, Gao Y, Zhang GZ, Li B, Li M,Woelfer M, Martin W, Wang L. Resting-state mapping of neural signatures ofvulnerability to depression relapse. J Affect Disord. 2019 May1;250:371-379.

9.       Liu CH（刘春红）, LiuCZ, Zhu XQ, Fang JL, Lu SL, Tang LR, Wang CY, Liu QQ. Increased posteriorinsula-sensorimotor connectivity is associated with cognitive function inhealthy participants with sleep complaints. Frontiers in Human Neuroscience.2018;9:20.

10.   Liu CH（刘春红）, Guo J, LuSL, Tang LR, Fan J, Wang CY, Wang L, Liu QQ, Liu CZ. Increased Salience NetworkActivity in Patients With Insomnia Complaints in Major Depressive Disorder. Front Psychiatry. 2018 Mar 20;9:93.

11.   Liu CH（刘春红）, Ma X, YuanZ, Song LP, Jing B, Lu HY, Tang LR, Fan J, Walter M, Liu CZ, Wang L, Wang CY.Decreased resting-state activity in the precuneus is associated with depressiveepisodes in recurrent depression. J Clin Psychiatry. 2017;78(4):e372-e382.

12.   Liu CH（刘春红）, Liu CZ, Zhang J, Yuan Z, Tang LR, Tie CL, Fan J, Liu QQ. Reduced spontaneous neuronal activity in the insularcortex and thalamus in healthy adults with insomnia symptoms. Brain Res. 2016;1648(Pt A):317-24.

13.   Liu CH（刘春红）, Ma X, SongLP, Fan J, Wang WD, Lv XY, Zhang Y, Li F, Wang L, Wang CY. Abnormal spontaneousneural activity in the anterior insular and anterior cingulate cortices inanxious depression. Behav Brain Res. 2015;281:339-47.

14.   Liu CH（刘春红）, Ma X, SongLP, Tang LR, Jing B, Zhang Y, Li F, Zhou Z, Fan J, Wang CY. Alteration ofspontaneous neuronal activity within the salience network in partially remitteddepression. Brain Res.2015;1599:93-102.

15.   Liu CH（刘春红）, Jing B, MaX, Xu PF, Zhang Y, Li F, Wang YP, Tang LR, Wang YJ, Li HY, Wang CY. Voxel-basedmorphometry study of the insular cortex in female patients with current andremitted depression. Neuroscience.2014; 262(3):190-9.

16.   Liu CH（刘春红）, Ma X, Wu X,Zhang Y, Zhou FC, Li F, Tie CL, Dong J, Wang YJ, Yang Z, Wang CY. Regionalhomogeneity of resting-state brain abnormalities in bipolar and unipolardepression. Prog Neuropsychopharmacol Biol Psychiatry. 2013; 41(5):52-9.

17.   Liu CH（刘春红）, Ma X, Wu X,Fan TT, Zhang Y, Zhou FC, Li LJ, Li F, Tie CL, Li SF, Zhang D, Zhou Z, Dong J,Wang YJ, Yao L, Wang CY. Resting-state brain activity in major depressivedisorder patients and their siblings. J Affect Disord. 2013;149(1-3):299-306.

18.   Liu CH（刘春红）, Li F, Li SF,Wang YJ, Tie CL, Wu HY, Zhou Z, Zhang D, Dong J, Yang Z, Wang CY. Abnormalbaseline brain activity in bipolar depression: a resting state functionalmagnetic resonance imaging study. Psychiatry Res. 2012; 203(2-3):175-9.

19.   Liu CH（刘春红）, Ma X, Li F, Wang YJ, Tie CL, Li SF, Chen TL, Fan TT,Zhang Y, Dong J, Yao L, Wu X, Wang CY.Regional homogeneity within the defaultmode network in bipolar depression: a resting-state functional magneticresonance imaging study. PLoS One. 2012; 7(11):e48181.

20.   Liu CH（刘春红）, Ma X, Wu X, Li F, Zhang Y, Zhou FC, Wang YJ, Tie CL,Zhou Z, Zhang D, Dong J, Yao L, Wang CY. Resting-state abnormal baseline brainactivity in unipolar and bipolar depression. Neurosci Lett. 2012;516(2):202-6.

21.   Tang LR#, Liu CH（刘春红）#, Jing B, Ma X, Li HY, Zhang Y, Li F, Wang YP, Yang Z, WangCY. Voxel-based morphometry study of the insular cortex in bipolar depression. PsychiatryRes. 2014; 24(2):89-95.

22.   Jing B#, Liu CH（刘春红）#, Ma X, YanHG, Zhuo ZZ, Zhang Y, Wang SH, Li HY, Wang CY. Difference in amplitude oflow-frequency fluctuation between currently depressed and remitted females withmajor depressive disorder. Brain Res. 2013; 1540:74-83.