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2000年毕业于北京协和医学院神经病学专业,2002年~2004年分别赴瑞典卡罗林斯卡医学院神经科和英国牛津大学临床神经科留学,现为北京安贞医院综合神经内科主任。西安交通大学全球健康研究院特聘教授。首都医科大学神经病学系副主任、北京神经科学学会血管神经病学专委会主任委员、中华医学会神经病学分会神经免疫学组委员、中国医师协会神经免疫学专委会委员、中国卒中学会免疫分会常委、中国免疫学会神经免疫学分会委员、中国微循环学会理事等。专业方向为脑血管病、神经免疫性疾病的诊治。
本团队在刘广志教授的带领下,在心源性卒中及神经免疫性疾病方面取得了大量国内外高水平成果。主持国家自然科学基金、北京市自然科学基金5项;牵头撰写“心源性卒中诊断专家共识(2019)”、“心源性卒中治疗专家共识(2022)”等多项指南。累及发表各类文章140余篇,其中SCI 68篇,参与编写及翻译主译《多发性硬化和脱髓鞘疾病》,主编《多发性硬化》及第2版、《临床神经病学手册》专著四部。
发表文章成果:
1. Liu PJ, Yang TT, Fan ZX, Yuan GB, Ma L, Wang ZY, Lu JF, Yuan BY, Zou WL, Zhang XH, Liu GZ. Characterization of antigen-specific CD8+ memory T cell subsets in peripheral blood of patients with multiple sclerosis. Front Immunol. 2023 May 4;14:1110672. doi: 10.3389/fimmu.2023.1110672. PMID: 37215118; PMCID: PMC10192904.
2. Lu JF, Fan ZX, Li Y, Wang ZY, Ma L, Yuan BY, Yang TT, Liu PJ, Liu GZ. Risk factors, clinical features, and outcomes of patients with hypertrophic cardiomyopathy complicated by ischemic stroke: A single-center retrospective study. Front Cardiovasc Med. 2022 Dec 8;9:1054199. doi: 10.3389/fcvm.2022.1054199. PMID: 36568560; PMCID: PMC9772473.
3. Qiao ML, Ma L, Wang CB, Fang LB, Fan ZX, Niu TT, Wang ZY, Lu JF, Yuan BY, Liu GZ. Clinical features, risk factors and survival in cardiac myxoma-related ischemic stroke: A multicenter case-control study. J Neurol Sci. 2023 Jan 15;444:120517. doi: 10.1016/j.jns.2022.120517. Epub 2022 Dec 6. PMID: 36528975.
4. Niu TT, Yin H, Xu BL, Yang TT, Li HQ, Sun Y, Liu GZ. Protective Effects of Ginkgolide on a Cellular Model of Alzheimer's Disease via Suppression of the NF-κB Signaling Pathway. Appl Biochem Biotechnol. 2022 Jun;194(6):2448-2464. doi: 10.1007/s12010-022-03828-5. Epub 2022 Feb 7. PMID: 35129804; PMCID: PMC9117391.
5. Niu TT, Yuan BY, Liu GZ. Ginkgolides and bilobalide for treatment of Alzheimer's disease and COVID-19: potential mechanisms of action. Eur Rev Med Pharmacol Sci. 2022 Dec;26(24):9502-9510. doi: 10.26355/eurrev_202212_30702. PMID: 36591860.
6. Fan ZX, Yuan SJ, Li XQ, Yang TT, Niu TT, Ma L, Sun K, Wang L, Liu GZ. Preliminary study on the differentiation of vulnerable carotid plaques via analysis of calcium content and spectral curve slope by using gemstone spectral imaging. Exp Ther Med. 2022 May;23(5):325. doi: 10.3892/etm.2022.11254. Epub 2022 Mar 14. PMID: 35386621; PMCID: PMC8972840.
7. Fan ZX, Wang CB, Fang LB, Ma L, Niu TT, Wang ZY, Lu JF, Yuan BY, Liu GZ. Risk factors and a Bayesian network model to predict ischemic stroke in patients with dilated cardiomyopathy. Front Neurosci. 2022 Nov 9;16:1043922. doi: 10.3389/fnins.2022.1043922. PMID: 36440270; PMCID: PMC9683474.
8. Guang-Zhi Liu#, Rong Hu, Dan-Tao Peng .Chinese expert consensus on the diagnosis of cardiogenic stroke (2019).Chinese Medical Journal.2021.134(5).505-507.SCI
9. Ting-Ting Tang#, He Yin, Pen-Ju Liu, Tian-Tong Niu, Ze-Yi Wang, Guang-Zhi Liu*.A preliminary study of association of cigarette smoking with risk of neuromyelitis optica spectrum disorder.Medicine.2021.100(37).e27234.SCI
10. Li XQ, Wang YY, Yang TT, Qian YN, Yin H, Zhong SS, A R, He Y, Xu BL, Liu GZ. .Increased Peripheral CD137 Expression in a Mouse Model of Permanent Focal Cerebral Ischemia.Cell Mol Neurobiol.2019.Epub ahead of print.doi: 10.1007/s10571-019-00661-z.SCI
11. He Y, Ao DH, Li XQ, Zhong SS, A R, Wang YY, Xiang YJ, Xu BL, Yang TT, Gao XG, Liu GZ.Increased Soluble CD137 Levels and CD4+ T-Cell-Associated Expression of CD137 in Acute Atherothrombotic Stroke.Clin Transl Sci.2018.11-4.428-434.SCI
12. Zhong SS, Xiang YJ, Liu PJ,He Y, Yang TT, Wang YY, R A, Xu BL, *Liu GZ.A pilot study of Cordyceps sinensis in treatment of experimental autoimmune encephalomyelitis..Chin Med J (English).2017.130(19).2296-2301.SCI
13. Xiang YJ, Ren M, Jiang H, Yang TT, He Y, Ao DH, Wang YY, Zhang Q, He XJ, Gao XG, *Liu GZ.Ex vivo expansion of antigen-specific CD4+CD25+ .European Review for Medical and Pharmacological Sciences.2016.20(24).5261-5270.SCI
14. Yang TT, He Y, Xiang YJ,Jiang H, Gao XG, *Liu GZ.No association of AQP4 polymorphisms with NMO and multiple sclerosis..Translational Neuroscience.2016.7(1).76-83.SCI
15. Guan R#, Gao J#, Liu G#, Cheng F, Ge B*..The Mediating Effect of Perceived Social Acknowledgment on the Relationship Between Patient Assaults and Posttraumatic Stress Reactions in Emergency Nurses..Journal of Interpersonal Violence.2016.Epub ahead of print.Epub ahead of print.SCI
社会任职:
1. 北京神经科学学会血管神经病学专委会主任委员
2. 首都医科大学神经病学学系副主任
3. 中国医师协会北京市神经内科专科医师分会常务理事
4. 心肺血管病杂志编委
5. 西安交通大学全球健康研究院特聘教授
6. 中国免疫学会神经免疫学分会委员
7. 国家自然科学基金委和北京市自然基金委评审专家
8. 中国医师协会神经病学分会神经免疫学专委会委员
9. 中华医学会神经病学分会神经免疫学组委员
主编或副主编的著作/译著:
1. 《临床神经病学手册》,主编,北京大学医学出版社,202105
2. 《多发性硬化(第二版)》,主编,北京大学医学出版社,201910
3. 《多发性硬化》,主编,多发性硬化和脱髓鞘疾病,201210
4. 《多发性硬化和脱髓鞘疾病》,主译,人民卫生出版社,200804
1、国家自然科学基金面上项目 “多发性硬化抗原特异性CD8+记忆性T细胞亚群的免疫学特征及其作用机制”(项目编号:81870951)(负责人)
2、北京市自然科学基金-北京市教育委员会重点项目“抗原特异性CD4+CD25+调节性T细胞注射治疗EAE的疗效及其作用机制”(项目编号:KZ201910025030)(负责人)
3、国家自然科学基金面上项目 “CD137-CD137L通路在脑缺血早期的效应机制及其治疗干预”(项目编号:82071342)(负责人)
4、北京大学医学部-德国乌尔姆大学神经科学联合中心联合项目“中德两国视神经脊髓炎和多发性硬化的流行状况:微生物体的作用”(中方负责人)
5、国家自然科学基金应急管理项目“4-1BBL/4-1BB通路在脑梗死发病机制中的作用及其干预策略研究”(项目编号:81441040)(负责人)
6、国家自然科学基金面上项目”多发性硬化抗原特异性CD4+CD25+调节性T细胞的体外扩增及其治疗潜能的研究”(项目编号:81171123)(负责人)
1. Liu PJ, Yang TT, Fan ZX, Yuan GB, Ma L, Wang ZY, Lu JF, Yuan BY, Zou WL, Zhang XH, Liu GZ. Characterization of antigen-specific CD8+ memory T cell subsets in peripheral blood of patients with multiple sclerosis. Front Immunol. 2023 May 4;14:1110672. doi: 10.3389/fimmu.2023.1110672. PMID: 37215118; PMCID: PMC10192904.
2. Lu JF, Fan ZX, Li Y, Wang ZY, Ma L, Yuan BY, Yang TT, Liu PJ, Liu GZ. Risk factors, clinical features, and outcomes of patients with hypertrophic cardiomyopathy complicated by ischemic stroke: A single-center retrospective study. Front Cardiovasc Med. 2022 Dec 8;9:1054199. doi: 10.3389/fcvm.2022.1054199. PMID: 36568560; PMCID: PMC9772473.
3. Qiao ML, Ma L, Wang CB, Fang LB, Fan ZX, Niu TT, Wang ZY, Lu JF, Yuan BY, Liu GZ. Clinical features, risk factors and survival in cardiac myxoma-related ischemic stroke: A multicenter case-control study. J Neurol Sci. 2023 Jan 15;444:120517. doi: 10.1016/j.jns.2022.120517. Epub 2022 Dec 6. PMID: 36528975.
4. Niu TT, Yin H, Xu BL, Yang TT, Li HQ, Sun Y, Liu GZ. Protective Effects of Ginkgolide on a Cellular Model of Alzheimer's Disease via Suppression of the NF-κB Signaling Pathway. Appl Biochem Biotechnol. 2022 Jun;194(6):2448-2464. doi: 10.1007/s12010-022-03828-5. Epub 2022 Feb 7. PMID: 35129804; PMCID: PMC9117391.
5. Niu TT, Yuan BY, Liu GZ. Ginkgolides and bilobalide for treatment of Alzheimer's disease and COVID-19: potential mechanisms of action. Eur Rev Med Pharmacol Sci. 2022 Dec;26(24):9502-9510. doi: 10.26355/eurrev_202212_30702. PMID: 36591860.
6. Fan ZX, Yuan SJ, Li XQ, Yang TT, Niu TT, Ma L, Sun K, Wang L, Liu GZ. Preliminary study on the differentiation of vulnerable carotid plaques via analysis of calcium content and spectral curve slope by using gemstone spectral imaging. Exp Ther Med. 2022 May;23(5):325. doi: 10.3892/etm.2022.11254. Epub 2022 Mar 14. PMID: 35386621; PMCID: PMC8972840.
7. Fan ZX, Wang CB, Fang LB, Ma L, Niu TT, Wang ZY, Lu JF, Yuan BY, Liu GZ. Risk factors and a Bayesian network model to predict ischemic stroke in patients with dilated cardiomyopathy. Front Neurosci. 2022 Nov 9;16:1043922. doi: 10.3389/fnins.2022.1043922. PMID: 36440270; PMCID: PMC9683474.
8. Guang-Zhi Liu#, Rong Hu, Dan-Tao Peng .Chinese expert consensus on the diagnosis of cardiogenic stroke (2019).Chinese Medical Journal.2021.134(5).505-507.SCI
9. Ting-Ting Tang#, He Yin, Pen-Ju Liu, Tian-Tong Niu, Ze-Yi Wang, Guang-Zhi Liu*.A preliminary study of association of cigarette smoking with risk of neuromyelitis optica spectrum disorder.Medicine.2021.100(37).e27234.SCI
10. Li XQ, Wang YY, Yang TT, Qian YN, Yin H, Zhong SS, A R, He Y, Xu BL, Liu GZ. .Increased Peripheral CD137 Expression in a Mouse Model of Permanent Focal Cerebral Ischemia.Cell Mol Neurobiol.2019.Epub ahead of print.doi: 10.1007/s10571-019-00661-z.SCI
11. He Y, Ao DH, Li XQ, Zhong SS, A R, Wang YY, Xiang YJ, Xu BL, Yang TT, Gao XG, Liu GZ.Increased Soluble CD137 Levels and CD4+ T-Cell-Associated Expression of CD137 in Acute Atherothrombotic Stroke.Clin Transl Sci.2018.11-4.428-434.SCI
12. Zhong SS, Xiang YJ, Liu PJ,He Y, Yang TT, Wang YY, R A, Xu BL, *Liu GZ.A pilot study of Cordyceps sinensis in treatment of experimental autoimmune encephalomyelitis..Chin Med J (English).2017.130(19).2296-2301.SCI
13. Xiang YJ, Ren M, Jiang H, Yang TT, He Y, Ao DH, Wang YY, Zhang Q, He XJ, Gao XG, *Liu GZ.Ex vivo expansion of antigen-specific CD4+CD25+ .European Review for Medical and Pharmacological Sciences.2016.20(24).5261-5270.SCI
14. Yang TT, He Y, Xiang YJ,Jiang H, Gao XG, *Liu GZ.No association of AQP4 polymorphisms with NMO and multiple sclerosis..Translational Neuroscience.2016.7(1).76-83.SCI
15. Guan R#, Gao J#, Liu G#, Cheng F, Ge B*..The Mediating Effect of Perceived Social Acknowledgment on the Relationship Between Patient Assaults and Posttraumatic Stress Reactions in Emergency Nurses..Journal of Interpersonal Violence.2016.Epub ahead of print.Epub ahead of print.SCI
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