1.临床资源丰富

团队所在的首都医科大学附属北京佑安医院是1990年开始收治艾滋病患者，目前累计收治有10000余例艾滋病患者，平均年诊治HIV/AIDS患者约2万人次，在艾滋病基础研究和临床诊治方面积累了丰富经验。自2006年起，在国家自然科学基金委、艾滋病和病毒性肝炎等重大传染病防治科技重大专项及北京市科委的支持下，先后获批北京市艾滋病领域临床医学研究中心、北京市性病艾滋病临床诊疗中心、艾滋病研究北京市重点实验室等平台，建立了全球最大的单中心HIV感染开放队列及标本库，包含4000余例HIV阴性高危队列、10000例HIV ART队列、700例HIV急性期感染队列、3000例HIV相关神经精神队列和1400例免疫重建不良队列。

2.实验室设备完善

团队实验室为艾滋病研究北京市重点实验室、中法HIV感染体液免疫应答研究联合实验室。常规使用流式细胞术开展免疫细胞计数和功能检测，以及高通量细胞因子定量检测、HIV病毒载量的检测、HIV耐药检测等艾滋病相关技术，为临床检测和科研服务。此外，所在单位还可提供深度测序实验平台及核酸分析平台等设备和技术。

3.团队人才济济

团队当前有北京市科技领军人才，北京市高创领军人才，北京海外高层次人才，北京市百千万人才，北京市卫生系统高层次公共卫生技术人才，北京市“登峰”人才等艾滋病领域相关技术人员100余人，高级职称人员38人。博士生导师4人，硕士生导师9人，在读博士研究生10人，在读硕士研究生20人。

1. HIV急性期感染者干扰素联合抗逆转录病毒治疗清除病毒库的随机、平行对照、开放标签临床研究

北京市医院管理中心第三期“扬帆”计划临床技术创新项目，600万，2025~2027

2. 基于痘苗病毒的天花疫苗诱导的免疫应答及其对猴痘病毒感染的交叉保护作用研究

国家自然科学基金科学部综合研究项目，180万，2023~2025

3.  NK细胞受体表达和功能在艾滋病患者免疫重建中的作用机制

国家自然科学基金委员会面上项目，55万，2021～2024

4. 巡诊查房智能化机器人临床功能与关键技术研究

科技部国家重点研发计划子课题，100万，2021～2025

5. 北京市卫生系统高层次公共卫生技术人才

北京市卫生健康委员会，200万，2022～2024

6.  HIV感染者结核分枝杆菌共感染队列建设及肺结核临床诊疗优化研究

北京市卫生健康委员会首都卫生发展专项，90万，2022～2024

7. 北京市疫苗研发转化示范中心

北京市卫生健康委员会北京市卫生健康科技成果和适宜技术推广项目，73.6万，2020～2023

8. 北京市医院管理中心人才培养计划“登峰”项目

北京市医院管理中心，189.28万，2020～2023

1. HIV急性期感染者干扰素联合抗逆转录病毒治疗清除病毒库的随机、平行对照、开放标签临床研究

北京市医院管理中心第三期“扬帆”计划临床技术创新项目，600万，2025~2027

2. 基于痘苗病毒的天花疫苗诱导的免疫应答及其对猴痘病毒感染的交叉保护作用研究

国家自然科学基金科学部综合研究项目，180万，2023~2025

3.  NK细胞受体表达和功能在艾滋病患者免疫重建中的作用机制

国家自然科学基金委员会面上项目，55万，2021～2024

4. 巡诊查房智能化机器人临床功能与关键技术研究

科技部国家重点研发计划子课题，100万，2021～2025

5. 北京市卫生系统高层次公共卫生技术人才

北京市卫生健康委员会，200万，2022～2024

6.  HIV感染者结核分枝杆菌共感染队列建设及肺结核临床诊疗优化研究

北京市卫生健康委员会首都卫生发展专项，90万，2022～2024

7. 北京市疫苗研发转化示范中心

北京市卫生健康委员会北京市卫生健康科技成果和适宜技术推广项目，73.6万，2020～2023

8. 北京市医院管理中心人才培养计划“登峰”项目

北京市医院管理中心，189.28万，2020～2023

一、近五年已发表的代表性论文（#并列第一作者，*通讯作者）

1.      Fang Y, Wang F, Ji J, Jia H, Ren M, Zheng L, Jia L, Guo C, Wang W, JiangT, Zhang T. Disseminated Pyrazinamide-Resistant Mycobacterium Bovis in an AIDSPatient: The Role of Molecular Diagnosis and Optimized Therapy. Infect DrugResist. 2025 May 19;18:2599-2604. doi: 10.2147/IDR.S522721

2.      He Y, Liu H, Ren M, Sun G, Ma Y, Cai M, Wang R, Wang L, Zhang T, ZhangY. Brain injury, endocrine disruption, and immune dysregulation in HIV-positivemen who have sex with men with late HIV diagnosis. Front Immunol. 2025 Mar19;16:1436589. doi: 10.3389/fimmu.2025.1436589（5.9   2）

3.      Wang X, Liu L, Wang W, Zhang Y, Chen H, Wang Z, Li J, Gao Y, Huang Y,Sun L, Zhang T, Li A. Mortality risk prediction modelin AIDS patients with pneumocystis pneumonia in China. Front Cell InfectMicrobiol. 2025 Feb 7;14:1485231. doi: 10.3389/fcimb.2024.1485231 

4.      Zhao S, Wang W, Li S, He J, Duan W, Fang Z, Ma X, Li Z, Guo C, Wang W,Wu H, Zhang T, Huang X. The prevalence of low-level viraemia and itsassociation with virological failure in people living with HIV: a systematicreview and meta-analysis. Emerg Microbes Infect. 2025 Dec;14(1):2447613. doi:10.1080/22221751.2024.2447613

5.      Zhang Y, He Y, Fang Y, Cai M, Sun G, Wang R, Zhen J, Zhang Y, Li Z, MaY, Zhang T. Brain function abnormalities and inflammation in HIV-positive menwho have sex with men with depressive disorders. Front Psychiatry. 2025 Jan20;15:1438085. doi: 10.3389/fpsyt.2024.1438085

6.      Zhang X, Li Z, Ji J, Ma Y, Sun G, Chen X, Zhang L, Zhang T, Zhang Y,Zhang Y. CD8+T cells and monocytes were associated with brain alterations inhuman immunodeficiency virus-infected individuals with cognitive impairment.Brain Res Bull. 2025 Mar;222:111231. doi: 10.1016/j.brainresbull.2025.111231

7.      He Y, Zhang Y, Jiang T, Cai M, Sun G, Ma Y, Ji J, Yang B, Yang B, DuanJ, Wu D, Sun L, Dai L, Zhang Y, Wu H, Jiang W, Zhang T, Wang L. The associationbetween rapid antiretroviral therapy initiation and brain structure andfunction based on multimodal magnetic resonance imaging in HIV-positive men whohave sex with men. BMC Infect Dis. 2025 Jan 8;25(1):41. doi:10.1186/s12879-024-10397-x 

8.      Shao Y, Zhang M, Sun LJ, Zhang HW, Liu A, Wang X, Xin RL, Li JW, Ye JZ,Gao Y, Wang ZL, Li ZC, Zhang T. Effectiveness of onsite and online education inenhancing knowledge and use of human immunodeficiency virus pre- andpost-exposure prophylaxis. World J Clin Cases. 2024 Aug 6;12(22):5042-5050.doi: 10.12998/wjcc.v12.i22.5042.

9.      Xiao J, Wang F, Yan H, Wang B, Su B, Lu X, Zhang T. Memory stem CD8+Tcells in HIV/Mtb mono- and co-infection: characteristics, implications, andclinical significance. Front Cell Infect Microbiol. 2024 Dec 10;14:1485825.doi: 10.3389/fcimb.2024.1485825

10.   Xie K, Zhang Y, Zhang M, Wu H, Zheng L, Ji J, Li Z, Wang W, Zhang T.Association of vitamin D with HIV infected individuals, TB infectedindividuals, and HIV-TB co-infected individuals: a systematic review andmeta-analysis. Front Public Health. 2024 Feb 14;12:1344024. doi:10.3389/fpubh.2024.1344024

11.   Chen X, Wei J, Zhang M, Su B, Ren M, Cai M, Zhang Y, Zhang T.Prevalence, incidence, and case fatality of tuberculous meningitis in adultsliving with HIV: a systematic review and meta-analysis. BMC Public Health. 2024Aug 7;24(1):2145. doi: 10.1186/s12889-024-19683-4

12.   He Y, Zhang Y, Zhen J, Sun G, Li Z, Yang B, Yang B, Chang K, Chen X,Zhang Y, Guo C, Wang W, Wu P, Zhang T, Wang L. The differential effects ofintegrase strand transfer inhibitors and efavirenz on neuropsychiatricconditions and brain imaging in HIV-positive men who have sex with men. BiosafHealth. 2024 Jul 6;6(4):216-224. doi: 10.1016/j.bsheal.2024.07.001

13.   Zhang Y, Ji J, Zheng L, Cai M, Sun G, Ma Y, Zhang X, Chen X, Zhang Y,Lin X, Li Z, Zhang T. Unveiling neuroimmunology profile of immunologicalnon-responders in HIV: a multimodal MRI approach. Front Immunol. 2024 Dec13;15:1452532. doi: 10.3389/fimmu.2024.1452532

14.   Liu H, Wang W, Zhang Y, Wang F, Duan J, Huang T, Huang X, Zhang T.Global perspectives on smallpox vaccine against monkeypox: a comprehensivemeta-analysis and systematic review of effectiveness, protection, safety andcross-immunogenicity. Emerg Microbes Infect. 2024 Dec;13(1):2387442. doi:10.1080/22221751.2024.2387442

15.   Fang Y, Wang F, Jiang T, Duan J, Huang T, Liu H, Jia L, Jia H, Yan B,Zhang M, Wang W, Guo C, Liu L, Zhang Y, Zhang T. Human mpox co-infection withadvanced HIV-1 and XDR-TB in a MSM patient previously vaccinated againstsmallpox: A case report. Biosaf Health. 2024 May 1;6(3):186-190. doi:10.1016/j.bsheal.2024.04.005

16.   Chen X#, Wei J#, Li Z, Zhang Y, Zhang X, Zhang L,Wang X, Zhang Y*, Zhang T*. Dysregulation of Gut Microbiota-DerivedNeuromodulatory Amino Acid Metabolism in Human ImmunodeficiencyVirus-Associated Neurocognitive Disorder: An Integrative Metagenomic andMetabolomic Analysis. Ann Neurol. 2024 May 16. doi: 10.1002/ana.26963

17.   Zhang Y#, Ji J#, Xie K#, Cai M, Wang R, Zhang X, Chen X, Zhang Y, Wu H,Wang W*, Li Z*, Zhang T*. Pathological proliferation: a potential mechanism forpoor CD4+ T cell recovery in people living with HIV. Front Cell InfectMicrobiol. 2024 Mar 27;14:1344778. doi: 10.3389/fcimb.2024.1344778

18.   Shan Y#, Sun G#, Ji J#, Li Z, Chen X, Zhang X, MaY, Zhang Y*, Zhang T*, Zhang Y*. Brain functionabnormalities and neuroinflammation in people living with HIV-associatedanxiety disorders. Front Psychiatry. 2024 Mar 18;15:1336233. doi:10.3389/fpsyt.2024.1336233

19.   Chen X#, Wei J#, Zhang Y, Zhang Y*, Zhang T*. Crosstalk between gut microbiome and neuroinflammation in pathogenesisof HIV-associated neurocognitive disorder. J Neurol Sci. 2024 Feb15;457:122889. doi: 10.1016/j.jns.2024.122889

20.   Xinsheng Wu#, Guohui Wu#, Ping Ma#, Rugang Wang#, Linghua Li#, YuanyiChen, Junjie Xu, Yuwei Li, Quanmin Li, Yuecheng Yang, Lijing Wang, Xiaoli Xin,Ying Qiao, Gengfeng Fu*, Xiaojie Huang*, Bin Su*, Tong Zhang*, Hui Wang*,Huachun Zou*. Associations of modern initial antiretroviral therapy regimenswith all-cause mortality in people living with HIV in resource-limitedsettings: a retrospective multicenter cohort study in China. NatureCommunications. 2023 Sep 2;14(1):5334. 

21.   Chi Zhou#, Yaxin Wu#, Yang Zhang#, Yingying Wang, Hao Wu, Tong Zhang*,Guanzhi Chen*, Xiaojie Huang*. Factors Associated with Post-treatment Controlof Viral Load in HIV-Infected Patients: A Systematic Review and Meta-analysis.Int J Infect Dis. 2023 Apr;129:216-227. 

22.   Li S#, Su B#, Wu H, He Q*, Zhang T*. Integrated analysis of gut and oralmicrobiome in men who have sex with men with HIV Infection. Microbiol Spectr.2023 Oct 18:e0106423. 

23.   Li S#, Wang H#, Guo N#, Su B*, Lambotte O*, ZhangT*. Targeting the HIV reservoir: chimeric antigenreceptor therapy for HIV cure. Chin Med J (Engl). 2023 Nov20;136(22):2658-2667. 

24.   Yang X#, Wang X#, Zhang X#, Ding H, Wang H, Huang T, Zhang G, Duan J,Xia W, Su B, Jin C*, Wu H*, Zhang T*. Durable natural killer cell responseafter three doses of SARS-CoV-2 inactivated vaccine in HIV-infectedindividuals. Chin Med J (Engl). 2023 Nov 28. 

25.   Chen, X#, Ding, W#, Cui, X, Wei, J, Zhang, Y,Zhang, X, Zhang, T*, & Zhang, Y*. HIV protease inhibitorattenuated astrocyte autophagy involvement in inflammation via p38 MAPKpathway. Antiviral Res. 2022;208:105463. 

26.   Li S, Yang X, Moog C, Wu H, Su B*, Zhang T*. Neglected mycobiome in HIVinfection: Alterations, common fungal diseases and antifungal immunity.FRONTIERS IN IMMUNOLOGY, 2022 Nov 10;13:1015775 

27.   Su B#, Yao C#, Zhao QX#, Cai WP#, Wang M#, Lu HZ#, Mu TT#, Chen YY, LiuL, Wang H, He Y, Zheng YH, Li LH, Chen JF, Yu JH, Zhu B, Zhao M, Sun YT, LunWH, Zhang YH, Wang H, Xia W, Sun LJ, Dai LL, Jiang TY, Wang MX, Zheng QS, PengHY, Wang Y, Hu M, Liu X, Lu RJ, Hu JH, Sun CC, Xing H, Shao YM, Xie D*, ZhangT*, Zhang FJ*, Wu H*. Long-acting HIV fusion inhibitor albuvirtide combinedwith ritonavir-boosted lopinavir for HIV-1-infected patients after failing thefirst-line antiretroviral therapy: 48-week randomized, controlled, phase 3non-inferiority TALENT study. JOURNAL OF INFECTION, 2022 Sep;85(3):334-363 

28.   Wu X#, Wu G#, Ma Y#, Huang X#, Yang Y#, Cai Y#, Luo G, Ma P, Qiao Y,Chen Y, Lin YF, Gao Y, Zhan Y, Song W, Wang Y, Wang R, Yang X, Sun L, Wei H, LiQ, Xin X, Wang L, Wang X, Xie R, Yang L, Meng X, Zhao J*, Li L*, Zhang T*, XuJ*, Fu G*, Zou H*. The impact of COVID-19 non-pharmaceutical interventions onHIV care continuum in China: An interrupted time series analysis. Lancet RegHealth West Pac. 2022 Aug 10;29:100569. 

29.   Chen X, Jia L, Zhang X, Zhang T*, Zhang Y*. One arrow for two targets: potential co-treatment regimens for lymphomaand HIV. Blood Rev, 2022 Apr 23:100965. 

30.   Wei J#, Hou J#, Mu T, Sun J, Li S, Wu H, Su B*,Zhang T*. Evaluation of Computerized Cognitive Trainingand Cognitive and Daily Function in Patients Living With HIV: A Meta-analysis.JAMA NETWORK OPEN, 2022 Mar 1;5(3):e220970

31.   Lu X#, Zhang X#, Cheung AKL, Moog C, Xia H, Li Z, Wang R, Ji Y, Xia W,Liu Z, Yuan L, Wang X, Wu H, Zhang T*, Su B*. Abnormal Shift in B Memory CellProfile Is Associated With the Expansion of Circulating T Follicular HelperCells via ICOS Signaling During Acute HIV-1 Infection. FRONTIERS IN IMMUNOLOGY,2022 Feb 10;13:837921

32.  WangR#, Zhang Q#, Ge J#, Ren W, Zhang R, Lan J, Ju B, Su B, Yu F, Chen P, Liao H,Feng Y, Li X, Shi X, Zhang Z, Zhang F, Ding Q, Zhang T*, Wang X*, Zhang L*.Analysis of SARS-CoV-2 variant mutations reveals neutralization escapemechanisms and the ability to use ACE2 receptors from additional species.Immunity. 2021 Jul 13;54(7):1611-1621.e5.

33.   Li S, Zhu J, Su B, Wei H, Chen F, Liu H, Wei J, Yang X, Zhang Q, Xia W,Wu H, He Q, Zhang T. Alteration in Oral Microbiome Among Men Who Have Sex WithMen With Acute and Chronic HIV Infection on Antiretroviral Therapy. Front CellInfect Microbiol. 2021 Jul 14;11:695515.

34.  Weng W, Hou J, Song B, Zhang M, Zhang T, Gao Y.Identification of the factors associated with post-treatment asymptomaticneurosyphilis in HIV-negative patients with serological non-response syphilis:a retrospective study. Int J STD AIDS. 2021 Mar;32(4):331-335.

35.  Zhang Y, Jiang T, Li A, Li Z, Hou J, Gao M,Huang X, Su B, Wu H, Zhang T, Jiang W. Adjunct Therapy for CD4+ T-CellRecovery, Inflammation and Immune Activation in People Living With HIV: ASystematic Review and Meta-Analysis. Front Immunol. 2021 Feb17;12:632119. 

36.  Zhang X, Lu X, Cheung AKL, Zhang Q, Liu Z, LiZ, Yuan L, Wang R, Liu Y, Tang B, Xia H, Wu H, Zhang T, Su B. Analysis of theCharacteristics of TIGIT-Expressing CD3-CD56+NKCells in Controlling Different Stages of HIV-1 Infection. Front Immunol. 2021Feb 26;12:602492.

37.  Lu X, Sun H, Li H, Xia W, Wu H, Chen D, Tan M,Yu S, Zhang T, Sheng H, Zhu Z. Validation of the BD FACSPresto system for themeasurement of CD4 T-lymphocytes and hemoglobin concentration in HIV-negativeand HIV-positive subjects. Sci Rep. 2020 Nov 11;10(1):19605. 

38.  Wei J, Hou J, Su B, Jiang T, Guo C, Wang W,Zhang Y, Chang B, Wu H, Zhang T. The Prevalence of Frascati-Criteria-BasedHIV-Associated Neurocognitive Disorder (HAND) in HIV-Infected Adults: ASystematic Review and Meta-Analysis. Front Neurol. 2020 Dec 1;11:581346。

39.  Su B, Yao C, Zhao QX, Cai WP, Wang M, Lu HZ,Chen YY, Liu L, Wang H, He Y, Zheng YH, Li LH, Chen JF, Yu JH, Zhu B, Zhao M,Sun YT, Lun WH, Xia W, Sun LJ, Dai LL, Jiang TY, Wang MX, Zheng QS, Peng HY,Wang Y, Lu RJ, Hu JH, Xing H, Shao YM, Xie D, Zhang T, Zhang FJ, Wu H; TALENTStudy Team. Efficacy and safety of the long-acting fusion inhibitor albuvirtidein antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized, controlled, phase 3, non-inferiority TALENTstudy. Chin Med J (Engl). 2020 Nov 25;133(24):2919-2927.

40.  Zhang T, Zhu J, Su B, Cao L, Li Z, Wei H, HuangX, Zheng K, Li A, Chen N, Liu L, Xia W, Wu H, He Q. Effects of TLR7Polymorphisms on the Susceptibility and Progression of HIV-1 Infection inChinese MSM Population. Front Immunol. 2020 Oct 26;11:589010.

41.  Hou J, Fu J, Meng S, JiangT, Guo C, Wu H, Su B, Zhang T. Posttraumatic Stress Disorder and Nonadherenceto Treatment in People Living With HIV: A Systematic Review and Meta-analysis.Front Psychiatry. 2020 Aug 19;11:834.

42.  Liu L, Deng R, Lan Y, Li L, Li M, Su B,Gnanashanmugam D, Tang YW, Wu H, Wang J, Cai X, Zhang T. Multicenter evaluationof Xpert HIV-1 viral load assay for HIV quantification in China. J Med Virol.2020 Jul 11. 

43.  Guo N, Chen Y, Su B, Yang X, Zhang Q, Song T,Wu H, Liu C, Liu L, Zhang T. Alterations of CCR2 and CX3CR1 on Three MonocyteSubsets During HIV-1/Treponema pallidum Coinfection. Front Med(Lausanne). 2020 Jun 18;7:272.

44.  Chen X, Zhang T, Zhang Y. Endoplasmic reticulumstress and autophagy in HIV-1-associated neurocognitive disorders. JNeurovirol. 2020 Dec;26(6):824-833.

45.   Hou J, Jiang T, Fu J, Su B, Wu H, Sun R, Zhang T. The Long-Term Efficacyof Working Memory Training in Healthy Older Adults: A Systematic Review andMeta-Analysis of 22 Randomized Controlled Trials. J Gerontol B Psychol Sci Soc Sci. 2020 Sep 14;75(8):e174-e188.

46.   Yang X, Su B, Zhang X, Liu Y, Wu H, Zhang T.Incomplete immune reconstitution in HIV/AIDS patients on antiretroviraltherapy: Challenges of immunological non-responders. J Leukoc Biol. 2020 Apr;107(4):597-612.（4.012）

二、重要奖项

1. 北京市卫生系统高层次公共卫生技术人才（领军人才)  202204

2. 北京市“登峰”人才  2022

3. HIV/HCV共感染及HIV单独感染者临床特点及发病机制研究与应用 北京市科技进步奖 二等奖 202008

4. HIV/HCV共感染及HIV单独感染者临床特点及发病机制研究 中华医学科技奖 二等奖 201812

5. HIV/HCV共感染及HIV单独感染者临床特点及发病机制研究 北京医学科技奖 二等奖 201805