1.临床资源丰富

团队所在的首都医科大学附属北京佑安医院是1990年开始收治艾滋病患者，目前累计收治有10000余例艾滋病患者，平均年诊治HIV/AIDS患者约2万人次，在艾滋病基础研究和临床诊治方面积累了丰富经验。自2006年起，在国家自然科学基金委、艾滋病和病毒性肝炎等重大传染病防治科技重大专项及北京市科委的支持下，先后获批北京市艾滋病领域临床医学研究中心、北京市性病艾滋病临床诊疗中心、艾滋病研究北京市重点实验室等平台，建立了全球最大的单中心HIV感染开放队列及标本库，包含4000余例HIV阴性高危队列、10000例HIV ART队列、700例HIV急性期感染队列、3000例HIV相关神经精神队列和1400例免疫重建不良队列。

2.实验室设备完善

团队实验室为艾滋病研究北京市重点实验室、中法HIV感染体液免疫应答研究联合实验室。常规使用流式细胞术开展免疫细胞计数和功能检测，以及高通量细胞因子定量检测、HIV病毒载量的检测、HIV耐药检测等艾滋病相关技术，为临床检测和科研服务。此外，所在单位还可提供深度测序实验平台及核酸分析平台等设备和技术。

3.团队人才济济

团队当前有北京市科技领军人才，北京市高创领军人才，北京海外高层次人才，北京市百千万人才，北京市卫生系统高层次公共卫生技术人才，北京市“登峰”人才等艾滋病领域相关技术人员100余人，高级职称人员38人。博士生导师4人，硕士生导师9人，在读博士研究生10人，在读硕士研究生20人。

1.     基于痘苗病毒的天花疫苗诱导的免疫应答及其对猴痘病毒感染的交叉保护作用研究

国家自然科学基金科学部综合研究项目，180万，2023~2025

2.     NK细胞受体表达和功能在艾滋病患者免疫重建中的作用机制

国家自然科学基金委员会面上项目，55万，2021～2024

3.     巡诊查房智能化机器人临床功能与关键技术研究

科技部国家重点研发计划子课题，100万，2021～2025

4.     北京市卫生系统高层次公共卫生技术人才

北京市卫生健康委员会，200万，2022～2024

5.     HIV感染者结核分枝杆菌共感染队列建设及肺结核临床诊疗优化研究

北京市卫生健康委员会首都卫生发展专项，90万，2022～2024

6.     北京市疫苗研发转化示范中心

北京市卫生健康委员会北京市卫生健康科技成果和适宜技术推广项目，73.6万，2020～2023

7.     北京市医院管理中心人才培养计划“登峰”项目

北京市医院管理中心，189.28万，2020～2023

1.     基于痘苗病毒的天花疫苗诱导的免疫应答及其对猴痘病毒感染的交叉保护作用研究

国家自然科学基金科学部综合研究项目，180万，2023~2025

2.     NK细胞受体表达和功能在艾滋病患者免疫重建中的作用机制

国家自然科学基金委员会面上项目，55万，2021～2024

3.     巡诊查房智能化机器人临床功能与关键技术研究

科技部国家重点研发计划子课题，100万，2021～2025

4.     北京市卫生系统高层次公共卫生技术人才

北京市卫生健康委员会，200万，2022～2024

5.     HIV感染者结核分枝杆菌共感染队列建设及肺结核临床诊疗优化研究

北京市卫生健康委员会首都卫生发展专项，90万，2022～2024

6.     北京市疫苗研发转化示范中心

北京市卫生健康委员会北京市卫生健康科技成果和适宜技术推广项目，73.6万，2020～2023

7.     北京市医院管理中心人才培养计划“登峰”项目

北京市医院管理中心，189.28万，2020～2023

一、近五年已发表的代表性论文（#并列第一作者，*通讯作者）

1.  Chen, X#, Ding, W#, Cui,X, Wei, J, Zhang, Y, Zhang, X, Zhang, T*, & Zhang, Y*. HIVprotease inhibitor attenuated astrocyte autophagy involvement in inflammationvia p38 MAPK pathway. Antiviral Res. 2022;208:105463.

2.  Li S, Yang X, Moog C, WuH, Su B*, Zhang T*. Neglected mycobiome in HIV infection:Alterations, common fungal diseases and antifungal immunity. FRONTIERS INIMMUNOLOGY, 2022 Nov 10;13:1015775

3.  Su B#, Yao C#, Zhao QX#,Cai WP#, Wang M#, Lu HZ#, Mu TT#, Chen YY, Liu L, Wang H, He Y, Zheng YH, LiLH, Chen JF, Yu JH, Zhu B, Zhao M, Sun YT, Lun WH, Zhang YH, Wang H, Xia W, SunLJ, Dai LL, Jiang TY, Wang MX, Zheng QS, Peng HY, Wang Y, Hu M, Liu X, Lu RJ,Hu JH, Sun CC, Xing H, Shao YM, Xie D*, Zhang T*, Zhang FJ*, WuH*. Long-acting HIV fusion inhibitor albuvirtide combined withritonavir-boosted lopinavir for HIV-1-infected patients after failing thefirst-line antiretroviral therapy: 48-week randomized, controlled, phase 3non-inferiority TALENT study. JOURNAL OF INFECTION, 2022 Sep;85(3):334-363

4.  Wu X#, Wu G#, Ma Y#,Huang X#, Yang Y#, Cai Y#, Luo G, Ma P, Qiao Y, Chen Y, Lin YF, Gao Y, Zhan Y,Song W, Wang Y, Wang R, Yang X, Sun L, Wei H, Li Q, Xin X, Wang L, Wang X, XieR, Yang L, Meng X, Zhao J*, Li L*, Zhang T*, Xu J*, Fu G*, ZouH*. The impact of COVID-19 non-pharmaceutical interventions on HIV carecontinuum in China: An interrupted time series analysis. Lancet Reg Health WestPac. 2022 Aug 10;29:100569.

5．Chen X#, Jia L, Zhang X, ZhangT*, Zhang Y*. One arrow for two targets: potentialco-treatment regimens for lymphoma and HIV. Blood Rev 2022 Apr 23:100965. 

6．Wei J#, Hou J#, Mu T, Sun J, Li S, Wu H, Su B*,Zhang T*. Evaluation of ComputerizedCognitive Training and Cognitive and Daily Function in Patients Living WithHIV: A Meta-analysis. JAMA Netw Open 2022 Mar 1, 5(3):e220970.

7．Lu X#, Zhang X#, Cheung AKL, Moog C, Xia H, Li Z,Wang R, Ji Y, Xia W, Liu Z, Yuan L, Wang X, Wu H, Zhang T*,Su B*. Abnormal Shift in B Memory Cell Profile Is Associated Withthe Expansion of Circulating T Follicular Helper Cells via ICOS SignalingDuring Acute HIV-1 Infection. FRONTIERS INIMMUNOLOGY, 2022 Feb 10;13:837921. 

8．Wang R#, Zhang Q#, Ge J#, Ren W, ZhangR, Lan J, Ju B, Su B, Yu F, Chen P, Liao H, Feng Y, Li X, Shi X, Zhang Z, ZhangF, Ding Q, Zhang T*, Wang X*, Zhang L*.Analysis of SARS-CoV-2 variant mutations reveals neutralization escapemechanisms and the ability to use ACE2 receptors from additional species.Immunity. 2021 Jul 13;54(7):1611-1621.e5. 

9．Li S#, Zhu J#, Su B#, Wei H, Chen F,Liu H, Wei J, Yang X, Zhang Q, Xia W, Wu H, He Q*, Zhang T*. Alteration in Oral Microbiome Among Men Who Have Sex With Men With Acuteand Chronic HIV Infection on Antiretroviral Therapy. Front Cell Infect Microbiol 2021 Jul 14, 11:695515.

10．Weng W#, Hou J#, Song B, Zhang M, Zhang T*, Gao Y*.Identification of the factors associated with post-treatment asymptomaticneurosyphilis in HIV-negative patients with serological non-response syphilis:a retrospective study. Int J STD AIDS 2021 Mar, 32(4):331-335.

11．Zhang X#, Lu X#, Cheung AKL, Zhang Q, Liu Z, Li Z,Yuan L, Wang R, Liu Y, Tang B, Xia H, Wu H, Zhang T*, Su B*. Analysis of theCharacteristics of TIGIT-Expressing CD3-CD56+NK Cells in Controlling DifferentStages of HIV-1 Infection. Front Immunol 2021 Feb 26, 12:602492.

12．Zhang Y#, Jiang T#, Li A#, Li Z, Hou J,Gao M, Huang X, Su B, Wu H*, ZhangT*, Jiang W*. Adjunct Therapy forCD4+ T-Cell Recovery, Inflammation and Immune Activation in People LivingWith HIV: A Systematic Review and Meta-Analysis. Front Immunol 2021 Feb 17,12:632119. 

13．Chen X#, Zhang T*,Zhang Y*. Endoplasmic reticulum stress and autophagy inHIV-1-associated neurocognitive disorders. J Neurovirol 2020 Dec, 26(6):824-833.

14．Wei J#, Hou J#, Su B, Jiang T, Guo C, Wang W,Zhang Y, Chang B, Wu H, Zhang T*.The Prevalence of Frascati-Criteria-Based HIV-Associated NeurocognitiveDisorder (HAND) in HIV-Infected Adults: A Systematic Review and Meta-Analysis.Front Neurol 2020 Dec 1, 11:581346.

15．Su B#, Yao C#, Zhao QX#, Cai WP#,Wang M#, Lu HZ#, Chen YY, Liu L, Wang H, He Y, Zheng YH,Li LH, Chen JF, Yu JH, Zhu B, Zhao M, Sun YT, Lun WH, Xia W, Sun LJ, Dai LL,Jiang TY, Wang MX, Zheng QS, Peng HY, Wang Y, Lu RJ, Hu JH, Xing H, Shao YM,Xie D*, Zhang T*,Zhang FJ*, Wu H*, TALENT Study Team. Efficacy and safetyof the long-acting fusion inhibitor albuvirtide in antiretroviral-experiencedadults with human immunodeficiency virus-1: interim analysis of the randomized,controlled, phase 3, non-inferiority TALENT study. Chin Med J (Engl) 2020 Nov25, 133(24):2919-2927.

16．Lu X#, Sun H#, Li H#, Xia W, Wu H, ChenD, Tan M, Yu S, Zhang T*,Sheng H*, Zhu Z*. Validation of the BD FACSPresto systemfor the measurement of CD4 T-lymphocytes and hemoglobin concentration inHIV-negative and HIV-positive subjects. Sci Rep 2020 Nov 11, 10(1):19605.

17．Zhang T#, Zhu J#,Su B, Cao L, Li Z, Wei H, Huang X, Zheng K, Li A, Chen N, Liu L, Xia W, Wu H*,He Q*. Effects of TLR7 Polymorphisms on the Susceptibility andProgression of HIV-1 Infection in Chinese MSM Population. Front Immunol 2020Oct 26, 11:589010.

18．Hou J#, Jiang T#, Fu J, Su B, Wu H, Sun R, Zhang T*. The Long-TermEfficacy of Working Memory Training in Healthy Older Adults: A SystematicReview and Meta-Analysis of 22 Randomized Controlled Trials. J Gerontol BPsychol Sci Soc Sci 2020 Sep 14, 75(8):e174-e188.

19．Hou J#, Fu J, Meng S, Jiang T, Guo C, Wu H, Su B, Zhang T*. PosttraumaticStress Disorder and Nonadherence to Treatment in People Living With HIV: ASystematic Review and Meta-analysis. Front Psychiatry 2020 Aug 19, 11:834.

20．Liu L#, Deng R#, Lan Y#, Li L, Li M, SuB, Gnanashanmugam D, Tang YW, Wu H, Wang J*, Cai X*, Zhang T*. Multicenterevaluation of Xpert HIV-1 viral load assay for HIV quantification in China. JMed Virol 2020 Jul 11. 

21．Guo N#, Chen Y#, Su B, Yang X, Zhang Q, Song T, WuH, Liu C*, Liu L*, ZhangT*. Alterations of CCR2 and CX3CR1 on Three Monocyte SubsetsDuring HIV-1/Treponema pallidum Coinfection. Front Med (Lausanne) 2020 Jun18, 7:272.

22．Yang X#, Su B#, Zhang X, Liu Y, Wu H, Zhang T*. Incomplete immunereconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges ofimmunological non-responders. J Leukoc Biol 2020 Apr, 107(4):597-612.

23．Liu L#, Zhang Q#, Chen P, Guo N, Song A, Huang X,Xia W, Li L, Moog C, Wu H, Su B*, Zhang T*. Foxp3+Helios+ regulatory T cells areassociated with monocyte subsets and their PD-1 expression during acute HIV-1infection. BMC Immunol 2019 Oct 24, 20(1):38.

24．Liu L#, Dai L#, Yao J, Pan P, Li L, Liu Z, An X,Sun L, Wu H, Su B*, Zhang T.Lack of HIV-1 integrase inhibitor resistance among 392 antiretroviral-naïveindividuals in a tertiary care hospital in Beijing, China. AIDS 2019 Oct 1, 33(12):1945-1947.

25．Jiang T#, Su B#, Song T, Zhu Z, Xia W, Dai L, WangW, Zhang T*, Wu H*.Immunological Efficacy of Tenofovir Disproxil Fumarate-Containing Regimens inPatients With HIV-HBV Coinfection: A Systematic Review and Meta-Analysis. FrontPharmacol 2019 Sep 12, 10:1023.

26．Guo N#, Liu L#, Yang X#, Song T, Li G,Li L, Jiang T, Gao Y, Zhang T*,Su B*, Wu H*. Immunological Changes in Monocyte Subsetsand Their Association With Foxp3(+) Regulatory T Cells in HIV-1-InfectedIndividuals With Syphilis: A Brief Research Report. Frontiers in immunology2019, 10:714.

27．Su B#, Fu Y#, Liu Y, Wu H, Ma P, Zeng W, Zhang T*, Lian S*, Wu H*. Potential Application of microRNA Profiling to the Diagnosis andPrognosis of HIV-1 Infection. FRONTIERS INMICROBIOLOGY 2018 Dec 10.

28．Zhen Li#, Xiaofan Lu#, Zhiliang Hu, Zhenwu Luo,Wei Jiang, Hao Wu, Yanqing Gao, Junling Yan, Qiuyue Zhang, Aixin Song, XiaojieHuang, Danlei Mou, Bin Su*, Tong Zhang*. SyphilisInfection Differentially Regulates the Phenotype and Function of γδ T Cells inHIV-1-Infected Patients Depends on the HIV-1 Disease Stage. FRONTIERS INIMMUNOLOGY 2017 Aug 21, 8:991.

29．Zhang X#, Lu X#, Moog C, Yuan L, Liu Z, Li Z, XiaW, Zhou Y, Wu H*, Zhang T*,Su B*. KIR3DL1-negative CD8 T cells andKIR3DL1-negative NK cells contribute to the advantageous control of early HIV-1infection in HLA-B Bw4 homozygous individuals. FRONTIERS IN IMMUNOLOGY 2018 Aug10, 9:1855.

30．Zhu J#, Zhang T#,Cao L, Li A, Zheng K, Zhang N, Su B, Chen Z, Chen N, Wu H*, He Q*.Toll like receptor 7 polymorphisms in relationto disease susceptibility and progression in Chinese patients with chronic HBVinfection. SCIENTIFIC REPORTS 2017 Sep 29, 7(1):12417.

二、重要奖项

1. 北京市卫生系统高层次公共卫生技术人才（领军人才)  202204

2. 北京市“登峰”人才  2022

3. HIV/HCV共感染及HIV单独感染者临床特点及发病机制研究与应用 北京市科技进步奖 二等奖 202008

4. HIV/HCV共感染及HIV单独感染者临床特点及发病机制研究 中华医学科技奖 二等奖 201812

5. HIV/HCV共感染及HIV单独感染者临床特点及发病机制研究 北京医学科技奖 二等奖 201805