承担的主要国家级科研项目：

(1) 国家自然科学基金委员会, 面上项目,  潘多拉魔盒的秘密：兼职蛋白特异性IgE的产生机制及其在免疫性疾病中的潜在意义, 在研, 主持

(2) 国家自然科学基金委员会, 面上项目, IL-33/ST2应答轴在低氧相关性肺动脉高压发病机制中的作用研究, 结题, 主持

(3) 国家自然科学基金委员会，面上项目，IL-25/IL-33/TSLP应答轴在调节Th2型免疫应答和哮喘发生与转归过程中的作用研究项目，结题，主持

（1）近五年发表的代表性论文

[1] Qiong Huang, Chenduo Li, Yiran Yang, Xiaofeng Qin, JingjingWang, Xin Zhang, Xiaonan Du, Xia Yang, Ying Wang, Lun Li, Mi Mu, Zhe Lv,Ye Cui, Kewu Huang, Chris J Corrigan, Wei Wang, Sun Ying*. Role of theIL-33/ST2 axis in cigarette smoke-induced airways remodelling in chronicobstructive pulmonary disease. Thorax. 2021, 76(8): 750-762. doi:10.1136/thoraxjnl-2020-214712. Online ahead of print.

[2] Yiran Yang, Yan Li, Yingjie Xu,Hanxiao Zhang, YuhanDiao, Shihao Chen, Ye Cui, Chris J Corrigan, Wei Wang*, SunYing*. Group 2 innate lymphoid cells can engulf and destroy bacteria. CellMol Immunol. 2021, 18(11):2569-2571.

[3] Chenduo Li, Xiaonan Du, Qiong Huang, Yiran Yang, JingjingWang, Xiaofeng Qin, Wenjun Wang, Huihui Yuan, Jie Liu, Zhe Lv, YanLi, Yan Chen, Chris J. Corrigan, Kewu Huang, Wei Wang, Sun Ying*. Repeated exposure to inactivated Streptococcus pneumoniae inducesasthma-like pathological changes in mice in the presence of IL-33. Cell Immunol.2021, 369:104438.

[4] Wenjun Wang, Gao An, Yan Li, JingjingWang, Zhe Lv, Yan Chen, Chris J Corrigan, Wei Wang, Kewu Huang*, SunYing*. IL-33 amplifies airways inflammation in a murine surrogate ofasthma putatively via activation of dendritic cells.Cell Immunol. 2021,366:104395.

[5] Yan Li, Wei Wang, Sun Ying*. Factorsaffecting the migration of ILC2s in allergic disease. Cell Mol Immunol. 2021,18(8):2069-2070.

[6] Yan Chen, WeiWang, Huihui Yuan, Yan Li, ZheLv, Ye Cui, Jie Liu, Sun Ying*. Current state of monoclonal antibodytherapy for allergic diseases. Engineering. 2021, 7(11): 1552-1556.

[7] Xiaonan Du, Chenduo Li, Wenjun Wang,Qiong Huang, Jingjing Wang, Zhaohui Tong, Kewu Huang, Yan Chen, HuihuiYuan, Zhe Lv, Chris J Corrigan, Wei Wang, Sun Ying*. IL-33induced airways inflammation is partially dependent on IL-9. Cell Immunol.2020, 352:104098.

[8] Wenjun Wang, GaoAn, Yan Li, Chris J Corrigan, WeiWang, Sun Ying*, Kewu Huang*. Similarities and differences in theeffects of sensitisation and challenge with Dermatophagoides farinae andDermatophagoides pteronyssinus extracts in a murine asthma surrogate. CellImmunol. 2020, 348:104038.

[9] Shuang Liu,Yuxiang Zhi*, Sun Ying*.COVID-19 and Asthma: Reflection during the pandemic.Clin Rev AllergyImmunol. 2020, 59(1):78-88.

[10] Yan Li, ShihaoChen, Yafei Chi, Yiran Yang, Xiwen Chen, Huating Wang, Zhe Lv, Jingjing Wang, Linjie Yuan,Ping Huang, Kewu Huang, Chris J Corrigan, Wei Wang*, Sun Ying*. Kineticsof accumulation of group 2 innate lymphoid cells in IL-33 and IL-25induced murine models of asthma: a potential role of the chemokine CXCL16.CellMol Immunol. 2019, 16(1): 75-86.

[11] Qin Li, Yue Hu, Yan Chen, Zhe Lv, JingjingWang, Gao An, Xiaonan Du, Huating Wang, Chris J Corrigan, Wei Wang, SunYing*.IL-33 induces production of autoantibody against autologousrespiratory epithelial cells: a potential mechanism for the pathogenesis ofCOPD. Immunology. 2019, 157(2): 137-150.

[12] Wei Wang, Yan Li, Zhe Lv, Yan Chen, Yun Li, KewuHuang, Chris J Corrigan, Sun Ying*. Bronchial allergen challengeof patients with atopic asthma triggers an alarmin (IL-33, TSLP, and IL-25) responsein the airwaysepithelium and submucosa. J Immunol. 2018, 201(8): 2221-2231.

[13] Gao An, Xin Zhang, Wenjun Wang, Qiong Huang, Yan Li,Shan Shan, Chris J Corrigan, Wei Wang, Sun Ying*.The effects of interleukin-33 on airways collagen deposition and matrixmetalloproteinase expression in a murine surrogate of asthma. Immunology. 2018,154(4):637-650.

[14] Yan Li#,Wei Wang#, Zhe Lv,Yun Li, Yan Chen, Kewu Huang, Chris J Corrigan, Sun Ying*. Elevated expression of IL-33and TSLP in the airways of human asthmatics in vivo: A potential biomarker of severerefractory disease. J Immunol. 2018, 200(7):2253-2262.

[15] Ping Huang, Yan Li, Ze Lv, JingjingWang, Qian Zhang, Xiujuan Yao, Chris J Corrigan, Kewu Huang, Wei Wang, SunYing*. Comprehensive attenuation of IL-25-induced airwayhyperresponsiveness, inflammation and remodelling by the PI3K inhibitorLY294002. Respirology. 2017, 22(1):78-85.

（2）获得奖励

孙英 (1/9)，预警素类细胞因子及固有淋巴样2型细胞在哮喘中的作用和临床研究, 北京市人民政府, 自然科学, 省部二等奖,2021