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李静,教授、主任医师、博士生导师,现任首都医科大学宣武医院老年医学(综合)科主任及全科医学科主任、首都医科大学心血管病学系副主任;担任中国老年医学学会常务理事及高血压分会总干事、中国医师协会高血压专业委员会委员、北京市高血压防治协会常务理事及副秘书长、北京医学伦理学会临床研究分会副主任委员、国家老年疾病临床医学研究中心老年心血管病防治联盟执行主任委员、Fellow of European Society of Cardiology(FESC)等;主持包括国家自然科学基金、北京市自然科学基金在内多项国家级、省部级课题;入选北京市百千万人才工程计划、北京市高层次创新创业人才支持计划、北京市科技新星;研究成果发表在心血管领域顶级期刊。
1.国家自然科学基金委员会,面上项目,82170347,内皮祖细胞分泌骨钙素通过羧基化修饰在血管内皮修复中发挥双向作用的机制,2022/01-2025/12,55万元,在研,主持;
2.北京市科学技术委员会,新星交叉项目,基于多模态生理信息的高血压驾驶人行为决策机理研究,2023/10-2025/10,50万元,在研,主持;
3.国家自然科学基金委员会,面上项目,81470491,内皮功能和成骨表型内皮祖细胞在血管钙化中的作用和调控机制,2015/01-2018/12,73万元,已结题,主持;
4.北京市自然科学基金委员会,面上项目,7192078,骨钙素阳性内皮祖细胞在血管内皮损伤修复中诱导血管钙化的机制研究,2019/01-2021/12,22万元,已结题,主持。
1.国家自然科学基金委员会,面上项目,82170347,内皮祖细胞分泌骨钙素通过羧基化修饰在血管内皮修复中发挥双向作用的机制,2022/01-2025/12,55万元,在研,主持;
2.北京市科学技术委员会,新星交叉项目,基于多模态生理信息的高血压驾驶人行为决策机理研究,2023/10-2025/10,50万元,在研,主持;
3.国家自然科学基金委员会,面上项目,81470491,内皮功能和成骨表型内皮祖细胞在血管钙化中的作用和调控机制,2015/01-2018/12,73万元,已结题,主持;
4.北京市自然科学基金委员会,面上项目,7192078,骨钙素阳性内皮祖细胞在血管内皮损伤修复中诱导血管钙化的机制研究,2019/01-2021/12,22万元,已结题,主持。
一、第一作者或通讯作者期刊论文
(1) LiY, Zhang Y, Xiao K, Si J, Zhang H, Sun L, Miao Z, Zhao T, Sun J, Sun X, Liu Z,Gao J, Zhao J, Chu X, Li J. The incidence of subclinical atherosclerosis insubjects with low and moderate cardiovascular risk. Clin Cardiol. 2023 Jul 31.doi: 10.1002/clc.24087. Epub ahead of print. PMID: 37522647.
(2) TanJ, Zhang YH, Si J, Xiao KL, Hua Q, Li J. Incidence, predictors and prognosis ofacute kidney injury in acute ST-segment elevation myocardial infarctionpatients undergoing emergent coronary angiography/primary percutaneous coronaryintervention. J Geriatr Cardiol. 2023 Feb 28;20(2):139-149. doi:10.26599/1671-5411.2023.02.004. PMID: 36910244; PMCID: PMC9992945.
(3) XiaoK, Liu M, Sun X, Zhang Y, Si J, Shi N, Sun L, Miao Z, Zhang H, Zhao T, Liu Z,Fan Z, Gao J, Li J. Association of vascular endothelial function and quality oflife in patients with ischemia and non-obstructive coronary artery disease.Heart Vessels. 2023 May;38(5):617-625. doi: 10.1007/s00380-022-02213-w. Epub2023 Jan 4. PMID: 36598570.
(4) 中国老年医学学会高血压分会,北京高血压防治协会,国家老年疾病临床医学研究中心. 中国老年高血压管理指南2023[J]. 中华高血压杂志,2023,06:508-538.(执笔)
(5) 李静,孙璟皓,李晓洁,刘颖,俞梦越,李冬梅,马艺欣,罗鸿宇,杨跃进.新型冠状病毒感染对北京市STEMI患者行PPCI的影响[J].中华心血管病杂志,2023,51(9):977-983.DOI:10.3760/cma.j.cn112148-20230104-00007.
(6) 吴晴晴,闫蕊,郭明,赵伟,李紫旋,郭金成,李静.糖尿病病程对急性ST段抬高型心肌梗死患者行经皮冠状动脉介入治疗后冠状动脉微血管阻塞及近期预后的影响[J].中国心血管病研究,2023,21(6):511-517.DOI:10.3969/j.issn.1672-5301.2023.06.006.
(7) 赵婷,张迎花,肖克令,司瑾,相前,李严,孙丽杰,苗祖霈,张浩宇,孙璟皓,李静.青年急性ST段抬高型心肌梗死患者的危险因素、治疗方式和住院转归的变化趋势[J].中国心血管杂志,2023,28(3):211-216.DOI:10.3969/j.issn.1007-5410.2023.03.005.
(8) ZhangH, Yi M, Wang Y, Zhang Y, Xiao K, Si J, Shi N, Sun L, Miao Z, Zhao T, Sun X,Liu Z, Gao J, Li J. Air pollution and recurrence of cardiovascular events afterST-segment elevation myocardial infarction. Atherosclerosis. 2022 Feb;342:1-8.doi: 10.1016/j.atherosclerosis.2021.12.012. Epub 2021 Dec 21. PMID: 34974197.
(9) SunL, Xiao K, Miao Z, Zhang Y, Si J, Shi N, Zhang H, Zhao T, Li J. PrognosticValue of Normal Thyroid Stimulating Hormone in Long-Term Mortality in PatientsWith STEMI. Front Endocrinol (Lausanne). 2022 Feb 22;13:806997. doi:10.3389/fendo.2022.806997. PMID: 35273563; PMCID: PMC8902238.
(10)GuoJ, Chen J, Wang G, Liu Z, Niu D, Wu Y, Song J, Gao J, Fan Z, Zhang Y, Si J, ZuoX, Shi N, Miao Z, Bai Z, Zhang L, Liu B, Li J. Plaque characteristics inpatients with ST-segment elevation myocardial infarction and early spontaneousreperfusion. EuroIntervention. 2021 Oct 1;17(8):e664-e671. doi:10.4244/EIJ-D-20-00812. PMID: 33495143.
(11)KongQ, Shi L, Yu R, Long D, Zhang Y, Chen Y, Li J. Biatrial enlargement as apredictor for reablation of atrial fibrillation. Int J Med Sci. 2020 Oct18;17(18):3031-3038. doi: 10.7150/ijms.47568. PMID: 33173423; PMCID:PMC7646094.
(12)LiY, Li X, Zhang Y, Zhang L, Wu Q, Bai Z, Si J, Zuo X, Shi N, Li J, Chu X. Impactof glycemic control status on patients with ST-segment elevation myocardialinfarction undergoing percutaneous coronary intervention. BMC CardiovascDisord. 2020 Jan 30;20(1):36. doi: 10.1186/s12872-020-01339-x. PMID: 32000678;PMCID: PMC6993353.
(13)LiYP, Fan ZX, Gao J, Sun XP, Zhu GH, Zhang YH, Si J, Zuo XB, Liu Z, Hua Q, Li J.Influencing factors of vascular endothelial function in patients withnon-obstructive coronary atherosclerosis: a 1-year observational study. BMCCardiovasc Disord. 2020 Jan 30;20(1):40. doi: 10.1186/s12872-020-01326-2. PMID:32000667; PMCID: PMC6993456.
(14)YiM, Wu Y, Long J, Liu F, Liu Z, Zhang YH, Sun XP, Fan ZX, Gao J, Si J, Zuo XB,Zhang LM, Shi N, Miao ZP, Bai ZR, Liu BY, Liu HR, Li J. Exosomes secreted fromosteocalcin-overexpressing endothelial progenitor cells promote endothelialcell angiogenesis. Am J Physiol Cell Physiol. 2019 Nov 1;317(5):C932-C941. doi:10.1152/ajpcell.00534.2018. Epub 2019 Aug 14. PMID: 31411920.
(15)LiuD, Wu L, Wu Y, Wei X, Wang W, Zhang S, Yi M, Li J, Liu H, Ma X. Heat shockfactor 1-mediated transcription activation of Omi/HtrA2 induces myocardialmitochondrial apoptosis in the aging heart. Aging (Albany NY). 2019 Oct18;11(20):8982-8997. doi: 10.18632/aging.102361. Epub 2019 Oct 18. PMID:31627188; PMCID: PMC6834417.
(16)LiuZ, Xu Y, Wan Y, Gao J, Chu Y, Li J. Exosomes from adipose-derived mesenchymalstem cells prevent cardiomyocyte apoptosis induced by oxidative stress. CellDeath Discov. 2019 Mar 19;5:79. doi: 10.1038/s41420-019-0159-5. PMID: 30911413;PMCID: PMC6425027.
(17)SiJ, Li XW, Wang Y, Zhang YH, Wu QQ, Zhang LM, Zuo XB, Gao J, Li J. Relationshipbetween serum homocysteine levels and long-term outcomes in patients withST-segment elevation myocardial infarction. Chin Med J (Engl). 2019 May5;132(9):1028-1036. doi: 10.1097/CM9.0000000000000159. PMID: 30829711; PMCID:PMC6595884.
(18)ZhangYH, Li J, Flammer AJ, Matsuo Y, Lee MS, Lennon RJ, Bell MR, Holmes DR,Bresnahan JF, Rihal CS, Lerman LO, Lerman A. Long-term outcomes afterfractional flow reserve-guided percutaneous coronary intervention in patientswith severe coronary stenosis. J Geriatr Cardiol. 2019 Apr;16(4):329-337. doi:10.11909/j.issn.1671-5411.2019.04.001. PMID: 31105753; PMCID: PMC6503473.
(19)李静,范利*,华琦*,蔡军,陈鲁原,陈伟伟,陈晓平,郭艺芳,何青,胡亦新,姜一农,李南方,李为民,李燕,李悦,李勇,马青峰,皮林,宋海庆,孙希鹏,王青,王增武,吴海英,吴海云,谢良地,杨进刚,杨伟,中国老年高血压管理指南2019,中华高血压杂志,2019,27(2):25.(撰写组长)
(20)JingLi, Muhamad Y Elrashidi, Andreas JFlammer, Ryan J Lennon, Malcolm R Bell, DavidR Holmes, John F Bresnahan,Charanjit S Rihal, Lilach O Lerman, Amir Lerman*,Long-term outcomesof fractional flow reserve-guided vs. angiography-guidedpercutaneous coronaryintervention in contemporary practice, Eur Heart J, 2013,34(18):1375-1383.
(21)JingLi, Charanjit S Rihal, Yoshiki Matsuo,Muhamad Y Elrashidi, Andreas J Flammer,Moo-Sik Lee, Andrew Cassar, Ryan JLennon, Joerg Herrmann, Malcolm R Bell, DavidR Holmes, John F Bresnahan, QiHua, Lilach O Lerman, Amir Lerman*, Sex-relateddifferences infractional flow reserve-guided treatment, Circ Cardiovasc Interv,2013, 6(6):662-670.
(22)JingLi, Andreas J Flammer, Martin K Reriani,Yoshiki Matsuo, Rajiv Gulati, Paul AFriedman, Randal J Thomas, Nicole PSandhu, Lilach O Lerman, Amir Lerman*, Highleukocyte count is associatedwith peripheral vascular dysfunction inindividuals with low cardiovascularrisk, Circ J, 2013, 77(3):780-785.
(23)JingLi, Andreas J Flammer, Ryan J Lennon,Rebecca E Nelson, Rajiv Gulati, Paul AFriedman, Randal J Thomas, Nicole PSandhu, Qi Hua, Lilach O Lerman, AmirLerman*, Comparison of theeffect of the metabolic syndrome and multipletraditional cardiovascular riskfactors on vascular function, Mayo Clin Proc,2012, 87(10):968-975.
二、会议论文
Jincheng Guo, Jing Li*,Non-rupturedplaque and platelet-rich thrombi in ST-segment elevation myocardialinfarction:new insight into early spontaneous reperfusion, ESC Congress 2019,France,Paris, 2019.8.31-9.4.
三、授权发明专利
(1) 李静, 张迎花,司瑾, 吴晴晴, 左雪冰,石宁, eNOS突变体在促进血管生成中的应用, 2020.02.18,中国,ZL201711013899.0.
(2) 李静, 张迎花,司瑾, 吴晴晴, 左雪冰,石宁, 骨钙素在调节内皮祖细胞外泌体中的应用, 2020.02.18,中国,ZL201711218900.3.
四、获得学术奖励
(1) 李静(1/1),老年医学奖“杰出贡献奖”,中国老年医学学会-北京医学奖励基金会,杰出贡献奖,其他,2017(李静)
(2) 李静(2/8),经灌注球囊冠状动脉注射维拉帕米处理介入术中慢血流与无复流的疗效,北京市通州区人民政府,自然科学,其他,2017(郭金成,李静,李东宝,王德昭,华琦,徐荣,王国忠,陈文明)
(3) 李静(8/8),生理性舒张功能减退与舒张性心力衰竭的鉴别诊断及临床意义,北京市人民政府,自然科学,省部二等奖,2004(华琦,张建,高敬,秦俭,沈祖培,陈海翎,皮林,李静)
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