团队名称：张宏家教授心脏大血管疾病知名专家团队　　

二、团队专长：

    1、主动脉夹层诊治

    2、主动脉扩张，主动脉瘤诊疗　　

    3、心脏移植，心室辅助治疗　

    4、冠脉疾病外科治疗　

    5、瓣膜病外科治疗

    6、成人先天性心脏病诊疗　　

三、团队成员：

    刘愚勇主任医师

    王晓龙主任医师

    李海洋主任医师

    贡鸣主任医师

    姜文剑主任医师

    关欣亮主任医师

    郭东主治医师

    郭家隆主治医师

1 胸主动脉瘤/夹层发病机制及围手术期脏器灌注不良综合征防治策略研究 国家自然科学基金重点项目 2023.01-2025.12 400万 主持 在研

2 心脏外科围术期脑损伤的创新防治技术体系 北京市科委项目重点项目 2022.12-2026.11 1000万 主持 在研

3 心血管疾病精准医学北京实验室 北京市教委 2016.01-2027.12 4000万 主持 在研

4 基于5G+人工智能关键技术的实时多通道术中协同及质控系统 工信部 2021.5-2023.5 自筹 主持 已结题

5 “基于第三方平台的重大疾病临床样本资源库建设与共享的应用研究” 北京市科委 2019年1月-2021年月 800万 主持 已结题 

6 急性主动脉综合征高危预警及干预研究 科技部重大专项 2017年1月-2021年6月 1183万 主持 已结题 

7 CD40配体加重内皮损伤介导的炎症反应及其在主动脉瘤发病与进展中的作用机制研究 国家自然科学基金（面上项目） 2015年1月-2018年12月 75万主持 已结题 

8 温度梯度分级对Stanford A型主动脉夹层围手术期凝血系统影响的系列研究 北京市科委  2014年-2017年 80万 主持 已结题 

9 血小板源性P-选择素在主动脉瘤发病中的作用及机制研究 国家自然科学基金（面上项目） 2012年-2015年 60万 主持 已结题 

10 血小板源性P-选择素在主动脉瘤发病中的作用及机制研究 教育部新世纪人才 2012年-2014年 50万 主持 已结题 

1 胸主动脉瘤/夹层发病机制及围手术期脏器灌注不良综合征防治策略研究 国家自然科学基金重点项目 2023.01-2025.12 400万 主持 在研

2 心脏外科围术期脑损伤的创新防治技术体系 北京市科委项目重点项目 2022.12-2026.11 1000万 主持 在研

3 心血管疾病精准医学北京实验室 北京市教委 2016.01-2027.12 4000万 主持 在研

4 基于5G+人工智能关键技术的实时多通道术中协同及质控系统 工信部 2021.5-2023.5 自筹 主持 已结题

5 “基于第三方平台的重大疾病临床样本资源库建设与共享的应用研究” 北京市科委 2019年1月-2021年月 800万 主持 已结题 

6 急性主动脉综合征高危预警及干预研究 科技部重大专项 2017年1月-2021年6月 1183万 主持 已结题 

7 CD40配体加重内皮损伤介导的炎症反应及其在主动脉瘤发病与进展中的作用机制研究 国家自然科学基金（面上项目） 2015年1月-2018年12月 75万主持 已结题 

8 温度梯度分级对Stanford A型主动脉夹层围手术期凝血系统影响的系列研究 北京市科委  2014年-2017年 80万 主持 已结题 

9 血小板源性P-选择素在主动脉瘤发病中的作用及机制研究 国家自然科学基金（面上项目） 2012年-2015年 60万 主持 已结题 

10 血小板源性P-选择素在主动脉瘤发病中的作用及机制研究 教育部新世纪人才 2012年-2014年 50万 主持 已结题 

1、Hong Liu,Yi-Fei Diao, Si-Chong Qian, Yong Feng Shao, Zhi-Hua Zeng, Guo-Liang Fan, Lu-YaoMa, Hong-Jia Zhang. Prognostic implication of residual inflammatorytrajectories in acute type I aortic dissection: dual-center prospective cohortstudy. International Journal of Surgery. 2024 Mar 4. doi:10.1097/JS9.0000000000001245. (IF:15.3)

2、Zhao Ma,Chenchen Tu, Baoen Zhang, Dongfeng Zhang, Xiantao Song, Hongjia Zhang. Ameta-analysis comparing the diagnostic performance of computed tomography-derivedfractional flow reserve and coronary computed tomography angiography atdifferent levels of coronary artery calcium score. European Radiology. 2024 Feb9. doi: 10.1007/s00330-024-10591-0. (IF:5.9)

3、Luo Y, LuoJ, An P, Zhao Y, Zhao W, Fang Z, Xia Y, Zhu L, Xu T, Zhang X, Zhou S, Yang M,Li J, Zhu J, Liu Y, Li H, Gong M, Liu Y, Han J, Guo H*, Zhang H*, Jiang W*, RenF*. The activator protein-1 complexgoverns a vascular degenerative transcriptional programme in smooth musclecells to trigger aortic dissection and rupture. EuropeanHeart Journal. 2024 Jan 27;45(4):287-305. doi: 10.1093/eurheartj/ehad534. (IF:39.3)

4、MaozhouWang, Hongkai Zhang, Zhou Liu, Jie Han, Jing Liu, Nan Zhang, Shuang Li, WenjieTang, Peiyi Liu, Baiyu Tian, Tiange Luo, Jiangang Wang, Xu Meng, Hongyu Ye*,Lei Xu*, Hongjia Zhang*, Wenjian Jiang*. European Radiology. 2024 Jan 22. doi:10.1007/s00330-023-10470-0. (IF:5.9)

5、SonghaoJia, Maozhou Wang, Yuyong Liu, Ming Gong, Wenjian Jiang, Hongjia Zhang. Effectof Asymptomatic Common Carotid Artery Dissection on the Prognosis of PatientsWith Acute Type A Aortic Dissection. Journal of the American Heart Association.2024 Jan 2;13(1):e031542. doi: 10.1161/JAHA.123.031542. (IF:5.4)

6、Hong Liu, HaiyangLi, Lu Han, Yingyuan Zhang, Ying Wu, Liang Hong, Jinong Yang, Jisheng Zhong,Yuqi Wang, Dongkai Wu, Guoliang Fan, Junquan Chen, Shengqiang Zhang, XingxingPeng, Zhihua Zeng, Zhiwei Tang, Zhanjie Lu, Lizhong Sun, Sichong Qian∗, Yongfeng Shao∗, Hongjia Zhang∗. Inflammatoryrisk stratification individualizes anti-inflammatory pharmacotherapy for acutetype A aortic dissection. The Innovation. 2023 May 25;4(4):100448. doi:10.1016/j.xinn.2023.100448. (IF:32.1)

7、Xiaohui He,Jing Wang, Yuan Xue, Shipan Wang, Yanjun Dong, Hongjia Zhang∗，Meili Wang∗.Mammalian sterile 20-like kinase 1 acts as a candidate biomarker of mortalityof emergency surgical repair for acute type a aortic dissection. BMCCardiovascular Disorders. 2023 Apr 10;23(1):188. doi:10.1186/s12872-023-03144-8. (IF:2.1)

8、Shijun Xu,Zining Wu, Yongmin Liu, Junming Zhu, Ming Gong, Lizhong Sun, Dong Ran, HongjiaZhang. Influence of Preoperative Serum Albumin on Acute Kidney Injury afterAortic Surgery for Acute Type A Aortic Dissection: A Retrospective Cohort Study.Journal of Clinical Medicine. 2023 Feb 16;12(4):1581. doi: 10.3390/jcm12041581.(IF:3.9)

9、JingWenYong, JinFan Tian, HuiJuan Zuo, JiaXin Cao, HuiHui Kong, Xin Zhao, XueYao Yang,HongJia Zhang∗,Yi He, XianTao Song∗. Microvascular Research. 2023 May:147:104493. doi:10.1016/j.mvr.2023.104493. (IF:3.1)

10、XinLiangGuan, Lei Li, XuRan Lu, Ming Gong, HaiYang Li, YuYong Liu, WenJian Jiang, FengLan, XiaoLong Wang，HongJiaZhang. Safety and efficacy of fibrinogen concentrate in aortic arch surgeryinvolving moderate hypothermic circulatory arrest. Journal of Thrombosis andThrombolysis. 2023 Jan;55(1):67-73. doi: 10.1007/s11239-022-02706-5. (IF:4.0)

11、Hong Liu,Si-Chong Qian, Lu Han, Ying-Yuan Zhang, Ying Wu, Liang Hong, Ji-Nong Yang,Ji-Sheng Zhong, Yu-Qi Wang, Dong-Kai Wu, Guo-Liang Fan, Jun-Quan Chen,Sheng-Qiang Zhang, Xing-Xing Peng, Zhi-Wei Tang, Al-Wajih Hamzah, Yong-FengShao, Hai-Yang Li, Hong-Jia Zhang. Circulating biomarker-based riskstratifications individualize arch repair strategy of acute Type A aorticdissection via the XGBoosting algorithm. Eur Heart J Digit Health. 2022 Nov1;3(4):587-599. doi: 10.1093/ehjdh/ztac068.

12、SonghaoJia, Maozhou Wang, Ming Gong, Hongjia Zhang∗，WenjianJiang∗.Midterm outcomes of simultaneous carotid revascularization combined withcoronary artery bypass grafting. BMC Cardiovascular Disorders. 2022 Dec8;22(1):535. doi: 10.1186/s12872-022-02986-y. (IF:2.1)

13、Hong Liu,Si-Chong Qian, Yong-Feng Shao, Hai-Yang Li, Hong-Jia Zhang. Prognostic Impactof Systemic Coagulation-Inflammation Index in Acute Type A Aortic DissectionSurgery. JACC Asia. 2022 Oct 4;2(6):763-776. doi: 10.1016/j.jacasi.2022.06.007.

14、Ziyu An,Jinfan Tian , Yue Liu, Xin Zhao, Xueyao Yang, Jingwen Yong, Libo Liu, LijunZhang, Wenjian Jiang, Xiantao Song, Hongjia Zhang. Exosomes as a Cell-freeTherapy for Myocardial Injury Following Acute Myocardial Infarction or IschemicReperfusion. 2022 Dec 1;13(6):1770-1786. doi: 10.14336/AD.2022.0416. (IF:7.4)

15、Li J, GongM, Joshi Y, Sun L, Huang L, Fan R, Gu T, Zhang Z, Zou C, Zhang G, Qian X, QiaoC, Chen Y, Jiang W* and Zhang H* . Machine Learning Prediction Model for AcuteRenal Failure After Acute Aortic Syndrome Surgery. Front Med (Lausanne).2022;8:728521. Published 2022 Jan 17. doi:10.3389/fmed.2021.728521. (IF:5.091)

16、HairuiSun1†, Siyao Zhang1†, Jingyi Wang, Xiaoxue Zhou, Hongjia Zhang*, Huixia Yangand Yihua He1*.Expanding the phenotype associated with SMARCC2 variants: afetus with tetralogy of Fallot. BMC Med Genomics. 2022;15(1):40. Published 2022Mar 3. doi:10.1186/s12920-022-01185-0.(IF:3.063)

17、Li, Lei#;Wang, Maozhou#; Li, Jinzhang#; Guan, Xinliang; Xin, Pu; Wang, Xiaolong; Liu,Yuyong; Li, Haiyang; Jiang, Wenjian; Gong, Ming*; Zhang, Hongjia*. Short TermPrognosis of Renal Artery Stenosis Secondary to Acute Type B Aortic DissectionWith TEVAR. Front Cardiovasc Med. 2021;8:658952. Published 2021 Apr 23.doi:10.3389/fcvm.2021.658952(IF:6.050)

18、Lei L#,Xinliang G#, Ming G#, Xiaolong W, Yuyong L,Yang L, Zining W, Feng L,Haiyang L*,Hongjia Z.*.Changing of haemostatic system in a pig model during differenttypes of hypothermic circulatory arrest . J Therm Biol. 2021 Jul;99:102974]. JTherm Biol. 2021;95:102817. doi:10.1016/j.jtherbio.2020.102817.(IF:2.902)

19、Wang MZ,Fan R, Gu T, Zou C, Zhang Z, Liu Z, Qiao C, Sun L, Gong M, Li H, ZhangH.Short-term outcomes of acute coronary involvement in type A aortic dissectionwithout myocardial ischemia: a multiple center retrospective cohort study. JCardiothorac Surg. 2021;16(1):107. Published 2021 Apr 23.doi:10.1186/s13019-021- 01469-z .(IF:1.637)

20、Wang MZ#,Jia SH#, Xin Pu, Sun LZ，Gong M*，Zhang HJ*. Mid-term Patency of the Great SaphenousBypass to Aorta vs. Non-aortic Arteries in Stanford Type A Aortic DissectionSurgery With Concomitant CABG. Front Cardiovasc Med. 2021;8:743562. Published2021 Oct 26. doi:10.3389/fcvm.2021.743562.(IF:6.050)

21、WangMZ#, Li L, MD#, Li JZ#, Xu MH, Pu X, Li QX, Sun LZ, Zhang HJ, Gong M. Influenceof Dynamic and Static Obstructive Renal Artery on Early Prognosis in StandfordType A Aortic Dissection [published online ahead of print, 2022 Jan 21]. HeartLung Circ. 2022;S1443-9506(21)01345-7. doi:10.1016/j.hlc.2021.11.002 .(IF:2.975)

22、Li J, Li L,Wang M, Li H, Sun L, Liu Y, Fan R, Zhang Z, Zou C, Zhang H, Gong M. Comparisonof Prognosis Between Hybrid Debranching Surgery and Total Open Arch ReplacementWith Frozen Elephant Trunk for Type A Acute Aortic Syndrome Patients. FrontCardiovasc Med. 2021;8:689507. Published 2021 Jul 27. doi:10.3389/fcvm.2021.689507. (IF:6.050)

23、Yuan Xue,Bridget Hwang, Shipan Wang, Songhao Jia, Haiyang Li, Hongjia Zhang, WenjianJiang.Effect of left ventricular ejection fraction (LVEF) on mortality of totalarch replacement in subacute/chronic type A aortic dissection. J Thorac Dis.2022;14(2):405-413. doi:10.21037/jtd-21-1905. (IF:2.895)

24、Wu Yuduo.,Gong Ming., Fan Ruixin., Gu Tianxiang., Qian Ximing., Zhang Hongjia*. Analysisof ascending aortic diameter and long-term prognosis in patients with ascendingaortic dissection. Echocardiography. 2021;38(4):531-539.doi:10.1111/echo.14980.(IF:1.724)

25、Wu Yuduo,Sun Hairui, He Yihua, Zhang Hongjia. A novel intron mutation in FBN-1 geneidentified in a pregnant woman with Marfan syndrome. Hereditas. 2021;158(1):6.Published 2021 Jan 6. doi:10.1186/s41065-020-00170-w.(IF:3.271)

26、Hao Xu, MD,Wenjian Jiang, MD,* Yashutosh Joshi, MD, Lu Han, MD, Haiyang Li, MD, Feng Lan,MD, Junming Zhu, MD, Lizhong Sun, MD, Ming Gong, MD, and Hongjia Zhang,MD*.  Primary Cardiac Impairment inPatients With Marfan Syndrome Undergoing a Bentall Procedure. Ann Thorac Surg.2021;112(4):1193-1200. doi:10.1016/j.athoracsur.2020.10.044(IF:4.330)

27、Wu Yuduo.,Sun Hairui., Wang Jianbin., Wang Xin., Gong Ming., Han Lu., He Yihua., ZhangHongjia.(2020). Marfan syndrome: whole-exome sequencing reveals de novomutations, second gene and genotype-phenotype correlations in the Chinesepopulation. Biosci Rep. 2020;40(12):BSR20203356. doi:10.1042/BSR20203356.(IF:3.840)

28、WenjianJiang, Yuan Xue, Haibin Li, Hongjia Zhang，YuanfeiZhao. TAZ Is Related to Postoperative In-Hospital Mortality of Acute Type AAortic Dissection. Front Cardiovasc Med. 2020;7:587996. Published 2020 Nov 3.doi:10.3389/fcvm.2020.587996.(IF:6.050)

29、WenjianJiang, Jihong Liu, Lu Dai, Yang Liu, Zining Wu, Hongjia Zhang. Are dilatedascending aortas of Chinese patients more likely to dissect?. Cardiovasc DiagnTher. 2020;10(4):786-795. doi:10.21037/cdt-20-313(IF:2.845)

30、Sheng Yang,Yuan Xue, Jie Liu, Hongjia Zhang*, and Wenjian Jiang*. Is fibrinogen plasmalevel a risk factor for the first 24-hour death of medically treated acute typeA aortic dissection patients?. Ann Transl Med. 2020;8(16):1015.doi:10.21037/atm-20-5466. (IF:3.932)

31、Jihong Liu,Yuan Xue, Wenjian Jiang, Hongjia Zhang*, Yuanfei Zhao*. Thyroid Hormone IsRelated to Postoperative AKI in Acute Type A Aortic Dissection. FrontEndocrinol (Lausanne). 2020;11:588149. Published 2020 Nov 18.doi:10.3389/fendo.2020.588149.(IF:5.555)

32、Wu ZN, GuanXL, Xu SJ, Wang XL , Li HY, Gong M* , Zhang HJ*. Does preoperative serumcreatinine affect the early surgical outcomes of acute Stanford type A aorticdissection?. J Chin Med Assoc. 2020;83(3):266-271.doi:10.1097/JCMA.0000000000000264.(IF:1.54)

33、Sun H#,Zhou X#, Hao X, Zhang Y, Zhang H* , He Y*.  Characteristics of CardiacPhenotype in Prenatal Familial Cases With NONO Mutations. Circ Genom PrecisMed. 2020;13(3):e002847. doi:10.1161/CIRCGEN.119.002847 (IF=6.054)

34、Sun H#, YuS#, Zhou X, Han L, Zhang H* , He Y*. Expanding the phenotype of STRA6-relateddisorder to include left ventricular non-compaction. Mol Genet Genomic Med.2020;8(9):e1377. doi:10.1002/mgg3.1377. (IF=2.183)

35、H Sun , TYi , X Hao , H Yan , J Wang , Q Li , X Gu 3, X Zhou , S Wang , X Wang , P Wan ,L Han , J Chen , H Zhu , H Zhang , Y He.Contribution of single-gene defects tocongenital cardiac left-sided lesions in the prenatal setting. UltrasoundObstet Gynecol. 2020;56(2):225-232. doi:10.1002/uog.21883.(7.299)

36、Hairui Sun,Xiaoyan Hao, Xin Wang, Xiaoxue Zhou, Ye Zhang, Xiaowei Liu, Jiancheng Han,Xiaoyan Gu, Lin Sun, Ying Zhao, Tong Yi, Hongjia Zhang* and Yihua He*.Geneticsand Clinical Features of Noncompaction Cardiomyopathy in the Fetal Population.Front Cardiovasc Med. 2021;7:617561. Published 2021 Jan 20.doi:10.3389/fcvm.2020.617561.(6.050)

37、Zi-Ning Wu,Xin-Liang Guan, Shi-Jun Xu, Xiao-Long Wang, Hai-Yang Li,Ming Gong*, HongJiaZhang*.Does preoperative serum creatinine affect the early surgical outcomes ofacute Stanford type A aortic dissection?. J Chin Med Assoc. 2020;83(3):266-271.doi:10.1097/JCMA.0000000000000264(IF: 2.743)

38、Shijun Xu,Lei Li，Yuwei Fu, Xin Wang, Hairui Sun,Jianbin Wang, Lu Han, Zining Wu, Yongmin Liu, Junming Zhu, Lizhong Sun, FengLan, Yihua He*, Hongjia Zhang*.Increased frequency of FBN1 frameshift andnonsense mutations in Marfan syndrome patients with aortic dissection. MolGenet Genomic Med. 2020;8(1):e1041. doi:10.1002/mgg3.1041 (IF: 2.183)

39、Yang Liu ,Zining Wu, Lu Dai, Haiyang Li,Ming Gong, Feng Lan, Xinliang Guan* ,and HongjiaZhang*. Deep Hypothermic Circulatory Arrest Does Not Show Better Protection forVital Organs Compared with Moderate Hypothermic Circulatory Arrest in PigModel. Biomed Res Int. 2019;2019:1420216. Published 2019 Apr 17.doi:10.1155/2019/1420216.(IF: 3.411)

40、H. Sun,T.Yi,X. Hao,H. Yan,J. Wang,Q. Li,X. Gu,X. Zhou,S. Wang,X. Wang,P. Wan,L. Han,J.Chen,H. Zhu,H. Zhang* andY. He. 2019. Contribution of single-gene defects tocongenital cardiac left-sided lesions in the prenatal setting. UltrasoundObstet Gynecol. 2020;56(2):225-232. doi:10.1002/uog.21883. (IF=7.299)