首都医科大学三博脑科医院功能及癫痫疾病诊疗中心由国内知名神经外科专家栾国明教授领衔，整合多个学科，是北京市脑重大疾病研究院癫痫研究所常设机构，也是中国抗癫痫协会癫痫疑难症会诊中心。

近五年部分科研项目：

1.国家自然科学基金重大项目：影像引导下的癫痫神经调控与外科干预2018.01-2022.12

2.国家自然科学基金面上项目：电相关癫痫网络效应连接构建及在癫痫外科中的应用2017.01-2020.12

3.北京市科委首都临床特色应用研究与成果推广、十大疾病科技成果推广项目：国产迷走神经刺激器临床推广及应用示范2016.07-2018.06

4.北京市科委“北京脑科学专项”——脑认知与脑医学领域项目：效应连接在表达皮层脑功能图谱研究及神经外科手术评估中的应用2016.06 -2019.05

5.首都卫生发展科研专项：机器人辅助立体定向引导下热相关外科干预治疗局灶性药物难治性癫痫的前瞻性多中心研究2022.01-2024.12

6.首都卫生发展科研专项：皮层电凝热灼治疗脑功能区局灶性癫痫的临床研究2016.01-2018.12

7.医院国家自然科学基金培育项目：HCMV激活小胶质细胞参与Rasmussen脑炎发病的机制研究2019.04-2019.12

8.横向项目：致痫灶神经元代谢与癫痫临床诊断和治疗的研究2020.09.-2023.08

1. 近三年主编专著：

（1）主编《立体定向脑电图与癫痫——病例精解》科学出版社 2021.3

（2）主编《神经外科机器人技术》湖北科学出版社 2021.9

2.近五年发表学术论文：

2022

1.       Correlation Between Ictal Signs and Anatomical Subgroups in TemporalLobe Seizures: A Stereoelectroencephalography Study. Front Neurol, 2022. 13: p.917079.

2.       Vagus nerve stimulation for drug-resistant epilepsy induced bytuberous sclerosis complex. Epilepsy Behav, 2022. 126: p. 108431.

3.       Analysis of power spectrum and phase lag index changes followingdeep brain stimulation of the anterior nucleus of the thalamus in patients withdrug-resistant epilepsy: A retrospective study. Seizure, 2022. 96: p. 6-12.

4.       The correspondence between morphometric MRI and metabolic profile inRasmussen's encephalitis. Neuroimage Clin, 2022. 33: p. 102918.

5.       The influencing factors and changes of cognitive function within 40Rasmussen encephalitis patients that received a hemispherectomy. Neurol Res,2022. 44(8): p. 700-707.

2021

1.       Epileptic seizures in a heterogeneous excitatory network withshort-term plasticity. Cogn Neurodyn, 2021. 15(1): p. 43-51.

2.       Prognostic value of histopathologic pattern for long-term surgicaloutcomes of 198 patients with confirmed mesial temporal lobe epilepsy. HumPathol, 2021. 115: p. 47-55.

3.       Long-term efficacy and cognitive effects of bilateral hippocampaldeep brain stimulation in patients with drug-resistant temporal lobe epilepsy.Neurol Sci, 2021. 42(1): p. 225-233.

4.       Characteristics, surgical outcomes, and influential factors ofepilepsy in Sturge-Weber syndrome. Brain, 2021.

5.       Increased inflammasome-activated pyroptosis mediated by caspase-1 inRasmussen's encephalitis. Epilepsy Res, 2021. 179: p. 106843.

6.       Rare manifestations and malignancies in tuberous sclerosis complex:findings from the TuberOus SClerosis registry to increAse disease awareness(TOSCA). Orphanet J Rare Dis, 2021. 16(1): p. 301.

7.       The diagnostic value of pain evoked potential by electricalstimulation combined with noceciptive blink reflex in trigeminal neuralgia. JIntegr Neurosci, 2021. 20(2): p. 425-429.

8.       Magnetoencephalography STOUT Method Adapted to RadiofrequencyThermocoagulation for MR-Negative Insular Epilepsy: A Case Report. FrontNeurol, 2021. 12: p. 683299.

9.       Alkaline brain pH shift in rodent lithium-pilocarpine model ofepilepsy with chronic seizures. Brain Res, 2021. 1758: p. 147345.

10.     Epileptogenic Zone Location of Temporal Lobe Epilepsy byCross-Frequency Coupling Analysis. Front Neurol, 2021. 12: p. 764821.

11.     Predictors and Long-term Outcome of Resective Epilepsy Surgery inPatients with Tuberous Sclerosis Complex: A Single-centre Retrospective CohortStudy. Seizure, 2021. 88: p. 45-52.

12.     A concordance study determining language dominance between navigatedtranscranial magnetic stimulation and the Wada test in patients withdrug-resistant epilepsy. Epilepsy Behav, 2021. 117: p. 107711.

13.     Clinically localized seizure focus maybe not exactly the position ofabating seizures: a computational evidence. Nonlinear Dynamics, 2021. 105(2):p. 1773-1789.

14.     Genetic Factors in Rasmussen's Encephalitis Characterized by Whole-ExomeSequencing. Front Neurosci, 2021. 15: p. 744429.

15.  刘钊,周健,关宇光,翟锋,王梦阳,王静,赵萌,王雄飞,张尧,滕鹏飞,栾国明.局灶性中央区药物难治性癫痫的临床特点、外科治疗方法及预后分析[J].中华医学杂志,2021,101(41):3380-3385.

16.  蔡璞,刘长青,栾国明.胼胝体切开术与迷走神经刺激术治疗儿童耐药性癫痫疗效对比[J].中华小儿外科杂志,2021,42(10):872-877.

17.  王澍,赵萌,潘军红,王雄飞,张春生,马皓伟,王梦阳,李天富,王静,周健,刘长青,栾国明,关宇光.1岁及以下Sturge-Weber综合征患儿的半球手术治疗与预后[J].中华临床医师杂志(电子版),2021,15(08):578-583.

18.  张艺帆,贺星惠,唐重阳,郭梦依,刘思奇,熊中华,栾国明,李天富.低级别胶质瘤合并癫患者腺苷A2A受体信号通路变化的研究[J].中国临床神经科学,2021,29(03):247-256.

2020

1.       Comparisons of the seizure-free outcome and visual field deficitsbetween anterior temporal lobectomy and selective amygdalohippocampectomy: Asystematic review and meta-analysis. Seizure, 2020. 81: p. 228-235.

2.       The role of adenosine A1 receptor agonist in adenosine augmentationtherapy for patients with refractory epilepsy in Sturge-Weber syndrome: An invitro electrophysiological study. Epilepsy Behav, 2020. 106: p. 107034.

3.       Stereotactic radiofrequency thermocoagulation and resective surgeryfor patients with hypothalamic hamartoma. J Neurosurg, 2020. 134(3): p. 1019-1026.

4.       Color perception matches selectivity in human early visual cortex.Brain Stimul, 2020. 13(1): p. 253-255.

5.       Rasmussen's encephalitis: mechanisms update and potential therapytarget. Ther Adv Chronic Dis, 2020. 11: p. 2040622320971413.

6.       Distinguishing Dependent-Stage Secondary Epileptogenesis in aComplex Case of Giant Hypothalamic Hamartoma With Assistance of a ComputationalMethod. Front Neurol, 2020. 11: p. 478.

7.       The impact of MEG results on surgical outcomes in patients withdrug-resistant epilepsy associated with focal encephalomalacia: a single-centerexperience. J Neurol, 2020. 267(3): p. 812-822.

8.       Prognostic factors of postoperative seizure outcomes in olderpatients with temporal lobe epilepsy. Neurosurg Focus, 2020. 48(4): p. E7.

9.   Upregulation of adenosine A2A receptor and downregulation of GLT1 isassociated with neuronal cell death in Rasmussen's encephalitis. Brain Pathol,2020. 30(2): p. 246-260.

10.  王澍,赵萌,王军,王雄飞,潘军红,刘长青,刘钊,张春生,张小英,韩一仙,栾国明,关宇光.不同麻醉方式下帕金森病脑深部电刺激术疗效对比分析[J].中国现代神经疾病杂志,2020,20(12):1057-1065.

11.  闫兆芬,王静,栾国明,周健,光宇光,翟峰,王梦阳.不同年龄阶段Rasmussen脑炎临床与脑电图特征[J].中国现代神经疾病杂志,2020,20(09):821-826.

2019

1.       Globus Pallidus Internus Electric High-Frequency StimulationModulates Dopaminergic Activity in the Striatum of a Rat Model of TouretteSyndrome. World Neurosurg, 2019. 127: p. e881-e887.

2.       Dynamical analysis of epileptic characteristics based on recurrencequantification of SEEG recordings. Physica A: Statistical Mechanics and itsApplications, 2019. 523: p. 507-515.

3.       Clinical Characteristics of Subependymal Giant Cell Astrocytoma inTuberous Sclerosis Complex. Front Neurol, 2019. 10: p. 705.

4.       Surgical outcomes and prognostic factors of drug-resistant epilepsysecondary to encephalomalacia. Epilepsia, 2019. 60(5): p. 948-957.

5.       Resective surgery for drug-resistant posttraumatic epilepsy:predictors of seizure outcome. J Neurosurg, 2019. 133(5): p. 1-8.

6.   Role of DNA Methylation andAdenosine in Ketogenic Diet for Pharmacoresistant Epilepsy: Focus onEpileptogenesis and Associated Comorbidities. Front Neurol, 2019. 10: p. 119.

7.   刘长青,程前,关宇光,栾国明.机器人引导立体脑电射频毁损治疗下丘脑错构瘤所致癫痫[J].中国临床神经外科杂志,2019,24(08):489-491.

8.   刘长青,程前,关宇光,栾国明.运动皮层电刺激治疗丘脑痛3例并文献复习[J].中国临床神经外科杂志,2019,24(06):336-338.

9.   王雄飞,栾国明.癫痫外科的诊治进展[J].中国微侵袭神经外科杂志,2019,24(05):193-195.

2018

1.       Localization of Epileptogenic Zone With the Correction ofPathological Networks. Front Neurol, 2018. 9: p. 143.

2.       Occipital Lobe Epilepsy With Ictal Fear: Evidence From a Stereo-Electroencephalography(sEEG) Case. Front Neurol, 2018. 9: p. 644.

3.       Detection of EBV and HHV6 in the Brain Tissue of Patients withRasmussen's Encephalitis. Virol Sin, 2018. 33(5): p. 402-409.

4.       Presurgical Thalamus and Brainstem Shifts Predict Distal MotorFunction Recovery After Anatomic Hemispherectomy. World Neurosurg, 2018. 118:p. e713-e720.

5.   Treatment for patients withrecurrent intractable epilepsy after primary hemispherectomy. Epilepsy Res,2018. 139: p. 137-142.

6.   周健,栾国明.颞叶癫的外科治疗[J].中国微侵袭神经外科杂志,2018,23(01):1-5.

7.   翟锋,栾国明,周健,牛弘川,张尧,丁浩然,孙卫进,陈嘉芃.颞叶癫手术并发症的预防与处理[J].中国微侵袭神经外科杂志,2018,23(01):10-13.

8.   王静,周健,关宇光,陈述花,王梦阳,栾国明.颅内电极脑电图发作前期脑电活动特点在癫痫发作定位中的作用[J].中国微侵袭神经外科杂志,2018,23(01):6-9.