附属北京天坛医院-王群导师介绍

更新于 2025-10-20 导师主页
王群 教授 硕,博士生导师
附属北京天坛医院
神经病学
癫痫及发作性疾病,抗癫痫药物合理应用,顽固性癫痫术前评估
wangq@ccmu.edu.cn

王群,医学博士,留美博士后。神经病学主任医师、二级教授、博士生导师。首都医科大学附属北京天坛医院神经病学中心癫痫科首席科学家,郑州大学第一附属医院神经精神医学部主任及神经内科主任,河南省癫痫诊疗中心主任。脑功能疾病调控治疗北京市重点实验室副主任,癫痫病临床研究北京市重点实验室学术委员会主任。国家神经系统疾病临床医学研究中心和北京脑重大疾病研究院兼任教授。北京市海外高层次引进人才(海聚工程)及北京市特聘专家。中华医学会神经病学分会脑电图与癫痫学组副组长,中国抗癫痫协会常务理事及神经调控专委会、药物治疗专委会及神经重症专委会副主任委员。中国卒中学会神经调控分会副主任委员及脑血管病转化医学分会常委。中国神经科学学会神经系统疾病基础与临床分会常委和神经科学技术分会委员。国际神经修复学会中国委员会药物治疗分会副主任委员。北京抗癫痫协会副会长,北京神经内科学会副会长,北京神经科学学会理事及胶质细胞及相关疾病分会主任委员,北京医学会神经病学分会癫痫学组副组长,北京癫痫诊疗技术创新联盟理事长。


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科研项目

⽬前承担项⽬:

1. 科技部“十四五”重大专项: 成人癫痫专病队列建设和诊治关键技术及服务体系研究,2022YFC2503800,2022.10-2025.09,1500万,项目负责人。

2. 科技部“十三五”重大专项: 急性局灶性脑缺血后全脑保护评估体系及转化研究-急性局灶性脑缺血后神经保护新靶点和药物筛选,2017YFC1307501,2017.06-2021.06,294万,子课题负责人。

3. 国家自然科学基金面上项目:食欲素参与 LGI1 抗体脑炎相关癫痫合并睡眠障碍的神经内分泌机制研究,82371449,2024.01-2027.12,49万,负责人。

4. 国家自然科学基金区域联合重点项目:缺血性卒中后癫痫发病机制及修饰干预研究,U24A20695,2025. 01 -2028. 12,260万,项目负责人。

5. 国家留学基金委创新型人才国际合作培养项目:癫痫精准诊治及分子机制研究,2025-2028年,联合培养博士研究生2人/年、访问学者1人/年、博士后2人/年。项目负责人。

6. 北京市首都卫生发展科研专项重点项目:基于可穿戴设备及像电磁多模态信号构建人工智能辅助颞叶癫痫预警及诊疗决策体系研究,首发2024-1-2041,2024.01-2026.12,330万,项目负责人。

7. 北京市自然科学基金面上项目:Apocynin衍生物抑制NOX介导的铁死亡改善脑外伤后癫痫的机制研究,7232045,2023.01-2025.12,20万,负责人。

8. 北京市自然科学基金重点项目:基于像电磁一体化的多模态脑网络研究在颞叶癫痫精准诊断中的应用,Z200024,2020.09-2024.10,70万,子课题负责人。



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研究成果

重要学术论文:

1.Ren J, Ding M, Peng Y, Sun C, Yang C, Zhou S, Tian J, Wang Q, Li Z. A comparative study on the detection and localization of interictal epileptiform discharges in magnetoencephalography using optically pumped magnetometers versus superconducting quantum interference devices. Neuroimage. 2025 May 15; 312: 121232. 

2.Wang G, Yan H, Li W, Sheng D, Ren L, Wang Q, Zhang H, Zhang G, Yu T, Wang G. Seizure detection using the wristband accelerometer, gyroscope, and surface electromyogram signals based on in-hospital and out-of-hospital dataset. Seizure. 2025 Apr;127:127-134.

3.Yu LL, Sun L, Yu TT, Guo AC, Wu JP, Chen JM, Wang Q. CPCGI alleviates neural damage by modulating microglial pyroptosis after traumatic brain injury. CNS Neurosci Ther. 2025;31(3):e70322. 

4.Chen JM, Shi G, Yu LL, Shan W, Sun JY, Guo AC, Wu JP, Tang TS, Zhang XJ, Wang Q. 3-HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes. Adv Sci. 2025;12(11):e2412667. 

5.Li X, Qin X, Xie Y, Wang L, Wang J, Ji S, Jiang H, Wang Q. Metabolic characterization of cerebrospinal fluid for patients with autoimmune encephalitis: A preliminary study. CNS Neurosci Ther. 2025;31(1):e70203. 

6.Wei S, Shiwen W, Cao-Wenjing C, Huajun Y, Qun W. A randomized, double-blind, placebo-controlled, dose-escalating phase IIa trial to evaluate the safety, tolerability, efficacy, and pharmacokinetics of multiple oral doses of Pynegabine tablets as add-on therapy in patients with focal epilepsy. CNS Neurosci Ther. 2024;30(9):e70002. 

7.Weng S, Liu X, Wang D, Wang J, Ren Q, Wang Q, Shan W. Generation of a human induced pluripotent stem cell (iPSC) line from a patient with a CDKL5 gene mutation. Stem Cell Res. 2024;81:103607. 

8.Shi W, Sun H, Peng W, Chen Z, Wang Q, Lin W, Ding M, Sun H, Wang X, Wang T, Wang X, Liu Y, Chen Y, Zhu G, Zhou D, Li J. A cross-sectional, multicenter survey of the prevalence and influencing factors for migraine in epilepsy. Epilepsia Open. 2024 ; 9(4):1406-1415.

9.Sun T, Wu S, Liu X, Tao JX, Wang Q. Impact of intracranial subclinical seizures on seizure outcomes after SLAH in patients with mesial temporal lobe epilepsy. Clin Neurophysiol. 2024;160:121-129. 

10.Liu X, Zheng X, Shu Y, Qu X, Wang Q, Liu X, Hu FY, Liu J, Lian Y, He BM, Li C, Zhou D, Qiu W, Sun L, Hong Z. Genome-Wide Association Study Identifies IFIH1 and HLA-DQB1*05:02 Loci Associated With Anti-NMDAR Encephalitis. Neurol Neuroimmunol Neuroinflamm. 2024;11(3):e200221.

11.Sun Y, Li G, Liu X, Zhao X, Ren J, Ren G, Liu Y, Ai L, Wang Q. Cerebral glucose hypometabolism and hypoperfusion of cingulate gyrus: an imaging biomarker of autoimmune encephalitis with psychiatric symptoms. J Neurol. 2024;271(3):1247-1255.

12.Liu R, Sun L, Shi X, Li C, Guo X, Wang Y, Wang X, Zhang K, Wang Y, Wang Q, Wu J. Increased Expression of KNa1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Inju ry. Neurochem Res. 2024;49(2):427-440.

13.Shi X, Liu R, Wang Y, Yu T, Zhang K, Zhang C, Gu Y, Zhang L, Wu J, Wang Q, Zhu F. Inhibiting acid-sensing ion channel exerts neuroprotective effects in experimental epilepsy via suppressing ferroptosis. CNS Neurosci Ther. 2024;30(2):e14596.

14.Weng S, Liu X, Wang D, Wang J, Ren Q, Wang Q, Shan W. Generation of a human induced pluripotent stem cell (iPSC) line from a patient with a CDKL5 gene mutation. Stem Cell Res. 2024;81:103607. 

15.Liu R, Sun L, Du L, Guo X, Jia M, Wang Q and Wu J. Enhanced KNa1.1 Channel Underlies Cortical Hyperexcitability and Seizure Susceptibility after Traumatic Brain Injury. Elife 2023, 12:RP93304

16.Jia M, Guo X, Liu R, Sun L, Wang Q, Wu J. Overexpress miR-132 in the Brain Parenchyma by a Non-invasive Way Improves Tissue Repairment and Releases Memory Impairment After Traumatic Brain Injury. Cell Mol Neurobiol. 2023;44(1):5.

17.Xu L, Wang Q. The bidirectional relationship between Alzheimer's disease (AD) and epilepsy: A Mendelian randomization study. Brain Behav. 2023, 13(11):e3221. 

18.Shi W, Sun H, Peng W, Chen Z, Wang Q, Lin W, Ding M, Sun H, Wang X, Wang T, Wang X, Liu Y, Chen Y, Zhu G, Zhou D, Li J.Prevalence and risk factors of anxiety and depression in adult patients with epilepsy: a multicenter survey-based study. Ther Adv Neurol Disord. 2023.16:17562864231187194. 

19.Liu X, Wang Q, Ren L, Fang X, He Z, Ding J, Wang K, Xu H, Zhang H, Song Y, Lu Q, Sun M, Han X, Cao L, Lin W, Li X, Zhang Q, Ding Y, Wang F, Wang T, Wang J, Liu X, Wu Y, Chen Y, Feng Z, Wang S, Wang X, Guan Y, Xie X, Huang H, Zhang M, Wang X, Hong Z, Jiang W, Han Y, Deng Y, Zhao J, Liao J, Wang Y, Lian Y. COVID-19 vaccination for patients with epilepsy: A Chinese expert consensus. Epilepsy Behav. 2023:147:109387.

20.Pan J, Lv R, Wang Q, Zhao X, Liu J, Ai L. Discrimination between leucine-rich glioma-inactivated 1 antibody encephalitis and gamma-aminobutyric acid B receptor antibody encephalitis based on ResNet18. Vis Comput Ind Biomed Art. 2023; 6(1):17. 

21.Xu N, Qin X, Zhou Z, Shan W, Ren J, Yang C, Lu L, Wang Q. Age differentially modulates the cortical tracking of the lower and higher level linguistic structures during speech comprehension. Cereb Cortex. 2023,33(19):10463-10474.

22.Sun Y, Zhou Z, Wang Q, Yan J, Zhang Z, Cui T. MRI characteristics due to gene mutations in a Chinese pedigree with Lafora disease. Mol Genet Genomic Med. 2023;11(10):e2228. 

23.Guo X, Liu R, Jia M, Wang Q, Wu J. Ischemia Reperfusion Injury Induced Blood Brain Barrier Dysfunction and the Involved Molecular Mechanism. Neurochem Res. 2023;48(8):2320-2334. 

24.Sun Y, Tao JX, Han X, Wang X, Zhu Y, Lian Y, Ren G, Wang Q. Clinical features and brain MRI volumetric changes in anti-mGluR5 encephalitis. Ann Clin Transl Neurol. 2023 Aug;10(8):1407-1416

25.Qiu D, Wang W, Mei Y, Tang H, Yuan Z, Zhang P, Zhang Y, Yu X, Yang C, Wang Q, Wang Y. Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI. J Headache Pain. 2023 Apr 26;24(1):45. 

26.Sun Y, Qin X, Huang D, Zhou Z, Zhang Y, Wang Q. Anti-amphiphysin encephalitis: Expanding the clinical spectrum. Front Immunol. 2023;14:1084883. 

27.Liu R, Sun L, Wang Y, Wang Q, Wu J. New use for an old drug: quinidine in KCNT1-related epilepsy therapy. Neurol Sci. 2023 Apr;44(4):1201-1206. 

28.Yang H, Shi W, Fan J, Wang X, Song Y, Lian Y, Shan W, Wang Q. Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial. Neurotherapeutics. 2023 Apr;20(3):870-880. 

29.Li G, Wang M, Zheng M, Liu X, Yu T, Ren J, Wang Q. Causal effect of psychiatric disorders on epilepsy: A two-sample Mendelian randomization study. Brain Behav. 2023;13(4):e2939. 

30.Wang K, Zhao X, Yuan L, Chen Q, Wang Q, Ai L. Cortical metabolic characteristics of anti-leucine-rich glioma-inactivated 1 antibody encephalitis based on 18F-FDG PET. Front Neurol. 2023;14:1100760. 

31.Sun Y, Zhao X, Ai L, Wang Q. Metabolic phenotyping of pilomotor seizures in autoimmune encephalitis. CNS Neurosci Ther. CNS Neurosci Ther. 2023 Sep;29(9):2522-2529.

32.Xu N, Zhao B, Luo L, Zhang K, Shao X, Luan G, Wang Q, Hu W, Wang Q. Two stages of speech envelope tracking in human auditory cortex modulated by speech intelligibility. Cereb Cortex. 2023 Feb 20;33(5):2215-2228. 

33.Zhang X, Zeng J, Gu X, Zhang F, Han Y, Zhang P, Wang Q, Gu R. Relapse After Drug Withdrawal in Patients with Epilepsy After Two Years of Seizure-Free: A Cohort Study. Neuropsychiatr Dis Treat. 2023;19:85-95. 

34.Jia M, Zhang Q, Guo X, Liu R, Liu S, Chen N, Wang Y, Wang Q, Wu J, Campbell SL. Na+/HCO3- Co-transporters Inhibitor S0859 Attenuates Global Cerebral Ischemia-reperfusion Injury of the CA1 Neurons in the Gerbil's Hippocampus. CNS Neurol Disord Drug Targets. 2023;22(7):1109-1119. 

35.Liu X, Li G, Yu T, Lv R, Cui T, Hogan RE, Wang Q. Prognostic significance and extra-hypothalamus dysfunction of hyponatremia in anti-leucine-rich glioma-inactivated protein 1 encephalitis. J Neuroimmunol. 2022;373:578000. 

36.Sun L, Liu R, Yang H, Yu T, Wu J, Wang Q. Characteristics of Epileptiform Spike-wave Discharges and Chronic Histopathology in Controlled Cortical Impact Model of Sprague-Dawley Rats. Neurochem Res. 2022;47(12):3615-3626. 

37.Yang H, Qi C, Su F, Shan W, Guo A, Wu J, Wang Y, You H, Wang Q. Cerebral Ischemia/Reperfusion Injury and Pharmacologic Preconditioning as a Means to Reduce Stroke-induced Inflammation and Damage. Neurochem Res. 2022;47(12):3598-3614. 

38.Li G, Liu X, Yu T, Ren J, Wang Q. Positron emission tomography in autoimmune encephalitis: Clinical implications and future directions. Acta Neurol Scand. 2022;146(6):708-715. 

39.Zhang Q, Jia M, Wang Y, Wang Q, Wu J. Cell Death Mechanisms in Cerebral Ischemia-Reperfusion Injury. Neurochem Res. 2022;47(12):3525-3542.

40.Zhao Y, Yang H, Shan W, Guo A, Wang Q. Moderate Ethanol-Preconditioning Offers Ischemic Tolerance Against Focal Cerebral Ischemic/Reperfusion: Role of Large Conductance Calcium-Activated Potassium Channel. Neurochem Res. 2022;47(12):3647-3658. 

41.Liu R, Sun L, Wang Y, Wang Q, Wu J. New use for an old drug: quinidine in KCNT1-related epilepsy therapy. Neurol Sci. 2023 Apr;44(4):1201-1206.

42.Yang H, Shan W, Fan J, Deng J, Luan G, Wang Q, Zhang Y, You H. Mapping the neural circuits responding to deep brain stimulation of the anterior nucleus of the thalamus in the rat brain. Epilepsy Res. 2022;187:107027. 

43.Shan W, Yang H, Ren Q, Wang Q, An G. Generation of TSC1 knockout induced pluripotent stem cell (iPSC) line. Stem Cell Res. 2022;64:102888.

44.Sun J, Wu G, Qu B, Qi J, Deng J, Shao X, Du Y, Wang Q. Changes in heart rate during the peri-ictal period in focal epilepsy. Epileptic Disord. 2022;24(5):906-916. 

45.Yu T, Liu X, Sun L, Lv R, Wu J, Wang Q. Risk factors for Drug-resistant Epilepsy (DRE) and a nomogram model to predict DRE development in post-traumatic epilepsy patients. CNS Neurosci Ther. 2022;28(10):1557-1567. 

46.Li G, Liu X, Wang M, Yu T, Ren J, Wang Q. Predicting the functional outcomes of anti-LGI1 encephalitis using a random forest model. Acta Neurol Scand. 2022;146(2):137-143. 

47.Cao Q, Cui T, Wang Q, Li ZM, Fan SH, Xiao ZM, Pan SQ, Zhou Q, Lu ZN, Shao XQ. The localization and lateralization of fear aura and its surgical prognostic value in patients with focal epilepsy. Ann Clin Transl Neurol. 2022;9(8):1116-1124. 

48.Xia H, Zahra A, Jia M, Wang Q, Wang Y, Campbell SL, Wu J. Na+/H+ Exchanger 1, a Potential Therapeutic Drug Target for Cardiac Hypertrophy and Heart Failure. Pharmaceuticals (Basel). 2022;15(7). doi: 10.3390/ph15070875. 

49.Liu X, Yu T, Qi J, Lv R, Wang Q. Factors predicting neuronal surface antibodies in the elderly with new-onset and unknown seizures. Ann Clin Transl Neurol. 2022;9(7):1039-1049. 

50.Xu N, Zhao B, Luo L, Zhang K, Shao X, Luan G, Wang Q, Hu W, Wang Q. Two stages of speech envelope tracking in human auditory cortex modulated by speech intelligibility. Cereb Cortex. 2023 Feb 20;33(5):2215-2228.

51.Pan J, Lv R, Zhou G, Si R, Wang Q, Zhao X, Liu J, Ai L. The Detection of Invisible Abnormal Metabolism in the FDG-PET Images of Patients With Anti-LGI1 Encephalitis by Machine Learning. Front Neurol. 2022;13:812439. 

52.Yu T, Liu X, Sun L, Lv R, Wu J, Wang Q. Predicting Global Functional Outcomes Among Post-traumatic Epilepsy Patients After Moderate-to-Severe Traumatic Brain Injury: Development of a Prognostic Model. Front Neurol. 2022;13:874491. 

53.Jia M, Zhang Q, Guo X, Liu R, Liu S, Chen N, Wang Y, Wang Q, Campbell SL, Wu J. Na+/HCO3- Co-transporters Inhibitor S0859 Attenuates Global Cerebral Ischemia-reperfusion Injury of the CA1 Neurons in the Gerbil's Hippocampus. CNS Neurol Disord Drug Targets. 2023;22(7):1109-1119.

54.Zahra A, Wang Y, Wang Q, Wu J. Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability. Behav Neurol. 2022;2022:5893519. 

55.Fan P, Shan W, Yang H, Zheng Y, Wu Z, Chan SW, Wang Q, Gao P, Liu Y, He K, Sui B. Cerebral Microbleed Automatic Detection System Based on the "Deep Learning". Front Med (Lausanne). 2022;9:807443. 

56.Zahra A, Du L, Jia M, Butt MU, Wang Q, Wang Y, Wu J. Prenatal exposure of citalopram elicits depression-like and anxiety-like behaviors and alteration of morphology and protein expression of medial prefrontal cortex in young adult mice. J Integr Neurosci. 2022;21(2):61. 

57.Qi J, Liu X, Xu N, Wang Q. The Clinical Characteristics of New-Onset Epilepsy in the Elderly and Risk Factors for Treatment Outcomes of Antiseizure Medications. Front Neurol. 2022;13:819889. 

58.Sun Y, Ren G, Ren J, Wang Q. Intrinsic Brain Activity in Temporal Lobe Epilepsy With and Without Depression: Insights From EEG Microstates. Front Neurol. 2022;12:753113.

59.Sun Y, Ren G, Ren J, Shan W, Han X, Lian Y, Wang T, Wang Q. The prognosis of late-onset anti-N-methyl-D-aspartate receptor encephalitis in China. Acta Neurol Scand. 2022;145(4):449-455. 

60.Yu T, Liu X, Wu J, Wang Q. Electrophysiological Biomarkers of Epileptogenicity in Alzheimer's Disease. Front Hum Neurosci. 2021;15:747077.

61.Liu R, Sun L, Wang Y, Jia M, Wang Q, Cai X, Wu J. Double-edged Role of KNa Channels in Brain Tuning: Identifying Epileptogenic Network Micro-Macro Disconnection. Current Neuropharmacol, 2022: 20(5): 916-928.  

62.Shan W, Duan Y, Zheng Y, Wu Z, Chan SW, Wang Q, Gao P, Liu Y, He K, Wang Y. Segmentation of Cerebral Small Vessel Diseases-White Matter Hyperintensities Based on a Deep Learning System. Front Med. 2021;8:681183.

63.Liu X, Yu T, Zhao X, Yu P, Lv R, Wang C, Ai L, Wang Q. Risk Factors and Brain Metabolic Mechanism of Sleep Disorders in Autoimmune Encephalitis. Front Immunol. 2021;12:738097. 

64.Liu X, Yu T, Zhao X, Li G, Lv R, Ai L, Wang Q. 18F-fluorodeoxy-glucose positron emission tomography pattern and prognostic predictors in patients with anti-GABAB receptor encephalitis. CNS Neurosci Ther. 2022;28(2):269-278. 

65.Shan W, Guo J, Mao X, Zhang Y, Huang Y, Wang S, Li Z, Meng X, Zhang P, Wu Z, Wang Q, Liu Y, He K, Wang Y. Automated Identification of Skull Fractures With Deep Learning: A Comparison Between Object Detection and Segmentation Approach. Front Neurol. 2021;12:687931.

66.Su F, Yang H, Guo A, Qu Z, Wu J, Wang Q. Mitochondrial BKCa Mediates the Protective Effect of Low-Dose Ethanol Preconditioning on Oxygen-Glucose Deprivation and Reperfusion-Induced Neuronal Apoptosis. Front Physiol. 2021;12:719753. 

67.Ren G, Sun Y, Wang D, Ren J, Dai J, Mei S, Li Y, Wang X, Yang X, Yan J, Wang Q. Identification of Epileptogenic and Non-epileptogenic High-Frequency Oscillations Using a Multi-Feature Convolutional Neural Network Model. Front Neurol. 2021;12:640526. 

68.Shan W, An G, Ren Q, Wang Q. Generation of SCN1B knock out induced pluripotent stem cell (iPSC) line (refractory epilepsy syndrome and Brugada syndrome related cell line). Stem Cell Res. 2021;56:102545. 

69.Li TR, Zhang YD, Wang Q, Shao XQ, Lv RJ. Recognition of seizure semiology and semiquantitative FDG-PET analysis of anti-LGI1 encephalitis. CNS Neurosci Ther. 2021;27(10):1173-1181. 

70.Du L, Zahra A, Jia M, Wang Q, Wu J. Understanding the Functional Expression of Na+-Coupled SLC4 Transporters in the Renal and Nervous Systems: A Review. Brain Sci. 2021;11(10). 

71.Zhao X, Zhao S, Chen Y, Zhang Z, Li X, Liu X, Lv R, Wang Q, Ai L. Subcortical Hypermetabolism Associated With Cortical Hypometabolism Is a Common Metabolic Pattern in Patients With Anti-Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis. Front Immunol. 2021;12:672846. 

72.Xie N, Qin W, Deng J, Qi J, Niu D, Lu G, Wang Q. A novel KCNT1 mutation in a Chinese family with severe autosomal-dominant nocturnal frontal lobe epilepsy. Transl Neurosci. 2021;12(1):330-334. 

73.Li W, Guo A, Sun M, Wang J, Wang Q. Neuroprotective Effects of Deproteinized Calf Serum in Ischemic Stroke. Front Neurol. 2021;12:636494. 

74.Yu T, Liu X, Sun L, Wu J, Wang Q. Clinical characteristics of post-traumatic epilepsy and the factors affecting the latency of PTE. BMC Neurol. 2021;21(1):301. 

75.Shan W, Yang X, Ren Q, Wang Q. Generation of SCN1A Knock out induced pluripotent stem cell (iPSC) line. Stem Cell Res. 2021;55:102452. 

76.Li Z, Ren G, Liu C, Wang Q, Liang K, Han C, Qiao H, Zhang J, Wang Q, Meng F. Dysfunctional Brain Dynamics of Parkinson's Disease and the Effect of Acute Deep Brain Stimulation. Front Neurosci. 2021;15:697909. 

77.Xu N, Shan W, Qi J, Wu J, Wang Q. Presurgical Evaluation of Epilepsy Using Resting-State MEG Functional Connectivity. Front Hum Neurosci. 2021;15:649074. 

78.Li TR, Zhang YD, Wang Q, Shao XQ, Lyu DY, Lv RJ. Clinical Characteristics and Long-Term Prognosis of Anti-LGI1 Encephalitis: A Single-Center Cohort Study in Beijing, China. Front Neurol. 2021;12:674368. 

79.Shan W, Mao X, Wang X, Hogan RE, Wang Q. Potential surgical therapies for drug-resistant focal epilepsy. CNS Neurosci Ther. 2021; 00:1-17

80.Sun L, Shan W, Yang H, Liu R, Wu J and Wang Q. The Role of Neuroinflammation in Post-traumatic Epilepsy. Front. Neurol. 2021;12:646152.

81.Qin X, Yang H, Zhu F, Wang Q, Shan W. Clinical Character of CASPR2 Autoimmune Encephalitis: A Multiple Center Retrospective Study. Front Immunol. 2021;12:652864.

82.Zeng C, Meng H, Zhu Y, Yao L, Lian Y, Zhu Y, Zhang M, Dai Y, Wang K, Han X, Li L, Zhang L, Xu H, Yao D, Luo X, Jiang W, Wang X, Zhao C, Chen Y, Deng X, Liu C, Feng L, Song Y, Wu Y, Liao W, Wang F, Zhu S, Xiao B, Wang Q, Long L. Correlation of Seizure Increase and COVID-19 Outbreak in Adult Patients with Epilepsy: Findings and Suggestions from a Nationwide Multi-centre Survey in China. Seizure. 2021;88:102-108.

83.Lu M, Jia M, Wang Q, Guo Y, Li C, Ren B, Qian F, Wu J. The electrogenic sodium bicarbonate cotransporter and its roles in the myocardial ischemia-reperfusion induced cardiac diseases. Life Sci. 2021;270:119153.

84.Sun Y, Ren G, Ren J, Shan W, Han X, Lian Y, Wang T, Wang Q. A Validated Nomogram that Predicts Prognosis of Autoimmune Encephalitis: A Multicenter Study in China. Front Neurol, 2021:12:612569. 

85.Zhou Y, Sood R, Wang Q, Carrington B, Park M, Young AC, Birnbaum D, Liu Z, Ashizawa T, Mullikin JC, Koubeissi MZ, Liu P. Clinical and genomic analysis of a large Chinese  family with familial cortical myoclonic tremor with epilepsy and SAMD12 intronic repeat expansion. Epilepsia Open. 2021;6:102–111.

86.Shan W, Yang H and Wang Q. Neuronal Surface Antibody-Medicated Autoimmune Encephalitis (Limbic Encephalitis) in China: A Multiple-Center, Retrospective Study. Front. Immunol. 2021,12:621599.

87.Sun Y, Ren G, Ren J, Shan W, Han X, Lian Y, Wang T, Wang Q. The Association Between Age and Prognosis in Patients Under 45 Years of Age With Anti-NMDA Receptor Encephalitis. Front Neurol. 2020 ;11:612632.

88.Ren G, Yan J, Sun Y, Ren J, Dai J, Mei S, Li Y, Wang X, Yang X, Wang Q. Association Between Interictal High-Frequency Oscillations and Slow Wave in Refractory Focal Epilepsy With Good Surgical Outcome. Front Hum Neurosci. 2020;14:335. 

89.Sun T, Liu X, Issa NP, Rose S, Wu S, Wang Q, Martinez R, Towle VL, Jr DRN, Warnke P, Tao JX. RTTBD-like activity in association with hippocampal ictal discharges in patients with temporal lobe epilepsy. Epileptic Disord. 2020;22(4):462-472. 

90.Kong Z, Wang Y, Zhang Y, Shan W, Wu J, Wang Q. MicroRNA-126 promotes endothelial progenitor cell proliferation and migration ability via the Notch pathway. Cardiovasc Diagn Ther. 2020;10(3):490-499. 

91.Liu X, Shan W, Zhao X, Ren J, Ren G, Chen C, Shi W, Lv R, Li Z, Liu Y, Ai L, Wang Q. The Clinical Value of 18 F-FDG-PET in Autoimmune Encephalitis Associated With LGI1 Antibody. Front Neurol. 2020;11:418. 

92.Duan Y, Shan W, Liu L, Wang Q, Wu Z, Liu P, Ji J, Liu Y, He K, Wang Y. Primary Categorizing and Masking Cerebral Small Vessel Disease Based on "Deep Learning System". Front Neuroinform. 2020;14:17. 

93.Zhu F, Shan W, Lv R, Li Z, Wang Q. Clinical Characteristics of Anti-GABA-B Receptor Encephalitis. Front Neurol. 2020;11:403. 

94.Lv RJ, Li TR, Zhang YD, Shao XQ, Wang Q, Jin LR. Clinical and genetic characteristics of type I sialidosis patients in mainland China. Ann Clin Transl Neurol. 2020;7(6):911-923.

95.Zhu F, Shan W, Lv R, Li Z, Wang Q. Clinical characteristics of GAD 65-associated autoimmune encephalitis. Acta Neurol Scand. 2020;142(3):281-293. 

96.Shi Y, Zhang X, Yang CL, Ren JC, Li ZM, Wang Q. A review on epileptic foci localization using resting-state functional magnetic resonance imaging. Math Biosci Eng. 2020;17(3):2496-2515. 

97.Li TR, Zhang YD, Wang Q, Shao XQ, Li ZM, Lv RJ. Intravenous methylprednisolone or immunoglobulin for anti-glutamic acid decarboxylase 65 antibody autoimmune encephalitis: which is better? BMC Neurosci. 2020;21(1):13. 

98. Fan J, Shan W, Yang H, Zhu F, Liu X, Wang Q. Neural Activities in Multiple Rat Brain Regions in Lithium-Pilocarpine-Induced Status Epilepticus Model. Front Mol Neurosci. 2020;12:323. 

主要中文文章:

1.王群, 史晓瑞, 朱飞.癫痫疾病修饰治疗:从理念走向实践的现状与挑战. 中华医学杂志, 2025, 105(31):2625-2629.

2.余露露, 陈俊敏, 郭安臣, 吴建平, 王群. 烟酰胺腺嘌呤二核苷酸磷酸氧化酶在癫痫发生发展中的作用. 中华医学杂志, 2025, 105(5): 399-404.

3.徐莹, 张贵丽, 王群. 路易体痴呆中癫痫及亚临床癫痫活动研究进展. 中华神经科杂志, 2025, 58(1): 109-115

4.王群,翁诗雯,杨华俊,单伟. 回眸2023——癫痫诊疗研究进展. 中华神经科杂志, 2024, 57(10): 1037-1044.

5.陈秋蕾,翁诗雯,王娜,李志梅,邵晓秋,王群,吕瑞娟. 假性甲状旁腺功能减退症导致发作性运动诱发性运动障碍2例并文献复习. 中华神经科杂志, 2023, 56(10): 1119-1127.

6.王娜,王鸿儒,邵晓秋,李志梅,王群,吕瑞娟. 失神持续状态癫痫1例并文献复习. 中华神经科杂志, 2023, 56(10): 1166-1173.

7.张祎凡,史伟雄,刘霄,王群. 抗富亮氨酸胶质瘤失活蛋白1抗体相关脑炎脑电图特征分析.中国现代神经疾病杂志, 2023, 23(12): 1120-1128.

8.王雪,刘霄,王群. 急性症状性发作对抗NMDA受体脑炎患者预后的影响. 脑与神经疾病杂志, 2023, 31(08): 463-467.

9.王娜,翁诗雯,邵晓秋,王群. 神经梅毒合并猫立克次体感染一例并文献复习. 中国现代神经疾病杂志, 2023, 23(04): 368-374.

10.李承玉,徐连萍,王圣松,王群. 不同抗癫痫发作药物单药治疗在卒中后癫痫中的保留率和有效性分析. 中华脑血管病杂志, 2023; 17(4): 325-330.

11.王群,单伟,杨华俊. 2022年癫痫领域十大研究进展.中国现代神经疾病杂志, 2023, 23(03): 149-155.

12.徐莹,齐婧,王群.脑卒中后癫痫药物修饰治疗进展.中国现代神经疾病杂志, 2023, 23(03): 167-172.

13.任国平,遇涛,邢悦,王群. 快速低温对癫痫患者致痫灶锥体神经元和中间神经元的差异性影响. 中国现代神经疾病杂志, 2023, 23(03): 179-188.

14.李承玉,王圣松,陈超,邵晓秋,王群. 抗富亮氨酸胶质瘤失活蛋白1抗体相关脑炎症状性发作临床与脑电图特征. 中国现代神经疾病杂志, 2023, 23(03): 214-222.

15.张玉笛,吕瑞娟,李娜,王群. 伴睡眠障碍的抗Amphiphysin抗体相关边缘叶脑炎一例.中国现代神经疾病杂志,2023,23(03):233-237.

16.孟桃,任洁钏,崔韬,王群. 伴癫痫发作的22例LGI1抗体脑炎临床特点及预后分析.脑与神经疾病杂志, 2023, 31(03): 175-180.

17.崔韬,李志梅,陈超,王群.高血糖性枕叶癫痫二例.脑与神经疾病杂志, 2022, 30(08): 476-480.

18.孙太欣,James X.Tao,王群. 颞叶良性脑电图变异型脑电-临床研究进展. 中国现代神经疾病杂志, 2022, 22(07): 549-554.

19.任洁钏,杨春兰,任国平,王群. 正常人脑磁图睡眠期枕区一过性正相尖波特点:同步脑磁图与脑电图对比分析. 中国现代神经疾病杂志, 2022, 22(07): 555-563.

20.任洁钏,任国平,杨春兰,王群. 正常人睡眠期脑磁图顶尖波的特点-同步脑磁图-脑电图对比研究. 脑与神经疾病杂志, 2022, 30(05): 265-270.

21.王雪,刘霄,李志梅,王群. 基于Nomogram模型的抗N-甲基-D-天冬氨酸受体脑炎合并急性症状性癫发作的危险因素分析. 中国现代神经疾病杂志, 2022, 22(03): 179-186.

22.齐婧,刘霄,王群.老年癫痫患者新型抗癫痫药物的治疗进展. 中华神经科杂志, 2022; 55(10): 1185-1190.

23.齐婧,王群. 癫痫治疗模式的转变:抗癫痫发生和疾病修正治疗.中华神经科杂志, 2022; 55(8): 801-806.

24.王颖婷,刘如,孙磊,余婷婷,吴建平,王群. β-淀粉样蛋白寡聚物作为阿尔茨海默病合并癫痫病理机制关键分子的相关研究进展. 中华神经科杂志, 2022; 102(43): 3482-3486.

25.秦晓筱,杨华俊,王越,刘丽萍,王群. 重症患者连续脑电图监测中发作期-发作间期连续体的研究进展. 中华神经科杂志, 2021;54(2):159-166.

26.任国平,杨小枫,王群. 脑电图相位振幅耦合在癫痫研究中的应用. 临床神经病学杂志, 2020, 33(04): 305-308.

27.孙建奎,曹京波,吕瑞娟,李志梅,邵晓秋,王群. 癫痫相关心脏功能变化研究进展. 中国现代神经疾病杂志, 2020, 20(06): 556-560.

28.孔朝红,王群. 癫痫的脑血流动力学研究进展. 中国卒中杂志, 2020, 15(01): 98-101.

29.刘霄,单伟,张玉笛,吕瑞娟,王群. 自身免疫性脑炎相关癫痫功能影像学研究进展. 中国现代神经疾病杂志, 2020, 20(01): 9-14.

主编或副主编的著作/译

1.王群、江文、王芙蓉主译,《癫痫持续状态》,科学出版社,2024年出版。

2.秦兵、周东、王群主译,《婴儿、儿童和青少年癫痫综合症》,人民卫生出版社,2024年。

3.刘丽萍、张哲、王群主译。《ICU脑电图监测手册》,北京大学医学出版社,北京,2023年。

4.龚守会、王群、周东主编。《癫痫规范化诊断治疗和管理》。科学出版社,北京,2022年。

5.王群、孙美珍、李晓裔主译。《耐药性癫痫的诊治》。AccScience Publishing,Singapore,2022年。

6.王玉平主编,王群副主编。《癫痫中心工作手册》第二版。人民卫生出版社,北京,2023年。

7.王拥军主编,王群副主编。《神经系统单基因遗传病诊断》。人民卫生出版社,北京,2016年。

8.王拥军主编,王群副主编。《神经病学新进展》。人民卫生出版社,北京,2018年。

9.王拥军主编,王群副主编。《临床路径释义·神经内科分册》。中国协和医科大学出版社,北京,2018年。

10.周东主编,王群编委。《神经病学》第四版。高等教育出版社,北京,2022年。 

主要获批专利:

1.王群. 多中心临床科研运维监控报警系统 V1.0,2024-10-09,中国,登记号:2024SR1477891

2.王群,李志青,陈应杰,廖永乐. 耳迷走神经刺激仪主机,2023-09-06,中国,专利号:ZL 2023 3 0576260.3

3.王群,李志青,陈应杰,廖永乐. 耳迷走神经刺激仪耳部电极,2023-09-06,中国,专利号:ZL 2023 3 0576283.4

4.王群,李志青,陈应杰,廖永乐. 一种挂耳式多点固定耳迷走神经刺激仪耳部电极,2023-09-06,中国,专利号:ZL 2023 2 2409914.0

5.王群,李志青,陈应杰,廖永乐. 一种可拆卸更换导电硅胶的耳迷走神经刺激仪耳部电极,2023-09-06,中国,专利号:ZL 2023 2 2410061.2

6.王群, 郭安臣, 杨涛. 一类用于治疗神经系统疾病的化合物,2020-2-28,中国,专利号:ZL201710671494.X

7.郭安臣, 王群, 王拥军. 一种神经元冻存液的制备方法,2021-11-19,中国,专利号:ZL201910517771.0


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学校介绍


  首都医科大学建校于1960年,是北京市重点高等院校,著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部;附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。

  学校和附属医院现有教职员工和医护人员22575人。有院士4人,正高职称700余人,副高职称1800余人。学校学科专业齐全,学科力量雄厚,在基础和临床各专业拥有一大批具有很高造诣的专家学者,现有3个国家级重点学科,有38个博士学位授予权学科,58个硕士学位授予权学科和2个博士后科研流动站。

  校本部和附属医院总占地面积97.3万平方米,总建筑面积134万平方米 ,固定资产总值近46.5亿元,图书馆藏书108.3万册 ,住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学;五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等;四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向;在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才,位于全国先进医学院校行列的高等学府。

  学校具有较强的学术发展与科研实力,在校本部和附属医院建有一批国家级和市级重点学科和重点实验室,建有高水平的国家级或市级研究和培训机构,如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉,很多学科的研究和医疗水平已经达到或接近国际先进水平。

  学校十分重视对外交流与合作,改革开放以来,先后与世界20多个国家和地区签定了友好交流协议, 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时,学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。

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