附属北京天坛医院-王永刚导师介绍
王永刚
主任医师
博士生导师
男
附属北京天坛医院
神经病学
原发性头痛与脑血管病；神经损伤与修复
w100yg@163.com
首都医科大学附属北京天坛医院 头痛科 主 任
中华医学会神经病学分会 头痛协作组 组 长
中 国 卒 中 学 会 头痛分会 主任委员
北京神经内科学会 头痛分会 主任委员
Journal of Headache and Pain杂志副主编
研究领域 1. 原发性头痛的临床与基础研究
2. 脑血管病的基础研究
3. 神经损伤与修复的机制研究
负责课题：国家自然科学基金项目7项
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科研项目
1. 口服艾地苯醌在成人偏头痛患者中预防偏头痛发作的安全性和有效性─多中心、随机、双盲、安慰剂平行对照临床研究（ITEM）
2. 养血清脑颗粒（丸）在原发性头痛中的疗效和安全性：登记研究
3. 中国头痛登记研究（CHAIRS）
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研究成果
1.Xiong Z, Zhao L, Mei Y, Qiu D, Li X, Zhang P, Zhang M, Cao J, Wang Y*. Proteome-wide Mendelian randomization identified potential drug targets for migraine. J Headache Pain. 2024 Sep 11;25(1):148.
2.Chen T, Bai X, Wang W, Zhang X, Pei X, Zhang X, Yuan Z, Zhao Y, Yang Q, Wang Y*, Sui B. Gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray in new daily persistent headache: a magnetic resonance spectroscopy study. J Headache Pain. 2024 Aug 29;25(1):142.
3.Wang L, Liu X, Zhu C, Wu S, Li Z, Jing L, Zhang Z, Jing Y, Wang Y*. Environmental enrichment alleviates hyperalgesia by modulating central sensitization in a nitroglycerin-induced chronic migraine model of mice. J Headache Pain. 2024 May 10;25(1):74. doi: 10.1186/s10194-024-01779-2.
4.Wang W, Qiu D, Mei Y, Bai X, Yuan Z, Zhang X, Xiong Z, Tang H, Zhang P, Zhang Y, Yu X, Wang Z, Ge Z, Sui B, Wang Y*. Altered functional connectivity of brainstem nuclei in new daily persistent headache: Evidence from resting-state functional magnetic resonance imaging. CNS Neurosci Ther. 2024 Mar;30(3):e14686.
5.Shuangjie Li, Jingjing Shi, Chengyuan Mao, Chan Zhang, Yafang Xu, Yu Fan, Zhengwei Hu, Wenkai Yu, Xiaoyan Hao, Mengjie Li, Jiadi Li, Dongrui Ma, Mengnan Guo, Chunyan Zuo, Yuanyuan Liang, Yuming Xu, Jun Wu, Shilei Sun, Yonggang Wang*, Changhe Shi*. Identifying causal genes for migraine by integrating the proteome and transcriptome. The Journal of Headache and Pain. 2023;24(1):111.
6.Qiu D, Ge Z, Mei Y, Wang W, Xiong Z, Li X, Yuan Z, Zhang P, Zhang M, Liu X, Zhang Y, Yu X, Tang H, Wang Y*. Mapping brain functional networks topological characteristics in new daily persistent headache: a magnetoencephalography study. J Headache Pain. 2023 Dec 6;24(1):161.
7.Bai X, Wang W, Zhang X, Hu Z, Zhang X, Zhang Y, Tang H, Zhang Y, Yu X, Yuan Z, Zhang P, Li Z, Pei X, Wang Y*, Sui B*. Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study. J Headache Pain. 2023 Oct 18;24(1):138.
8.Zhang X, Wang W, Bai X, Zhang X, Yuan Z, Jiao B, Zhang Y, Li Z, Zhang P, Tang H, Zhang Y, Yu X, Bai R, Wang Y*, Sui B*. Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space. J Headache Pain. 2023 Nov 6;24(1):147.
9.Li SJ, Shi JJ, Mao CY, Zhang C, Xu YF, Fan Y, Hu ZW, Yu WK, Hao XY, Li MJ, Li JD, Ma DR, Guo MN, Zuo CY, Liang YY, Xu YM, Wu J, Sun SL, Wang YG*, Shi CH*. Identifying causal genes for migraine by integrating the proteome and transcriptome. J Headache Pain. 2023 Aug 17;24(1):111.
10.Mei Y, Wang W, Qiu D, Yuan Z, Bai X, Tang H, Zhang P, Zhang X, Zhang Y, Yu X, Sui B, Wang Y. Micro-structural white matter abnormalities in new daily persistent headache: a DTI study using TBSS analysis. J Headache Pain. 2023 Jul 2;24(1):80.
11.Ziyu Yuan, Wei Li, Hefei Tang, Yanliang Mei, Min Zhang, Wei Wang, Dong Qiu, Qian Sun, Peng Zhang, Xueyan Zhang, Yaqing Zhang, Zhaochao Ma, Yonggang Wang* and Xueying Yu*. Enlarged perivascular spaces in patients with migraine: A case-control study based on 3T MRI, Annals of Clinical and Translational Neurology. 10.1002/acn3.51798. 6 Jun. 2023.
12.Wei Wang, Ziyu Yuan, Xueyan Zhang, Xiaoyan Bai, Hefei Tang, Yanliang Mei, Dong Qiu, Yingkui Zhang, Peng Zhang, Xue Zhang, Yaqing Zhang, Xueying Yu, Binbin Sui*, Yonggang Wang*. Mapping the aberrant brain functional connectivity in new daily persistent headache: a resting-state functional magnetic resonance imaging study, Journal of Headache and Pain.2023;24(1):46.
13.Dong Qiu#, Wei Wang#, Yanliang Mei, Xueyan Zhang, Hefei Tang, Ziyu Yuan, Peng Zhang, Yaqing Zhang, Xueying Yu, Qun Wang, Chunqing Yang, Yonggang Wang*. Brain structure and cortical activity changes in new daily persistent headache: a multimodal study, Journal of Headache and Pain.2023.2023;24(1):45.
14.Xue Zhang#, Wei Wang#, Xueyan Zhang, Xiaoyan Bai, Ziyu Yuan, Peng Zhang, Ruiliang Bai, Bingjie Jiao, Yingkui Zhang, Zhiye Li, Hefei Tang, Yaqing Zhang, Xueying Yu, Yonggang Wang* and Binbin Sui*.Normal glymphatic system function in patients with new daily persistent headache using diffusion tensor image analysis along the perivascular space, Headache.2023.10.1111/head.14514. 4 May. 2023
15.Xueyan Zhang#, Wei Wang#, Xiaoyan Bai, Hefei Tang, Ziyu Yuan, Xue Zhang, Zhiye Li, Peng Zhang, Zhangxuan Hu, Yaqing Zhang, Xueying Yu, Binbin Sui*, Yonggang Wang*. Alterations of Regional Homogeneity and Multiple Frequency Amplitude of Low-Frequency Fluctuation in patients with New Daily Persistent Headache: A Resting-State Functional Magnetic Resonance Imaging Study, Journal of Headache and Pain.2023;24(1):14.
16.Xiaoyan Bai#, Wei Wang#, Xueyan Zhang#, Zhangxuan Hu, Yingkui Zhang, Zhiye Li, Xue Zhang, Ziyu Yuan, Hefei Tang, Yaqing Zhang, Xueying Yu, Peng Zhang, Yonggang Wang*, Binbin Sui*. Cerebral perfusion variance in new daily persistent headache and chronic migraine: an arterial spin-labeled MR imaging study, Journal of Headache and Pain. 2022;23(1):156.
17.Xueyan Zhang#, Wei Wang#, Xiaoyan Bai#, Yingkui Zhang, Ziyu Yuan, Hefei Tang, Xue Zhang, Zhiye Li, Peng Zhang, Zhangxuan Hu, Yaqing Zhang, Xueying Yu, Xue Man, Binbin Sui*, Yonggang Wang*. Changes in gamma-aminobutyric acid and glutamate/glutamine levels in the right thalamus of patients with episodic and chronic migraine: A proton magnetic resonance spectroscopy study, Headache.2023;63(1):104-113.
18.Xueyan Zhang#, Wei Wang#, Xiaoyan Bai#, Yingkui Zhang, Ziyu Yuan, Hefei Tang, Xue Zhang, Zhiye Li, Peng Zhang, Zhangxuan Hu, Yaqing Zhang, Xueying Yu, Xue Man, Binbin Sui*, Yonggang Wang*. Changes in gamma-aminobutyric acid and glutamate/glutamine levels in the right thalamus of patients with episodic and chronic migraine: A proton magnetic resonance spectroscopy study, Headache.2023;63(1):104-113.
19.Ziyu Yuan#, Wei Wang#, Xueyan Zhang, Xiaoyan Bai, Hefei Tang, Yanliang Mei, Peng Zhang, Dong Qiu, Xue Zhang, Yaqing Zhang, Xueying Yu, Binbin Sui* and Yonggang Wang*. Altered functional connectivity of the right caudate nucleus in chronic migraine: a resting-state fMRI study, Journal of Headache and Pain. 2022; 15;23(1):83
20.Wei Wang#, Xueyan Zhang#, Xiaoyan Bai#, Yingkui Zhang, Ziyu Yuan, Hefei Tang, Zhiye Li, Zhangxuan Hu, Yaqing Zhang, Xueying Yu, Binbin Sui* and Yonggang Wang*. Gamma-aminobutyric Acid and Glutamate/Glutamine Levels in the Dentate Nucleus and Periaqueductal Gray With Episodic and Chronic Migraine: A Proton Magnetic Resonance Spectroscopy Study, Journal of Headache and Pain. 2022; 15;23(1):83.
21.Shouyi Wu#, Xiao Ren#, Chenlu Zhu#, Wei Wang, Kaibo Zhang, Zhilei Li, Xuejiao Liu, Yonggang Wang*. A c-Fos activation map in nitroglycerin/ levcromakalim-induced models of migraine, Journal of Headache and Pain. 2022;23(1):128.
22.Ren X#, Yao LL#, Pan JX, Zhang JS, Mei L, Wang YG*, Xiong WC*. Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease-like vasculopathy. Neurobiol Dis. 2021;154:105339.
23.Xie Z#, Jiang W#, Deng M, Wang W, Xie X, Feng X, Shi Y, Zhang X, Song D, Yuan Z, Wang Y*. Alterations of oral microbiota in patients with panic disorder. Bioengineered, 2021,12(1), 9103-9112
24.Wang F, Jiang WQ, Gao L, Liu C, Deng MZ, Ren Xiao, Zhu CL, Guan JS*, Wang YG*. Detecting Abnormal Neuronal Activity in a Chronic Migraine Model by Egr1-EGFP Transgenic Mice. Frontiers in Neuroscience, 2021,15:1-11.
25.Jiang W, Liu C, Deng M, Wang F, Ren X, Fan Y, Du J, Wang Y*. H2S promotes developmental brain angiogenesis via the NOS/NO pathway in zebrafish. Stroke Vasc Neurol. 2021;6(2):244-251.
26.Jiang W#, Wang T#, Liu C#, Deng M#, Ren X, Wang F, Zhang Y, Yu X, Yao L*, Wang Y*. A 16S rRNA gene sequencing based study of oral microbiota in migraine patients in China. Bioengineered. 2021 Dec;12(1):2523-2533.
27.Deng M#, Liu C#, Jiang W#, Wang F, Zhou J, Wang D, Wang Y*. A novel genetic variant associated with benign paroxysmal positional vertigo within the LOXL1. Mol Genet Genomic Med. 2020;8(10):e1469.
28.Zhang H, Li X, Ma C, Wang K, Zhou J, Chen J, Wang Y*, Shi Y*. Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population. Mol Genet Genomic Med. 2020;8(7):e1190.
29.Liu C, Jiang W, Deng M, Wang F, Wang Y*. Lower vitamin D levels in panic attacks in Shanghai: A case-control study. Asian J Psychiatr. 2020;51:101948.
30.Jian X, Chen J, Li Z, Song Z, Zhou J, Xu W, Liu Y, Shen J, Wang Y*, Yi Q*, Shi Y*. SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study. BMC Psychiatry. 2019;18;19(1):293.
31.Yuan X, Jiang W, Ren X, Liu C, Pan Y, Zou J, Jiang X, Ji W, Li Y, Feng Z, Yao L*, Wang Y*. Predictors of relapse in patients with medication overuse headache in Shanghai: A retrospective study with a 6-month follow-up. J Clin Neurosci. 2019;70:33-36.
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学校介绍
首都医科大学建校于1960年，是北京市重点高等院校，著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部；附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。
学校和附属医院现有教职员工和医护人员22575人。有院士4人，正高职称700余人，副高职称1800余人。学校学科专业齐全，学科力量雄厚，在基础和临床各专业拥有一大批具有很高造诣的专家学者，现有3个国家级重点学科，有38个博士学位授予权学科，58个硕士学位授予权学科和2个博士后科研流动站。
校本部和附属医院总占地面积97.3万平方米，总建筑面积134万平方米 ，固定资产总值近46.5亿元，图书馆藏书108.3万册 ，住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学；五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等；四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向；在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才，位于全国先进医学院校行列的高等学府。
学校具有较强的学术发展与科研实力，在校本部和附属医院建有一批国家级和市级重点学科和重点实验室，建有高水平的国家级或市级研究和培训机构，如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉，很多学科的研究和医疗水平已经达到或接近国际先进水平。
学校十分重视对外交流与合作，改革开放以来，先后与世界20多个国家和地区签定了友好交流协议， 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时，学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。
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