北京脑重大疾病研究院-王仁喜导师介绍

更新于 2026-01-01 导师主页
王仁喜 教授 硕,博士生导师
北京脑重大疾病研究院
免疫学 ,神经生物学
脑重大疾病的免疫学机制研究,神经生物学神经环路机制研究,生物信息学,神经免疫交互作用机制研究,自身免疫病发病机制及潜在治疗靶点,B细胞分化、发育及功能,小胶质细胞分化、发育及功能
renxi_wang@ccmu.edu.cn

受教育及工作情况:

2019-至今    首都医科大学  脑重大疾病研究院   教授 博士研究生导师

2014-2019年  军事医学科学院  基础医学研究所  免疫学   副研究员  硕士研究生导师

2010-2012年  美国NIH          眼科研究所     分子免疫    博士后

2009-2010年  美国Nebreska大学  医学中心      肿瘤        博士后

2006-2014年  军事医学科学院  基础医学研究所  免疫学   助理研究员

2003-2006年  军事医学科学院  基础医学研究所  免疫学     博士学位

2000-2003年  军事医学科学院  基础医学研究所  免疫学     硕士学位

1995-1999年  河南师范大学    生物系          生物技术   学士学位

科研业绩简介:

从事免疫相关疾病特别是脑重大疾病免疫学机制及潜在治疗靶点的研究。主持国家科技重大专项项目1项(2014-2016年,555.15万元),国家自然科学基金面上项目4项(2023-2026年,54万元;2021-2024年,55万元;2018-2021年,60万元;2015-2018年, 70万元),北京市自然科学基金项目-北京市教育委员会科技计划重点项目1项(2022-2024年,80万元),北京市自然科学基金面上项目2项(2018-2020年,20万元;2013-2015年, 14万元),首都医科大学基础-临床联合实验室:脑功能与神经调控基础-临床联合实验室(2024-2026,300万元),首都医学科学创新中心科研项目(2024-2025,70万元),首都医科大学脑重大疾病研究院科研经费(2021年,50万元;2020年,50万元);参与军事课题2项,参与国家973课题3项,国家863项目2项,国家自然科学基金面上项目4项。分别获得2021、2022年度首都医科大学自然科学奖三等奖和二等奖。获得授权中国国家发明专利12项和PCT专利2项。发表SCI论文123篇(如Nat Med, J Infect, J Med Virol, J Transl Med, Crit Care Med, Cell Mol Immunol, Mol Ther),总影响因子800余分(单篇最高87.241),他引5000余次(单篇最高800余次),H指数46。参编专著2部。培养博士后1名、博士研究生10、硕士研究生6名。兼职第六届中国免疫学会基础免疫分会委员、第一届北京神经科学学会癫痫专业委员会委员、北京脑重大疾病研究院第四届/第五届学位委员会委员、癫痫病临床医学研究北京市重点实验室学术委员会委员、中国免疫学会会员,兼职Frontiers in Immunology、Frontiers in Nutrition、Frontiers in Genetics等杂志副主编、多个SCI杂志编委/审稿人,捷克国家自然科学基金、北京市自然科学基金及国家自然科学基金通讯评审人、国家万人计划青年拔尖人才项目会议评审人、北京人才项目会议评审人、北京市科技计划“生命科学前沿创新”项目会议评审人等。入选全球前2%顶尖科学家榜单。

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科研项目

主持首都医科大学和北京脑重大疾病研究院课题:

1.       首都医学科学创新中心科研项目:C15orf39(1700017B05Rik)在系统性红斑狼疮B细胞中作用及机制(课题编号:CX24PY07。课题起止年限:2024年7月至2025年12月。资助金额:70万元)

2.       首都医科大学基础-临床联合实验室:脑功能与神经调控基础-临床联合实验室(课题起止年限:2024年1月至2026年12月。资助金额:300万元)

3.       首都医科大学脑重大疾病研究院科研经费(课题起止年限:2021年1月至2021年12月。资助金额:50万元)

4.       首都医科大学脑重大疾病研究院科研经费(课题起止年限:2020年1月至2020年12月。资助金额:50万元)

 

主持国家及北京市课题:

1.       国家自然科学基金面上项目:9430038I01Rik(C10orf143)在自身免疫病生发中心母细胞中的表达及功能(课题编号:32270933。课题起止年限:2023-01-01至2026-12-31。资助金额:54万元)

2.       北京市自然科学基金项目-北京市教育委员会科技计划重点项目:C15orf39(1700017B05Rik)在系统性红斑狼疮B细胞中作用及机制.( 课题编号: KZ202210025035。课题起止年限:2022年1月至2024年12月。资助金额:80万元)

3.       国家自然科学基金面上项目:Gm614(Cxorf65)在自身免疫病生发中心B细胞中的作用及机制(课题编号:82071758。课题起止年限:2021年1月至2024年12月。资助金额:55万元)

4.       国家自然科学基金面上项目:Stch调控生发中心B细胞反应和抗体产生的分子与细胞机制(课题编号:31770956。课题起止年限:2018年1月至2021年12月。资助金额:60万元)

5.       北京市自然科学基金面上项目:4933402N22Rik调控生发中心B细胞反应和抗体产生的机制(课题编号:7182121。课题起止年限:2018年1月至2020年12月。资助金额:20万元)

6.       国家自然科学基金面上项目:代谢型谷氨酸受体3(Grm3)在自身反应性记忆B细胞中的功能研究(课题编号:81471529。课题起止年限:2015年1月至2018年12月。资助金额:70万元)

7.       国家科技重大专项:人源化抗C5a抗体的制备及急性肺损伤中的应用(课题编号:2014ZX09J14105-04B。课题起止年限:2014年1月至2016年12月。资助金额:555.15万元)

8.       北京市自然科学基金面上项目:BAFF通过活化自身反应性B细胞引发自身免疫性疾病的机制研究(课题编号:7132139。课题起止年限:2013年1月至2015年12月。资助金额:14万元)


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研究成果

In 2025

1.       Wang R. Mendelian randomization study on the causal association of dairy smoothie intake with Alzheimer's disease. Aging Medicine and Healthcare. 2025. (IF: 1.1)

2.       Gao R#, Su W#, Deng J#, Zhai B#, Zhu G, Qiu J, Bian Z, Xiao He, Luan G*, Wang R*. Genome-wide meta-analysis with 2,206,440 individuals identifies 322 novel risk loci for obesity. Int J Obes (Lond). 2025. https://doi.org/10.1038/s41366-025-01979-z. (IF: 3.8)

3.       Gao R#, Xiong Z#, Su W, Deng J, Zhai B, Zhu G, Zhang M, Zeng Q, Qiu J, Bian Z, Xiao H, Luan G*, Wang R*. Microglial Feimin Alleviates Cognitive Impairment in High-Fat Diet-Fed Mice. Adv Sci (Weinh). 2025 Dec;12(48):e12023. doi: 10.1002/advs.202512023. (IF: 14.1)

4.       Wang R. A Potential Causal Association of Pyroglutamine with Systemic Lupus Erythematosus Revealed by a Mendelian Randomization Analysis. J Clini Nephrol. 2025 July 09; 9(7): 076-082.

5.       Gao R, Gao Y, Su W, Wang R*. Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and Therapy. Aging Dis. 2025 Feb; 17(1): 1-23. http://dx.doi.org/10.14336/AD.2024.1629. (IF: 6.9)

6.       Gao R*, Xu Y, Zhang M, Zeng Q, Zhu G, Su W*, Wang R*. From Gene Discovery to Stroke Risk: C5orf24's Pivotal Role Uncovered. Mol Neurobiol. 2025 Jul;62(7):8796-8808. doi: 10.1007/s12035-025-04802-y. (IF: 4.3)

7.       Zhang M#, Su W#, Deng J#, Zhai B#, Zhu G, Gao R, Zeng Q, Qiu J, Bian Z, Xiao H, Luan G*, Wang R*. Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis. J Transl Med. 2025 Jan 30;23(1):133. doi: 10.1186/s12967-024-06015-8. (IF: 7.5)

8.       Wang R*. Global burden of Alzheimer's disease and other dementias during 1990-2021: a Global Burden of Disease and Risk Factors Study 2021-based study. Neuroepidemiology. 2025 Jan 21:1-24. doi: 10.1159/000543578. (IF: 4.0)

9.       Gao R, Wang R*, Xiong Z*. Causal proteomic insights into drug target discovery for tension-type headache. J Headache Pain. 2025 Dec 2. doi: 10.1186/s10194-025-02235-5. (IF: 7.9)

10.    Xiong Z#, Gao R#, Wang R*, Li T*. Proteome-Wide Mendelian Randomization Reveals Novel Protein Targets for Epilepsy. Curr Neuropharmacol. 2025 Oct 16. doi: 10.2174/011570159X400018250919160015. (IF: 5.3)

11.    Qiu J, Zhu F, Quan R, Ye H, Su W, Wang R*, Fu Y*. Comparative efficacy and safety of therapeutic strategies for EGFRvIII positive recurrent glioblastoma. iScience. 2025 Aug 13;28(9):113346. doi: 10.1016/j.isci.2025.113346. (IF: 4.1)

12.    Zhu F, Qiu J, Ye H, Su W, Wang R*, Fu Y*. The Prognostic Significance of Epidermal Growth Factor Receptor Amplification and Epidermal Growth Factor Receptor Variant III Mutation in Glioblastoma: A Systematic Review and Meta-Analysis with Implications for Targeted Therapy. Int J Mol Sci. 2025 Apr 9; 26(8):3539. doi: 10.3390/ijms26083539. (IF: 4.9).

13.    Xing C*, Cui H, Li G, Liu X, Liu K, Wen Q, Huang X*, Wang R*, Song L*. Hspa13 Deficiency Impaired Marginal Zone B Cells Regulatory Function and Contributed to Lupus Pathogenesis. Adv Sci (Weinh). 2025 Feb;12(8): e2413144. doi: 10.1002/advs.202413144. (IF: 14.1)

14.    Qiao J, Tang C, Xie M, Gong M, Fu C, Cheng Z, Chen Z, Mei A, Bo Y, Zhao M, Li T, Ji T, Wang R, Deng J*, Luan G*. Aberrant activation of the mTOR signaling pathway in Rasmussen encephalitis. Sci Rep. 2025 Feb 21;15(1):6347. doi: 10.1038/s41598-025-89426-x. (IF: 3.9)

15.    Gao Z, Gao Y, Li Y, Zhou J, Li G, Xie S, Jia R, Wang L, Jiang Z, Liang M, Du C, Chen Y, Liu Y, Du L, Wang C, Dou S, Lv Z, Wang L, Wang R, Shen B, Wang Z, Li Y, Han G. 5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination. J Adv Res. 2025 Feb; 68: 317-330. doi: 10.1016/j.jare.2024.02.017. (IF: 13.0)

In 2024

16.    Qiu J, Zhang M, Zeng Q, Zhu G, Gao R, Xiao H, Su W*, Wang R*. Mendelian randomization study on causal association of IL-6 with intelligence. J Clin Exp Immunol. 2024 Dec 02. 9(2): 01-07.

17.    Xu Y, Gao R, Zhang M, Zeng Q, Zhu G, Qiu J, Su W*, Wang R*. Deletion of the Mitochondrial Membrane Protein Fam210b Is Associated with the Development of Systemic Lupus Erythematosus. Int J Mol Sci. 2024 Jul 1; 25(13): 7253. doi: 10.3390/ijms25137253. (IF: 4.9).

18.    Zhang M#, Qiu J#, Wang R*. Mendelian randomization study on the causal effect of herpes simplex virus infection on idiopathic pulmonary fibrosis. Expert Rev Respir Med. 2024 May; 18(5): 341-347. doi: 10.1080/17476348.2024.2369253. (IF: 2.9)

19.    Zhang M, Xu Y, Zhu G, Zeng Q, Gao R, Qiu J, Su W*, Wang R*. Human C15orf39 Inhibits Inflammatory Response via PRMT2 in Human Microglial HMC3 Cell Line. Int J Mol Sci. 2024 May 30; 25(11): 6025. doi: 10.3390/ijms25116025. (IF: 4.9)

20.    Zeng Q, Zhang M, Wang R*. Causal link between gut microbiome and schizophrenia: a Mendelian randomization study. Psychiatr Genet. 2024 Apr 1;34(2):43-53. doi: 10.1097/YPG.0000000000000361. (IF: 1.5)

21.    Xing C*, #, Zhai B#, Zhang Y#, Fang Y, Zhang M, Zhang C, Wang W, Ding M, Huang X, Shen B, Wang R*, Song L*. Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression. Biochem Biophys Res Commun. 2024. 691: 149326. (IF: 2.5)

22.    Chen N, Wang R, Zhu W, Hao X, Wang J, Chen G, Qiao C, Li X, Liu C, Shen B, Feng J, Chai L, Yu Z, Xiao H. Development and characterization of an antibody that recognizes influenza virus N1 neuraminidases. PLoS One. 2024 May 9;19(5): e0302865. doi: 10.1371/journal.pone.0302865. (IF: 2.9)

23.    Xu Y*, Gao R, Zhang M, Zeng Q, Zhou S, Zhu G, Su W, Wang R. Mendelian randomization study on causal association of FAM210B with drug-induced lupus. Clin Rheumatol. 2024 May;43(5): 1513-1520. doi: 10.1007/s10067-024-06903-w. (IF: 2.9)

24.    Li Y, Wang L, Gao Z, Zhou J, Xie S, Li G, Hou C, Wang Z, Lv Z, Wang R, Han G. Neuropeptide Calcitonin Gene-Related Peptide Promotes Immune Homeostasis of Bacterial Meningitis by Inducing Major Histocompatibility Complex Class II Ubiquitination. J Infect Dis. 2024 Mar 14; 229(3): 855-865. doi: 10.1093/infdis/jiad358. (IF: 5)

In 2023

25.    Zhang M#, Zeng Q#, Zhou S, Zhu G, Xu Y, Gao R, Su W*, Wang R*. Mendelian randomization study on causal association of IL-6 signaling with pulmonary arterial hypertension. Clin Exp Hypertens. 2023 Dec 31;45(1):2183963. doi: 10.1080/10641963.2023.2183963. (IF: 2.6)

26.    Zhang M#, Ma N#, Wang R*. Mendelian randomization study on causal association of IL-6 with breast cancer. Clin Breast Cancer. 2023 Jun; 23(4): e182-e188. doi: 10.1016/j.clbc.2023.01.015. (IF: 3.1)

27.    Zhou S, Zhu G, Xu Y, Gao R, Zhang M, Zeng Q, Su W*, Wang R*. Mendelian randomization study on the causal effect of chickenpox on dementia. J Med Virol. 2023 Jan; 95(1): e28420. DOI: 10.1002/jmv.28420. (IF: 20.693)

28.    Zhu G*, Zhou S, Xu Y, Gao R, Zhang M, Zeng Q, Su W*, Wang R*. Chickenpox and multiple sclerosis: A Mendelian randomization study. J Med Virol. 2023 Jan; 95(1): e28315. doi: 10.1002/jmv.28315. (IF: 20.693)

29.    Zhang J, Wang X, Wang R, Chen G, Wang J, Feng J, Li Y, Yu Z, Xiao H. Rapamycin Treatment Alleviates Chronic GVHD-Induced Lupus Nephritis in Mice by Recovering IL-2 Production and Regulatory T Cells While Inhibiting Effector T Cells Activation. Biomedicines. 2023. 11(3): 949. https://doi.org/10.3390/biomedicines11030949. (IF: 4.757)

30.    Liu X, Wang J, Shen L, Wang R, Zhang L, Li C. Single-cell atlas reveals a high selection of IgA1- or IgG1-expressing plasma cells in patients with psoriasis. Mol Immunol. 2023 Jan; 153: 85–93. (IF: 4.174)

In 2022

31.    Su W, Zhou S, Zhu G, Xu Y, Gao R, Zhang M, Zeng Q, Wang R*. Mendelian randomization study on causal association of pyroglutamine with COVID-19. J Epidemiol Glob Health. 2022 Dec; 12(4): 541-547. doi: 10.1007/s44197-022-00073-1. (IF: 5.959)

32.    Ma N, Wang R*. Mendelian randomization study on the effect of tumor necrosis factor on schizophrenia. Psychiat Genet. 2022 Dec 1; 32(6): 238-245. doi: 10.1097/YPG.0000000000000329. (IF: 2.574)

33.    Zhu G#, Zhou S#, Xu Y, Gao R, Li H, Su W*, Han G*, Wang R*. Mendelian randomization study on the causal effects of COVID-19 on childhood intelligence. J Med Virol. 2022 Jul. 94(7): 3233-3239. doi: 10.1002/jmv.27736. (IF: 20.693)

34.    Zhou S#, Zhu G#, Xu Y, Gao R, Li H, Han G*, Su W*, Wang R*. Mendelian randomization study on the putative causal effects of omega-3 fatty acids on low back pain. Front Nutr. 2022. Feb 14. 9: 819635. doi: 10.3389/fnut.2022.819635. (IF: 6.590)

35.    Gao R#, Xu Y#, Zhu G, Zhou S, Li H, Han G*, Su W*, Wang R*. Genetic variation associated with COVID-19 is also associated with endometrial cancer. J Infect. 2022 Jan 22. 84(5): e85-6. doi: 10.1016/j.jinf.2022.01.026. (IF: 38.637)

36.    Xu Y#, Gao R#, Zhu G, Zhou S, Li H, Su W*, Han G*, Wang R*. Genetic variation associated with allergic disease is also associated with susceptibility to COVID-19. J Infect. 2022. Jan 14. 84(5): e92-3. doi: 10.1016/j.jinf.2022.01.015. (IF: 38.637)

37.    Zhu G#, Zhou S#, Xu Y, Gao R, Li H, Zhai B, Liu X, He Y, Wang X, Han G*, Su W*, Wang R*. Mendelian randomization study on the causal effects of omega-3 fatty acids on rheumatoid arthritis. Clin Rheumatol. 2022 May. 41(5): 1305-1312. doi: 10.1007/s10067-022-06052-y (IF: 3.650)

38.    Wang R*. Genetic variation of interleukin-1 receptor type 1 is associated with severity of COVID-19 disease. J Infect. 2022. Feb. 84(2): e19–e21. doi: 10.1016/j.jinf.2021.12.010. (IF: 38.637)

39.    Wang R*. Mendelian randomization study updates the effect of 25-hydroxyvitamin D levels on the risk of multiple sclerosis. J Transl Med. 2022. Jan 3. 20(1): 3. doi: 10.1186/s12967-021-03205-6. (IF: 8.440) (Highly Cited Papers)

40.    Zhai B#, Liu X#,Xu Y#, Zhu G, Zhou S, He Y, Wang X, Su W*, Han G*, Wang R*. Single-cell atlas of splenocytes reveals a critical role of a novel plasma cell‒specific marker Hspa13 in antibody class-switching recombination and somatic hypermutation. Mol Immunol. 2022. Jan. 141: 79–86. https://doi.org/10.1016/j.molimm.2021.11.014 (IF: 4.174)

41.    Tang L#, Li G#, Zheng Y, Hou C, Gao Y, Hao Y, Gao Z, Mo R, Li Y, Shen B, Wang R*, Wang Z*, Han G*. Tim-3 Relieves Experimental Autoimmune Encephalomyelitis by Suppressing MHC-II. Front Immunol. 2022. Jan 13. 12: 770402. doi: 10.3389/fimmu.2021.770402. (IF: 8.786)

42.    Shi Q, Li G, Dou S, Tang L, Hou C, Wang Z, Gao Y, Gao Z, Hao Y, Mo R, Shen B, Wang R, Li Y*, Han G*. Negative Regulation of RIG-I by Tim-3 Promotes H1N1 Infection. Immunol Invest. 2022. Aug. 23:1-19. doi: 10.1080/08820139.2022.2113407. (IF: 3.044)

In 2021

43.    Zhou S, Wang R*. Targeted therapy of multiple myeloma. Explor Target Antitumor Ther. 2021;2:465-80. https://doi.org/10.37349/etat.2021.00057.

44.    He Y#, Fang Y#, Zhai B#, Liu X#, Zhu G#, Zhou S, Xu Y, Wang X, Su W*, Wang R*. Gm40600 promotes CD4+T cell responses by interacting with Ahnak. Immunology. 2021. Sep. 164:190–206. DOI: 10.1111/imm.13365. (IF: 7.397)

45.    Fang Y#, He Y#, Zhai B#, Hou C#, Xu R, Xing C, Wang X, Ma N, Han G*, Wang R*. The E3 ubiquitin ligase Itch deficiency promotes antigen-driven B-cell responses in mice. Eur J Immunol. 2021. 51(1): 103-114. DOI:10.1002/eji.202048640. (IF: 5.532)

46.    Li G, Tang L, Hou C, Wang Z, Gao Y, Dou S, Mo R, Hao Y, Gao Z, Li Y, Dong J, Zhang J, Shen B, Wang R*, Han G*. Peripheral Injection of Tim-3 Antibody Attenuates VSV Encephalitis by Enhancing MHC-I Presentation. Front Immunol. 2021. 12: 667478. doi: 10.3389/fimmu.2021.667478. (IF: 7.561)

47.    Zhang J, Hou C, Dou S, Li G, Wang Z, Liu Y, Zhang Y, Wang R*, Shen B, Han G*. T cell immunoglobulin and mucin domain protein 3 inhibits glycolysis in RAW 264.7 macrophages through Hexokinase 2. Scand J Immunol. 2021 Feb;93(2): e12981. doi: 10.1111/sji.12981. (IF: 3.487)

48.    Dou S, Li G, Li G, Hou C, Zheng Y, Tang L, Gao Y, Mo R, Li Y, Wang R*, Shen B, Zhang J*, Han G*. Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity. Elife. 2021 Jun 10; 10: e66501. doi: 10.7554/eLife.66501. (IF: 8.140)

In 2020

49.    He Y#, Xu R#, Zhai B#, Zhou S, Wang X, Wang R*. Gm614 protects germinal center B cells from death by suppressing caspase-1 transcription in lupus-prone mice. Front Immunol. 2020. 11:585726. doi: 10.3389/fimmu.2020.585726. (IF: 5.085)

50.    He Y, Zhai B, Zhou S, Wang X, Wang R*. Chemokine-Expressing Th1 and Treg Cells are Increased in the Lung of Patients with COVID-19. Available at SSRN: https://ssrn.com/abstract=3629437 or http://dx.doi.org/10.2139/ssrn.3629437.

51.    Zhai B#, He Y#, Zhou S#, Wang X, Wang R*. Characterization of Lung Bronchoalveolar Humoral Immunity in Patients with COVID-19. Adv Clin Transl Res. 2020. 4: 100026.

52.    He Y#, Xu R#, Zhai B#, Fang Y#, Hou C#, Xing C, Xiao H, Chen G, Wang X, Ma N, Han G*, Wang R*. Hspa13 promotes plasma cell production and antibody secretion. Front Immunol. 2020. 11:913. (IF: 5.085)

53.    Zhai B#, Hou C#, Xu R#, Fang Y#, Ma N, Xing C, Wang X, Xiao H, Chen G, Han G*, Wang R*. Gm6377 suppressed SP 2/0 xenograft tumor by down-regulating Myc transcription. Clin Transl Oncol. 2020. Sep. 22(9):1463-1471. (IF: 2.737)

54.    Wang Z, Li G, Dou S, Zhang Y, Liu Y, Zhang J, Li G, Hou C, Wang R, Shen B, Han G. Tim-3 Promotes Listeria monocytogenes Immune Evasion by Suppressing Major Histocompatibility Complex Class I. J Infect Dis. 2020 Feb 18; 221(5): 830-840. (IF: 5.022)

In 2019

55.    Fang Y, Xu R, Zhai B, Hou C, Ma N, Wang L, Han G, Jiang Z*, Wang R*. Gm40600 suppressed SP 2/0 isograft tumor by reducing Blimp1 and Xbp1 proteins. BMC Cancer. 2019 Jul 16. 19(1):700. (IF: 2.933)

56.    Wei Y#, Zhang F#, Zhang Y#, Wang X, Xing C, Guo J, Zhang H, Suo Z, Li Y, Wang J, Wang R*, Cai Z*. Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells. Cell Mol Immunol. 2019 Jun; 16(6):580-589. (IF: 7.551)

57.    Zhai B#, Hou C#, Xu R#, Fang Y#, Xiao H, Chen G, Wang X, Ma N, Han G*, Wang R*. Loc108167440 suppressed myeloma cell growth by p53-mediated apoptosis. Leuk Lymphoma. 2019. Oct; 60 (10): 2541-2548. (IF: 2.674)

58.    Liu X#, Zhang Y#, Wei Y#, Wang Z, Zhu G, Fang Y, Zhai B, Xu R, Han G, Chen G, Xiao H, Hou C, Shen B, Li Y, Ma N *, Wang R *. The E3 ubiquitin ligase Itch is required for B-cell development. Sci Rep. 2019. Jan 23. 9(1): 421. (IF: 4.011)

59.    Ma N#, Fang Y#, Xu R, Zhai B, Hou C, Wang X, Jiang Z, Wang L, Liu Q *, Han G *, Wang R *. Ebi3 promotes T- and B-cell division and differentiation via STAT3. Mol Immunol. 2019. Jan 18. 107: 61-70. (IF: 3.064)

60.    Li G, Hou C, Dou S, Zhang J, Zhang Y, Liu Y, Wang Z, Xiao H, Wang R*, Chen G, Li Y, Feng J, Shen B, Han G*. Monoclonal antibody against human Tim-3 enhances antiviral immune response. Scan J Immunol. 2019 Feb; 89(2):e12738. (IF: 2.563)

61.    Lv Z, Wang Z, Luo L, Chen Y, Han G, Wang R, Xiao H, Li X, Hou C, Feng J, Shen B, Wang Y, Peng H, Guo R, Li Y, Chen G. Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage. Mucosal Immunol. 2019 Sep;12(5):1164-1173. (IF: 7.352)

In 2018

62.    Xu R#, Fang Y#, Hou C#, Zhai B#, Jiang Z, Ma N, Wang L *, Han G *, Wang R *. BC094916 suppressed SP 2/0 xenograft tumor by down-regulating Creb1 and Bcl2 transcription. Cancer Cell Int. 2018. Sep 14; 18:138. (IF: 3.96)

63.    Zhu G#, Liu X#, Fang Y#, Zhai B, Xu R, Han G, Chen G, Xiao H, Hou C, Shen B, Li Y, Iwakura Y, Wang L, Jiang Z, Ma N *, Liu G*, Wang R*. Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells. Cell Immunol. 2018. Feb 24. 328: 9-17. (IF: 2.995)

64.    Wang X#, Zhang Y#, Wang Z#, Liu X, Zhu G, Han G, Chen G, Hou C, Wang T, Shen B, Li Y, Xiao H, Ma N*, Wang R*. Anti-IL-39 (IL-23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus-like mice. Mol Med Rep. 2018. Jan. 17(1): 1660-1666. (IF: 1.922)

65.    Sun S#, Jiang Y#, Wang R#, Liu C, Liu X, Song N, Guo Y, Guo R, Du L, Jiang S, Li Y, Qiu Z*, Zhao G*, Zhou Y*. Treatment of paraquat-induced lung injury with an anti-C5a antibody: potential clinical application. Crit Care Med. 2018. May. 46(5): e419-e425. (IF: 6.630)

66.    Wang W, Shi Q, Dou S, Li G, Shi X, Jiang X, Wang Z, Yu D, Chen G, Wang R, Xiao H, Hou C, Feng J, Shen B, Ma Y, Han G. Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis. Immunology. 2018. Jan. 153 (1): 71-83. (IF: 3.358)

In 2017

67.    Zhang Y#, Zhu G#, Xiao H#, Liu X, Han G, Chen G, Hou C, Shen B, Li Y, Ma N*, Wang R*. CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells. J Cell Mol Med. 2017. Jul 14. 21 (12): 3658-3669. (IF: 4.499)

68.    Xing C#, Zhu G#, Xiao H#, Fang Y, Liu X, Han G, Chen G, Hou C, Shen B, Li Y, Ma N*, Wang R*. B cells regulated thymic CD8+T cell differentiation in lupus-prone mice. Oncotarget. 2017. Jul 5. 8 (52): 89486-89499. (IF: 5.168)

69.    Zhu G #, Wang X #, Xiao H #, Liu X, Fang Y, Zhai B, Xu R, Han G, Chen G, Hou C, Shen B, Li Y, Ma N, Wu H*, Liu G*, Wang R*. Both Notch1 and its ligands in B cells promote antibody production. Mol Immunol. 2017. Aug 29; 91: 17-23. (IF: 3.236)

70.    Zhang Y#, Wang Z#, Xiao H#, Liu X, Zhu G, Han G, Chen G, Hou C, Ma N, Shen B, Li Y, Wang T *, Wang R*. Foxd3 suppresses interleukin-10 expression in B cells. Immunology 2017. Apr. 150(4): 478-488. (IF: 3.701)

71.    Ma N#, Zhang Y#, Liu Q#, Wang Z, Liu X, Zhu G, Yu D, Han G, Chen G, Hou C, Wang T, Ma Y, Shen B, Li Y, Xiao H*, Wang R*. B cell activating factor (BAFF) selects IL-10 - B cells over IL-10 + B cells during inflammatory responses. Mol Immunol. 2017. Feb. 85: 18-26. (IF: 3.236)

72.    Dambuza IM, He C, Choi JK, Yu CR, Wang R, Mattapallil MJ, Wingfield PT, Caspi RR, Egwuagu CE. IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease. Nat Commun. 2017 Sep 28; 8(1):719. (IF: 12.124)

73.    Chen Y, Zhao Z, Chen Y, Lv Z, Ding X, Wang R, Xiao H, Hou C, Shen B, Feng J, Guo R, Li Y, Peng H, Han G, Chen G. An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer. Sci Rep. 2017 Aug 15; 7(1): 8265. (IF: 4.259)

74.    Wang Z, Sun D, Chen G, Li G, Dou S, Wang R, Xiao H, Hou C, Li Y, Feng J, Shen B, Han G. Tim-3 inhibits macrophage control of Listeria monocytogenes by inhibiting Nrf2. Sci Rep. 2017 Feb 16; 7: 42095. (IF: 4.259)

75.    Li Y, Zhou T, Wang Y, Ning C, Lv Z, Han G, Morris JC, Taylor EN, Wang R, Xiao H, Hou C, Ma Y, Shen B, Feng J, Guo R, Li Y, Chen G. The protumorigenic potential of FTY720 by promoting extramedullary hematopoiesis and MDSC accumulation. Oncogene. 2017 Jun 29. 36(26):3760-3771. (IF: 7.519)

In 2016

76.    Wang X, Liu X, Zhang Y, Wang Z, Zhu G, Han G, Chen G, Hou C, Wang T, Ma N, Shen B, Li Y, Xiao H*, Wang R*. Interleukin (IL)-39 [IL-23p19/Epstein–Barr virus-induced 3 (Ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice. Clin Exp Immunol. 2016 Nov. 186 (2): 144-156. (IF: 3.148)

77.    Liu X, Zhang Y, Wang Z, Wang X, Zhu G, Han G, Chen G, Hou C, Wang T, Shen B, Li Y, Ma N, Xiao H*, Wang R*. Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis. Int J Oncol. 2016 Oct. 49 (4): 1469-1478. (IF: 3.018)

78.    Wang X#, Wei Y#, Xiao H#, Liu X, Zhang Y, Han G, Chen G, Hou C, Ma N, Shen B, Li Y, Egwuagu CE, Wang R*. Novel IL-23p19/Ebi3 (IL-39) Cytokine Mediates Inflammation in Lupus-like Mice. Eur J Immunol. 2016 Jun; 46(6): 1343-1350. (IF: 4.179)

79.    Wang X#, Wei Y#, Xiao H#, Liu X, Zhang Y, Han G, Chen G, Hou C, Zhang L, Ma N, Shen B, Li Y, Egwuagu CE*, Wang R*. Pre-existing CD19-independent GL7- Breg cells are expanded during inflammation and in mice with lupus-like disease. Mol Immunol. 2016 Mar; 71: 54-63. (IF: 3.375)

80.    Jiang X, Zhou T, Xiao Y, Yu J, Dou S, Chen G, Wang R, Xiao H, Hou C, Wang W, Shi Q, Feng J, Ma Y, Shen B, Li Y, Han G. Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis. OncoImmunology. 2016. Aug 3, 5(9): e1211219. (IF: 7.644)

In 2015

81.    Ma N#, Liu X#, Xing C#, Wang X, Wei Y, Han G, Chen G, Hou C, Shen B, Li Y, Xiao H*, Wang R*. Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells. Clin Immunol. 2015 Jun 9; 160(2): 142-154. (IF: 3.672)

82.    Wang X#, Wei Y#, Liu X#, Xing Chen, Han G, Chen G, Hou C, Dambuza IM, Shen B, Li Yan, Xiao H*, Wang R*. IL-15-secreting γδT cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice. Mol Immunol. 2015 Aug; 66(2): 402-408. (IF: 2.973)

83.    Wang R, Xiao H, Guo R, Li Y*, Shen B*. The role of C5a in acute lung injury induced by highly pathogenic viral infections. Emerg Microbes Infect. 2015 May; 4(5): e28. Review (IF: 2.258)

84.    Wang X, Xiao H, Wei Y, Liu X, Han G, Chen G, Hou C, Shen B, Li Y, Wang R*. Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice. Central Eur J Immunol. 2015. 40 (2): 142-148 (IF: 0.28)

85.    Xing C, Ma N, Xiao H, Wang X, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y*, Wang R*. Critical role for thymic CD19+CD5+CD1dhiIL-10+ regulatory B cells in immune homeostasis. J Leukoc Biol. 2015 Mar; 97(3):547-556. (IF: 4.289)

86.    He Y#, Ma N#, Xing C, Wang X, Xiao H, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y, Jiang Z*, Wang R*, Wu W*. Novel IL-6-secreting γδT cells increased in patients with atherosclerotic cerebral infarction. Mol Med Rep. 2015 Feb; 11(2): 1497-1503. (IF: 1.554)

87.    Egwuagu CE, Yu CR, Sun L, Wang R. Interleukin 35: Critical Regulator of Immunity and Lymphocyte-mediated Diseases. Cytokine Growth F R. 2015. Oct; 26 (5): 587-593. Review (IF: 5.357).

88.    Ning C, Li YY, Wang Y, Han GC, Wang RX, Xiao H, Li XY, Hou CM, Ma YF, Sheng DS, Shen BF, Feng JN, Guo RF, Li Y, Chen GJ. Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1β/IL-17A axis. Mucosal Immunol. 2015 Nov; 8(6): 1275-84. (IF: 7.374)

89.    Jiang X, Yu J, Shi Q, Xiao Y, Wang W, Chen G, Zhao Z, Wang R, Xiao H, Hou C, Feng J, Ma Y, Shen B, Wang L, Li Y, Han G. Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages. Clin Immunol. 2015 Jul 21; 160: 328–335. (IF: 3.672)

90.    Sun S, Zhao G, Liu C, Fan W, Zhou X, Zeng L, Guo Y, Kou Z, Yu H, Li J, Wang R, Li Y, Schneider C, Habel M, Riedemann NC, Du L, Jiang S, Guo R, Zhou Y. Treatment With Anti-C5a Antibody Improves the Outcome of H7N9 Virus Infection in African Green Monkeys. Clin Infect Dis. 2015 Feb 15; 60(4): 586-95. (IF: 8.886)

In 2014

91.    Zheng M#, Xing C#, Xiao H#, Ma N, Wang X, Han G, Chen G, Hou C, Shen B, Li Y*, Wang R*. Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis. Immunol Invest. 2014. 43:705-716. (IF: 1.903)

92.    Wang RX, Yu CR, Dambuza IM, Mahdi RM, Dolinska M, Sergeey YV, Wingfield PT, Kim SH, Egwuagu CE*. Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat Med. 2014. 20: 633-641. (IF: 28.054) (Highly Cited Papers)

93.    Ma N#, Xing C#, Xiao H#, He Y, Han G, Chen G, Hou C, Marrero B, Wang Y, Zhang S, Shen B, Li Y*, Wang R*. BAFF Suppresses IL-15 Expression in B Cells. J Immunol. 2014. 192: 4192-4201. (IF: 5.362)

94.    Ma N#, He Y#, Xiao H#, Han G, Chen G, Wang Y, Wang K, Hou C, Yang X, Marrero B, Wang Y, Shen B, Li Y*, Wang R*. BAFF Maintains T-Cell Survival by Inducing OPN Expression in B Cells. Mol Immunol. 2014. 57: 129-137. (IF: 3.003)

95.    Ma N, Xiao H, Marrero B, Xing C, Wang X, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y, Wang R,Jiang Z*. Combination of TACI-IgG and Anti-IL-15 Treats Murine Lupus by reducing mature and memory B cells. Cell Immunol. 2014. 289: 140-144. (IF: 1.874)

96.    Zhao Z, Jiang X, Kang C, Xiao Y, Hou C, Yu J, Wang R, Xiao H, Zhou T, Wen Z, Feng J, Chen G, Ma Y, Shen B, Li Y, Han G. Blockade of the T cell immunoglobulin and mucin domain protein 3 pathway exacerbates sepsis-induced immune deviation and immunosuppression. Clin Exp Immunol. 2014 Nov. 178 (2): 279-91.  (IF: 3.278)

97.    Wang Y, Han G, Wang K, Liu G, Wang R, Xiao H, Li X, Hou C, Shen B, Guo R, Li Y, Chen G. Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF. Cancer Res. 2014. 74: 716-726. (IF: 9.284)

98.    Wang Y, Wang K, Han GC, Wang R, Xiao H, Hou CM, Guo RF, Dou Y, Shen BF, Li Y, Chen GJ. Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis. Mucosal Immunol. 2014. Sep. 7(5): 1106-15. (IF: 7.537)

99.    Guo X, Jiang X, Xiao Y, Zhou T, Guo Y, Wang R, Zhao Z, Xiao H, Hou C, Ma L, Lin Y, Lang X, Feng J, Chen G, Shen B, Han G, Li Y. IL-17A signaling in colonic epithelial cells inhibits pro-inflammatory cytokine production by enhancing the activity of ERK and PI3K. PLoS One. 2014. 9: e89714. (IF: 3.534)

In 2013

100.He Y#, Ma N#, Xiao H#, Xing C, Han G, Chen G, Hou C, Shen B, Li Y, Wang R*, Hu W. BAFF induces the transcription of recombination-activating genes in transitional stage 1 B cells. Centr Eur J Immunol. 2013. 38 (3): 336-342. (IF: 0.378)

101.Ma N#, Xing C#, Xiao H#, Wang Y, Wang K, Hou C, Han G, Chen G, Marrero B, Wang Y, Shen B, Li Y*, Wang R*. C5a regulates IL-12+DC migration to induce pathogenic Th1 and Th17 cells in sepsis. Plos one. 2013. 8(7): e69779. (IF: 3.73)

102.Wang R#, Wang R#, Ma N, Guo Y, Xiao H, Chen G, Han G, Hou C, Shen B, Feng J*, Li Y*. Identify the key amino acid of BAFF binding with TACI. Cell Immunol. 2013. 284:84-90. (IF: 1.743)

103.Wang Y, Han G, Chen Y, Wang K, Liu G, Wang R, Xiao H, Li X, Hou C, Shen B, Guo R, Li Y, Chen G. Protective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response. Lab Invest. 2013. 93(9):1024-1035. (IF: 3.961)

104.Yang X, Jiang X, Chen G, Xiao Y, Geng S, Kang C, Zhou T, Li Y, Guo X, Xiao H, Hou C, Wang R, Lin Z, Li X, Feng J, Ma Y, Shen B, Li Y, Han G. T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response. J Immunol. 2013. 190: 2068-79. (IF: 5.52)

In 2012

105.Wang RX, Yu CR, Mahdi RM, Egwuagu CE. Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cells. J Biol Chem. 2012. 287: 36012-21. (IF: 4.773)

106.Wang YJ, Shen DF, Wang VM, Yu CR, Wang R, Tuo JS, Chan CC. Enhanced apoptosis in retinal pigment epithelium under inflammatory stimuli and oxidative stress. Apoptosis. 2012. 17: 1144-55. (IF: 4.788)

107.Wang K, Han G, Dou Y, Wang Y, Liu G, Wang R, Xiao H, Li X, Hou C, Shen B, Guo R, Li Y, Shi Y, Chen G. Opposite role of tumor necrosis factor receptors in dextran sulfate sodium-induced colitis in mice. PLoS One. 2012. 7: e52924. (IF: 4.537)

108.Shi F, Guo X, Jiang X, Zhou P, Xiao Y, Zhou T, Chen G, Zhao Z, Xiao H, Hou C, Li X, Yang X, Wang R, Feng J, Shen B, Li Y, Han G. Dysregulated Tim-3 expression and its correlation with imbalanced CD4 helper T cell function in ulcerative colitis. Clin Immunol. 2012. 145: 230-40. (IF: 4.046)

In 2011

109.Yang Y, Wang H, Dou Y, Wang Y, Han G, Wang R, Wang L, Guo R, Xiao H, Li X, Shen B, Shi Y, Chen G, Li Y. Colitogenic role of tumour necrosis factor (TNF) receptors in trinitrobenzene sulphonic acid colitis: TNF-R1 ablation does not affect systemic inflammatory response. Clin Exp Immunol. 2011 Sep. 165: 372-82. (IF: 3.134)

110.Han G, Geng S, Li Y, Chen G, Wang R, Li X, Ma Y, Shen B, Li Y. γδT-cell function in sepsis is modulated by C5a receptor signalling. Immunology. 2011 Jul. 133: 340-9. (IF: 3.302)

111.Li Y, Feng J, Geng S, Geng S, Wei H, Chen G, Li X, Wang L, Wang R, Peng H, Han G, Shen B, Li Y. The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity. Mol Immunol. 2011 Jan. 48: 670-7. (IF: 2.916)

112.Chen G, Yang Y, Gao X, Dou Y, Wang H, Han G, Wang R, Wang J, Wang L, Li X, Guo R, Xiao H, Shen B, Li Y. Blockade of complement activation product C5a activity using specific antibody attenuates intestinal damage in trinitrobenzene sulfonic acid induced model of colitis. Lab Invest. 2011 Mar. 91: 472-83. (IF: 4.405)

In 2010

113.Xu R#, Wang R #, Han G #, Wang J, Chen G, Wang L, Li X, Guo R, Shen B, Li Y. Complement C5a regulates IL-17 by affecting the crosstalk between DC and gammadelta T cells in CLP-induced sepsis. Eur J Immunol. 2010. 40: 1079-88. (IF: 4.942)

114.Han G, Wang R #, Chen G #, Wang J, Xu R, Wang L, Feng J, Li X, Guo R, Fu L, Shen B, Li Y. Interleukin-17-producing gammadelta (+) T cells protect NOD mice from type I diabetes through a mechanism involving transforming growth factor-beta. Immunology. 2010. 129: 197-206. (IF: 3.302)

115.Wang L, Han G, Wang R, Chen G, Xu R, Xiao H, Li X, Geng S, Li Y, Li X, Wang J, Feng J, Riedemann NC, Guo R, Shen B, Li Y. Regulation of IL-8 production by complement activated product, C5a, in vitro and in vivo during sepsis. Clin Immunol. 2010 Oct; 137(1):157-65. (IF: 3.932)

116.Li X, Chen G, Li Y, Wang R, Wang L, Lin Z, Gao X, Feng J, Ma Y, Shen B, Li Y, Han G. Involvement of T cell Ig Mucin-3 (Tim-3) in the negative regulation of inflammatory bowel disease. Clin Immunol. 2010. 134: 169-177. (IF: 3.932)

In 2009

117.Wang R#, Han G #, Song L, Wang J, Chen G, Xu R, Yu M, Qian J, Shen B, Li Y. CD8+ regulatory T cells are responsible for GAD-IgG gene-transferred tolerance induction in NOD mice. Immunology. 2009. 126: 123-131. (IF: 3.398)

118.Wang R, Gencheng Han, Jianan Wang, Guojiang Chen, Ruonan Xu,Liyan Wang, Xia Li, Beifen Shen and Yan Li. Foxp3-mediated immunity of human pancreatic cancer cell line PANC-1. Am J Immunol. 2009. 5: 101-107.

119.Chen G, Han G, Feng J, Wang J, Wang R, Xu R, Shen B, Qian J, Li Y. Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4+CD25+ regulatory T cells. Plos One. 2009. 13: e7034.

120.Chen G, Han G, Wang J, Wang R, Xu R, Shen B, Qian J, Li Y. Natural killer cells modulate overt autoimmunity to homeostasis in nonobese diabetic mice after anti-CD3 F(ab’)2 antibody treatment through secreting transforming growth factor-beta. Am J Pathol. 2009. 175: 1086-1094. (IF:5.487)

In 2008

121.Wang R#, Han G #, Wang J, Chen G, Xu R, Wang L, Li X, Shen B, Li Y. The pathogenic role of interleukin-27 in autoimmune diabetes. Cell Mol Life Sci. 2008. 65: 3851-3860. (IF: 5.239)

122.Wang R #, Han G #, Wang J, Song L, Chen G, Xu R, Wang L, Li X, Shen B, Li Y. Diabetes is not prevented by Foxp3-transduced CD4(+)T cells under the IL-12Rbeta2 promoter control. Mol Immunol. 2008. 45: 3814-3817. (IF: 3.742)

123.Wang R#, Han G#, Wang J, Song L, Chen G, Xu R, Zhang C, Yu M, Qian J, Shen B, Li Y. GAD-IgG-inducing CD4+Foxp3+Treg cells suppressing diabetes is involved in the increasing ratio of CD80+: CD86+ cells in NOD mice. Arch Med Res. 2008. 39: 299-305. (IF: 1.772)

124.Han G#, Wang R #, Chen G #, Wang J, Xu R, Feng J, Yu M, Wu X, Qian J, Shen B, Li Y. Gene delivery GAD 500 autoantigen by AAV serotype 1 prevented diabetes in NOD mice: transduction efficiency do not play important roles. Immunol Lett. 2008. 115:110-116. (IF:2.628)

125.Chen G, Han G, Wang J, Wang R, Xu R, Shen B, Qian J, Li Y. Induction of active tolerance and involvement of CD1d-restricted natural killer T cells in anti-CD3 F(ab')2 treatment-reversed new-onset diabetes in nonobese diabetic mice. Am J Pathol. 2008. 172: 972-979. (IF:5.487)

126.Chen G, Han G, Wang J, Wang R, Xu R, Shen B, Qian J, Li Y. Essential roles of TGF-{beta} in anti-CD3 antibody therapy: reversal of diabetes in nonobese diabetic mice independent of Foxp3+CD4+ regulatory T cells. J Leukoc Biol. 2008. 83: 280-287. (IF: 4.128)

In 2007

127.Wang R #, Han G #, Wang J, Song L, Chen G, Xu R, Yu M, Qian J, Shen B, Li Y. Foxp3-expressing CD4(+)T cells under the control of INF-gamma promoter prevent diabetes in NOD mice. Mol Ther. 2007. 15: 1551-1557. (IF: 5.841)

128.Wang R #, Song L #, Han G #, Wang J, Chen G, Xu R, Yu M, Qian J, Shen B, Li Y. Mechanisms of regulatory T cell induction by antigen-IgG-transduced splenocytes. Scand J Immunol. 2007. 66: 515-522. (IF: 2.09)

129.Wang R #, Han G #, Wang J, Song L, Chen G, Xu R, Yu M, Qian J, Shen B, Li Y. The role of STAT3 in antigen-IgG inducing regulatory CD4+Foxp3+T cells. Cell Immunol. 2007. 246: 103-109. (IF: 1.709)

130.Wang R #, Han G #, Wang J, Song L, Chen G, Xu R, Yu M, Qian J, Shen B, Li Y. Mechanisms underlying B-cell tolerance induction by antigen-immunoglobulin G gene transfer. J Int Med Res. 2007. 35: 781 –789. (IF: 0.665)

131.Zhang C, Xu R, Wang J, Han G, Chen G, Wang R, Huawei Wei, Beifen Shen, Yuanfang Ma and Yan Li. Functional identification of the stable transfection C5aR cell line Molt-4. Cell Mol Immunol. 2007. 4: 461-465.

In 2005

132.Han G, Li Y, Wang J, Wang R, Chen G, Song L, Xu R, Yu M, Wu X, Qian J, Shen B. Active tolerance induction and prevention of autoimmune diabetes by immunogene therapy using recombinant adenoassociated virus expressing glutamic acid decarboxylase 65 peptide GAD(500-585). J Immunol. 2005. 174: 4516-4524. (IF:6.702)

133.Xu R, Wang J, Chen G, Han G, Wang R, Shen BF, Li Y. The effects of CD3-Specific Molecular Antibody on Treating Experimental Autoimmune Myasthenia Gravis. Cell Mol Immunol. 2005. 2: 461-465.

In 2004

134.Song L, Wang J, Wang R, Yu M, Sun Y, Han G, Li Y, Qian J, Scott DW, Kang Y, Soukhareva N, Shen B. Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: a role for CD4+ regulatory T cells and TGF-beta? Gene Ther. 2004. 11:1487-1496. (IF:5.237)

 

中文论文:

注:# 代表共同第一作者;*代表共同通讯作者

1.        李华, 朱改只, 周珊, 徐雅琪, 崔秀玉, 周岩, 王仁喜*, 粟文婷*。老年小鼠海马离体脑片长时程增强方法的建立。《实验技术与管理》。2021。38(8):51-54。

2.        刘艺琼,李葛,王智鼎,窦帅杰,张嘉诚,张艳玲,李国贤,侯春梅,王仁喜,黎燕,韩根成。Tim-3对神经小胶质细胞极化的调控作用及机制研究。《军事医学》。2018(11):839-844。

3.        丁欣,吕忠霖,许可,侯春梅,肖鹤,王仁喜,韩根成,冯健男,黎燕,沈倍奋,陈国江。粒细胞-巨噬细胞集落刺激因子对结肠癌肝转移的促进作用及其可能机制。《中国肿瘤生物治疗杂志》。2018 (1) : 56-61。

4.        李葛,王智鼎,窦帅杰,侯春梅,肖鹤,王仁喜,陈国江,黎燕,韩根成。可溶性Tim- 3体外增强免疫应答的作用及机制研究[J]。《军事医学》。2017,41(1):33-37。

5.        王仁喜,黎燕。补体C5a在百草枯诱导急性肺损伤中的作用和机制。《中国药理学与毒理学杂志》。2016。第12月。30 (12):1379-1384。

6.        李娜,魏寅祥,侯春梅,韩根成,陈国江,沈倍奋,冯健男,黎燕,王仁喜*,肖鹤*。雌二醇体外诱导对调节性B 细胞分泌IL-10 的影响。《国际药学研究杂志》。2016. 第6月。43(3):524-528.

7.        李娜,李金亮,魏寅祥,韩根成,陈国江,侯春梅,黎燕,王仁喜*,肖鹤*。雌激素对实验性自身免疫性脑脊髓炎的保护作用。《国际药学研究杂志》。2016. 第2月,43(2):290-295.

8.        于佳卉,侯春梅,蒋兴伟,王 位,史青竹,陈国江,王仁喜,肖 鹤,冯健男,沈倍奋,黎 燕,马远方,韩根成。百草枯中毒急性炎症反应中Tim-3的调控作用研究。《军事医学》。2016. 1月。40(1):45-50.

9.        李 娜,李金亮,王仁喜,肖 鹤。富马酸二甲酯在多发性硬化中的应用及其机制研究进展。《军事医学》。2015. 11月。39(11):881-883.

10.     王小茜; 邢陈; 黎燕; 沈倍奋; 王仁喜。IL-12家族在自身免疫性疾病中的免疫调节作用。《军事医学》。2015-08-25。2015. 39 (8): 637-640. (综述)

11.     邢陈; 黎燕; 沈倍奋; 王仁喜。调节性B细胞的研究进展。《国际药学研究杂志》。2015-06-30。2015. 42: 326-330。(综述)

12.     李娜; 王仁喜; 肖鹤。雌激素对实验性自身免疫性脑脊髓炎免疫性保护机制的研究进展。《国际药学研究杂志》。2015-06-30。 2015. 42: 323-325。(综述)

13.     侯春梅; 郎小玲; 肖燕; 郑明克; 蒋兴伟; 肖鹤; 陈国江; 王仁喜; 冯健男; 韩根成; 沈倍奋; 黎燕。Tim-3抗体的生物学活性及应用研究。《军事医学》2014-08-25。2014. 38 (8): 617-625.

14.     郑明克; 侯春梅; 王仁喜; 魏应林; 张及禄; 李新颖; 陈国江; 韩根成; 沈倍奋; 黎燕; 马远方; 肖鹤。西罗莫司对慢性排斥反应诱发小鼠肾炎的治疗作用及可能机制。《国际药学研究杂志》。2014-06-30。2014(3):335-341。

15.     郑明克; 侯春梅; 张仁文; 韩根成; 陈国江; 李新颖; 沈倍奋; 马远方; 黎燕; 王仁喜*; 肖鹤*。芬戈莫德对小鼠皮肤胶原沉着病的治疗作用及可能机制。《国际药学研究杂志》。2013-06-30。2013. 40 (3): 318-322.

16.     王柯; 王一; 刘桂君; 韩根成; 王仁喜; 肖鹤; 侯春梅; 彭晖; 沈倍奋; 黎燕; 陈国江。VEGF在溃疡性结肠炎癌变中的作用及其可能的机制。《中国肿瘤生物治疗杂志》。2013-04-24。2013,20 (2): 159-165.

17.     王立燕; 徐若男; 韩根成; 王仁喜; 陈国江; 肖鹤; 侯春梅; 沈倍奋; 黎燕。实验性败血症小鼠模型的建立及评价。《中国实验血液学杂志》。2010-06-20。2010. 18: 766-770.

18.     陈国江; 王建安; 韩根成; 王仁喜; 宋伦; 池木根; 沈倍奋; 黎燕。重症肌无力小鼠模型的建立。《中国实验动物学报》。2006-02-28。2006. 14:59-62.

19.     王仁喜; 黎燕。T细胞耐受的信号转导研究进展。《细胞与分子免疫学杂志》2005. 21 (Suppl): S8-S9. (综述)

20.     王仁喜; 王建安; 宋伦; 韩根成; 沈倍奋; 吴小兵; 黎燕。用于IDDM基因治疗的rAAV2-GAD-Ig的研制。《细胞与分子免疫学杂志》2005-01-18。2005. 21: 24-28.

21.     王建安; 王仁喜; 宋伦; 钱家华; 韩根成; 沈倍奋; 黎燕。GAD抗原肽抗体对IDDM糖尿病基因治疗研究。《中华微生物学和免疫学杂志》。2004-07-30。2004. 24: 545-548.

22.     王仁喜; 黎燕。抗原肽抗体诱导抗原特异性免疫耐受。《细胞与分子免疫学杂志》。2003. 19: S23-S24. (综述)

 


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学校介绍


  首都医科大学建校于1960年,是北京市重点高等院校,著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部;附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。

  学校和附属医院现有教职员工和医护人员22575人。有院士4人,正高职称700余人,副高职称1800余人。学校学科专业齐全,学科力量雄厚,在基础和临床各专业拥有一大批具有很高造诣的专家学者,现有3个国家级重点学科,有38个博士学位授予权学科,58个硕士学位授予权学科和2个博士后科研流动站。

  校本部和附属医院总占地面积97.3万平方米,总建筑面积134万平方米 ,固定资产总值近46.5亿元,图书馆藏书108.3万册 ,住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学;五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等;四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向;在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才,位于全国先进医学院校行列的高等学府。

  学校具有较强的学术发展与科研实力,在校本部和附属医院建有一批国家级和市级重点学科和重点实验室,建有高水平的国家级或市级研究和培训机构,如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉,很多学科的研究和医疗水平已经达到或接近国际先进水平。

  学校十分重视对外交流与合作,改革开放以来,先后与世界20多个国家和地区签定了友好交流协议, 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时,学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。

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