公共卫生学院-陈瑞导师介绍

更新于 2023-10-19 导师主页
陈瑞 教授 硕，博士生导师
男
公共卫生学院
卫生毒理学
环境暴露组学,肿瘤表观遗传学、纳米载药体系及细胞免疫治
ruichen@ccmu.edu.cn

首都医科大学公共卫生学院院长，国家杰出青年基金获得者，青年北京学者，教授，博士生导师。主要从事环境化合物健康效应的生物学机制和评价体系研究。2015年入选中组部“青年千人计划”，主持国家自然科学基金重点项目、国家自然科学基金国际合作项目、国家自然科学基金重大研究计划集成项目子课题、科技部重点研发计划（子课题）等项目。以第一作者和通讯作者在Science，Nature Medicine，  Advanced Science，Hepatology，PNAS，Nano Today，Acs Nano，Cancer Research等期刊发表SCI收录论文50余篇，获得国家发明专利授权4项，参编教材3部。担任中华预防医学会卫生毒理学分会副主任委员、中国毒理学会呼吸毒理学副主任委员、中国营养学会营养与组学技术分会副主任委员、国家健康科普专家等学术兼职。


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科研项目

研究成果

(1) Ren C, Yan R, Yuan Z, Yin L, Li H, Ding J, Wu T*, Chen R*. Maternal exposure to sunlight-irradiated graphene oxide induces neurodegeneration-like symptoms in zebrafish offspring through intergenerational translocation and genomic DNA methylation alterations. Environ Int, 2023 Sep;179:108188. doi: 10.1016/j.envint.2023.108188 .

(2) Wang J, Shen S, Yan B, He Y, Zhang G, Shan C, Yang Q, Qin L, Duan Z, Jiang L, Wang X, Wei X, Wang C, Chen R*, Zhang L*. Individual exposure of ambient particulate matters and eosinophilic chronic rhinosinusitis with nasal Polyps: Dose-Response, mediation effects and recurrence prediction. Environ Int, 2023 Jul;177:108031. doi: 10.1016/j.envint.2023.108031 .

(3) Ren Q, Ma J, Li X, Meng Q, Wu S, Xie Y, Qi Y*, Liu S, Chen R*. Intestinal Toxicity of Metal Nanoparticles: Silver Nanoparticles Disorder the Intestinal Immune Microenvironment. ACS Appl Mater Interfaces. 2023 Jun 14;15(23):27774-27788. doi: 10.1021/acsami.3c05692 .

(4) Wu S, Yun J, Tang W, Familiari G, Relucenti M, Wu J, Li X, Chen H*, Chen R*, Therapeutic m6A Eraser ALKBH5 mRNA-Loaded Exosome-Liposome Hybrid Nanoparticles Inhibit Progression of Colorectal Cancer in Preclinical Tumor Models, ACS Nano, 2023 Jun 27;17(12):11838-11854.

(5) Shenshen Wu, Jiajia Wang Zan Fu, Giuseppe Familiari, Michela Relucenti, Michael Aschner, Xiaobo Li, Hanqing Chen*, Rui Chen*, Matairesinol Nanoparticles Restore Chemosensitivity and Suppress Colorectal Cancer Progression in Preclinical Models: Role of Lipid Metabolism Reprogramming, Nano Letters, 2023 Mar 8;23(5):1970-1980.

(6) Qingtao Meng, Hao Sun, Shenshen Wu, Giuseppe Familiari, Michela Relucenti, Aschner, Xiaobo Li*, Rui Chen*, Epstein-Barr Virus-encoded MicroRNA-BART18-3p Promotes Colorectal Cancer Progression by Targeting de novo Lipogenesis, Advanced Science, 2022, Oct 28;e2202116.

(7) Qingtao Meng, Jing Wang, Bo Jiang, Xinwei Zhang, Jie Xu, Yuanyuan Cao, Hongbao Yang, Shenshen Wu, Na Gao, Yu Zhang, Jin Xu, Hanqing Chen*, Xiaobo Li*, Rui Chen*, SiRNA-based delivery nanoplatform attenuates the CRC progression via HIF1α-AS2, Nano Today, 2022, 101667.

(8) Sun H, Meng Q, Shi C, Yang H, Li X, Wu S, Familiari G, Relucenti M, Aschner M, Wang X*, Chen R*. Hypoxia-inducible exosomes facilitate liver-tropic pre-metastatic niche in colorectal cancer. Hepatology. 2021 Nov;74(5):2633-2651.

(9) Li X, Sun H, Li B, Zhang X, Cui J, Yun J, Yang Y, Zhang L, Meng Q, Wu S, Duan J, Yang H, Wu J, Sun Z, Zou Y, Chen R*. Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure. Advanced Science, 2019 Jul 22;6(18):1900972. DOI: 10.1002/advs.201900972 IF: 17.521 Q1 .

(10) Yang H, Li X, Meng Q, Sun H, Wu S, Hu W, Liu G, Li X, Yang Y*, Chen R*. CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer. Mol Cancer. 2020 Jan 23;19(1):13.

(11) Li X, Cui J, Yang H, Sun H, Lu R, Gao N, Meng Q, Wu S, Wu J, Aschner M, Chen R*. Colonic Injuries Induced by Inhalational Exposure to Particulate-Matter Air Pollution. Advanced Science. 2019 Apr 9;6(11):1900180. doi: 10.1002/advs.201900180 IF: 17.521 Q1 .

(12) Meng Q#, Wu S#, Wang Y, Sun H, Lu R, Gao N, Yang H, Li X, Achner M, Chen R*. MPO promoter polymorphism rs2333227 enhances malignant phenotypes of colorectal cancer by altering the binding affinity of AP-2α. Cancer Res. 2018 May 15;78(10):2760-2769. doi: 10.1158/0008-5472.CAN-17-2538 IF: 13.312 Q1 .

(13) Li X, Yang H, Sun H, Lu R, Zhang C, Gao N, Meng Q, Wu S, Wang S, Achner M, Wu J, Tang B, Gu A, Kay S*, Chen R*, Taurine Ameliorates Particulate Matter-induced Emphysema by Switching on Mitochondrial NADH Dehydrogenase Genes, Proceedings of the National Academy of Sciences. 2017 Nov 7; 114(45): E9655-E9664. 

(14) Li X, Yang H, Wu S, Meng Q, Sun H, Lu R, Cui J, Zheng Y, Chen W, Zhang R, Aschner M, Chen R*. Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway. Particle and fibre toxicology. 2017 Dec 12;14(1):53. doi: 10.1186. 

(15) Qingtao Meng#, Jiajia Wang#, Jian Cui#, Bin Li, Shenshen Wu, Jun Yun, Michael Aschner, Chengshuo Wang, Luo Zhang*, Xiaobo Li*, Rui Chen*, Prediction of COPD Acute Exacerbation in Response to Air Pollution using Exosomal circRNA Profile and Machine Learning, Environment International, 2022 Aug 20;168:107469. 

(16) Shenshen Wu, Lijia Yin, Ke Han, Bo Jiang, Qingtao Meng, Michael Aschner, Xiaobo Li, Rui Chen*, NAT10 accelerates pulmonary fibrosis through N4-acetylated TGFB1-initiated epithelial-to-mesenchymal transition upon ambient fine particulate matter exposure. Environmental Pollution. 2023 Apr 1;322:121149. 

(17) Qing Li, Xiaobo Li, Pengyou Zhou, Rui Chen***, Rui Xiao**, Yuanfeng Pang*, Split aptamer regulated CRISPR/Cas12a biosensor for 17β-estradiol through a gap-enhanced Raman tags based lateral flow strategy. Biosensors and Bioelectronics.2022 Nov 1;215:114548. 

(18) Shenshen Wu, Xi Yang, Weiyan Tang, Giuseppe Familiari, Michela Relucenti, Michael Aschner, Xiaobo Li*, Rui Chen*, Chemotherapeutic Risk lncRNA-PVT1 SNP Sensitizes Metastatic Colorectal Cancer to FOLFOX Regimen. Frontiers in Oncology. 2022 Mar 31;12:808889. 

(19) Yanran Huang#, Yuan Zhang#, Jiajia Wang, Xiaobo Li, Chengshuo Wang, Rui Chen*, Luo Zhang*, Impact of Air Pollutants and Pollen on the Severity of Nonallergic Rhinitis: A Data-Oriented Analysis. Journal of Asthma and Allergy, 2022 Aug 6;15:1045-1054. 

(20) Wang J(#), Wu S(#), Cui J, Ding Z, Meng Q, Sun H, Li B, Teng J, Dong Y, Aschner M, Wu S, Li X, Chen R*, The influences of ambient fine particulate matter constituents on plasma hormones, circulating TMAO levels and blood pressure: A panel study in China. Environmental Pollution. 2022 Mar 1;296:118746. 

(21) Meng Q(#), Li B(#), Huang N, Wei S, Ren Q, Wu S, Li X*, Chen R*, Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential. Journal of Hazardous Materials. 2022 Feb 15;424(Pt B):127354. 

(22) Guan R, Wang T, Dong X, Du K, Li J, Zhao F, Xu J, Li B, Zheng G, Shen X, Cao B, Wang J, Aschner M, Liu M, Chen R*. Effects of co-exposure to lead and manganese on learning and memory deficits. Journal of Environmental Sciences. 2021.doi:10.1016/j.jes.2021.09.012 . 

(23) Xu J, Meng Q, Sun H, Zhang X, Yun J, Li B, Wu S, Li X, Yang H, Zhu H, Aschner M, Relucenti M, Familiari G, Chen R*, HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer. Cell Death & Disease. 2021 Nov 27;12(12):1109.

(24) Fu Y, Li B, Yun J, Xu J, Meng Q, Li X*, Chen R*. lncRNA SOX2-OT ceRNA network enhances the malignancy of long-term PM 2.5-exposed human bronchial epithelia. Ecotoxicology and Environmental Safety. 2021 Jul 1; 217: 112242.

(25) Li B, Huang N, Wei S, Xu J, Meng Q, Aschner M, Li X*, Chen R*. lncRNA TUG1 as a ceRNA promotes PM exposure-induced airway hyper-reactivity. Journal of Hazardous Materials. 2021 Aug: 15 (416).

(26) Zhang X, Zhang Y, Meng Q, Sun H, Wu S, Xu J, Yun J, Yang Y, Li B, Zhu H, Xue L, Li X, Chen R*. MicroRNA-382-5p Is Involved in Pulmonary Inflammation Induced by Fine Particulate Matter Exposure. Environ Pollut, 2020 Jul;262:114278.

(27) Li X, Zhang Y, Li B, Yang H, Cui J, Li X, Zhang X, Sun H, Meng Q, Wu S, Li S, Wang J, Aschner M, Chen R*. Activation of NLRP3 in Microglia Exacerbates Diesel Exhaust Particles-Induced Impairment in Learning and Memory in Mice. Environ Int, 2020 Mar;136:105487.

(28) Yang X, Wu S, Li X, Yin Y, Chen R*. MAGI2-AS3 rs7783388 Polymorphism Contributes to Colorectal Cancer Risk Through Altering the Binding Affinity of the Transcription Factor GR to the MAGI2-AS3 Promoter. J Clin Lab Anal.2020 Jun 12; e23431.doi: 10.1002/jcla.23431 .

(29) Kassim SA, Abbas M, Tang Wy, Wu Ss, Meng QT, Naee S, Li X, Chen R*. Retrospective study on melanosis coli as risk factor of colorectal neoplasm: a 3-year colonoscopic finding in Zhuhai Hospital, China. International Journal of Colorectal Disease. 2020 Feb;35(2):213-222. 

(30) Li X(#), Zhang Y(#), Li B, Cui J, Gao N, Sun H, Meng Q, Wu S, Bo J, Yan L, Wu J, Chen R*. Prebiotic protects against anatase titanium dioxide nanoparticles-induced microbiota-mediated colonic barrier defects. NanoImpact. 2019 Feb: 14. 

(31) Li Y(#), Duan J(#), Chai X, Yang M, Wang J, Chen R*, Sun Z*. Microarray- assisted size-effect study of amorphous silica nanoparticles on human bronchial epithelial cells. Nanoscale. 2019 Dec 21;11(47):22907-22923. 

(32) Yun J, Yang H, Li X, Sun H, Meng Q, Wu S, Zhang X, Yang X, Li B, Chen R*. Up-regulation of miR-297 mediates aluminum oxide nanoparticle-induced lung inflammation through activation of Notch pathway. Environ Pollut. 2019 Dec 23; 259:113839. 

(33) Kassim SA(#), Yang X(#), Abbas M, Wu S, Faran Ashraf Baig MM, Meng QT, Zhang C, Li X, Chen R*. Pri-miR-34b/c rs4938723 Polymorphism is Associated with Decreased Risk and Better Prognosis for Colorectal Cancer Patients. Arch Med Res. 2019 Feb;50(2):55-62. 

(34) Wang Y, Wu S, Yang X, Li X, Chen R*. Association between polymorphism in the promoter region of lncRNA GAS5 and the risk of colorectal cancer. Biosci Rep. 2019 Apr 16;39(4). 

(35) Abasse Kassim S, Tang W, Abbas M, Wu S, Meng Q, Zhang C, Li X, Chen R*. Clinicopathologic and epidemiological characteristics of prognostic factors in post-surgical survival of colorectal cancer patients in Jiangsu Province, China. Cancer Epidemiol. 2019 Jul 16;62:101565. 

(36) Wu S, Sun H, Wang Y, Yang X, Meng Q, Yang H, Zhu H, Tang W, Li X, Aschner M, Chen R*. MALAT1 rs664589 polymorphism inhibits binding to miR-194-5p contributing to colorectal cancer risk, growth and metastasis. Cancer Res. 2019 Jul 16.

(37) Xu J#, Meng Q#, Li X, Yang H, Xu J, Gao N, Sun H, Wu S, Familiari G, Relucenti M, Zhu H, Wu J, Chen R*. Long non-coding RNA MIR17HG promotes colorectal cancer progression via miR-17-5p. Cancer Res. 2019 Aug 13.

(38) Wu S, Meng Q, Zhang C, Sun H, Lu R, Gao N, Yang H, Li X, Achner M, Chen R*. DR4 mediated progression, invasion, metastasis and survival of colorectal cancer through the SP1/NF1 switch axis on genomic locus. Int J Cancer. 2018 Jul 15;143(2):289-297. doi: 10.1002/ijc.31318 IF: 7.316 Q1 .


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学校介绍


　　首都医科大学建校于1960年，是北京市重点高等院校，著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部；附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。

　　学校和附属医院现有教职员工和医护人员22575人。有院士4人，正高职称700余人，副高职称1800余人。学校学科专业齐全，学科力量雄厚，在基础和临床各专业拥有一大批具有很高造诣的专家学者，现有3个国家级重点学科，有38个博士学位授予权学科，58个硕士学位授予权学科和2个博士后科研流动站。

　　校本部和附属医院总占地面积97.3万平方米，总建筑面积134万平方米 ，固定资产总值近46.5亿元，图书馆藏书108.3万册 ，住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学；五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等；四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向；在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才，位于全国先进医学院校行列的高等学府。

　　学校具有较强的学术发展与科研实力，在校本部和附属医院建有一批国家级和市级重点学科和重点实验室，建有高水平的国家级或市级研究和培训机构，如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉，很多学科的研究和医疗水平已经达到或接近国际先进水平。

　　学校十分重视对外交流与合作，改革开放以来，先后与世界20多个国家和地区签定了友好交流协议， 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时，学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。

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