公共卫生学院-周显青导师介绍

更新于 2023-10-19 导师主页
周显青 教授 硕,博士生导师
公共卫生学院
卫生毒理学
生殖毒理学/环境毒理学
xqzhou@ccmu.edu.cn

       主要从事环境有害化学物质(内分泌干扰物、纳米颗粒、PM2.5,尤其是持久性有机污染物)的有害生物效应及其毒作用机制研究,特别是在生殖毒理方面有很好的工作基础。先后主持和参与省部级以上科研项目近20项,其中主持包括国家自然科学基金委国际(地区)合作与交流项目和面上项目等9项;在Environment International、Journal ofHazardous Materials、Scienceof the Total Environment 和Environmental Pollution等SCI收录的国外期刊和国家核心期刊发表论文130多篇,其中发表SCI论文100余篇;获批国家发明专利1项。先后获北京市优秀人才、北京市优秀中青年骨干教师和首都医科大学优秀教师等荣誉称号和资助。

      兼任中国环境诱变剂学会委员、中国环境诱变剂学会环境与生育健康专业委员会常务委员,中国动物学会生理生态学专业委员会常务委员、中国毒理学会免疫毒理学专业委员会常务委员、中国预防医学会卫生毒理专业委员会委员、中国动物学会生殖生物学专业委员会委员、中国生理学会比较生理专业委员会委员,中国毒理学会毒理学教育专业委员会委员,中国毒理学会生殖毒理专业委员会委员、北京预防医学会卫生毒理专业委员会常务委员等。《毒理学杂志》编委。


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科研项目

先后主持和参与省部级以上科研项目和人才项目近20项,其中主持国家自然科学基金9项。以下为近五年主持的省部级以上科研项目:

1. 国家自然科学基金委国际(地区)合作与交流项目(内地-澳门),32261160641,环境纳米颗粒暴露对生殖发育和功能的影响及其调 控机制研究,直接费用:165.00万元,2023/01-2025/12, 在研,主持。

2. 国家自然科学基金项目,32171492,支持细胞在环境十溴联苯醚致小鼠精子发生障碍中的调控作用 ,直接费用:59.00万元,2022/01-2025/12, 在研,主持。

3. 国家自然科学基金项目,31971415,减数分裂调控因子和组蛋白泛素化途径在环境十溴联苯醚致小鼠精子发生障碍中的调控作用,直接费用:58.00万元,2020/ 01-2023/12, 在研,主持。

4. 国家自然科学基金项目,31770441,环境多溴联苯醚对小鼠精子发生过程的影响及其机制研究,直接费用:55.00万元,2018/ 01-2021/12,已结题,主持。

5. 国家重点研发计划重点专项, 2017YFC0211600,大气污染对呼吸和心血管系统健康影响的早期识别技术,2017/07-2020/12,2967万元,已结题,参加。

6.北京市教委科技发展计划暨北京市自然科学基金重点项目,KZ201510025028,环境纳米二氧化硅对生精过程的影响及其机制研究,2015/01-2017/12, 50万,已结题,主持。



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研究成果

近年发表的部分SCI论文:

1. Guiqing Zhou#, Ji Wang#, Lihua Ren, Jianhui Liu, Xiangyang Li , Yue Zhang , Yujian Sang, Leqiang Gao, Yanbo Li, Zhiwei Sun, Xianqing Zhou*. Silica nanoparticles suppressed the spermatogenesis via downregulation of miR-450b-3p by targeting Layilin in spermatocyte of mouse. Environmental Pollution, Environmental Pollution, 2023, 318: 120864. (5 year IF=10.3659,Q1)

2. Yue Zhang, Jianhui Liu, Xiangyang Li, Guiqing Zhou, Yujian Sang, Mingyuan Zhang , Leqiang Gao, Jinglong Xue, Moxuan Zhao, Huanling Yu*, Xianqing Zhou*. Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice. Food and Chemical Toxicology,2023,171:113556. (共通讯)

3. Xiangyang Li#, Yue Zhang#, Leqiang Gao, Xiaodi Yang, Guiqing Zhou, Yujian Sang, Jinglong Xue, Zhixiong Shi , Zhiwei Sun, Xianqing Zhou. BDE-209 induced spermatogenesis disorder by inhibiting SETD8/ H4K20me1 related histone methylation in mice. Science of the Total Environment,2023,864:161162.. (5 year IF=10.237,Q1)

4. JianhuiLiu, Jing Huang, Leqiang Gao, Yujian Sang, Xiangyang Li, Guiqing Zhou, LinlinCao, Hong Lu, Xianqing Zhou*, Lihua Ren*.Maternalexposure to PM2.5 disrupting offspring spermatogenesis through induced sertolicells apoptosis via inhibin B hypermethylation in mice. Ecotoxicology andEnvironmental Safety,2022, 241:113760. (5 year IF=7.2845)

5. Leqiang Gao# , Yue Zhang#, Jianhui Liu , Xiangyang Li,Yujian Sang, Guiqing Zhou, Jinglong Xue , Li Jing , Zhixiong Shi, Jialiu Wei *, Xiangfeng Lu, Xianqing Zhou*..Fat mass and obesity-associated gene(FTO) hypermethylation induced by decabromodiphenyl ethane causing cardiacdysfunction via glucolipid metabolism disorder. Ecotoxicology and EnvironmentalSafety, 2022, 237:113534. (5 year IF=7.2845)

6.Yupeng Zhu#,Li Jing#,Xiangyang Li,GuiqingZhou,Yue Zhang,Yujian Sang,LeqiangGao,Sitong Liu,Zhixiong Shi,ZhiweiSun,Wei Ge*,Xianqing Zhou*. Decabromodiphenyl ether-inducedPRKACA hypermethylation contributed to glycolipid metabolism disorder viaregulating PKA/AMPK pathway in rat and L-02 cells. Environmental Toxicology andPharmacology,2022,90:103808. (5 year IF=4.9521)

7. MingmingQin, Qingping Xie, Kun Wu, Xianqing Zhou, Wei Ge*. Loss of Noboxprevents ovarian differentiation from juvenile ovaries in zebrafish, Biologyof Reproduction, 2022;, ioac036, https://doi.org/10.1093/biolre/ioac036 (5 year IF=4.5216)

8. Xiangyang Li, Jianhui Liu, Guiqing Zhou, Yujian Sang, Yue Zhang, LiJing, Zhixiong Shi, Xianqing Zhou*,Zhiwei Sun. BDE-209 and DBDPE induce male reproductive toxicity throughtelomere-related cell senescence and apoptosis in SD rat. EnvironmentInternational, 2021, 146: 106307. (5 year IF=13.2380)

9. Yupeng Zhu#, Li Jing#, Xiangyang Li, Dan Zheng,Guiqing Zhou, Yue Zhang, Yujian Sang, Zhixiong Shi, Zhiwei Sun, XianqingZhou*. Decabromodiphenyl ether disturbs hepatic glycolipid metabolism byregulating the PI3K/AKT/GLUT4 and mTOR/PPARγ/RXRα pathway in mice and L02cells. Science of The Total Environment, 2021, 763: 142936. (5 yearIF=10.237)

10. Guiqing Zhou, Jianhui Liu, Xiangyang Li, Yujian Sang, Yue Zhang,Leqiang Gao, Ji Wang , Yang Yu, Wei Ge, Zhiwei Sun, Xianqing Zhou*.Silica nanoparticles inducing the apoptosis via microRNA-450b-3p targetingMTCH2 in mice and spermatocyte cell. Environmental Pollution,2021,277:116771.(5 yearIF=10.3659)

11.Hua Qin, Jiao Chen,Yang Li,Lifang Gao, JiWang, Guangbo Qu, ManYang*, XianqingZhou, Zhiwei Sun. Inflammatory response induced by black phosphorusnanosheets in mice and macrophages. Science of The Total Environment, 2021,782: 146860. (5 year IF=10.2371)

12. Xiangyang Li#, Yue Zhang#,Xiaomin Dong , Guiqing Zhou , Yujian Sang , Leqiang Gao, Xianqing Zhou*,Zhiwei Sun. DNA methylation changes induced by BDE-209 are related to DNAdamage response and germ cell development in GC-2spd. Journal of environmentalsciences, 2021, 109: 161-170.  (5 year IF=6.1275)

13.Jianhui Liu, Xiangyang Li, Guiqing Zhou, Yue Zhang, Yujian Sang, JiWang, Yanbo Li, Wei Ge, Zhiwei Sun, Xianqing Zhou*. Silica nanoparticlesinhibiting the differentiation of round spermatid and chromatin remodeling ofhaploid period via MIWI in mice. Environmental Pollution, 2021, 284, 117446. (5year IF=10.36591)

14. Yue Zhang#,Xiangyang Li#, Guiqing Zhou, Yujian Sang, Leqiang Gao, Shuqin Jiang*, Zhixiong Shi, Wei Ge, Zhiwei Sun, Xianqing Zhou*. Decabromodiphenyl ether inducesmale reproductive toxicity by activating mitochondrial apoptotic pathwaythrough glycolipid metabolism dysbiosis. Chemosphere, 2021, 285: 131512. (5 year IF=8.5197)

15. Li Jing, Yanmin Sun, Ji Wang, Xianqing Zhou,Zhixiong Shi*. Oxidative stress and endoplasmic reticulum stress contributed tohepatotoxicity of decabromodiphenyl ethane (DBDPE) in L-02 cells. Chemosphere,2021,286(2022):131550. (5 year IF=8.5197)

16. Guiqing Zhou #, Lihua Ren#, HaipingYin , Jianhui Liu, Xiangyang Li , Ji Wang , Yanbo Li , Yujian Sang, YanzhiZhao*, Xianqing Zhou*, Zhiwei Sun. The alterations of miRNA and mRNAexpression profile and their integration analysis induced by silicananoparticles in spermatocyte cells. NanoImpact, 2021, 23 :100348. (5 year IF=6.4942)

17. Yujian Sang, Jianhui Liu, Xiangyang Li, Guiqing Zhou, Yue Zhang,Leqiang Gao, Yanzhi Zhao*, Xianqing Zhou*. The effect of SiNPs on DNAmethylation of genome in mouse spermatocytes, Environmental Science andPollution Research, 2021, 28: 43684-43697. (5 year IF=5.0530)

18. Lianshuang Zhang#, Jialiu Wei#, Junchao Duan#,Caixia Guo, Jin Zhang, Lihua Ren, Jianhui Liu, Yanbo Li*, Zhiwei Sun, Xianqing Zhou*. Silica Nanoparticlesexacerbates reproductive toxicity development in high-fat diet-treated Wistarrats. Journal of Hazardous Materials, 2020, 384: 121361. (5 year IF=12.9845)

19. Lihua Ren, Jing Huang, Jialiu Wei, Zang Yu, Yang Zhao, Shaowei Wu,Xiaohong Zhao, Xianqing Zhou, Zhiwei Sun, Hong Lu*. Maternal exposure tofine particle matters cause autophagy via UPR-mediated PI3K-mTOR pathway intesticular tissue of adult male mice in offspring. Ecotoxicology andEnvironmental Safety, 2020, 189: 109943. (5 year IF=7.2845)

20. Yanmin Sun, Yuwei Wang, Baolu Liang, Tian Chen, Dan Zheng, XuezhenZhao, Li Jing*, Xianqing Zhou, Zhiwei Sun, Zhixiong Shi*. Hepatotoxicityof decabromodiphenyl ethane (DBDPE) and decabromodiphenyl ether (BDE-209) in28-day exposed Sprague-Dawley rats. Science of the Total Environment, 2020,705: 135783. (5 year IF=10.237)

21. Jialiu Wei, Jianhui Liu, Lianshuang Zhang, Yupeng Zhu, Xiangyang Li, GuiqingZhou, Yanzhi Zhao*, Zhiwei Sun, Xianqing Zhou*. Endosulfan inducescardiotoxicity through apoptosis via unbalance of pro-survival andmitochondrial-mediated apoptotic pathways. Science of the Total Environment,2020, 727: 138790. (5 year IF=10.237)

22. Jianhui Liu, Xiangyang Li, Guiqing Zhou, Yujian Sang, Yue Zhang,Yanzhi Zhao, Wei Ge, Zhiwei Sun, Xianqing Zhou*. Silica nanoparticlesinduce spermatogenesis disorders via L3MBTL2-DNA damage-p53 apoptosis andRNF8-ubH2A/ubH2B pathway in mice. Environmental Pollution, 2020, 265: 114974. (5year IF=10.3659)

23. Lihua Ren, Jianhui Liu, Jialiu Wei, Yefan Du, Kaiyue Zou, YongyangYan, Zhihao Wang, Linruo Zhang, Tong Zhang, Hong Lu, Xianqing Zhou*,Zhiwei Sun. Silica nanoparticles induce unfolded protein reaction mediatedapoptosis in spermatocyte cells. Toxicology Research, 2020, 9(4): 454-460. (5year IF=2.9500)

24. Yupeng Zhu, Xiangyang Li, Jianhui Liu, Guiqing Zhou, Yang Yu*, LiJing, Zhixiong Shi, Xianqing Zhou*, Zhiwei Sun. The effects ofdecabromodiphenyl ether on glycolipid metabolism and related signaling pathwaysin mice. Chemosphere, 2019, 222: 849-855. (5 year IF=8.5197)

25. Lihua Ren#, Jin Zhang#, Ji Wang, Jialiu Wei,Jianhui Liu, Xiangyang Li, Yupeng Zhu, Yanbo Li, Caixia Guo, Junchao Duan,Zhiwei Sun, Xianqing Zhou*. Silica nanoparticles induce spermatocytecell apoptosis 2 through microRNA-2861 targeting death receptor pathway.Chemosphere, 2019, 228: 709-720. (5 year IF=8.5197)

26. Jianhui Liu#, Jin Zhang#, Lihua Ren, JialiuWei, Yupeng Zhu, Junchao Duan, Li Jing, Zhiwei Sun*, Xianqing Zhou*.Fine particulate matters induce apoptosis via the ATM/P53/CDK2 and mitochondriaapoptosis pathway triggered by oxidative stress in rat and GC-2spd cell.Ecotoxicology and Environmental Safety, 2019, 180: 280–287. (5 yearIF=7.2845)

27. Yanbo Li, Ru Ma, Xiaoying Liu, Yi Qi, Alimire Abulikemul, XinyingZhao, Huawei Duan, Xianqing Zhou, Caixia Guo*, Zhiwei Sun*. Endoplasmicreticulum stress-dependent oxidative stress mediated vascular injury induced bysilica nanoparticles in vivo and in vitro. NanoImpact, 2019, 14: 100169. (5year IF=6.4942)

28. Xiangyang Li, Yupeng Zhu, Chonghai Zhang, Jianhui Liu, Guiqing Zhou,Li Jing, Zhixiong Shi, Zhiwei Sun, Xianqing Zhou*. BDE-209 induces malereproductive toxicity via cell cycle arrest and apoptosis mediated by DNAdamage response signaling pathways. Environmental Pollution, 2019, 255: 113097. (5 year IF=10.3659)

29. Lihua Ren#, Jianhui Liu#, Jin Zhang, Ji Wang,Jialiu Wei, Yanbo Li, Caixia Guo, Zhiwei Sun, Xianqing Zhou*. Silicananoparticles induce spermatocyte cell autophagy through microRNA-494 targetingAKT in GC-2spd cells. Environmental Pollution, 2019, 255: 113172.  (5 year IF=10.3659)

30. Yuwei Wang, Tian Chen, Yanmin Sun, Xuezhen Zhao, Dan Zheng, Li Jing*,Xianqing Zhou, Zhiwei Sun, Zhixiong Shi*. A comparison of the thyroiddisruption induced by decabrominated diphenyl ethers (BDE-209) and decabromodiphenylethane (DBDPE) in rats. Ecotoxicology and Environmental Safety, 2019, 174:224-235. (5 year IF=7.2845)

31. Li Jing, Yanmin Sun, Yuwei Wang, Baolu Liang, Tian Chen, Dan Zheng,Xuezhen Zhao, Xianqing Zhou, Zhiwei Sun, Zhixiong Shi*. Cardiovasculartoxicity of decabrominated diphenyl ethers (BDE-209) and decabromodiphenylethane (DBDPE) in rats. Chemosphere, 2019, 223: 675-685. (5 year IF=8.5197)

32. Jiandi Wang, Yuwei Wang, Zhixiong Shi*, Xianqing Zhou, ZhiweiSun. Legacy and novel brominated flame retardants in indoor dust from Beijing,China: Occurrence, human exposure assessment and evidence for PBDEsreplacement. Science of The Total Environment, 2018, 618: 48-59. (5 yearIF=10.237)

33. Caixia Guo, Ru Ma, Xiaoying Liu, Tian Chen, Yang Li, Yang Yu, JunchaoDuan, Xianqing Zhou, Yanbo Li*, Zhiwei Sun*. Silica nanoparticlespromote oxLDL-induced macrophage lipid accumulation and apoptosis viaendoplasmic reticulum stress signaling. Science of The Total Environment, 2018,631-632: 570-579. (5 year IF=10.237)

34. Caixia Guo, Ji Wang, Li Jing, Ru Ma, Xiaoying Liu, Lifang Gao, LigeCao, Junchao Duan, Xianqing Zhou, Yanbo Li*, Zhiwei Sun. Mitochondrialdysfunction, perturbations of mitochondrial dynamics and biogenesis involved inendothelial injury induced by silica nanoparticles. Environmental Pollution,2018, 236: 926-936. (5 year IF=10.3659)

35. Jianhui Liu, Man Yang, Li Jing, Lihua Ren, Jialiu Wei,Feng Zhang, Junchao Duan, Xianqing Zhou*, Zhiwei Sun.Silica nanoparticle exposure inducing granulosa cell apoptosis and follicularatresia in female Balb/c mice. Environmental Science and Pollution Research,2018, 25: 3423-3434. (5 year IF=5.0530)

36. Jianhui Liu, Lihua Ren, Jialiu Wei, Jin Zhang, Yupeng Zhu,Xiangyang Li, Li Jing, Junchao Duan, Xianqing Zhou*,Zhiwei Sun. Fine particle matter disrupts the blood–testis barrier byactivating TGF-b3/p38 MAPK pathway and decreasing testosterone secretion inrat. Environmental Toxicology, 2018, 33(7): 711-719. (5 year IF=3.7470)

37. Jin Zhang#, Jianhui Liu#, Lihua Ren, JialiuWei, Junchao Duan, Lefeng Zhang*, Xianqing Zhou*, Zhiwei Sun. PM2.5induces male reproductive toxicity via mitochondrial dysfunction, DNA damageand RIPK1 mediated apoptotic signaling pathway. Science of the TotalEnvironment, 2018, 634: 1435–1444. (5 year IF=10.237)

38. Ji Wang, Yang Li, Junchao Duan, Man Yang, Yang Yu, Lin Feng, XiaozheYang, Xianqing Zhou, Zhendong Zhao*, Zhiwei Sun*. Silica nanoparticlesinduce autophagosome accumulation via activation of the EIF2AK3 and ATF6 UPRpathways in hepatocytes. Autophagy, 2018, 14(7): 1185-1200. (5 year IF=16.1425)

39. Jin Zhang#, Jianhui Liu#, Lihua Ren, JialiuWei, Feng Zhang, Yanbo Li, Caixia Guo, Junchao Duan, Zhiwei Sun, XianqingZhou*. Silica nanoparticles induce abnormal mitosis and apoptosis via PKC-δmediated negative signaling pathway in GC-2 cells of mice. Chemosphere, 2018,208: 942-950. (5 year IF=8.5197)

40. Caixia Guo, Ru Ma, Xiaoying Liu, Yinye Xia, Piye Niu, Junxiang Ma, XianqingZhou, Yanbo Li*, Zhiwei Sun. Silica nanoparticles induced endothelialapoptosis via endoplasmic reticulum stress-mitochondrial apoptotic signaling pathway.Chemosphere, 2018, 210: 183-192. (5 year IF=8.5197)

41. Yuwei Wang, Yanmin Sun, Tian Chen, Zhixiong Shi*, Xianqing Zhou,Zhiwei Sun, Lei Zhang, Jingguang Li*. Determination of polybrominated diphenylethers and novel brominated flame retardants in human serum by gaschromatography-atmospheric pressure chemical ionization-tandem massspectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 2018, 1099: 64-72.(5 year IF=3.1642)

42. Lianshuang Zhang, Jialiu Wei, Lihua Ren, JinZhang, Ji Wang, Li Jing, Man Yang, Yang Yu, Zhiwei Sun, Xianqing Zhou*. Endosulfaninduces autophagy and endothelial dysfunction via the AMPK/mTOR signalingpathway triggered by oxidative stress. Environmental Pollution, 2017, 220:843-852. (5 year IF=10.3659)

43. Jialiu Wei, Lianshuang Zhang, Lihua Ren, Jin Zhang, Yang Yu, Ji Wang,Junchao Duan, Cheng Peng, Zhiwei Sun, Xianqing Zhou*.Endosulfan induces proliferation inhibition through Notch signaling pathway in human umbilical vein endothelial cells.Environmental Pollution, 2017, 221: 26-36. (5 year IF=10.3659)

44. Ji Wang, Yongbo Yu, Ke Lu, Man Yang, Yang Li, Xianqing Zhou,Zhiwei Sun*. Silica nanoparticles induce autophagy dysfunction via lysosomalimpairment and inhibition of autophagosome degradation in hepatocytes.International Journal of Nanomedicine, 2017, 12: 809–825. (5 year IF=7.4194)

45. Jian Li#, Tian Chen#, Yuwei Wang, ZhixiongShi*, Xianqing Zhou, Zhiwei Sun, Dejun Wang*, Yongning Wu. Simple andfast analysis of tetrabromobisphenol A, hexabromocyclododecane isomers, andpolybrominated diphenyl ethers in serum using solid-phase extraction orQuEChERS extraction followed by tandem mass spectrometry coupled to HPLC andGC. Journal of Separation Science, 2017, 40: 709–716. (5 year IF=2.9040)

46. Lianshuang Zhang, Jialiu Wei, Lihua Ren, Jin Zhang, Man Yang*, LiJing, Ji Wang, Zhiwei Sun, Xianqing Zhou*. Endosulfan inducing apoptosisand necroptosis through activation RIPK signaling pathway in human umbilicalvascular endothelial cells. Environmental Science and Pollution Research, 2017,24: 215–225. (5 year IF=5.0530)

47. Fangzi Guo#, Ying Xu#, Lihua Ren#,Jin Zhang, Feng Zhang, Junchao Duan, Xianqing Zhou*, Zhiwei Sun.Endosulfan induces apoptosis by activating the negative regulation pathway ofcell cycle and death receptor pathway in spermatogenic cells. ToxicologyResearch, 2017, 6: 223-231. (5 year IF=2.9500)

48. Jialiu Wei, Lianshuang Zhang, Lihua Ren, Jin Zhang, Jianhui Liu,Junchao Duan, Yang Yu, Yanbo Li, Cheng Peng, Xianqing Zhou*, Zhiwei Sun.Endosulfan induces cell dysfunction through cycle arrest resulting from DNAdamage and DNA damage response signaling pathways. Science of the TotalEnvironment, 2017, 589: 97–106.  (5year IF=10.237)

49. Junchao Duan, Yang Yu, Yang Li, Li Jing, Man Yang, Ji Wang, Yanbo Li,Xianqing Zhou, Mark R. Miller, Zhiwei Sun*. Comprehensiveunderstanding of PM2.5 on gene and microRNA expression patterns in zebrafish(Danio rerio) model. Science of the Total Environment, 2017, 586: 666-674. (5 year IF=10.237)

50. Zhixiong Shi*, Lei Zhang, Yunfeng Zhao, Zhiwei Sun, Xianqing Zhou,Jingguang Li, Yongning Wu. A national survey of tetrabromobisphenol-A,hexabromocyclododecane and decabrominated diphenyl ether in human milk fromChina: Occurrence and exposure assessment. Science of The Total Environment,2017, 599–600: 237-245.  (5 yearIF=10.237)

51. Zhixiong Shi*, Lei Zhang, Zhiwei Sun, Xianqing Zhou, JingguangLi*, Yongning Wu. Dietary exposure assessment of Chinese population totetrabromobisphenol-A, hexabromocyclododecane and decabrominated diphenylether: Results of the 5th Chinese Total Diet Study. Environmental Pollution,229: 539-547. (5 year IF=10.3659)

52. Li Jing, Man Yang, Yang Li, Yang Yu, Baolu Liang, Lige Cao, XianqingZhou, Shuangqing Peng*, Zhiwei Sun*. Metallothionein prevents doxorubicincardiac toxicity by indirectly regulating the uncoupling proteins 2. Food andChemical Toxicology, 2017, 110: 204-213. (5 year IF=5.6922)

53. Caixia Guo, Ji Wang, Man Yang, Yang Li, Shuxiang Cui, XianqingZhou, Yanbo Li, Zhiwei Sun. Amorphous silica nanoparticles induce malignanttransformation and tumorigenesis of human lung epithelial cells via P53signaling. Nanotoxicology, 2017, 11(9-10): 1176-1194. (5 year IF=6.3193)

54. Zhixiong Shi*, Lei Zhang, Yunfeng Zhao, Zhiwei Sun, Xianqing Zhou,Jingguang Li*, Yongning Wu. A national survey of tetrabromobisphenol-A, hexabromocyclododecaneand decabrominated diphenyl ether in human milk from China: Occurrence andexposure assessment. Science of the Total Environment, 2017, 599–600: 237–245.  (5 year IF=10.237)


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学校介绍


  首都医科大学建校于1960年,是北京市重点高等院校,著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部;附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。

  学校和附属医院现有教职员工和医护人员22575人。有院士4人,正高职称700余人,副高职称1800余人。学校学科专业齐全,学科力量雄厚,在基础和临床各专业拥有一大批具有很高造诣的专家学者,现有3个国家级重点学科,有38个博士学位授予权学科,58个硕士学位授予权学科和2个博士后科研流动站。

  校本部和附属医院总占地面积97.3万平方米,总建筑面积134万平方米 ,固定资产总值近46.5亿元,图书馆藏书108.3万册 ,住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学;五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等;四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向;在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才,位于全国先进医学院校行列的高等学府。

  学校具有较强的学术发展与科研实力,在校本部和附属医院建有一批国家级和市级重点学科和重点实验室,建有高水平的国家级或市级研究和培训机构,如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉,很多学科的研究和医疗水平已经达到或接近国际先进水平。

  学校十分重视对外交流与合作,改革开放以来,先后与世界20多个国家和地区签定了友好交流协议, 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时,学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。

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